Tag: M.W:100-200

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.184950-35-4,(Tetrahydrofuran-3-yl)methanamine hydrochloride,as a common compound, the synthetic route is as follows.

Production Example 5 (0218) 5-[2-(1-Naphthyloxy)ethyl]pyridine-2-carboxylic acid sodium salt (300 mg, 0.95 mmol) obtained in Reference Production Example 14, (tetrahydrofuran-3-yl)methylamine hydrochloride (176 mg, 1.25 mmol) and 1-hydroxybenzotriazole (14 mg, 0.10 mmol) were added to chloroform (6 mL), and triethylamine (0.29 mL, 2.05 mmol) was further added, then 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride (225 mg, 1.18 mmol) was added, and the mixture was stirred at room temperature for 4 hours, and concentrated under reduced pressure conditions. The residue was applied to a silica gel column chromatography to obtain 319 mg of N-(tetrahydrofuran-3-ylmethyl)-5-[2-(1-naphthyloxy)ethyl]pyridine-2-carboxylic acid amide (hereinafter, referred to as Compound of the Present Invention (5).) represented by the following formula. Compound of the Present Invention (5) (0219) 1H-NMR (CDCl3, TMS) delta(ppm): 1.66-1.76 (m, 1H), 2.03-2.14 (m, 1H), 2.56-2.65 (m, 1H), 3.29-3.35 (m, 2H), 3.47-3.54 (m, 2H), 3.58-3.64 (m, 1H), 3.73-3.81 (m, 1H), 3.85-3.95 (m, 2H), 4.38-4.43 (m, 2H), 6.78-6.81 (m, 1H), 7.35-7.37 (m, 1H), 7.41-7.51 (m, 2H), 7.77-7.89 (m, 3H), 8.13-8.22 (m, 3H), 8.57-8.60 (m, 1H)., 184950-35-4

The synthetic route of 184950-35-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Sumitomo Chemical Company, Limited; AWASAGUCHI, Kenichiro; (20 pag.)US2017/144995; (2017); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.42417-39-0,3-Aminodihydrofuran-2(3H)-one hydrochloride,as a common compound, the synthetic route is as follows.,42417-39-0

Dissolving 3-chloro-4-(5-(4-isopropoxy-3-cyanophenyl)-1,2,4-oxadiazol-3-yl)benzaldehyde (200 mg, 0.54 mmol) In 35 ml of dichloromethane,Add to it in orderDL-homoserine lactone hydrochloride(112mg, 0.82mmol), glacial acetic acid (0.12ml, 2.18mmol), N,N-diisopropylethylamine (0.13ml, 0.82mmol), 5ml of methanol, reacted at room temperature for 3h, then added sodium cyanoborohydride (34mg , 0.47 mmol), reacted under argon for 5 h. A saturated sodium hydrogencarbonate solution was added, and the mixture was extracted with dichloromethane (3¡Á30 mL). Concentrated and separated by column chromatography. The eluent was dichloromethane: methanol = 20:1.A white solid 154 mg was obtained in a yield of 62.5%.

The synthetic route of 42417-39-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Chinese Academy Of Medical Sciences Pharmaceutical Institute; Wang Xiaojian; Liu Tianqi; Jin Jing; Hu Jinping; Chen Xiaoguang; Yin Dali; (70 pag.)CN109956912; (2019); A;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.124391-75-9,(S)-(Tetrahydrofuran-3-yl)methanol,as a common compound, the synthetic route is as follows.

A mixture comprising 10.0 g of (tetrahydro-3-furanyl) methanol, 29.5 g of trifluoromethanesulfonic anhydride, 10.0 g of pyridine and 200 ml of dichloromethane was stirred for an hour at room temperature. Water was poured into the reaction solution to separate the organic layer, which was washed with 1 N hydrochloric acid, water and a saturated saline solution, dried, and concentrated to obtain 20 g [OF 3-TETRAHYDRO-FURANYLMETHYL TRIFLATE.] 3.25 g of 60% sodium hydride were added to 12.5 g of [1,] [5-DIMETHYL-2-NITROIMINOHEXAHYDRO-1,] 3,5-triazine and 60 ml of DMF at room temperature, followed by stirring for an hour. 20.0 g of the 3- [TETRAHYDROFURANYLMETHYL] [TRIFLATE] were added thereto, and the mixture was stirred at [50] C for 2 hours. After cooling the mixture to room temperature, 50 ml [OF 2N] hydrochloric acid were added thereto, followed by stirring at [50 C] for 2 hours. The resultant mixture was neutralized with sodium bicarbonate and extracted with dichloromethane, and the extract was dried and concentrated. The residue thus obtained was purified by silica gel column chromatography (eluent: ethyl [ACETATE/HEXANE=L/L)] to obtain 7.8 g of [1-{(TETRAHYDRO-3-FURANYL) METHYL}-2-NIERO-] 3-methylguanidine (dinotefuran).

124391-75-9, 124391-75-9 (S)-(Tetrahydrofuran-3-yl)methanol 40784875, aTetrahydrofurans compound, is more and more widely used in various fields.

Reference£º
Patent; THE HARTZ MOUNTAIN CORPORATION; WO2004/23873; (2004); A2;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

696-59-3,696-59-3, 2,5-Dimethoxytetrahydrofuran is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

The raw material 4-nitroaniline (3.45g, 0.025mol),2,5-dimethoxytetrahydrofuran (3.96g, 0.30mol) and FeCl3 (0.1g, 0.38mmol) were added to water (50mL), and reacted at 100 C for 4hThe reaction solution was cooled to room temperature and suction filtered to obtain 3.92 g of a solid with a yield of 83.5%.

As the paragraph descriping shows that 696-59-3 is playing an increasingly important role.

Reference£º
Patent; Liaoning University; Chen Ye; Liu Ju; Ding Shi; Li Jun; Liu Yutong; Shi Jiantao; Li Jie; Zhou Ziyun; Zhang Jiaojiao; Gong Yilin; (42 pag.)CN110372705; (2019); A;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1679-47-6,3-Methyldihydrofuran-2(3H)-one,as a common compound, the synthetic route is as follows.

Synthesis of (¡À)-2-methyl-4-bromobutyric acid (II) Under nitrogen protection, (¡À)-alpha-methyl-gamma-butyrolactone (I) (7.33 g, 73.3 mmol) was transferred to a reaction flask in ice water. Under a bath condition, slowly add 33% HBr acetic acid solution (51.3 mL, 147 mmol, 2.0 eq.) to the reaction flask. After stirring for 6 hours at room temperature, TLC monitoring showed that the conversion of the starting material I was completed, stirring was stopped, and the reaction solution was placed in a fume hood. After pouring into 250 mL of CH2Cl2 cooled in an ice water bath, a large amount of white smoke emerged and the resulting solution was successively treated with water (50 mL x 2). After washing with saturated NaHSO 3 solution (100 mL¡Á2) and saturated brine (50 mL), the solid was dried over anhydrous Na 2 SO 4 Dry, filter, and concentrate the filtrate under reduced pressure to give 12.5 g of pale yellow oil II (yield 94.2%). The product was not purified. Can be used for the next reaction., 1679-47-6

Big data shows that 1679-47-6 is playing an increasingly important role.

Reference£º
Patent; Zhejiang Pharmaceutical Co., Ltd. Xinchang Pharmaceutical Factory; Ji Li; Lao Xuejun; Jin Xin; Shen Dadong; Wu Guofeng; (11 pag.)CN107488176; (2017); A;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.16874-33-2,Tetrahydrofuran-2-carboxylic acid,as a common compound, the synthetic route is as follows.

Add L-phenylalaninol resolving agent (0.5g, 3.3mmol, 99percent ee) to a 50mL two-neck reaction flaskAnd 15mL of acetone,After stirring and dissolving the dissolving agent,Add 5 mL of a mixture of ethyl acetate and (RS)-THFA (0.58 g, 5 mmol).Reaction at 20 ¡ã C for 1 h,A white solid was precipitated, which was quickly filtered and weighed to give 0.397 g of diastereomer salt.The resulting diastereomer salt was recrystallized from ethyl acetate.Heat to about 77 ¡ã C first, to clear the transparent liquid,Stop heating, slowly cool naturally and stir at low speed until the temperature drops to 20 ¡ã C. After constant temperature and low speed stirring and crystallization for 1 h, filter, filter cake is dissolved with 5 mol / L sulfuric acid aqueous solution and adjusted to pH < 2, and added with DCM (3 ¡Á 10 mL) The layers are separated and the extracted organic phase is combined and dried over anhydrous Na2SO4.The solvent was again concentrated to give (S)-2-THFA (0.175 g), 99.1percent ee, yield: 60.7percent. 16874-33-2, As the paragraph descriping shows that 16874-33-2 is playing an increasingly important role.

Reference£º
Patent; Zhejiang University of Technology; Li Zhenhua; Ruan Yiyi; Li Juan; (9 pag.)CN109705064; (2019); A;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

124391-75-9, (S)-(Tetrahydrofuran-3-yl)methanol is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 140 Methanesulfonic acid tetrahydro-furan-3-ylmethyl ester To a solution of (tetrahydro-furan-3-yl)-methanol (60 muL, 0.62 mmol) and triethylamine (174 muL, 1.25 mmol) in dichloromethane (4 mL) at 0¡ã C., methanesulfonylchloride (96 muL, 1.24 mmol) was added. The reaction was allowed to slowly warm to ambient temperature and stir overnight. Saturated sodium bicarbonate (2 mL) was added, and the mixture was stirred at ambient temperature for 30 minutes. Then the reaction was extracted with dichloromethane (3*10 mL). The organic layers were combined, dried with magnesium sulfate, filtered, and concentrated. No other purification steps were taken.

124391-75-9, The synthetic route of 124391-75-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Genelabs Technologies, Inc.; US2009/226398; (2009); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5061-21-2,2-Bromo-4-butanolide,as a common compound, the synthetic route is as follows.,5061-21-2

General procedure: To a stirred mixture of thiols 12a-12k (100 mmol) and K2CO3(27.64 g, 200 mmol) in DMF (120 mL) at room temperaturewas added alpha-bromobutyrolactone (10, 14.85 g, 90 mmol), andthe resulting mixture was stirred at room temperature until thecompletion of reaction as indicated by TLC analysis (typicallywithin 12 h).The reaction mixture was poured into ice-water (400 mL),and the mixture thus obtained was extracted with CH2Cl2 (3 ¡Á100 mL). The combined extracts were washed successively with10% aqueous Na2CO3 (2 ¡Á 100 mL) and 5% brine (3 ¡Á 100 mL),dried over anhydrous Na2SO4 and evaporated on a rotary evaporator to aord a residue, which was purifed by columnchromatography to yield 13a-13k after trituration withEtOAc/n-hexane if the product was a solid.

As the paragraph descriping shows that 5061-21-2 is playing an increasingly important role.

Reference£º
Article; Zhang, Xiansheng; Wu, Jingwei; Liu, Yuqiang; Xie, Yafei; Liu, Changying; Wang, Jianwu; Zhao, Guilong; Phosphorus, Sulfur and Silicon and the Related Elements; vol. 192; 7; (2017); p. 799 – 811;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

138498-97-2, 2-(Tetrahydrofuran-3-yl)acetic acid is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To a solution of 8 (0.2 mmol, 1 equiv) in CH2Cl2 (2 mL) were added NEt3 (0.6 mmol, 3 equiv), N,N,N?,N?-tetramethyl-O-(1H-benzotriazol-1-yl)uronium hexafluorophosphate (HBTU, 0.26 mmol, 1.3 equiv) and the appropriate carboxylic acid (1.25 equiv). The reaction was stirred overnight and then concentrated. The crude material was purified by silica gel column chromatography using a gradient of 0-100% EtOAc/hexanes.

138498-97-2, As the paragraph descriping shows that 138498-97-2 is playing an increasingly important role.

Reference£º
Article; Amato, George S.; Manke, Amruta; Vasukuttan, Vineetha; Wiethe, Robert W.; Snyder, Rodney W.; Runyon, Scott P.; Maitra, Rangan; Bioorganic and Medicinal Chemistry; vol. 26; 15; (2018); p. 4518 – 4531;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4100-80-5,3-Methyldihydrofuran-2,5-dione,as a common compound, the synthetic route is as follows.

Example 10: Preparation of Racemic 4-[{cis, cis-4-[(Benzyloxy)carbonyl]-2,3)3 )9,9a- hexahydro-lH-cyclopenta[b]quinolin-9-yl}(cyclopropyl)amino]-2-methyl-4-oxobutanoic acid (10); 10[00217] A solution of racemic benzyl cis, cis-9-(cyclopropylamino)-l,2,3,3a,9,9a- hexahydro-4H-cyclopenta[6]quinoline-4-carboxylate (IE) (25 mg, 0.069 mmol, 1 equiv) and 3- methyldihydrofuran-2,5-dione (0.15 mL, 1.6 mmol, 23 equiv) in dioxane (0.35 mL) was heated to 110 ¡ãC in a sealed tube. After heating for 1 h, the oil bath temperature was increased to 130 ¡ãC for 1 h. The reaction mixture was then cooled to 23 ¡ãC and partitioned between ethyl acetate and aqueous hydrochloric acid solution. The organic layer was washed with saturated aqueous sodium chloride solution, and the washed solution was dried over sodium sulfate. The dried solution was filtered, and the filtrate was concentrated. The residue was purified by flash- column chromatography (dichloromethane, grading to 10percent methanol-dichloromethane). The residue was then dissolved in DMSO (1 mL), and purified by reverse-phase HPLC (40percent acetonitrile- water, grading to 80percent acetonitrile- water, with 0.1percent trifluoroacetic acid in both the acetonitrile and water) to afford 10. [M+H]+: 477.2.

4100-80-5, The synthetic route of 4100-80-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; MERCK SHARP & DOHME CORP.; HUANG, Xianhai; BRUBAKER, Jason; PETERSON, Scott, L.; BUTCHER, John, W.; CLOSE, Joshua, T.; MARTINEZ, Michelle; MACCOSS, Rachel Nicola; JUNG, Joon, O.; SILIPHAIVANH, Phieng; ZHANG, Hongjun; ASLANIAN, Robert, G.; BIJU, Purakkattle Johny; DONG, Li; HUANG, Ying; MCCORMICK, Kevin, D.; PALANI, Anandan; SHAO, Ning; ZHOU, Wei; WO2012/174176; (2012); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem