Tag: M.W:200-300

111769-27-8, (R)-Tetrahydrofuran-3-amine 4-methylbenzenesulfonate is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

111769-27-8, To a mixture of l-(6-chloro-l-(6-fluoroquinolin-2-yl)-5-methyl-lH-benzo[Patent; NOVASAID AB; WANNBERG, Johan; ALTERMAN, Mathias; MALM, Johan; WO2012/117062; (2012); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.111769-27-8,(R)-Tetrahydrofuran-3-amine 4-methylbenzenesulfonate,as a common compound, the synthetic route is as follows.

To a mixture of l-(6-chloro-l-(6-chloroquinolin-2-yl)-5-methyl-lH-benzo[111769-27-8, The synthetic route of 111769-27-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; NOVASAID AB; WANNBERG, Johan; ALTERMAN, Mathias; MALM, Johan; WO2012/117062; (2012); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

111769-27-8, (R)-Tetrahydrofuran-3-amine 4-methylbenzenesulfonate is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A suspension of 2-(3-(4-( I H-indazol-5-ylamino)quinazolin-2- yl)phenoxy)acetic acid (70 my, 0.14 mmol), PyBOP* (40 mg, 0.077 mmol), DIEA (24 muL, 0.14 mmol) in dry CH2Cl2 : DMF (2 : 0.1 mL) was stirred at RT for 15 minutes. To this solution of activated acid was added (R)-tetrahydrofuran-3-aminium 4- methylbenzenesulfonate (24 mg, 0.091 mmol). After 30 minutes, 1.0 equivalent of DlEA and 0.55 equivalents of PyBOP* were added. After stirring the solution for 15 minutes, 0.65 equivalents of (R)-tetrahydrofuran-3-aminium 4-methylbenzenesulfonate were added and the mixture was stirred for an additional 30 minutes. The solvent was removed in vacuo and the crude product was purified using prep HPLC ( 15-40 90 mins) to afford 2- (3-(4-( l H-indazol-5-ylamino)quinazolin-2-yl)phenoxy)-N-((R)-tetrahydrofuran-3- yl)acetamide. (41 mg, 0.085 mmol, 61 %), 111769-27-8

111769-27-8 (R)-Tetrahydrofuran-3-amine 4-methylbenzenesulfonate 14243169, aTetrahydrofurans compound, is more and more widely used in various fields.

Reference£º
Patent; SURFACE LOGIX, INC.; SWEETNAM, Paul; BARTOLOZZI, Alessandra; CAMPBELL, Anthony; COLE, Bridget; FOUDOULAKIS, Hope; KIRK, Brian; SESHADRI, Hemalatha; RAM, Siya; WO2010/104851; (2010); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.219823-47-9,(R)-Tetrahydrofuran-3-yl 4-methylbenzenesulfonate,as a common compound, the synthetic route is as follows.

Step 2: Synthesis of 4-Bromo-1 -[(3S)-tetrahydrofuran-3-yl]pyrazole 3.6A mixture of 650 mg [(3R)-tetrahydrofuran-3-yl] 4-methylbenzenesulfonate, 400 mg 4-bromo- 1 H-pyrazole and 1 .40 g cesium carbonate in 10 mL Nu,Nu-dimethylformamide (DMF) was stirred at 65 C for 6 h. Additional 20 mg 4-bromo-1 H-pyrazole were added and the reaction mixture was stirred at 65 C overnight. The reaction mixture was diluted with ethyl acetate and washed with brine. The combined organic phases were dried over sodium sulfate, filtered and concentrated in vacuo. The crude material was purified by flash chromatography (cyclohexane/ethyl acetate 9:1 ->1 :1 ) to yield 476 mg of 4-bromo-1 -[(3S)-tetrahydrofuran-3- yl]pyrazole 3J3 as solid.Analysis: MS: M+H = 217 / 219

219823-47-9, 219823-47-9 (R)-Tetrahydrofuran-3-yl 4-methylbenzenesulfonate 13837325, aTetrahydrofurans compound, is more and more widely used in various fields.

Reference£º
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; DAHMANN, Georg; HOFFMANN, Matthias; KLICIC, Jasna; LAMB, David James; MCCARTHY, Clive; NAPIER, Spencer; PARRISH, Karen; SCOTT, John; SWANTEK FITZGERALD, Jennifer L.; WALKER, Edward; WO2015/140054; (2015); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

118399-28-3, (R)-Benzyl (5-oxotetrahydrofuran-3-yl)carbamate is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

(R)-Benzyl 5 -oxo-tetrahydrofuran-3 -ylcarbamate (24 g, 0.1 mol) was added to the solution ofMe2NH (45 g, 1 mol) in CH2Cl2 (500 ml). The mixture was stirred overnight. The solid was collected by filtration. Toluene (500 mL) was added to dissolve the solid, followed by (PhS)2 (32.7 g, 0.15 mol) and Bu3P (40 g, 0.2 mol). The mixture was heated to 80C and stirred for 18 h. The solvent was removed in vacuo. The residue was subjected to flash column chromatography on silica gel eluting with 50% EtO Ac/petroleum ether to provide 0123 (13.4 g, 35.3%). LC-MS: 373 [M+l]+. 1H NMR (CDCl3):delta 2.46 (m, 1H), 2.82 (s, 3H), 2.84 (s, 3H), 2.88 (m, 1H), 3.20 (m, 1H), 3.33 (m, 1H), 4.13 (m, 1H), 5.07 (s, 2H), 6.30 (d, J= 9.0 Hz, 1H), 7.15 (m, 1H), 7.32 (m, 9H).

118399-28-3, The synthetic route of 118399-28-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; CURIS, INC.; WO2009/36035; (2009); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

111769-27-8, (R)-Tetrahydrofuran-3-amine 4-methylbenzenesulfonate is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A mixture of l-methyl-5-(2-phenyl-[l,2,4]triazolo[l,5-a]pyridin-7-ylcarbamoyl)-lH-pyrazole-4- carboxylic acid (100 mg, 276 muiotaetaomicron), (R)-tetrahydrofuran-3-ylamine 4-methylbenzenesulfonate (143 mg, 552 muiotaetaomicron), diisopropylethylamine (193 mu, 1.1 mmol) and propylphosphonic anhydride (50% in ethyl acetate, 407 mu, 690 muiotaetaomicron) in tetrahydrofurane (7 ml) is refluxed for 18 hours. The solvent is evaporated and to the residue is added sat. aqueous sodium hydrogencarbonate solution. The mixture is stirred for 20 minutes while a white solid precipitates. The solid is collected by filtration, washed with diethylether and dried affording (R)-l-methyl-N5-(2-phenyl- [l,2,4]triazolo[l,5-a]pyridin-7-yl)-N4-(tetrahydrofuran-3-yl)-lH-pyrazole-4,5-dicarboxamide (114 mg, 95.7%) as a white solid, mp.: > 250C. MS: m/z= 432.3 (M+H+).

111769-27-8, The synthetic route of 111769-27-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; F. HOFFMANN-LA ROCHE AG; FLOHR, Alexander; GOBBI, Luca; GROEBKE ZBINDEN, Katrin; KOERNER, Matthias; PETERS, Jens-Uwe; WO2012/76430; (2012); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.111769-27-8,(R)-Tetrahydrofuran-3-amine 4-methylbenzenesulfonate,as a common compound, the synthetic route is as follows.

(R)-(+)-3-Aminotetrahydrofuran toluene-4-sulfonate (2.0 g, 7.7 mmol) was added to a suspension of (2S)-2-(4-bromophenyl)-4-((lR)-l-phenylethyl)morpholine (2.4 g, 6.9 mmol), palladium acetate (65 mg, 0.29 mmol), 2-(di-t-butylphosphino)biphenyl (170 mg, 0.57 mmol), and sodium tert-butoxide (3.4 g, 35.4 mmol) in tert-butanol (50 ml) at room temperature. After heating at 90 C for 6 hours, the resulting suspension was passed through a Celite column. The filtrate was concentrated under reduced pressure, and the residue was purified by silica gel chromatography eluting 5-10% methanol in chloroform to afford 4-((lR)-l-phenylethyl)-(2S)-2-(4-(N-((3R)-tetrahydrofuran-3-yl)amino)phenyl)morpholine (1.3 g, 53%) as white crystals. iH-NMR(CDCl3) 8 : 1.35 (3H, d, J=6.8 Hz), 2.04-2.16 (4H, m), 2.55-2.62 (lH, m), 3.08-3.12 (1H, m), 3.33-3.38 (lH, m), 3.67-3.93 (5H, m) ,3.98-4.02 (1H ,m) ,4.46-4.58 (2H ,m) ,6.57 (2H , d, J=7.2 Hz), 6.83 (lH, d, J=9.0 Hz), 7.21-7.33 (7H, m)

111769-27-8, As the paragraph descriping shows that 111769-27-8 is playing an increasingly important role.

Reference£º
Patent; MITSUBISHI PHARMA CORPORATION; SANOFI-AVENTIS; WO2006/28290; (2006); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

111769-27-8, (R)-Tetrahydrofuran-3-amine 4-methylbenzenesulfonate is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a mixture of l-(5-chloro-6-methyl-l-(quinolin-2-yl)-lH-benzo[111769-27-8

As the paragraph descriping shows that 111769-27-8 is playing an increasingly important role.

Reference£º
Patent; NOVASAID AB; WANNBERG, Johan; ALTERMAN, Mathias; MALM, Johan; WO2012/117062; (2012); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.219823-47-9,(R)-Tetrahydrofuran-3-yl 4-methylbenzenesulfonate,as a common compound, the synthetic route is as follows.

A mixture of 1.93 g (7.97 mmol) of (3R)-tetrabydrofuran-3-yl 4- methylbenzenesulfonate (WO 2016/91776 A1 (16.06.2016) EVOTEC AG), 2.46 mL (15.9 mmol) of ethyl piperidine-4-carboxyiate, 39 mL of acetonitrile and 4.4 g (31.9 mmol) of K2CO3 was stirred at 70C for 24 h, then cooled to room temperature and diluted with ethyl acetate. The so obtained mixture was washed with water and this water phase was discarded. The organic layer was washed with 1 M HCI solution and this acidic water phase was alkaiified with 10% K2CO3 solution, extracted with ethyl acetate, the combined organic layers were dried over Na2S04, filtered and concentrated. The residue was purified by flash column chromatography using dichloromethane : methanol = 91 :9 as eluent to yield 603 mg (27%) of the title compound. GC-MS (El) m/z 227., 219823-47-9

The synthetic route of 219823-47-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; RICHTER GEDEON NYRT.; BASKA, Ferenc; BOZO, Eva; BATA, Imre; SZONDINE KORDAS, Krisztina; VUKICS, Krisztina; (293 pag.)WO2019/116324; (2019); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

219823-47-9, (R)-Tetrahydrofuran-3-yl 4-methylbenzenesulfonate is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Intermediates E-I and E-II 4-Bwmo-l-(S)- tetrahydro-furan-3-yll-lH-pyridin-2-one and 4-bromo-2-[(S)-tetrahydro- furan-3 -yloxyl -pyridine A mixture of 4-bromo-lH-pyridin-2-one (0.50 g), (i?)-toluene-4 -sulfonic acid tetrahydro- furan-3-yl ester (0.40 g), and potassium carbonate (0.80 g) in dimethylsulfoxide (5 mL) was stirred at 80 0C overnight. After cooling to ambient temperature, water was added and the resulting mixture was extracted with ethyl acetate. The combined organic extracts were washed with brine, dried (MgSO/O, and concentrated. The residue was purified by HPLC on reversed phase (acetonitrile/water) to afford the title compounds in separate fractions.4-Bromo-l-[(S)- tetrahydro-furan-3-yl]-lH-pyridin-2-one: Yield: 0.11 g (16% of theory); Mass spectrum (ESI+): m/z = 244/246 (Br) [M+H]+.4-Bromo-2-[(S)-tetrahydro-furan-3-yloxy]-pyridine: Yield: 0.36 g (56% of theory); Mass spectrum (ESI+): m/z = 244/246 (Br) [M+H]+.

219823-47-9, The synthetic route of 219823-47-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; ECKHARDT, Matthias; HIMMELSBACH, Frank; WO2010/89303; (2010); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem