Tag: M.W:100-200

Ashmore, Jason; Bishop, Roger; Craig, Donald C.; Scudder, Marcia L. published the article 《The effect of chlorine substitution on the inclusion properties of a diquinoline host molecule》. Keywords: chloro substituted diquinoline host mol inclusion compound supramol crystallog.They researched the compound: 2-Amino-5-chlorobenzaldehyde( cas:20028-53-9 ).Application of 20028-53-9. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:20028-53-9) here.

The chloro-substituted diquinoline compounds 7 and 8 have been synthesized as part of our continuing search for new host mols. As intended, the latter forms lattice inclusion compounds with a range of mols., and here the X-ray structures of (8)4·(benzenes)5 and (8)·(toluene) are described. Host 8 exhibits entirely different inclusion behavior compared to its parent non-chlorinated analog 2. Edge-edge double C-H···N synthons, normally ubiquitous in inclusion structures formed by members of this diquinoline host family, vanish when 8 is used. Instead there is increased dependence on halogen-halogen and aryl-aryl interactions. Despite the similarity of the guests, the structures of the two inclusion compounds are very different. Crystal engineering anal. reveals, however, that the supramol. synthons present in the two cases are very similar.

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Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 2-Amino-5-chlorobenzaldehyde( cas:20028-53-9 ) is researched.Product Details of 20028-53-9.Rahman, A. Noman M. M.; Bishop, Roger; Craig, Donald C.; Scudder, Marcia L. published the article 《Inclusion properties of a chlorinated diquinoline host》 about this compound( cas:20028-53-9 ) in Journal of Supramolecular Chemistry. Keywords: inclusion chlorinated diquinoline host. Let’s learn more about this compound (cas:20028-53-9).

The new lattice inclusion host 6α,13α-dibromo-2,9-dichloro-5bα,6,12bα,13-tetrahydropentaleno[1,2-b:4,5-b’]diquinoline 8 was prepared, and found to include far fewer guests than its nonchlorinated analog 2. (8)2·(Et acetate) and (8)2·(benzene) form mol. pen and staircase inclusion compounds resp. Their x-ray structures are analyzed and compared in crystal engineering terms.

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Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Formula: C7H6ClNO. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 2-Amino-5-chlorobenzaldehyde, is researched, Molecular C7H6ClNO, CAS is 20028-53-9, about Bifunctional mesoporous MCF materials as catalysts in the Friedlaender condensation. Author is Smuszkiewicz, A.; Perez-Mayoral, E.; Soriano, E.; Sobczak, I.; Ziolek, M.; Martin-Aranda, R. M.; Lopez-Peinado, A. J..

We report herein the Friedlaender reaction of 2-aminoaryl aldehydes and Et acetatoacetate affording the corresponding quinolines. The condensation selectively leads to quinolines with good to excellent yields under mild reaction conditions. The first step of the condensation is the Knoevenagel reaction between reagents as exptl. confirmed. In addition, in order to justify our results we carried out a computational study based on DFT calculations analyzing this first step of the condensation. In this sense, we propose a cooperative catalysis mechanism involving the amine functions and metallic centers both of them acting as activating agents of the reagents and, therefore, favoring the process.

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Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 2-Amino-5-chlorobenzaldehyde(SMILESS: NC1=CC=C(Cl)C=C1C=O,cas:20028-53-9) is researched.Application of 3066-84-0. The article 《Copper(I)/ABNO-Catalyzed Aerobic Alcohol Oxidation: Alleviating Steric and Electronic Constraints of Cu/TEMPO Catalyst Systems》 in relation to this compound, is published in Journal of the American Chemical Society. Let’s take a look at the latest research on this compound (cas:20028-53-9).

Cu/TEMPO catalyst systems promote efficient aerobic oxidation of sterically unhindered primary alcs. and electronically activated substrates, but they show reduced reactivity with aliphatic and secondary alcs. Here, we report a catalyst system, consisting of (MeObpy)-CuI(OTf) and ABNO (MeObpy = 4,4′-dimethoxy-2,2′-bipyridine; ABNO = 9-azabicyclo[3.3.1]nonane N-oxyl), that mediates aerobic oxidation of all classes of alcs., including primary and secondary allylic, benzylic, and aliphatic alcs. with nearly equal efficiency. The catalyst exhibits broad functional group compatibility, and most reactions are complete within 1 h at room temperature using ambient air as the source of oxidant.

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Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Peroxide-induced reduction of 9,10-anthraquinone by sodium borohydride in diglyme》. Authors are Panson, Gilbert S.; Weill, C. Edwin.The article about the compound:(2-Methylthiazol-4-yl)methanolcas:76632-23-0,SMILESS:OCC1=CSC(C)=N1).Related Products of 76632-23-0. Through the article, more information about this compound (cas:76632-23-0) is conveyed.

9,10-Anthraquinone (I) is not reduced at 20° by NaBH4 in pure diglyme [O(CH2CH2OMe)2] (II). In the presence of peroxides I is reduced to 9,10-anthradiol (III). When 0.25 g. NaBH4 is added to 1 g. I in 20 cc. II which has been exposed to air for several weeks a vigorous exothermic reaction sets in and the solution turns deep red. The mixture is stirred in an Ar atm. 45 min. and poured into 500 cc. cold N HCl, causing the precipitation of 0.9 g. III, m. 157-80°, which, on recrystallization from EtOH, yields I again. In a similar experiment, treating the reaction mixture with 5 cc. Ac2O and 3 g. fused NaOAc, heating it 0.5 hr. at 70° in an Ar atm., and pouring it into ice-H2O give 0.8 g. III diacetate, needles, m. 268-71° (decomposition). A possible mechanism for the peroxide-promoted reduction may be the cleavage of the solvent to aldehydes by a peroxide-induced action followed by conversion of the aldehydes so formed to alkoxyborohydrides which are the effective reducing agents.

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Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Design, synthesis and in vitro anticancer activity of novel quinoline and oxadiazole derivatives of ursolic acid, published in 2017-09-01, which mentions a compound: 20028-53-9, Name is 2-Amino-5-chlorobenzaldehyde, Molecular C7H6ClNO, Electric Literature of C7H6ClNO.

A series of new quinoline derivatives of ursolic acid were designed and synthesized in an attempt to develop potential anticancer agents. The structures of these compounds were identified by 1H NMR, 13C NMR, IR and ESI-MS spectra anal. The target compounds were evaluated for their in vitro cytotoxicity against three human cancer cell lines (MDA-MB-231, HeLa and SMMC-7721). From the results, compounds I [R = H, OMe, Cl, F] displayed significant antitumor activity against three cancer cell lines. Especially, compound I [R = OMe] was found to be the most potent derivative with IC50 values of 0.61 ± 0.07, 0.36 ± 0.05, 12.49 ± 0.08 μM against MDA-MB-231, HeLa and SMMC-7721 cells, resp., stronger than pos. control etoposide. Furthermore, the Annexin V-FITC/PI dual staining assay revealed that compound I [R = OMe] could significantly induce the apoptosis of MDA-MB-231 cells in a dose-dependent manner. The cell cycle anal. also indicated that compound I [R = OMe] could cause cell cycle arrest of MDA-MB-231 cells at G0/G1 phase.

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Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Quality Control of 2-Amino-5-chlorobenzaldehyde. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 2-Amino-5-chlorobenzaldehyde, is researched, Molecular C7H6ClNO, CAS is 20028-53-9, about I2-Catalyzed Aerobic Oxidative C(sp3)-H Amination/C-N Cleavage of Tertiary Amine: Synthesis of Quinazolines and Quinazolinones. Author is Yan, Yizhe; Xu, Ying; Niu, Bin; Xie, Huifang; Liu, Yanqi.

An iodine-catalyzed oxidative C(sp3)-H amination/C-N cleavage of tertiary amines conducted under an oxygen atm. has been developed and affords a route to quinazolines I [R1 = Ph, 4-MeC6H4, cyclopropyl, etc.; R2 = H, 6-Cl, 6-Br, etc.] and quinazolinones II [R3 = Ph, Bn, n-Bu, etc.] in good to excellent yields via a domino ring annulation. The method is metal-free, peroxide-free, and operationally simple to implement with a wide scope of substrates and represents a new avenue for multiple C-N bond formations.

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Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

SDS of cas: 76632-23-0. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: (2-Methylthiazol-4-yl)methanol, is researched, Molecular C5H7NOS, CAS is 76632-23-0, about 4-Hydroxy-5,6-dihydropyrones as inhibitors of HIV protease: the effect of heterocyclic substituents at C-6 on antiviral potency and pharmacokinetic parameters. Author is Hagen, Susan E.; Domagala, John; Gajda, Christopher; Lovdahl, Michael; Tait, Bradley D.; Wise, Eric; Holler, Tod; Hupe, Donald; Nouhan, Carolyn; Urumov, Andrej; Zeikus, Greg; Zeikus, Eric; Lunney, Elizabeth A.; Pavlovsky, Alexander; Gracheck, Stephen J.; Saunders, James; VanderRoest, Steve; Brodfuehrer, Joanne.

Due largely to the emergence of multi-drug-resistant HIV strains, the development of new HIV protease inhibitors remains a high priority for the pharmaceutical industry. Toward this end, the authors previously identified a 4-hydroxy-5,6-dihydropyrone lead compound (CI-1029) which possesses excellent activity against the protease enzyme, good antiviral efficacy in cellular assays, and promising bioavailability in several animal species. The search for a suitable back-up candidate centered on the replacement of the aniline moiety at C-6 with an appropriately substituted heterocycle. In general, this series of heterocyclic inhibitors displayed good activity (in both enzymic and cellular tests) and low cellular toxicity; furthermore, several analogs exhibited improved pharmacokinetic parameters in animal models. The compound with the best combination of high potency, low toxicity, and favorable bioavailability was (S)-3-(2-tert-butyl-4-hydroxymethyl-5-methyl-phenylsulfanyl)-4-hydroxy-6-isopropyl-6-(2-thiophen-3-yl-ethyl)-5,6-dihydro-pyran-2-one (I). This thiophene derivative also exhibited excellent antiviral efficacy against mutant HIV protease and resistant HIV strains. For these reasons, I was chosen for further preclin. evaluation.

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Tetrahydrofuran – Wikipedia,
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Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Chemical Communications (Cambridge, United Kingdom) called A Au(I)-catalyzed hydrogen bond-directed tandem strategy to synthesize indeno-chromen-4-one and indeno-quinolin-4-one derivatives, Author is Jiang, Chongguo; Xiong, Zhiling; Jin, Shengfei; Gao, Peng; Tang, Yingzhan; Wang, Yanshi; Du, Chuan; Wang, Xiaoyu; Liu, Yang; Lin, Bin; Liu, Yongxiang; Cheng, Maosheng, which mentions a compound: 20028-53-9, SMILESS is NC1=CC=C(Cl)C=C1C=O, Molecular C7H6ClNO, Recommanded Product: 2-Amino-5-chlorobenzaldehyde.

A gold-catalyzed hydrogen bond-directed tandem cyclization strategy to synthesize indeno-chromen-4-one and indeno-quinolin-4-one derivatives was developed. The hydrogen bond existing between the hydroxyl group (or the amide group) and the carbonyl group played an essential role in controlling the selectivity, which was confirmed by both exptl. and theor. evidence.

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Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Identification of Inhibitors of Cholesterol Transport Proteins Through the Synthesis of a Diverse, Sterol-Inspired Compound Collection》. Authors are Whitmarsh-Everiss, Thomas; Olsen, Asger Hegelund; Laraia, Luca.The article about the compound:2-Amino-5-chlorobenzaldehydecas:20028-53-9,SMILESS:NC1=CC=C(Cl)C=C1C=O).Recommanded Product: 2-Amino-5-chlorobenzaldehyde. Through the article, more information about this compound (cas:20028-53-9) is conveyed.

Cholesterol transport proteins regulate a vast array of cellular processes including lipid metabolism, vesicular and non-vesicular trafficking, organelle contact sites, and autophagy. Despite their undoubted importance, the identification of selective modulators of this class of proteins has been challenging due to the structural similarities in the cholesterol-binding site. Herein we report a general strategy for the identification of selective inhibitors of cholesterol transport proteins via the synthesis of a diverse sterol-inspired compound collection. Fusion of a primary sterol fragment to an array of secondary privileged scaffolds led to the identification of potent and selective inhibitors of the cholesterol transport protein Aster-C, which displayed a surprising preference for the unnatural-sterol AB-ring stereochem. and new inhibitors of Aster-A. We propose that this strategy can and should be applied to any therapeutically relevant sterol-binding protein.

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Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem