Tag: M.W:100-200

184950-35-4, (Tetrahydrofuran-3-yl)methanamine hydrochloride is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,184950-35-4

5-propargyloxymethyl isoxazole-3-carboxylic acid (2.88 g, 15.9 mmol),Tetrahydrofuran-3-ylmethylamine hydrochloride (2.72 g, 19.8 mmol),Triethylamine (1.94 g, 19.8 mmol)And 1-hydroxybenzotriazole (0.22 g, 1.59 mmol)Was added to chloroform (amylene addition product) (30 mL).To the mixture,1-Ethyl-3- (3-dimethylaminopropyl) carbodiimide hydrochloride (3.80 g, 19.8 mmol) was added at room temperature,Stir at room temperature overnight,And concentrated under reduced pressure.Dilute hydrochloric acid was added to the concentrate,Extracted twice with ethyl acetate.The organic layer was washed with saturated brine,After drying with anhydrous sodium sulfate, decreaseAnd concentrated under reduced pressure.The residue was subjected to silica gel column chromatography,Represented by the following equationN- (tetrahydrofuran-3-ylmethyl) -5-propargyloxymethylisoxazole-3-carboxamide(Hereinafter referred to as the present amide compound (339))2.95 g was obtained.

184950-35-4 (Tetrahydrofuran-3-yl)methanamine hydrochloride 17750392, aTetrahydrofurans compound, is more and more widely used in various fields.

Reference£º
Patent; SUMITOMO CHEMICAL COMPANY LIMITED; SUMITA, YUSUKE; (264 pag.)JP2015/51963; (2015); A;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.16874-33-2,Tetrahydrofuran-2-carboxylic acid,as a common compound, the synthetic route is as follows.

Example 85A tetrahydrofuran-2-carboxamide To a mixture of tetrahydrofuran-2-carboxylic acid (12 g) in tetrahydrofuran (200 mL) was added di(1H-imidazol-1-yl) methanone (53.3 g) at 15 C. and the reaction was mixture was stirred for 2 hours. Ammonium hydroxide (100 mL) was added to the reaction at 0 C. and the reaction mixture was stirred at 15 C. for 2 hours. The reaction mixture was separated and the aqueous phase was extracted with dichloromethane (5*50 mL). The combined organic layers were dried over Na2SO4 and filtered. The filtrate was concentrated to give the residue which was purified by column chromatography on silica gel (eluted with dichloromethane_methane=200:1 to 30:1) to provide the title compound. 1H NMR (400 MHz, CDCl3) delta ppm 1.86-1.95 (m, 2H), 2.08 (td, J=13.37, 6.14 Hz, 1H), 2.23-2.34 (m, 1H), 3.85-4.00 (m, 2H), 4.35 (dd, J=8.55, 5.92 Hz, 1H), 5.97 (br s, 1H), 6.61 (br s, 1H).

16874-33-2, As the paragraph descriping shows that 16874-33-2 is playing an increasingly important role.

Reference£º
Patent; AbbVie Inc.; AbbVie Deutschland GmbH & Co. KG; Brady, Patrick B.; Braje, Wilfried; Dai, Yujia; Doherty, George A.; Gong, Jane; Jantos, Katja; Ji, Cheng; Judd, Andrew S.; Kunzer, Aaron R.; Lai, Chunqiu; Mastracchio, Anthony; Risi, Roberto M.; Song, Xiaohong; Souers, Andrew J.; Sullivan, Gerard M.; Tao, Zhi-Fu; Teske, Jesse A.; Wang, Xilu; Wendt, Michael D.; Yu, Yiyun; Zhu, Guidong; Penning, Thomas D.; (218 pag.)US2019/55264; (2019); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

184950-35-4, (Tetrahydrofuran-3-yl)methanamine hydrochloride is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Production Example 154 (0474) Tetrahydrofuran-3-ylmethylamine hydrochloride (0.20 g, 1.46 mmol) and triethylamine (0.15 g, 1.46 mmol) were added to chloroform (amylene addition product) (7 mL). 5-(4-Phenoxybenzyl)isoxazole-3-carboxylic acid (0.36 g, 1.22 mmol), 1-hydroxybenzotriazole (0.02 g, 0.12 mmol) and 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride (0.28 g, 1.46 mmol) were added to the mixture at room temperature, and the mixture was stirred overnight. Then, dilute hydrochloric acid was added thereto, and the mixture was extracted twice with chloroform. The organic layer was washed with a saturated aqueous sodium bicarbonate solution, dried over anhydrous sodium sulfate, and then concentrated under reduced pressure. The residue was applied to a silica gel column chromatography to obtain 0.34 g of N-(tetrahydrofuran-3-ylmethyl)-5-(4-phenoxybenzyl)isoxazole -3-carboxamide (hereinafter, referred to as Compound of Present Invention (162)) represented by the following formula. 1H-NMR(CDCl3, TMS, delta(ppm)):1.62-1.70(1H, m), 2.03-2.12(1H, m), 2.51-2.61(1H, m), 3.43-3.46(2H, m), 3.56-3.60(1H, m), 3.73-3.79(1H, m), 3. 83-3. 92 (2H, m), 4.09(2H, s), 6.41(1H, s), 6.96-7.02(5H, m), 7.09-7.14(1H, m), 7.20-7.22(2H, m)7.32-7.37(2H, m)

184950-35-4, 184950-35-4 (Tetrahydrofuran-3-yl)methanamine hydrochloride 17750392, aTetrahydrofurans compound, is more and more widely used in various fields.

Reference£º
Patent; Sumitomo Chemical Company, Limited; MITSUDERA, Hiromasa; AWASAGUCHI, Kenichiro; AWANO, Tomotsugu; UJIHARA, Kazuya; EP2952096; (2015); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

17347-61-4, 2,2-Dimethylsuccinicanhydride is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

4-(4-Bromophenyl)-2, 2-dimethyl-4-oxo-butyric acid 67. To a stirred suspension of 2,2-dimethylsuccinic anhydride (0.641 g, 5.0 mmol) in bromobenzene (3.3 mL), cooled to -10¡ã C (ice/acetone bath) was added aluminium trichloride (1.34 g, 10 mmol) and the reaction was allowed to warm slowly to rt with stirring overnight. The resulting brown solution was poured into cooled (ice bath) aqueous HCl (10 mL, 18percent) and stirred for a further 30 min while the solution was allowed to warm to r.t. No precipitate formed therefore DCM (10 mL) was added and the organic layer was separated and concentrated under reduced pressure to give a solution of the product in PhBr. To this was added hexane followed by a small amount of DCM and the resulting white needles were collected by filtration. Yield 51percent: 1H NMR delta (270 MHz, DMSO-d6) 1.24 (6H, s), 3.29 (2H, s), 7.69 (2H5 d, J= 8.7 Hz), 7.88 (2H, d, J= 8.7 Hz), 7.96 (IH5 s); HPLC > 93percent (R1 2.87, 70percent MeCN in H2O); APCI (M-H)” 283.15, 285.10 m/z.

17347-61-4, As the paragraph descriping shows that 17347-61-4 is playing an increasingly important role.

Reference£º
Patent; STERIX LIMITED; WO2007/96647; (2007); A2;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

16874-33-2, Tetrahydrofuran-2-carboxylic acid is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Add 2-(5-fluoro-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)pyrimidine-4,5,6- to a 50 mL two-necked vial Triamine (0.10 g, 0.27 mmol),Tetrahydrofuran-2-carboxylic acid (0.046 g, 0.40 mmol)And N,N-dimethylformamide (10.0 mL),2-(7-Azobenzotriazole)-N,N,N’,N’-tetramethyluronium hexafluorophosphate added at 0 ¡ãC(0.15g, 0.39mmol)N,N-Diisopropylethylamine (0.13 mL, 0.79 mmol) was stirred at room temperature overnight.Quenched with water, extracted with ethyl acetate (30 mL¡Á2).The organic phase was washed sequentially with water (30 mL) and brine (30 mL).Dry over anhydrous sodium sulfate, suction filtration,The residue was purified by silica gel column chromatography (dichloromethane/methanol (v/v) = 80/1, 0.5percent triethylamine).A white solid (0.067 g, 53.0percent) was obtained.

16874-33-2, 16874-33-2 Tetrahydrofuran-2-carboxylic acid 86079, aTetrahydrofurans compound, is more and more widely used in various fields.

Reference£º
Patent; Guangdong Dongyangguang Pharmaceutical Co., Ltd.; Wang Xiaojun; Zuo Yinglin; Yu Chuan; Yang Chuanwen; Wang Jiancheng; Li Jing; Cao Shengtian; Wu Fangyuan; Zhang Yingjun; S ¡¤geerdeman; (79 pag.)CN108690016; (2018); A;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

17347-61-4, 2,2-Dimethylsuccinicanhydride is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

The compound 6 (349 mg, 0.5 mmol) is dissolved in anhydrous pyridine (8 ml) in, adding 2, 2 – dimethyl succinic anhydride (320 mg, 2.5 mmol), DMAP (61 mg, 0.5 mmol), after dissolving completely, microwave reactor is heated to 160 ¡ãC, reaction 3 h. The end of the reaction, by adding ethyl acetate (50 ml), for 10percent HCl to adjust the pH 4 – 5; organic layer is saturated salt water washing (25 ml ¡Á 3), dried with anhydrous sodium sulfate, filtered, concentrated under reduced pressure to remove the solvent, silica gel column chromatography (hexane: ethyl acetate=1:1), to obtain white solid 302 g, is compound 9, yield 73percent.

17347-61-4, As the paragraph descriping shows that 17347-61-4 is playing an increasingly important role.

Reference£º
Patent; Chen Zhong; Duan Huaqing; Yang Shilin; Li Guoxiong; (26 pag.)CN109485688; (2019); A;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.17347-61-4,2,2-Dimethylsuccinicanhydride,as a common compound, the synthetic route is as follows.

Step E: Intermediate 26-2 To a solution of the intermediate 25-2 in pyridine (1 mL) were added DMAP (150 mg, 1.171 mmol) and 3, 3-dimethyldihydro-2,5-furandione (480 mg, 3.93 mmol). The reaction mixture was stirred at 80 ¡ãC for 1.5 h. After cooling down to room temperature, the reaction mixture was extracted with DCM (50 mL x 3). The organic phase was separated, washed with water, brine, and dried with Na2S04. Removal of the solvent provided a crude product, which was purified by column chromatography on silica gel (PE: EtOAc = 3:1 ) to afford the intermediate 26-2 (240 mg, 0.337 mmol, 70.3 percent yield) as a white solid.

17347-61-4, 17347-61-4 2,2-Dimethylsuccinicanhydride 87067, aTetrahydrofurans compound, is more and more widely used in various fields.

Reference£º
Patent; GLAXOSMITHKLINE LLC; GAO, Daxin; HAN, Nianhe; JOHNS, Brian; JIN, Zhimin; NING, Fangxian; TANG, Jun; WU, Yongyong; YANG, Heping; WO2013/20245; (2013); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1679-47-6,3-Methyldihydrofuran-2(3H)-one,as a common compound, the synthetic route is as follows.

Example 11 Hydrogenation of alpha-methyl-gamma-butyrolactone [Ru2(mu-Cl)3(triphos)2]Cl (3.0 mg), potassium tert-butoxide (5.5 mg), and 1. 5 ml of methanol were added into a 20-ml Schlenk tube under a nitrogen atmosphere, and the mixture was stirred for 20 minutes at room temperature. This solution and alpha-methyl-gamma-butyrolactone (0.12 g) were added into a 100-ml autoclave having a stirrer placed inside, under a nitrogen atmosphere. The autoclave was purged with hydrogen, and then hydrogen was further included in the autoclave up to 4.0 MPa. The contents of the autoclave were heated and stirred at 100C for 13 hours. After cooling, the reaction liquid was analyzed by gas chromatography, and it was found that 1,4-pentanediol was produced at a yield of 39.7%., 1679-47-6

The synthetic route of 1679-47-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Takasago International Corporation; EP2141142; (2010); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

184950-35-4, (Tetrahydrofuran-3-yl)methanamine hydrochloride is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Production Example 9 (0320) 1-Benzyl-1H-1,2,3-triazole-4-carboxylic acid (0.96 g, 4.7 mmol), tetrahydrofuran-3-ylmethylamine hydrochloride (0.71 g, 5.2 mmol), triethylamine (1.01 g, 10 mmol) and 1-hydroxybenzotriazole (0.08 g, 0.52 mmol) were added to chloroform (amylene addition product) (30 mL). 1-Ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride (1.00 g, 4.2 mmol) was added to the mixture at room temperature, and the mixture was stirred overnight and then concentrated under reduced pressure. Dilute hydrochloric acid was added to the concentrate, and the mixture was extracted twice with ethyl acetate. The organic layer was washed with saturated saline water, dried over anhydrous sodium sulfate, and then concentrated under reduced pressure. The residue was applied to a silica gel column chromatography to obtain 0.86 g of 31-benzyl-1H-1,2,3-triazole-4-carboxamide (hereinafter, referred to as Compound of Present Invention (9)) represented by the following formula. 1H-NMR(CDCl3, TMS, delta(ppm)): 1. 6.4-1 . 72 (1H, m), 2.03-2.11(1H, m), 2.54-2.59(1H, m), 3.46(2H, dd), 3.58(1H, dd), 3.75(1H, q), 3.93-3.84(2H, m), 5.55(2H, s), 7.41-7.27(5H, m), 7.97(1H, s), 184950-35-4

184950-35-4 (Tetrahydrofuran-3-yl)methanamine hydrochloride 17750392, aTetrahydrofurans compound, is more and more widely used in various fields.

Reference£º
Patent; Sumitomo Chemical Company, Limited; MITSUDERA, Hiromasa; AWASAGUCHI, Kenichiro; AWANO, Tomotsugu; UJIHARA, Kazuya; EP2952096; (2015); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

17347-61-4, 2,2-Dimethylsuccinicanhydride is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A stirring solution of compound 17-1 (112 mg, 0.232 mmol), DMAP (28 mg, 0.232 mmol) and 2,2-dimethylsuccinic anhydride (89 mg, 0.695 mmol) in dry pyridine (4 mL) is heated for 4 hours at 120¡ãC. Another 90 mg (0.7 mmol) of anhydride is added and heating is continued overnight. The mixture is concentrated to dryness and the residue is diluted in ethyl acetate, washed twice with HCl 1 N, water and brine, dried over sodium sulfate and concentrated to dryness. The residue is purified by flash chromatography on silica gel (ethyl acetate/hexanes 10percent to 30percent) to yield the title compound 14-1 as a white solid (87 mg, 61percent).1H NMR (400 MHz, DMSOd6): delta [ppm] 12.16 (s, 1 H), 6.33 (s, 1 H), 4.64 (d, 1 H), 4.54 (s, 1 H), 4.35 (d x d, 1 H), 3.47 (s, 3H), 2.73 (m, 1 H), 2.53 (d, 1 H), 2.45 (d, 1 H), 2.42 (m, 1 H), 2.15 (m, 1 H), 1.92 (m, 1 H), 1.75 (m, 1 H), 1.70-0.90 (m, 20H), 1.62 (s, 3H), 1.15 (s, 3H), 1.14 (s, 3H), 0.95 (s, 3H), 0.91 (s, 3H), 0.89 (s, 3H), 0.84 (s, 3H), 0.80 (s, 3H). LC/MS: m/z = 614.72 (M+H+). HPLC (Method A): tR = 31.62 min., 17347-61-4

The synthetic route of 17347-61-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; VIROCHEM PHARMA INC.; WO2009/100532; (2009); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem