Category: Tetrahydrofurans

Ahn, Woo-Chan; Aroli, Shashanka; Kim, Jin-Hahn; Moon, Jeong Hee; Lee, Ga Seal; Lee, Min-Ho; Sang, Pau Biak; Oh, Byung-Ha; Varshney, Umesh; Woo, Eui-Jeon published the artcile< Covalent binding of uracil DNA glycosylase UdgX to abasic DNA upon uracil excision>, Safety of ((2R,3S,4R,5R)-5-(2,4-Dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl dihydrogen phosphate, the main research area is covalent binding uracil DNA glycosylase udgx abasic upon excision.

Uracil DNA glycosylases (UDGs) are important DNA repair enzymes that excise uracil from DNA, yielding an abasic site. Recently, UdgX, an unconventional UDG with extremely tight binding to DNA containing uracil, was discovered. The structure of UdgX from Mycobacterium smegmatis in complex with DNA shows an overall similarity to that of family 4 UDGs except for a protruding loop at the entrance of the uracil-binding pocket. Surprisingly, H109 in the loop was found to make a covalent bond to the abasic site to form a stable intermediate, while the excised uracil remained in the pocket of the active site. H109 functions as a nucleophile to attack the oxocarbenium ion, substituting for the catalytic water mol. found in other UDGs. To our knowledge, this change from a catalytic water attack to a direct nucleophilic attack by the histidine residue is unprecedented. UdgX utilizes a unique mechanism of protecting cytotoxic abasic sites from exposure to the cellular environment.

Nature Chemical Biology published new progress about Enzyme functional sites, active. 58-97-9 belongs to class tetrahydrofurans, and the molecular formula is C9H13N2O9P, Safety of ((2R,3S,4R,5R)-5-(2,4-Dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl dihydrogen phosphate.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Hu, Si; Feng, Xi; Huang, Wen; Ibrahim, Salam A.; Liu, Ying published the artcile< Effects of drying methods on non-volatile taste components of Stropharia rugoso-annulata mushrooms.>, Recommanded Product: ((2R,3S,4R,5R)-5-(2,4-Dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl dihydrogen phosphate, the main research area is Stropharia non volatile compound hot air vacuum freeze drying.

In this study, the pileus and stipe of Stropharia rugoso-annulata were sep. dehydrated using natural air drying (NAD), hot air drying (HAD) and vacuum freeze drying (VFD), the proximate composition and non-volatile compounds (soluble sugars, organic acids, free amino acids and 5′-nucleotides) were investigated. We found that the contents of free amino acids (37.21-51.07 mg/g) and 5′-nucleotides (18.33-22.76 mg/g) in pileus were higher than those of stipe. The contents of MSG-like amino acids (3.61-11.70 mg/g) and flavor 5′-nucleotides (5.47-5.94 mg/g) in pileus were also higher than those of stipe. The dried S. rugoso-annulata treated with VFD had the highest levels of soluble sugars, organic acids, free amino acids and 5′-nucleotides. We found that NAD and HAD had medium levels of MSG-like amino acids (7.95-11.7 mg/g) and VFD had low levels of MSG-like amino acids (3.16-3.61 mg/g). Moreover, HAD had the highest level of equivalent umami concentration (EUC) value (784.05 g MSG/100 g). Our results suggested that VFD was better to preserve the non-volatile compounds in S. rugoso-annulata, but HAD would be a potential method to produce umami concentration of dried S. rugoso-annulata.

LWT–Food Science and Technology published new progress about Amino acids Role: FFD (Food or Feed Use), BIOL (Biological Study), USES (Uses). 58-97-9 belongs to class tetrahydrofurans, and the molecular formula is C9H13N2O9P, Recommanded Product: ((2R,3S,4R,5R)-5-(2,4-Dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl dihydrogen phosphate.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Tong, Zhikun; Li, Xiang; Dong, Jingyu; Gao, Rui; Deng, Qiang; Wang, Jun; Zeng, Zheling; Zou, Ji-Jun; Deng, Shuguang published the artcile< Adsorption Configuration-Determined Selective Hydrogenative Ring Opening and Ring Rearrangement of Furfural over Metal Phosphate>, Quality Control of 97-99-4, the main research area is adsorption configuration hydrogenative ring opening rearrangement furfural metal phosphate.

Developing an economic catalyst to upgrade furfural to alcs. (such as linear alc. and cyclopentanol) is highly significant for fine chem. synthesis and biomass utilization. Here, a class of metal phosphate nanoparticles (such as CoP, Co2P, and Ni2P) with different metal compositions and topol. structures is synthesized. The acidity and hydrogen activation ability were well adjusted according to the types. An 80.2% yield of 1,2,5-pentanetriol was reported for the first time via a hydrogenative ring-opening route over CoP, whereas Ni2P shows a high catalytic efficiency for cyclopentanol with a 62.8% yield via a hydrogenative ring-rearrangement route. Based on the catalytic performance of Pd/C and the result of attenuated total reflectance-IR spectroscopy, the route difference is derived from the adsorption configuration of furfural on the catalyst. After loading on the insert support, the metal phosphate/support catalysts show high activity and stability during the recycling experiments This work provides an effective strategy to regulate the reaction path through an adsorption mechanism and shows the precise synergistic effect of hydrogenation and acid catalysis.

ACS Catalysis published new progress about Acidity. 97-99-4 belongs to class tetrahydrofurans, and the molecular formula is C5H10O2, Quality Control of 97-99-4.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Li, Feng; Jiang, Shanshan; Huang, Jin; Wang, Yue; Lu, Shiyu; Li, Cuiqin published the artcile< Catalytic transfer hydrogenation of furfural to furfuryl alcohol over a magnetic Fe3O4@C catalyst>, SDS of cas: 97-99-4, the main research area is catalytic transfer hydrogenation furfural furfuryl alc catalyst.

Carbon-encapsulated Fe3O4 (Fe3O4@C) catalysts were prepared by a solvothermal method using glucose as the carbon source and their physicochem. properties were characterized via various anal. techniques. Catalytic transfer hydrogenation of furfural over Fe3O4@C catalysts was investigated with isopropanol as the solvent and hydrogen donor. The Fe3O4@C catalysts exhibited high catalytic furfural transfer hydrogenation activity, selectivity of furfuryl alc., and high reusability. The mechanism of catalytic transfer hydrogenation of furfural by Fe3O4@C obeys the Meerwein-Ponndorf-Verley reduction on a Lewis acid site (Fe3O4).

New Journal of Chemistry published new progress about Meerwein-Ponndorf-Verley reduction. 97-99-4 belongs to class tetrahydrofurans, and the molecular formula is C5H10O2, SDS of cas: 97-99-4.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Beaver, Matthew G.; Zhang, En-xuan; Liu, Zhi-qing; Zheng, Song-yuan; Wang, Bin; Lu, Jiang-ping; Tao, Jian; Gonzalez, Miguel; Jones, Sian; Tedrow, Jason S. published the artcile< Development and Execution of a Production-Scale Continuous [2 + 2] Photocycloaddition>, Recommanded Product: Cyclobuta[1,2-c:3,4-c’]difuran-1,3,4,6(3aH,3bH,6aH,6bH)-tetraone, the main research area is continuous photocycloaddition maleic anhydride ethylene cyclobutane.

This article details the approach to large-scale production of cyclobutane 2 by the continuous-flow [2 + 2] photocycloaddition of maleic anhydride and ethylene, including (1) focused reaction optimization and development of a robust isolation protocol, (2) the approach to equipment design and process safety, and (3) the results of commissioning tests and production runs delivering the target compound at throughputs exceeding 5 kg/day.

Organic Process Research & Development published new progress about Photocycloaddition reaction. 4415-87-6 belongs to class tetrahydrofurans, and the molecular formula is C8H4O6, Recommanded Product: Cyclobuta[1,2-c:3,4-c’]difuran-1,3,4,6(3aH,3bH,6aH,6bH)-tetraone.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Wang, Zhuangqing; Wang, Xinchao; Zhang, Chao; Arai, Masahiko; Zhou, Leilei; Zhao, Fengyu published the artcile< Selective hydrogenation of furfural to furfuryl alcohol over Pd/TiH2 catalyst>, Recommanded Product: (Tetrahydrofuran-2-yl)methanol, the main research area is palladium titanium hydride catalyst furfural hydrogenation furfuryl alc.

In this work, the selective hydrogenation of furfural to furfuryl alc. has been studied over Pd/TiH2 catalysts. The catalytic performances of several catalysts with different Pd loading (0.2-3% in weight) were discussed, among which a higher selectivity to furfuryl alc. was obtained over 0.5Pd/TiH2 and it gave rise to a 73% furfural alc. selectivity at complete conversion at 60°C. The physicochem. properties of catalysts were well characterized by TEM, XRD, XPS, Raman, TPR and TPD, as well as in-situ DRIFT for the adsorption of the reactant. The size and the electronic state of Pd particles, and the surface defects of catalysts presented significant influence on the catalytic performance. The furfural is preferentially adsorbed with its C = O bond on the boundary of Pd particle and TiH2 support, leading to the high selectivity to furfuryl alc.

Molecular Catalysis published new progress about Adsorption. 97-99-4 belongs to class tetrahydrofurans, and the molecular formula is C5H10O2, Recommanded Product: (Tetrahydrofuran-2-yl)methanol.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Seifert, Roland; Schirmer, Bastian published the artcile< cCMP and cUMP come into the spotlight, finally>, Reference of 58-97-9, the main research area is cytidylyl uridylyl cyclase identification; base-specificity; cCMP; cUMP; cytidylyl cyclase; second messenger; uridylyl cyclase.

cCMP and cUMP have been identified in numerous biol. systems and proposed to serve as second messengers. However, this proposal remained controversial because of the base-promiscuity of generators, effectors, phosphodiesterases, and bacterial toxins. With the identification of specific cytidylyl and uridylyl cyclases, cCMP and cUMP research enters a new era.

Trends in Biochemical Sciences published new progress about Enzymes Role: BSU (Biological Study, Unclassified), BIOL (Biological Study) (Uridylyl cyclase). 58-97-9 belongs to class tetrahydrofurans, and the molecular formula is C9H13N2O9P, Reference of 58-97-9.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Szubiakiewicz, Elzbieta; Modelska, Magdalena; Brzezinska, Magdalena; Binczarski, Michal J.; Severino, Courtney J.; Stanishevsky, Andrei; Witonska, Izabela published the artcile< Influence of modification of supported palladium systems by polymers: PVP, AMPS and AcrAMPS on their catalytic properties in the reaction of transformation of biomass into fuel bio-components>, Synthetic Route of 97-99-4, the main research area is acidic hydrolysis waste biomass furfural reduction palladium polymer catalyst.

Catalytic systems based on highly dispersed Pd nanoparticles deposited on SiO2 modified with PVP, AMPS and AcrAMPS were prepared and used in the hydrogenation of furfural obtained by the aqueous phase acidic hydrolysis of waste biomass (sugar beet pulp, sugar beet leaves, and brewing grain) from the food industry. Pd/PVP/SiO2 catalysts containing 50 g of Pd per 1 kg of catalyst were characterized by high activity in studied process, but lower selectivity to THFA in comparison to Pd/AMPS-SiO2 or Pd/AcrAMPS-SiO2 catalysts. The modification of SiO2 by PVP followed by the palladium catalyst loading, limited the adsorption of furfural by carbonyl group which probably leads to the improvement in THFA formation, which was confirmed by FTIR studies. The physico-chem. properties of the obtained palladium catalysts were investigated by XRD, CO chemisorption, TPR H2, TG-DTA-MS and BET techniques. The ICP-AES indicated no leaching of metal into the environment during furfural reduction, which confirms the stability of the Pd/PVP/SiO2, Pd/AMPS-SiO2 and Pd/AcrAMPS-SiO2 systems in the studied process.

Fuel published new progress about Acid hydrolysis. 97-99-4 belongs to class tetrahydrofurans, and the molecular formula is C5H10O2, Synthetic Route of 97-99-4.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Li, Feng; Jiang, Shanshan; Zhu, Tianhan; Wang, Yue; Huang, Tao; Li, Cuiqin published the artcile< Organodiphosphonate Metal-Organic Frameworks Derived Ni-P@C Catalyst for Hydrogenation of Furfural>, Electric Literature of 97-99-4, the main research area is organodiphosphonate metal organic framework furfural hydrogenation.

Tetra-Et p-xylenediphosphate is used as the organic ligand to prepare the Ni-P-MOFs material belonging to the category of organic phosphoric acids, through pyrolysis and in-situ reduction reaction of Ni-P-MOFs material during the high-temperature carbonization process, Ni-P@C catalyst with graphitized carbon-covering Ni2P particles is prepared Compared with Ni-P catalyst prepared through coprecipitation method, Ni-P@C catalyst prepared with Ni-P-MOFs material can obviously decrease the formation temperature of Ni2P active phase and retain the schistose morphol. of the Ni-P-MOFs material, which is of high specific area, and meanwhile effectively suppresses the agglomeration of Ni2P particles. It is indicated by research on furfural hydrogenation performance that, Ni-P@C catalyst presents a high activity and stability in furfural hydrogenation. Products of furfural hydrogenation catalyzed by Ni-P@C catalyst mainly contain furfuryl alc., 2-methylfuran and 2-methyltetra hydrofuran, and the reaction temperature and reaction time have great influence on the distribution of products. The carbon-covering structure of Ni-P@C catalyst can effectively protect the active components of Ni2P, thus presenting a high stability and good reusability.

ChemistrySelect published new progress about Crystallinity. 97-99-4 belongs to class tetrahydrofurans, and the molecular formula is C5H10O2, Electric Literature of 97-99-4.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Feliu, Catherine; Peyret, Helene; Vautier, Damien; Djerada, Zoubir published the artcile< Simultaneous quantification of 8 nucleotides and adenosine in cells and their medium using UHPLC-HRMS>, Recommanded Product: ((2R,3S,4R,5R)-5-(2,4-Dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl dihydrogen phosphate, the main research area is nucleotide adenosine UHPLC HRMS; Adenosine; Extracellular; High-resolution mass spectrometry; Intracellular; Nucleotides; Quantification.

Purinergic signaling is involved in physiol. processes, particularly during ischemia-reperfusion injuries for which it has a protective effect. The purpose of this work was to develop a method for simultaneous quantification of eight nucleotides and adenosine in biol. matrixes by liquid chromatog. coupled with high-resolution mass spectrometry. A method was developed that was sufficiently robust to quantify the targeted analytes in 20 min with good sensitivity. Anal. of extracellular media from cultured endothelial cells detected the release of nucleotides and adenosine during 2 h of hypoxia. The quantification of cylic adenosine monophosphate (cAMP) allowed to establish a dose-response curve after receptor stimulation. Therefore, the authors′ method allows the authors to study the involvement of nucleotides in various processes in both the intracellular and extracellular compartment.

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences published new progress about Cardiomyocyte. 58-97-9 belongs to class tetrahydrofurans, and the molecular formula is C9H13N2O9P, Recommanded Product: ((2R,3S,4R,5R)-5-(2,4-Dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl dihydrogen phosphate.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem