Tag: M.W:200-300

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Forensic Science International called Positive and negative ion mass spectrometry of ten xanthine derivatives and their rapid clean-up with Sep-Pak C18 cartridges from biological samples, Author is Kumazawa, Takeshi; Sato, Keizo; Seno, Hiroshi; Ishii, Akira; Suzuki, Osamu, which mentions a compound: 1028-33-7, SMILESS is CN1C=NC(N(C(N2CCCCCC)=O)C)=C1C2=O, Molecular C13H20N4O2, Formula: C13H20N4O2.

Pos. ion electron impact (PIEI), pos. ion chem. ionization (PICI) and neg. ion chem. ionization (NICI) mass spectra are presented for ten xanthine derivatives; and each fragmentation pathway has been analyzed. In the PIEI mode, mol. ions were generally intense and constituted base peaks in five compounds Peaks at m/z 42 (NCO) appeared in all compounds; fragment cations at m/z 55, 68 (or 67) and 82 were observed in many compounds In the PICI mode, all drugs showed intense [M+H]+ quasi-mol. peaks together with small peaks at m/z M+C2H5 and M+C3H5; fragment peaks at m/z 44, 58, 72 and/or 84 (or 86) were also observed In the NICI mode, [M-H]- quasi-mol. peaks appeared in nine compounds and constituted base peaks in five compounds; adduct anions at m/z M+32 and/or M+C3H7, and fragment anions at m/z 42, 165 and/or 179 were also observed in many compounds Detection limits for total ion monitoring of the drugs in the PIEI, PICI and NICI modes were 2.2-10 ng, 11-28 ng and 7.8-14 ng on column, resp. Xanthine derivatives present in human plasma or urine could be rapidly extracted by use of Sep-Pak C18 cartridges with chloroform/methanol as elution solvent; recovery of the drugs from the plasma and urine was > 75%. They were also detected by capillary gas chromatog. (GC) with both flame ionization detection (FID); their limits were 1.6-8.3 ng on column.

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Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Comparative Study, English Abstract, Article, Arzneimittel-Forschung called Absorption studies with purines. Part 2: In vitro determination with the Resomat II using the Dibbern method, Author is Heppt-Becker, I.; Schunack, W., which mentions a compound: 1028-33-7, SMILESS is CN1C=NC(N(C(N2CCCCCC)=O)C)=C1C2=O, Molecular C13H20N4O2, Safety of 1-Hexyl-3,7-dimethyl-1H-purine-2,6(3H,7H)-dione.

By means of the Resomat II partition apparatus, the diffusion of 8 purines from artificial gastric or intestinal juice to artificial plasma across acetate and polyamide membranes was determined by the method of H. W. Dibbern and G. H. Scholz (1969), and the diffusion rate constants were calculated according to H. Stricker (1973). The drugs showed a proportional relation between diffusion rate and lipid solubility The effect of the different membranes on the model absorption results was studied, with and without applied alternating pressure. The results are compared with those of the Sartorius absorption model. Diffusion constants are given for each drug for absorption from gastric juice (pH 1.1) and intestinal juice (pH 7.0), and relations with drug structure are considered. The compounds studied were 1-hexyltheobromine [1028-33-7], 8-chlorotheophylline [85-18-7], theophylline (I) [58-55-9], caffeine (II) [58-08-2], pentoxifylline [6493-05-6], theobromine [83-67-0], proxyphylline [603-00-9], and diprophylline [479-18-5].

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Elben, U.; Schroeer, R. published the article 《Calcium complexes of xanthine derivatives: a new aspect of the mode of action of hemorheologically active drugs》. Keywords: calcium xanthine complex preparation hemorheol.They researched the compound: 1-Hexyl-3,7-dimethyl-1H-purine-2,6(3H,7H)-dione( cas:1028-33-7 ).Application of 1028-33-7. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:1028-33-7) here.

Five Ca complexes of xanthine derivatives were prepared by reacting the xanthine derivative with Ca(SCN)2. The effects of the Ca complexes on red blood cell deformity were determined and related to the hemorheol. properties of the drugs.

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Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 1-Hexyl-3,7-dimethyl-1H-purine-2,6(3H,7H)-dione, is researched, Molecular C13H20N4O2, CAS is 1028-33-7, about Effect of methylxanthines on the concentration of gamma-aminobutyric acid in brain of normal and anoxic rats.Category: tetrahydrofurans.

In normal rats, caffeine (I) [58-08-2] (25 mg/kg, orally) increased cerebral GABA  [56-12-2] concentration (41.3%) whereas pentifylline (II) [1028-33-7] (25 mg/kg, orally) diminished the concentration of GABA by 23.1%, the effects of similar concentrations of theophylline  [58-55-9] and theobromine  [83-67-0] were not significant. In anoxic rats, I and II caused a significant decrease in GABA concentration whereas theophylline increased GABA levels. Thus structurally similar methylxanthines have different effects on GABA concentrations in the brain.

If you want to learn more about this compound(1-Hexyl-3,7-dimethyl-1H-purine-2,6(3H,7H)-dione)Category: tetrahydrofurans, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(1028-33-7).

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Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Research Support, Non-U.S. Gov’t, Bioscience Reports called Inhibition of sodium, potassium-dependent adenosine triphosphatase by adenosine in intact pigeon erythrocytes, Author is Leskovac, Vladimir, which mentions a compound: 1028-33-7, SMILESS is CN1C=NC(N(C(N2CCCCCC)=O)C)=C1C2=O, Molecular C13H20N4O2, Category: tetrahydrofurans.

In intact pigeon erythrocytes adenosine (I) [58-61-7] was a potent inhibitor of Na,K-dependent ATPase  [9000-83-3]. In purified cell-membrane preparations, adenosine was only a weak competitive inhibitor of Na,K-ATPase, with respect to ATP indicating that adenosine may not be a direct inhibitor of the Na pump in intact red cells per se. Adenosine may exert its inhibitor effect via endogenous cell factors.

If you want to learn more about this compound(1-Hexyl-3,7-dimethyl-1H-purine-2,6(3H,7H)-dione)Category: tetrahydrofurans, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(1028-33-7).

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So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Bruns, Robert F. researched the compound: 1-Hexyl-3,7-dimethyl-1H-purine-2,6(3H,7H)-dione( cas:1028-33-7 ).Recommanded Product: 1-Hexyl-3,7-dimethyl-1H-purine-2,6(3H,7H)-dione.They published the article 《Adenosine antagonism by purines, pteridines, and benzopteridines in human fibroblasts》 about this compound( cas:1028-33-7 ) in Biochemical Pharmacology. Keywords: adenosine antagonist structure activity. We’ll tell you more about this compound (cas:1028-33-7).

Testing of >100 purine bases and structurally related heterocycles as adenosine (I) [58-61-7] antagonists in VA13 fibroblasts (determined by cAMP increase) yielded 3 families of I antagonists: xanthines, benzo[g]pteridines, and 9-substituted adenines. For the xanthines, the optimal group at the 1-position was Bu (5-fold improvement vs. Me), at the 7-position was 2-chloroethyl (5-fold improvement vs. H), and at the 8-position was p-bromophenyl (100-fold improvement vs. H). The receptors apparently had butyl- and phenyl-sized pockets at the 1- and 8-positions, resp., since compounds with larger groups had greatly reduced activity.

There is still a lot of research devoted to this compound(SMILES：CN1C=NC(N(C(N2CCCCCC)=O)C)=C1C2=O)Recommanded Product: 1-Hexyl-3,7-dimethyl-1H-purine-2,6(3H,7H)-dione, and with the development of science, more effects of this compound(1028-33-7) can be discovered.

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Tetrahydrofuran – Wikipedia,
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Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 4-(((1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl)oxy)-4-oxobutanoic acid, is researched, Molecular C14H24O4, CAS is 77341-67-4, about Synthesis, mesomorphic and photo-switching behaviours of novel azobenzene chiral liquid crystals containing (-)-menthyl.Application of 77341-67-4.

A new series of chiral liquid crystal (CLC), Mt4AZOnAB (n = 2-18), containing a multi-chiral center menthyl and an azobenzene moiety connected with a flexible butanedioyloxy and a varying length of alkanoyloxy in a terminal chain, was designed and synthesized. The thermal properties and optical textures were investigated by differential scanning calorimetry and polarizing optical microscopy. Selective reflection of the CLCs was measured by UV/visible spectrometer. Their photo-switching properties were well-demonstrated by UV irradiation All CLCs showed characteristic of selective reflection in heating stage and BPI/II texture in cooling course. Before and after irradiation, CLCs underwent a transition from oily streak texture to focal conic texture; however, BPI/II texture in cooling stage showed a reversible phase transition.

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So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Dagenais, M.; Pomier-Layrargues, G.; Rocheleau, B.; Giroux, L.; Huet, P. M. researched the compound: 1-Hexyl-3,7-dimethyl-1H-purine-2,6(3H,7H)-dione( cas:1028-33-7 ).Computed Properties of C13H20N4O2.They published the article 《Systemic and splanchnic hemodynamic effects of pentifylline in rats with portal hypertension》 about this compound( cas:1028-33-7 ) in Clinical Science. Keywords: pentifylline hemodynamics portal hypertension. We’ll tell you more about this compound (cas:1028-33-7).

The systemic and splanchnic hemodynamic effects of pentifylline (40 mg/kg body weight i.v.) were assessed in rats with portal hypertension associated either with CCl4-induced cirrhosis or portal vein ligation. Heparinized catheters were placed into the portal vein, inferior vena cava, aorta and left ventricle with exits from the neck. Hemodynamic studies were performed 4 h after consciousness was regained. Cardiac output and regional blood flows were measured using radiolabeled microspheres and the reference sample method in seven rats in each group; portal-systemic shunting was measured using microsphere injection in the ileo-colic vein in six rats in each group. Forty-five minutes after injection, pentifylline had no effect on mean arterial pressure, cardiac output, peripheral resistance, portal venous flow, hepatic artery flow or portal-systemic shunting in either group of rats with portal hypertension. The drug lowered portal pressure (-18%) in cirrhotic rats, but not in portal-vein-ligated rats. These data demonstrate that pentifylline lowers portal pressure in cirrhotic rats without affecting portal venous flow and portal-systemic shunting; this effect is possibly mediated by changes in intrahepatic resistance related to the effects of pentifylline on blood viscosity and/or on intrahepatic vasomotor tone.

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While the job of a research scientist varies, most chemistry careers in research are based in laboratories, where research is conducted by teams following scientific methods and standards. Electric Literature of 87219-29-2

All four stereoisomers of 2-alkyl-3,4-iminobutanic acid, a novel class of beta-amino acids bearing a chemically versatile aziridine ring, were synthesized starting with aspartic acid. The synthetic strategy involves the introduction of an alkyl group at the beta-position of fully protected optically active aspartic acid followed by the construction of an aziridine ring making use of the alpha-carboxylate and alpha-amino groups. The alpha-carboxylate was reduced to the corresponding alcohol, which was then subjected to cyclization to form an aziridine ring with the N-protected amino group. Removal of the protection groups yielded the target compounds.

The design and synthesis of related molecules that are more effective, more selective, and less toxic than aspirin are important objectives of biomedical research.Keep reading other articles of 87219-29-2. Electric Literature of 87219-29-2

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The invention concerns compounds represented by general formula (I) wherein: Z represents a sulfur or oxygen atom; the groups R1 and R2, identical or different, represent each a alkyl group or an alkenyl group; X represents a CO, a CO2, an SO, or an SO2 and the group R represents an alkyl, aryl, alkenyl, or aralkyl group, provided that when Z represents an oxygen atom, X an SO2 and R a group (a), R1 and R2 do not both represent the methyl group. The invention also concerns methods for preparing said compounds, pharmaceutical compositions containing them and their use as promoter of gamma-aminobutyric acid and as medicine particularly designed for treating nervous disorders.

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