Category: Tetrahydrofurans

Vlasova, Nataliya; Markitan, Olga published the artcile< Phosphate-nucleotide-nucleic acid: Adsorption onto nanocrystalline ceria surface>, Computed Properties of 58-97-9, the main research area is cerium dioxide deoxyribonucleic acid phosphate nucleotide.

The adsorption of DNA (DNA) and its constituents – phosphate and nucleotides on the surface of nanocrystalline cerium dioxide (pHpzc = 6.3) in NaCl solutions was investigated using multi batch adsorption experiments over a wide range pH. The adsorption data of inorganic phosphate, and nucleotides were interpreted as a formation of outer and inner sphere surface complexes in term of the Basic Stern surface complexation model. The comparison of adsorptions of DNA, phosphate and nucleotides has revealed that double-stranded DNA is mainly adsorbed with the participation of phosphate backbone of its mol. The approach of DNA to the oxide surface due to the electrostatic attraction promotes other types of interaction, e.g. dispersion interaction and hydrogen bonding.

Colloids and Surfaces, A: Physicochemical and Engineering Aspects published new progress about DNA Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 58-97-9 belongs to class tetrahydrofurans, and the molecular formula is C9H13N2O9P, Computed Properties of 58-97-9.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Chuseang, Jirawat; Nakwachara, Rapeepong; Kalong, Munsuree; Ratchahat, Sakhon; Koo-amornpattana, Wanida; Klysubun, Wantana; Khemthong, Pongtanawat; Faungnawakij, Kajornsak; Assabumrungrat, Suttichai; Itthibenchapong, Vorranutch; Srifa, Atthapon published the artcile< Selective hydrogenolysis of furfural into fuel-additive 2-methylfuran over a rhenium-promoted copper catalyst>, SDS of cas: 97-99-4, the main research area is furfural hydrogenation methylfuran rhenium copper catalyst phys chem property.

The effect of Re promoter on Cu/γ-Al2O3 catalysts with various Cu : Re molar ratios was comprehensively investigated in comparison to the monometallic Cu/γ-Al2O3 and Re/γ-Al2O3 catalysts. The combination of Re and Cu resulted in a difficulty in reduction behavior of the Cu species, as detected using hydrogen temperature-programmed reduction, indicating that the Re promoter had stronger metal-support interactions. The acidity, as confirmed by ammonia temperature-programmed desorption, increased with the Re loading. X-ray diffraction and X-ray absorption near edge structure measurements of the spent CuRe catalyst revealed the existence of metallic Cu, Cu2O, CuO, amorphous CuAl2O4, ReO3, and NH4ReO4. The as-synthesized catalysts without reduction were directly utilized for the hydrogenolysis of furfural (FAL) into the fuel additive 2-methylfuran (2-MF). The highest 2-MF yield (86.4%) was accompanied by a 10.4% 2-methyltetrahydrofuran (2-MTHF) yield using the optimal Cu1Re0.14 catalyst under the investigated conditions (200°C, 6 h, and 20 bar H2). The kinetic study using furfuryl alc. (FOL), a primary intermediate, revealed that the rate of 2-MF production for the optimal Cu1Re0.14 catalyst was faster than that of the Cu benchmark. These results indicated that a small amount of oxophilic Re species could promote the hydrogenolysis of the C-OH bond in FOL to form 2-MF due to the synergistic effect between the Cu and Re active species. In addition, the activity of the Cu1Re0.14 catalyst remained highly stable through four consecutive experiments

Sustainable Energy & Fuels published new progress about Adsorption. 97-99-4 belongs to class tetrahydrofurans, and the molecular formula is C5H10O2, SDS of cas: 97-99-4.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Kiani, Salma; Staples, Richard J.; Ted Treves, S.; Packard, Alan B. published the artcile< Synthesis and characterization of a tetramethyl furanone functionalized diiminedioxime, a potential ligand for 64Cu radiopharmaceuticals, and its copper(II) and nickel(II) complexes>, Recommanded Product: 2,2,5,5-Tetramethyldihydrofuran-3(2H)-one, the main research area is copper nickel furanone functionalized imineoxime preparation structure; crystal structure copper nickel furanone functionalized imineoxime; furanone functionalized imineoxime preparation potential radiopharmaceutical imaging ligand.

As part of the authors’ on-going effort to develop 64Cu-based radiopharmaceuticals for PET (positron emission tomog.) imaging of multidrug resistance in cancer, the authors prepared a tetramethylfuranone-functionalized diiminedioxime ligand, TMFPreH (TMFPreH = 4-[3-(4-hydroxyimino-2,2,5,5-dimethyl-dihydro-furan-3-ylideneamino)-propylimino]-2,2,5,5-tetramethyl-dihydrofuran-3(2H)-one oxime) and its Cu(II) and Ni(II) complexes. When the Cu(II) complex was prepared from Cu(ClO4)2 in EtOH, it was isolated as a Cu(II)-bridged dimer, but when it was prepared from Cu(OAc)2 and heated in acetone, an unusual example of an acetone adduct of the ligand is formed by reduction of one of the imine double bonds by the solvent. The Ni(II) complex is square planar with the perchlorate counterion not bonded.

Polyhedron published new progress about Crystal structure. 5455-94-7 belongs to class tetrahydrofurans, and the molecular formula is C8H14O2, Recommanded Product: 2,2,5,5-Tetramethyldihydrofuran-3(2H)-one.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Zhang, Mei; Liu, Weili; Gao, Xia; Cui, Peng; Zou, Tao; Hu, Guanghui; Tao, Liming; Zhai, Lei published the artcile< Preparation and characterization of semi-alicyclic polyimides containing trifluoromethyl groups for optoelectronic application>, Electric Literature of 4415-87-6, the main research area is polyimide trifluoromethyl group optoelectronic application; alicyclic structure; polyimide; structure–property relationship; transparency; trifluoromethyl.

Transparent polyimides (PI) films with outstanding overall performance are attractive for next generation optoelectronic and microelectronic applications. Semi-alicyclic PIs derived from alicyclic dianhydrides and aromatic diamines have proved effective to prepare transparent PIs with high transmittance. To optimize the combined properties of semi-alicyclic PIs, incorporating bulky trifluoromethyl groups into the backbones is regarded as a powerful tool. However, the lack of fundamental understanding of structure-property relationships of fluorinated semi-alicyclic PIs constrains the design and engineering of advanced films for such challenging applications. Herein, a series of semi-alicyclic PIs derived from alicyclic dianhydrides and trifluoromethyl-containing aromatic diamines was synthesized by solution polycondensation at high temperature The effects of alicyclic structures and bulky trifluoromethyl groups on thermal, dielec. and optical properties of PIs were investigated systematically. These PI films had excellent solubility, low water absorption and good mech. property. They showed high heat resistance with Tg in the range of 294-390 °C. It is noted that tensile strength and thermal stability were greatly affected by the rigid linkages and alicyclic moieties, resp. These films exhibited obviously low refractive indexes and significantly reduced dielec. constants from 2.61 to 2.76, together with low optical birefringence and dielec. anisotropy. Highly transparent films exhibited cutoff wavelength even as low as 298 nm and transmittance at 500 nm over 85%, displaying almost colorless appearance with yellowness index (b*) below 4.2. The remarkable optical improvement should be mainly ascribed to both weak electron-accepting alicyclic units and bulky electron-withdrawing trifluoromethyl or sulfone groups. The present work provides an effective strategy to design mol. structures of optically transparent PIs for a trade-off between solution-processability, low water uptake, good toughness, high heat resistance, low dielec. constant and excellent optical transparency.

Polymers (Basel, Switzerland) published new progress about Absorption. 4415-87-6 belongs to class tetrahydrofurans, and the molecular formula is C8H4O6, Electric Literature of 4415-87-6.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Morandi, Sara; Manzoli, Maela; Chan-Thaw, Carine E.; Bonelli, Barbara; Stucchi, Marta; Prati, Laura; Stormer, Heike; Wang, Wu; Wang, Di; Pabel, Michael; Villa, Alberto published the artcile< Unraveling the effect of ZrO2 modifiers on the nature of active sites on AuRu/ZrO2 catalysts for furfural hydrogenation>, Recommanded Product: (Tetrahydrofuran-2-yl)methanol, the main research area is furfural hydrogenation ruthenium gold nanoparticle catalytic activity.

Ru and AuRu nanoparticles were prepared by a sol-immobilization methodol. and deposited on different doped zirconia supports (ZrO2, Y-ZrO2 and La-ZrO2). The catalysts were characterized by analytic transmission electron microscopy (TEM), Fourier transform IR spectroscopy (FTIR) in a controlled atm. and XPS. TEM anal. showed that AuRu catalysts consist of Au-Ru particle aggregates with small Ru particles enriched on the Au surface. FTIR experiments of adsorbed CO and XPS analyses revealed that the presence of gold modifies the electronic properties of Ru, confirming the bimetallic nature of AuRu nanoparticles. The catalysts were tested in furfural hydrogenation using isopropanol as the hydrogen donor. The addition of Au to Ru did not significantly modify the activity and selectivity but enhanced the resistance to deactivation. The acid-base properties were monitored by acetonitrile adsorption followed by FTIR spectroscopy. It was shown that the acidity of the support greatly influences the selectivity. In particular, 71% selectivity to gamma-valerolactone was achieved over AuRu/Y-ZrO2, due to the modified acidic strength of Zr4+ sites on the Y-doped oxide.

Sustainable Energy & Fuels published new progress about Absorption. 97-99-4 belongs to class tetrahydrofurans, and the molecular formula is C5H10O2, Recommanded Product: (Tetrahydrofuran-2-yl)methanol.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Hasegawa, Masatoshi; Takahashi, Shinya; Tsukuda, Soichi; Hirai, Tomoki; Ishii, Junichi; Yamashina, Yukari; Kawamura, Yoshinori published the artcile< Symmetric and asymmetric spiro-type colorless poly(ester imide)s with low coefficients of thermal expansion, high glass transition temperatures, and excellent solution-processability>, Reference of 4415-87-6, the main research area is spirofluorenylxanthenediol polyester polyimide thermal expansion transparency heat resistance solubility.

The authors present several new poly(ester imide)s (PEsIs) with low coefficients of thermal expansion (CTE), excellent optical transparency, very high heat resistance (Tg), film ductility, and solution-processability. Sym. and asym. spiro-type tetracarboxylic dianhydrides containing ester linkages (TA-s-Spiro and TA-a-Spiro) and diamines (AB-s-Spiro and AB-a-Spiro) were synthesized using xanthene-based isomeric bisphenols with a fluorenyl side group. The chem. imidized PEsIs were highly soluble in various common solvents including less polar nonamide solvents, and yielded stable solutions with high solid contents. The properties of the spiro-type PEsIs were systematically studied and compared with those of the cardo-type counterparts. A PEsI derived from 1,2,3,4-cyclobutanetetracarboxylic dianhydride (CBDA), AB-a-Spiro, and 2,2′-bis(trifluoromethyl)benzidine (TFMB) achieved outstanding combined properties, i.e., a very low CTE (10.5 ppm K-1), excellent optical transparency (YI = 3.4, T400 = 80.8%), a very high Tg (351°) and solution-processability. Thus, the PEsIs are promising candidates as novel plastic substrates for use in image display devices. The isomer effects on the properties were also studied and a possible mechanism for these effects is proposed.

Polymer published new progress about Atmospheric haze. 4415-87-6 belongs to class tetrahydrofurans, and the molecular formula is C8H4O6, Reference of 4415-87-6.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Qian, Min; Xuan, Xiao Yang published the artcile< Hyperthermal atomic oxygen durable transparent silicon-reinforced polyimide>, Electric Literature of 4415-87-6, the main research area is polyimide POSS erosion surface property atomic oxygen.

A clear poly(amic acid) was reinforced by a trisilanolphenyl polyhedral oligomeric silsesquioxane (POSS) by direct dissolution, and transparent silicon-reinforced polyimide (Si-RPI) films with different POSS loadings were obtained after curing, showing high transmittance of >90% within 380-800 nm. The Si-RPI films were exposed to a ground hyperthermal at. oxygen (AO) beam. The erosion depths and derived erosion yields of the materials decreased with POSS loadings. At a 20 wt% POSS loading, the Si-RPI showed an erosion yield of 0.13 x 10-24 cm3 atom-1 at a fluence of 2.79 x 1020 O atoms cm-2. Surface morphol. and element composition characterization on Si-RPI indicated that SiOx-based passivating layers were formed on surfaces upon the hyperthermal AO attack. This study suggests a facile way of reinforcing Si into transparent polyimide for a promising candidate of spacecraft coating material operating in low Earth orbit.

High Performance Polymers published new progress about Erosion (wear). 4415-87-6 belongs to class tetrahydrofurans, and the molecular formula is C8H4O6, Electric Literature of 4415-87-6.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Zalawadiya, Sandip K.; Lindenfeld, JoAnn; Shah, Ashish; Wigger, Mark; Danter, Matthew; Brinkley, D. Marshall; Menachem, Jonathan; Punnoose, Lynn; Balsara, Keki; Brown Sacks, Suzanne; Ooi, Henry; Perri, Roman; Awad, Joseph; Smith, Sarah; Fowler, Rachel; O’Dell, Heather; Darragh, Callie; Ruzevich-Scholl, Shelly; Schlendorf, Kelly published the artcile< Trends in Renal Function Among Heart Transplant Recipients of Donor-Derived Hepatitis C Virus>, Application In Synthesis of 58-97-9, the main research area is hepatitis C virus renal impairment heart transplantation sofosbuvir antiviral.

Donor-derived hepatitis C (dd-HCV) infection may increase the risk of renal impairment (RI) among heart transplantation (HT) recipients. Sofosbuvir, an integral component of HCV direct-acting antivirals (DAAs) has also been linked to RI. To date, no study has examined the trends in renal function for HT recipients of dd-HCV infection and assessed safety and efficacy of Sofosbuvir-based DAAs. Between Sept. 2016 and June 2018, 46 HCV-naive patients and one patient with a history of HCV treated pretransplant, underwent HT from HCV-pos. donors (follow-up available through Oct. 10, 2018). Patients were treated with Ledipasvir-Sofosbuvir (genotype 1) or Sofosbuvir-Velpatasvir (genotype 3) for 12 or 24 wk; no dose adjustments were made for renal function. Data on renal function were available for 23 patients who achieved a sustained virol. response at 12 wk after the treatment (SVR12; cohort A) and 18 patients who completed 1 yr of follow-up (cohort B). All patients tolerated DAAs well with 100% completion rate to the assigned therapy and duration and 100% success at achieving SVR12. In this first and largest reported case series to date of HT recipients with dd-HCV infection, we observed that neither the dd-HCV infection nor its treatment with Sofosbuvir-based DAAs increased the risk of RI. Sofosbuvir-based DAAs appear safe, tolerable, and effective for HCV treatment even in presence of severe RI.

ASAIO Journal published new progress about Antiviral agents (direct-acting antiviral). 58-97-9 belongs to class tetrahydrofurans, and the molecular formula is C9H13N2O9P, Application In Synthesis of 58-97-9.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Zhang, Qingfei; Kuang, Gaizhen; Zhou, Dongfang; Qi, Yanxin; Wang, Mingzhe; Li, Xiaoyuan; Huang, Yubin published the artcile< Photoactivated polyprodrug nanoparticles for effective light-controlled Pt(IV) and siRNA codelivery to achieve synergistic cancer therapy>, Reference of 4415-87-6, the main research area is photoactivated platinum polyprodrug nanoparticle Bcl2 siRNA synergy cancer therapy.

Endo/lysosomal escape and the subsequent controllable/precise release of drugs and genes are key challenges for efficient synergistic cancer therapy. Herein, we report a photoactivated polyprodrug nanoparticle system (PPNPsiRNA) centered on effective light-controlled codelivery of Pt(IV) prodrug and siRNA for synergistic cancer therapy. Under green-light irradiation, PPNPsiRNA can sustainedly generate oxygen-independent azidyl radicals to facilitate endo/lysosomal escape through the photochem. internalization (PCI) mechanism. Besides, concurrent Pt(II) release and siRNA unpacking could occur in a controllable manner after the decomposition of Pt(IV), main chain shattering of photoactivated polyprodrug and the PPNPsiRNA disassocn. Based on these innovative features, excellent synergistic therapeutic efficacy of chemo- and RNAi therapies of PPNPsiBcl-2 could be achieved on ovarian cancer cells under light irradiation The facile synthesized and prepared photoactivatable polyprodrug nanoparticle system provides a new strategy for effective gene/drug codelivery, where controllable endo/lysosomal escape and the subsequent drug/gene release/unpacking play vital roles, which could be adopted as a versatile codelivery nanoplatform for the treatment of various cancers.

Journal of Materials Chemistry B: Materials for Biology and Medicine published new progress about Antitumor agents. 4415-87-6 belongs to class tetrahydrofurans, and the molecular formula is C8H4O6, Reference of 4415-87-6.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Bruna, Lauriane; Cardona-Farreny, Miquel; Colliere, Vincent; Philippot, Karine; Axet, M. Rosa published the artcile< In Situ Ruthenium Catalyst Modification for the Conversion of Furfural to 1,2-Pentanediol>, COA of Formula: C5H10O2, the main research area is ruthenium supported PVP hydrogenation catalyst value added product; biomass; furfural; nanocatalysis; pentanediol; ruthenium.

Exploiting biomass to synthesize compounds that may replace fossil-based ones is of high interest in order to reduce dependence on non-renewable resources. 1,2-Pentanediol and 1,5-pentanediol can be produced from furfural, furfuryl alc. or tetrahydrofurfuryl alc. following a metal catalyzed hydrogenation/C-O cleavage procedure. Colloidal ruthenium nanoparticles stabilized with polyvinylpyrrolidone in situ modified with different organic compounds are able to produce 1,2-pentanediol directly from furfural in a 36% of selectivity at 125°C under 20 bar of H2 pressure.

Nanomaterials published new progress about Biomass conversion catalysts. 97-99-4 belongs to class tetrahydrofurans, and the molecular formula is C5H10O2, COA of Formula: C5H10O2.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem