Tag: M.W:100-200

184950-35-4, (Tetrahydrofuran-3-yl)methanamine hydrochloride is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Production Example 29 (0340) 5-(4-Methoxymethyl-2,3,5,6-tetrafluorobenzyl)oxymethy lisoxazole-3-carboxylic acid (0.20 g, 0.6 mmol), tetrahydrofuran-3-ylmethylamine hydrochloride (0.10 g, 0.9 mmol), triethylamine (0.07 g, 0.7 mmol) and 1-hydroxybenzotriazole (0.01 g, 0.07 mmol) were added to chloroform (amylene addition product) (2 mL). 1-Ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride (0.13 g, 0.7 mmol) was added to the mixture at room temperature, and the mixture was stirred overnight and then concentrated under reduced pressure. Dilute hydrochloric acid was added to the concentrate, and the mixture was extracted twice with ethyl acetate. The organic layer was washed with saturated saline water, dried over anhydrous sodium sulfate, and then concentrated under reduced pressure. The residue was applied to a silica gel column chromatography to obtain 0.12 g of N-(tetrahydrofuran-3-ylmethyl)-5-(4-methoxymethyl-2,3,5,6-t etrafluorobenzyl)oxymethylisoxazole-3-carboxamide (hereinafter, referred to as Compound of Present Invention (29)) represented by the following formula. 1H-NMR (CDCl3, TMS, delta(ppm)):1.63-1.68(1H, m), 2.03-2.12(1H, m), 2.51-2.61(1H, m), 3.39(3H, s), 3.45(2H, t), 3.58(1H, dd), 3.75(1H, dd), 3.83-3.85(1H, m), 3.89-3.91(1H, m), 4.57(2H, t), 4.68(2H, s), 4.71(2H, t), 6.74(1H, s), 6.94(1H, br s), 184950-35-4

As the paragraph descriping shows that 184950-35-4 is playing an increasingly important role.

Reference£º
Patent; Sumitomo Chemical Company, Limited; MITSUDERA, Hiromasa; AWASAGUCHI, Kenichiro; AWANO, Tomotsugu; UJIHARA, Kazuya; EP2952096; (2015); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

63095-51-2,63095-51-2, (R)-4-Propyldihydrofuran-2(3H)-one is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Add phenol (18.8g, 200.0mmol) and tetraisopropyl titanate (2.8g, 10.0mmol) to a 500ml three-necked bottle with stirring function, aan additional 250 ml of toluene was added and the mixture was stirred at reflux for 1 h. The solvent was evaporated under reduced pressure. Toluene (200 ml) and compound (R)-4-propyldihydrofuran-2-one (12.8 g, 10.0 mmol) were added to the reaction system, and the reaction was refluxed for 36 h. Reduce the reaction system to room temperature, add 2M dilute hydrochloric acid to adjust the pH to 5-6, the layers were separated and the organic phase was washed with water. Rotary evaporation to remove toluene, purification by column chromatography gave the compound (R)-3-hydroxymethylhexanoic acid phenyl ester.

As the paragraph descriping shows that 63095-51-2 is playing an increasingly important role.

Reference£º
Patent; Fujian Haixi New Drug Initiative Co., Ltd.; Kang Xinshan; Wang Ruyong; Ye Yizhang; Gong Xuan; Zhang Fengsen; Wang Zhonghong; Li Dandan; Fu Yueli; Feng Yan; (35 pag.)CN110357790; (2019); A;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

165253-29-2, 3-(Bromomethyl)tetrahydrofuran is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To the saturated Na2S03 aqueous solution (10 mL) was added 3-(bromomethyl)tetrahydrofuran (1.00 g, 6.06 mmol). The reaction mixture was heated to refluxand stirred for 24 h and concentrated in vacuo. The residue was stirred with EtOH (20 mL) at50 oc for 30 min, and then filtered immediately. The filtrate was concentrated in vacuo to affordthe title compound as a white solid (875.3 mg, yield 76.8percent).MS (ESI, neg. ion) m/z: 165.1 [M-Nar;1H NMR (400 MHz, DMSO-d6) 8 (ppm): 3.55-3.45 (m, 1H), 3.36 (td, J = 8.1, 5.0 Hz, 1H), 3.28(dd, J = 15.3, 7.7 Hz, 1H), 3.08 (dd, J = 8.3, 6.6 Hz, 1H), 2.29-2.23 (m, 1H), 2.19-2.10 (m, 2H),1.75-1.65 (m, 1H), 1.31-1.19 (m, 1H)., 165253-29-2

The synthetic route of 165253-29-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; SUNSHINE LAKE PHARMA CO., LTD.; CALITOR SCIENCES, LLC; DAI, Weilong; XI, Ning; LI, Minxiong; ZHANG, Tao; LI, Xiaobo; HU, Haiyang; CHEN, Wuhong; WANG, Tingjin; LIU, Jun; (188 pag.)WO2017/48675; (2017); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.16874-34-3,Ethyl tetrahydrofuran-2-carboxylate,as a common compound, the synthetic route is as follows.

To a solution of ethyl TETRAHYDROFURAN-2-CARBOXYLATE (Preparation 32) (1. 0965 g, 7. 604 MMOL) in anhydrous tetrahydrofuran (7 mL) AT-50 C, under an atmosphere of nitrogen, was added sodium bis (trimethylsilyl) amide (7. 6 mL of a 1. 0M solution in tetrahydrofuran, 7. 604 MMOL) dropwise. The reaction mixture was stirred for 1 hour and then a solution of 5-(tert-butyl-diphenyl-silanyloxy)-2-iodomethyl-pyridine (Preparation 31) (0. 72 G, 1. 5208 MMOL) in anhydrous tetrahydrofuran (7 mL) was added dropwise. The resulting solution was stirred at -50 C for 2 hours and then quenched with saturated aqueous ammonium chloride (25 mL). This was then extracted with ethyl acetate (3X25 mL), dried (anhydrous magnesium sulfate), filtered and concentrated in vacuo to afford the crude product. The residue was purified by flash column chromatography (hexanes to 40% ethyl acetate/hexanes) to yield a colorless oil (0. 2438 g, 33%). LRMS (m/z) : 490 (M+H) +. ‘H NMR (CDCI3, 300 MHz) 8. 07 (1 H, d, J= 2. 5 Hz), 7. 67-7. 63 (4H, m), 7. 41-7. 31 (6H, m), 6. 97 (1 H, d, J = 8. 5 HZ), 6. 86 (1 H, dd, J = 2. 8, 8. 5 HZ), 4. 21 (2H, q, J = 7. 2 Hz), 4. 09 (2H, q, J= 7. 2 HZ), 3. 22 (1 H, D, J = 13. 9 Hz), 3. 07 (1H, d, J= 13. 9 Hz), 2. 53-2. 44 (1 H, M), 2. 31-2. 15 (1 H, M), 1. 82-1. 72 (1H, m), 1. 60-1. 46 (1H, m), 1. 25 (3H, t, J = 7. 2 Hz), 1. 09 (9H, s)., 16874-34-3

As the paragraph descriping shows that 16874-34-3 is playing an increasingly important role.

Reference£º
Patent; PFIZER INC.; WO2004/92145; (2004); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

184950-35-4, (Tetrahydrofuran-3-yl)methanamine hydrochloride is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Production Example 3 (0314) 1-Methyl-3-propyl-1H-pyrazole-5-carboxylic acid (1.68 g, 10 mmol), tetrahydrofuran-3-ylmethylamine hydrochloride (1.38 g, 10 mmol), triethylamine (1.01 g, 10 mmol) and 1-hydroxybenzotriazole (0.15 g, 1.0 mmol) were added to chloroform (amylene addition product) (60 mL). 1-Ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride (1.92 g, 10 mmol) was added to the mixture at room temperature, and the mixture was stirred at room temperature overnight and then concentrated under reduced pressure. Dilute hydrochloric acid was added to the concentrate, and the mixture was extracted twice with ethyl acetate. The organic layer was washed with saturated saline water, dried over anhydrous sodium sulfate, and then concentrated under reduced pressure. The residue was applied to a silica gel column chromatography to obtain 2.02 g of N-(tetrahydrofuran-3-ylmethyl)-1-methyl-3-propyl-1H-pyrazol e-5-carboxamide (hereinafter, referred to as Compound of Present Invention (3)) represented by the following formula. 1H-NMR(CDCl3, TMS, delta(ppm)):0.96(3H, t), 1.64-1.68(3H, m), 2.05-2.14(1H, m), 2.56-2.58(3H, m), 3.41-3.43(2H, m), 3.61-3.63(1H, m), 3.75-3.77(1H, m), 3.82-3.84(1H, m), 3.92-3.94(1H, m), 4.11(3H, s), 6.15(1H, s), 6.26(1H, s), 184950-35-4

184950-35-4 (Tetrahydrofuran-3-yl)methanamine hydrochloride 17750392, aTetrahydrofurans compound, is more and more widely used in various fields.

Reference£º
Patent; Sumitomo Chemical Company, Limited; MITSUDERA, Hiromasa; AWASAGUCHI, Kenichiro; AWANO, Tomotsugu; UJIHARA, Kazuya; EP2952096; (2015); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.42417-39-0,3-Aminodihydrofuran-2(3H)-one hydrochloride,as a common compound, the synthetic route is as follows.

1 g of HSL ¡¤ HCl, 20 g of methanol, 20 g of chloroform and 0.1 g of Pt (5) / Ac were added to the reactor. The reaction was carried out in the presence of NO / N2 (15 atm, 1: 1 (v / v)) and the reaction was carried out at a reaction time and a reaction temperature as shown in Table 10. The product was partially recovered and the components were analyzed. The results are shown in Table 10 below., 42417-39-0

The synthetic route of 42417-39-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; CJ CHEILJEDANG CORPORATION; KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY; YANG, YOUNG RYEOL; KIM, BYUNG SIK; KIM, JEONG HYUN; LEE, JUNG HO; SHIN, HYUN KWAN; KIM, JU NAM; CHO, KYUNG HO; (40 pag.)KR2015/118287; (2015); A;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.184950-35-4,(Tetrahydrofuran-3-yl)methanamine hydrochloride,as a common compound, the synthetic route is as follows.

Tetrahydrofuran-3-ylmethylamine hydrochloride (0.23 g, 1.69 mmol) And triethylamine (0.17 g, 1.69 mmol) Was added to chloroform (amylene added product) (10 mL). To the mixture, 5- (4-phenoxybenzyl) oxymethyl isoxazole-3-carboxylic acid (0.46 g, 1.41 mmol) at room temperature, 1-Hydroxybenzotriazole (0.02 g, 0.14 mmol) And 1-ethyl-3- (3-dimethylaminopropyl) carbodiimide hydrochloride (0.32 g, 1.69 mmol) were added, After stirring at room temperature for 5 hours, Dilute hydrochloric acid was added, Extracted twice with chloroform . The organic layer was washed with saturated sodium bicarbonate water, After drying with anhydrous sodium sulfate, And concentrated under reduced pressure. The residue was subjected to silica gel column chromatography, Represented by the following equation N- (tetrahydrofuran-3-ylmethyl) -5- (4-phenoxybenzyl) oxymethyl isoxazole-3-carboxamide (Hereinafter referred to as the amide compound (11 7)) 0.29 g was obtained., 184950-35-4

The synthetic route of 184950-35-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; SUMITOMO CHEMICAL COMPANY LIMITED; SUMITA, YUSUKE; (264 pag.)JP2015/51963; (2015); A;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

124391-75-9, (S)-(Tetrahydrofuran-3-yl)methanol is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step 1 a Synthesis of (Tetrahydrofuran-3-yl)methyl 4-methylbenzenesulfonate To a solution of (tetrahydrofuran-3-yl)methanol (500 mg, 4.90 mM) in DCM (10 ml), triethyl amine (991 mg, 9.79 mM) was added. The reaction mixture was stirred for 5 min at 0 QC, followed by the addition of 4-methylbenzene-1 -sulfonyl chloride (933 mg, 4.90 mM) and DMAP (1 mg). The reaction mixture was further stirred for 2h, concentrated and purified by coloumn chromatography to afford the title compound (tetrahydrofuran-3-yl)methyl 4-methylbenzenesulfonate (1 .07 g) as a white solid; Yield: 86percent; 1 H NMR (DMSO-d6, 300 MHz): delta 7.82 (d, J=8.1 Hz, 2H), 7.39 (d, J=8.1 Hz, 2H), 4.03-3.90 (m, 2H), 3.84-3.66 (m, 4H), 3.53-3.49 (m, 1 H), 2.47 (s, 3H), 1 .60-1 .51 (m, 2H); MS: m/z 279 (M+Na)., 124391-75-9

As the paragraph descriping shows that 124391-75-9 is playing an increasingly important role.

Reference£º
Patent; PIRAMAL ENTERPRISES LIMITED; KUMAR, Sanjay; SHARMA, Rajiv; MAHAJAN, Vishal, Ashok; SAWARGAVE, Sangameshwar, Prabhakar; WO2013/128378; (2013); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

57595-23-0, Methyl 4-oxotetrahydrofuran-3-carboxylate is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,57595-23-0

3-(Trifluoromethylsulfonyloxy)-2,5-dihydrofuran-4-carboxylic acid methyl ester A solution of tetrahydrofuran-3-one-4-carboxylic acid-methyl ester (P. Dowd, S.-C. Choi, Tetrahedron 1991, 47, 4847) (2.88 g, 20 mmol) in dichloromethane (200 ml) is mixed at -78 C. with diisopropyl(ethyl)amine (3.96 ml, 23.2 mmol). After 10 minutes, trifluoromethanesulfonic acid anhydride (3.88 ml, 23.2 mmol) is slowly added in drops to it. The batch is warmed to room temperature, stirred for 2 hours and concentrated by evaporation. The residue is purified by column chromatography (SiO2) with ethyl acetate-hexane: 3.62 g (66%) of product. 1H-NMR (CDCl3): delta=3.85 (s, 3H), 4.80 (t, 2H), 4.92 (t, 2H).

57595-23-0 Methyl 4-oxotetrahydrofuran-3-carboxylate 14666564, aTetrahydrofurans compound, is more and more widely used in various fields.

Reference£º
Patent; Schering Aktiengesellschaft; US6391887; (2002); B1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

124391-75-9, (S)-(Tetrahydrofuran-3-yl)methanol is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

REFERENCE EXAMPLE 2 [(Tetrahydro-3-furanyl)methyl]bromide 10 g of (tetrahydro-3-furanyl)methanol was added dropwise to a mixture 31.8 g of phosphorus tribromide, 9.29 g of pyridine and 100 ml of ether over 30 minutes, and the mixture was then stirred for 5.5 hours. Next, the reaction mixture was concentrated under a reduced pressure, and the resultant residue was purified by silica gel column chromatography (1:1 ethyl acetate/hexane) to obtain 8.6 g of [(tetrahydro-3-furanyl)methyl]bromide. 1 H-NMR (CDCl3, ppm): 1.62-1.76 (1H, m), 2.05-2.16 (1H, m), 2.70 (1H, septet, J=7.3), 3.40 (2H, dd, J=1.5, J=7.3), 3.45-3.53 (1H, m), 3.60 (1H, dd, J=5.1, J=8.8), 3.80 (1H, t, J=7.3), 3.89-3.95 (1H, m)., 124391-75-9

The synthetic route of 124391-75-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Mitsui Toatsu Chemicals, Inc.; US5614527; (1997); A;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem