Tag: M.W:400-500

Application of 149809-43-8, Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics.In a document type is Patent, and a compound is mentioned, 149809-43-8, ((3R,5R)-5-((1H-1,2,4-Triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methyl 4-methylbenzenesulfonate, introducing its new discovery.

The present invention provides an industrial method production of amorphous posaconazole. The present invention also relates to a method for production of the posaconazole via and novel crystalline forms of posaconazole intermediate. More particularly the present invention relates to novel crystalline forms of posaconazole intermediate and methods for production of novel crystalline forms of posaconazole intermediate represented by the following structural formula III Which is key intermediate in the production of posaconazole. The present invention also provides for the one pot process for the preparation of amorphous posaconazole using novel crystalline forms of benzyl posaconazole.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Application of 149809-43-8. In my other articles, you can also check out more blogs about 149809-43-8

Reference：
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, Recommanded Product: 149809-43-8, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 149809-43-8, Name is ((3R,5R)-5-((1H-1,2,4-Triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methyl 4-methylbenzenesulfonate, molecular formula is C21H21F2N3O4S

The new heterocycle compound ((3S,5R)-5-((1H-1,2,4-triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methyl 4-methylbenzenesulfonate (1), designed using ((3R,5S)-5-(2,4-difluorophenyl)-5-iodotetrahydrofuran-3-yl)methyl isobutyrate (2) as the start material, was successfully obtained via multiple synthesis route and finally characterized by IR, 1H NMR, and single-crystal X-ray crystallography. In addition, the in vitro anticancer activities of the newly synthesized complex 1 have been emulated against three human breast cancer cell lines BT474, MCF7 and MB.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. Recommanded Product: 149809-43-8, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 149809-43-8, in my other articles.

Reference：
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Synthetic Route of 149809-43-8, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.149809-43-8, Name is ((3R,5R)-5-((1H-1,2,4-Triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methyl 4-methylbenzenesulfonate, molecular formula is C21H21F2N3O4S. In a Patent，once mentioned of 149809-43-8

This invention relates to compounds, as defined in the specification, useful in the treatment of mycoses, to compositions containing them and to their use in therapy.

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Reference：
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Application of 915095-87-3, Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.915095-87-3, Name is (S)-(2-Chloro-5-iodophenyl)(4-((tetrahydrofuran-3-yl)oxy)phenyl)methanone, molecular formula is C17H14ClIO3. In a article，once mentioned of 915095-87-3

The invention provides a net geleg intermediate, shown below its structural formula is: The invention also provides the process for the preparation of intermediates purifying geleg, the invention also provides the net geleg net geleg intermediates in the preparation of the application. The invention relates to a key intermediate in the manufacture of the net gelegspecial fifth heavenly stemgeleg only acyl protection, the intermediate can be obtained through the protection net gelegbase namely. (by machine translation)

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 915095-87-3

Reference：
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Related Products of 149809-43-8, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.149809-43-8, Name is ((3R,5R)-5-((1H-1,2,4-Triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methyl 4-methylbenzenesulfonate, molecular formula is C21H21F2N3O4S. In a Patent£¬once mentioned of 149809-43-8

The invention belongs to the field of medical technology, relates to a method of preparing intermediates of posaconazole, and the intermediate for the preparation of a new method of posaconazole. The method comprises the following steps: a) of formula III compound of the formula IV compound under alkaline condition, for […] etherification reaction in a solvent to obtain the compound of formula V; b) type V compounds of palladium and formic acid under the conditions of the reaction intermediate type II compounds posaconazole; c) of formula II compound alkali hydrolysis reaction to obtain the posaconazole. The method of the invention compared with the known method of the invention, the invention is a process for preparing posaconazole intermediate II of the new method, and the intermediate II alkali hydrolysis to obtain the final product posaconazole I; compared with the prior process, the new process of the present invention purified difficulty is greatly reduced, greatly reduces the impurity of the product, significantly improving the purity, reduces the amount of heavy crystallization times, improves the yield, and reduces the production cost, the operation is simple, safe and reliable, is extremely suitable for industrial production. (by machine translation)

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 149809-43-8

Reference£º
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, Formula: C21H21F2N3O4S, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 149809-43-8, Name is ((3R,5R)-5-((1H-1,2,4-Triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methyl 4-methylbenzenesulfonate, molecular formula is C21H21F2N3O4S

PROCESS FOR THE PREPARATION OF A CHIRAL COMPOUND

The present invention relates to a process for the preparation of a compound of formula (V), in particular posaconazole, wherein said process comprises the steps of (1) providing a mixture comprising a compound of formula (IV), a protic solvent system, and a suitable base; and (2) heating the mixture of (1) to obtain a mixture comprising the compound of formula (V).

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. Formula: C21H21F2N3O4S, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 149809-43-8, in my other articles.

Reference：
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Synthetic Route of 915095-87-3, Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.915095-87-3, Name is (S)-(2-Chloro-5-iodophenyl)(4-((tetrahydrofuran-3-yl)oxy)phenyl)methanone, molecular formula is C17H14ClIO3. In a article，once mentioned of 915095-87-3

METHOD FOR THE PREPARATION OF A CRYSTALLINE FORM OF 1-CHLORO-4- (BETA-D-GLUCOPYRANOS-1-YL)-2-(4-((S)-TETRAHYDROFURAN-3-YLOXY)BENZYL)BENZENE

The invention relates to a method for the preparation for a crystalline form of 1-chloro-4-(Beta-D-glucopyranos-1-yl)-2-[4-((S)-tetrahydrofuran-3-yloxy)-benzyl]-benzene. In addition the invention relates to a crystalline form obtainable by this method, to a pharmaceutical composition and to the use thereof for preparing medicaments.

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Reference：
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

149809-43-8, Name is ((3R,5R)-5-((1H-1,2,4-Triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methyl 4-methylbenzenesulfonate, belongs to tetrahydrofurans compound, is a common compound. Recommanded Product: 149809-43-8In an article, once mentioned the new application about 149809-43-8.

The present invention relates to a compound of formula III, wherein, R is selected from the group consisting of C1-C4 alkyl, substituted or unsubstituted phenyl, and substituted or unsubstituted benzyl, preferably isopropyl; and two Ar groups may be the same or different, and are each independently selected from the group consisting of substituted or unsubstituted aryl groups, preferably substituted or unsubstituted phenyl, such as p-methoxyphenyl and the like, wherein the compound is preferably in a solid form.

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Reference：
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

In heterogeneous catalysis, the catalyst is in a different phase from the reactants. Recommanded Product: 915095-87-3, At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 915095-87-3, name is (S)-(2-Chloro-5-iodophenyl)(4-((tetrahydrofuran-3-yl)oxy)phenyl)methanone. In an article£¬Which mentioned a new discovery about 915095-87-3

Glucoside bicyclic derivatives and its preparation and use (by machine translation)

The invention relates to a glucoside bicyclic derivatives and its preparation and use, in particular, the invention as shown in the formula I, a stereoisomer thereof or a pharmaceutically acceptable salt or ester of, its pharmaceutical composition and its use for preparation for the treatment of diabetes or its related diseases of the use. (by machine translation)

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Reference£º
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Synthetic Route of 149809-43-8, A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 149809-43-8, Name is ((3R,5R)-5-((1H-1,2,4-Triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methyl 4-methylbenzenesulfonate, molecular formula is C21H21F2N3O4S. In a Patent£¬once mentioned of 149809-43-8

For the preparation of a preparation method of the midbody of posaconazole (by machine translation)

This invention discloses a process for preparing the formula 1 shown in the process for the preparation of posaconazole intermediate compound 1 method. Preparation method of the invention is compound have been reported in the literature for 2 as raw material, first of all three alkyl silicon-based protection of hydroxy to obtain compound 3, then with the triazole sodium salt of 4 reaction, to obtain compound 5, then in toluene sulfonyl chloride and alkali escapes the silicon ether and perform under the action of toluene sulfonyl protection to obtain compound 1. The invention can overcome the disadvantages of the prior art, and does not pass the splitting step, reduced side reaction occurs and impurity appear, improves the reaction selectivity and yield. (by machine translation)

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Synthetic Route of 149809-43-8. In my other articles, you can also check out more blogs about 149809-43-8

Reference£º
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem