Tag: M.W:100-200

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.42417-39-0,3-Aminodihydrofuran-2(3H)-one hydrochloride,as a common compound, the synthetic route is as follows.

The autocatalytic reaction of homoserine lactone hydrochloride was performed using a high pressure reaction system. Specifically, 2 g of HSL.HCl, 45 g of chloroform and 1 g of conc. HCl was added to the reactor and reacted with NO / Air (O2) gas at room temperature (25 ) and high pressure (about 14 atm). After 2 hours of reaction, the product was recovered and the components were analyzed as 92.7% of Cl-GBL, 3.3% of HO-GBL, 3.8% of furanone and 0.2% of other components.

42417-39-0, As the paragraph descriping shows that 42417-39-0 is playing an increasingly important role.

Reference£º
Patent; CJ CHEILJEDANG CORPORATION; KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY; YANG, YOUNG RYEOL; KIM, BYUNG SIK; KIM, JEONG HYUN; LEE, JUNG HO; SHIN, HYUN KWAN; KIM, JU NAM; CHO, KYUNG HO; (40 pag.)KR2015/118287; (2015); A;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.184950-35-4,(Tetrahydrofuran-3-yl)methanamine hydrochloride,as a common compound, the synthetic route is as follows.

Tetrahydrofuran-3-ylmethylamine hydrochloride (0.20 g, 1.20 mmol) And triethylamine (0.12 g, 1.20 mmol) Was added to chloroform (amylene added product) (4 mL). To the mixture, Butyl-2H-1,2,3-triazole-4-carboxylic acid (0.17 g, 1.00 mmol) at room temperature, 1-Hydroxybenzotriazole (0.01 g, 0.10 mmol) And 1-ethyl-3- (3-dimethylaminopropyl) carbodiimide hydrochloride (0.23 g, 1.20 mmol) After stirring for 3 hours, Dilute hydrochloric acid was added, It was extracted twice with chloroform. The organic layer was washed with saturated sodium bicarbonate water, The filtrate was concentrated under reduced pressure. The residue was subjected to silica gel column chromatography, Represented by the following equation N- (Tetrahydrofuran-3-ylmethyl) -2-butyl-2H-1,2,3-triazole-4-carboxamide (Hereinafter referred to as the present amide compound (55))0.11 g.

184950-35-4, The synthetic route of 184950-35-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; SUMITOMO CHEMICAL COMPANY LIMITED; SUMITA, YUSUKE; (264 pag.)JP2015/51963; (2015); A;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

52079-23-9, (S)-(-)-alpha-Hydroxy-gamma-butyrolactone is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Methanesulfonic acid 2-oxo-tetrahydro-furan-3S-yl ester Methanesulfonyl chloride (1.67 ml, 21.56 mmol) was added to a stirred solution of (S)-3-hydroxy-2-oxo-tetrahydrofuran (2 g, 19.6 mmol), 4-N,N-dimethylaminopyridine (240 mg, 1.96 mmol) and diisopropylethylamine (3.76 ml, 21.56 mmol) in dry dichloromethane (20 ml), under nitrogen, at -40 C. The mixture was stirred for 30 minutes and then allowed to warm up to room temperature, then it was washed with 2M hydrochloric acid solution (50 ml), dried and evaporated to a solid. The crude product was purified by flash chromatography on silica gel, eluding with ethyl acetate-cyclohexane (1:1). Trituration with diethylether and drying in vacuo afforded the title compound as a crystalline white solid (2.23 g, 63%): mp. 70-75 C.; NMR delta (CDCl3) 5.33 (1H, t, J 8 Hz), 4.53 (1H, dt, J 9 and 2 Hz), 4.34 (1H, dt, J 10 and 6 Hz), 3.28 (3H, s), 2.86-2.72 (1H, m), 2.65-2.47 (1H, m)., 52079-23-9

The synthetic route of 52079-23-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Glaxo Wellcome Inc.; US6197761; (2001); B1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13031-04-4,4,4-Dimethyldihydrofuran-2,3-dione,as a common compound, the synthetic route is as follows.,13031-04-4

A rhodium catalyst precursor [Rh(COD)Cl]2, a chiral bisphosphine ligand 3 (R1 = Boc), a polyether alkylguanidinium salt ionic liquid [ (PG), CH3 (EO) 16TMG] SO3CH3, ketopantolactone and benzene, the molar ratio of 3 to Rh is 1.1: 1, the mass ratio of ionic liquid to rhodium catalyst precursor is 500: 1, the ratio of ketopantolactone to Rh The molar ratio is 100: 1, the volume ratio of benzene to ionic liquid is 4: 1, the atmosphere is replaced with nitrogen or argon for 4-6 times, and then pressurized with hydrogen to 5.0MPa, the reaction is carried out at 50 for 4 hours and then rapidly cooled After hydrogen was vented, the benzene was removed under reduced pressure and extracted twice with methyl tert-butyl ether. The volume ratio of methyl tert-butyl ether to benzene was 1: 1. The system was split into two phases and was isolated by simple phase separation The upper methyl tert-butyl ether phase containing D-pantolactone was analyzed by gas chromatography. The conversion of ketopantolactone was 77.6%, and the ee value of D-pantolactone was 60.7%. The reaction conditions and procedures were the same as in Example 1 except that the solvent was changed to toluene, the molar ratio of ketopantolactone to Rh was 200: 1, the pressure of hydrogen was 0.1 MPa, the reaction temperature was 25 C, and the reaction time was 2h. Analysis by gas chromatography showed that the conversion rate of ketopantolactone was 97.5% and that of D-pantolactone was 92.2%.

The synthetic route of 13031-04-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Qingdao University of Science and Technology; Jin Xin; Li Shumei; Cui Feifei; (8 pag.)CN104761518; (2017); B;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

4100-80-5, 3-Methyldihydrofuran-2,5-dione is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

0.190 mmol of 3-methyldihydrofuran-2,5-dione is added to a solution of 0.173 mmol of 2′-benzyl-2′-azabicyclo[2.2.1]hept-7′-ylmethyl 2-amino-5-bromobenzoate, obtained in accordance with Example 3, in 1 ml of acetic acid, and the mixture is heated at 80¡ã C. for 12 hours. The mixture is subjected to conventional work-up, giving 2-benzyl-2-azabicyclo[2.2.1]hept-7-ylmethyl 5-bromo-2-(3′-methyl-2′,5′-dioxopyrrolidin-1′-yl)benzoate; ESI 512; salt precipitation using 0.5M HCl solution gives 2-benzyl-2-azabicyclo[2.2.1]hept-7-ylmethyl 5-bromo-2-(3′-methyl-2′,5′-dioxopyrrolidin-1′-yl)benzoate hydrochloride., 4100-80-5

The synthetic route of 4100-80-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Schiemann, Kai; Leibrock, Joachim; US2004/110788; (2004); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

184950-35-4, (Tetrahydrofuran-3-yl)methanamine hydrochloride is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Production Example 235 (0556) 4-Chloro-3-(2-naphthylmethoxymethyl)-1-methyl-1H-pyra zole-5-carboxylic acid (0.72 g, 2.2 mmol), tetrahydrofuran-3-ylmethylamine hydrochloride (0.36 g, 2.6 mmol), triethylamine (0.27 g, 2.6 mmol) and 1-hydroxybenzotriazole (0.04 g, 0.26 mmol) were added to chloroform (amylene addition product) (5.4 mL). 1-Ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride (0.50 g, 2.6 mmol) was added to the mixture at room temperature, and the mixture was stirred overnight and then concentrated under reduced pressure. Dilute hydrochloric acid was added to the concentrate, and the mixture was extracted twice with ethyl acetate. The organic layer was washed with saturated saline water, dried over anhydrous sodium sulfate, and then concentrated under reduced pressure. The residue was applied to a silica gel column chromatography to obtain N-(tetrahydrofuran-3-ylmethyl)-4-chloro-3-(2-naphthylmethox ymethyl)-1-methyl-1H-pyrazole-5-carboxamide (hereinafter, referred to as Compound of Present Invention (244)) in the following formula. 1H-NMR(CDCl3, TMS, delta(ppm)):1.64-1.72(1H, m), 2.01-2.08(1H, m), 2.55-2.61(1H, m), 3.36-3.49 (2H, m), 3.59(1H, dd), 3.77(1H, q), 3.83-3.94(5H, dd), 4.59(2H, s), 4.65(2H, s), 6.89(1H, br.s), 7.41-7.44(1H, m), 7.47-7.51(2H, m), 7.77-7.85(4H, m)

184950-35-4, 184950-35-4 (Tetrahydrofuran-3-yl)methanamine hydrochloride 17750392, aTetrahydrofurans compound, is more and more widely used in various fields.

Reference£º
Patent; Sumitomo Chemical Company, Limited; MITSUDERA, Hiromasa; AWASAGUCHI, Kenichiro; AWANO, Tomotsugu; UJIHARA, Kazuya; EP2952096; (2015); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

112372-15-3, Furo[2,3-c]pyridine-2-carboxylic acid is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of trans-N-(4-aminocyclohexyl)-2-(4-chloro-3-fluorophenoxy)acetamide (0.200 g, 0.6 mmol, 1.0 equiv) in DMF (10 mL) was added furo[2,3-c]pyridine-2-carboxylic acid (0.108 g, 0.6 mmol, 1.0 equiv) and HATU (0.456 g, 1.2 mmol, 2.0 equiv) at RT. The reaction mixture was stir for 10 min. DIPEA (0.31 mL, 1.8 mmol, 3.0 equiv) was added and the resultant reaction mixture continued stirring at RT for overnight. Product formation was confirmed by LCMS. The reaction mixture was diluted with water (50 mL) and extracted with ethyl acetate (100 mL¡Á2). Combined organic extracts were washed with water (50 mL¡Á4), dried over anhydrous Na2SO4 and concentrated under reduced pressure to obtain crude which was purified by reversed phase HPLC to obtain trans-N-(4-(2-(4-chloro-3-fluorophenoxy)acetamido)cyclohexyl)furo[2,3-c]pyridine-2-carboxamide (Compound 24-90 mg, 30% Yield) as an off white solid. LCMS: 446 [M+H]+; 1HNMR (400 MHZ, DMSO-d6) delta 9.04 (s, 1H), 8.79 (d, J=7.9 Hz, 1H), 8.47 (d, J=5.3 Hz, 1H), 8.01 (d, J=8.3 Hz, 1H), 7.81 (d, J=5.3 Hz, 1H), 7.60 (s, 1H), 7.50 (t, J=9.0 Hz, 1H), 7.13-7.00 (m, 1H), 6.86 (d, J=8.3 Hz, 1H), 4.51 (s, 2H), 3.78 (br. s., 1H), 3.63 (br. s., 1H), 1.82 (d, J=16.2 Hz, 4H), 1.57-1.30 (m, 4H).

112372-15-3, The synthetic route of 112372-15-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Praxis Biotech LLC; BERNALES, Sebastian; DELGADO OYARZO, Luz Marina; NUNEZ VASQUEZ, Gonzalo Esteban; URETA DIAZ, Gonzalo Andres; PUJALA, Brahmam; PANPATIL, Dayanand; BHATT, Bhawana; CHAKRAVARTY, Sarvajit; US2019/177310; (2019); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

124391-75-9, (S)-(Tetrahydrofuran-3-yl)methanol is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Triphenylphosphine (7.7 g, 29.4 mmol) was added to a solution of (tetrahydrofuran-3-yl)methanol (2 g, 19.6 mmol) and carbon tetrabromide (7.7 g, 23.5 mmol) in DCM (30 mL) at 0 C. The reaction was stirred for 2 hours at room temperature. The mixture was poured into water (50 mL) and extracted with dichloromethane (50 mL x3). The organic extracts were combined, dried over anhydrous sodium sulfate, and concentrated. The residue was purified by silica gel column chromatography to give 3- (bromomethyl)tetrahydrofuran (2.0 g, 62% yield).

124391-75-9, 124391-75-9 (S)-(Tetrahydrofuran-3-yl)methanol 40784875, aTetrahydrofurans compound, is more and more widely used in various fields.

Reference£º
Patent; NEUROPORE THERAPIES, INC.; STOCKING, Emily M.; WRASIDLO, Wolfgang J.; (175 pag.)WO2019/199864; (2019); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.17347-61-4,2,2-Dimethylsuccinicanhydride,as a common compound, the synthetic route is as follows.

A mixture of N-(3-tert-butyl-phenyl)-6-piperazin-1-yl-nicotinamide (20 mg, 0.06 mmol) in CH2Cl2 (5 mL) was treated with 2,2-dimethylsuccinic anhydride (11 mg, 0.07 mmol). After stirring at rt overnight the solvent was evaporated. The residue was dissolved in a very small volume of CH2Cl2. The product was isolated by precipitation after addition of excess of hexanes (25 mg, Yield: 91percent) HRMS m/z calcd for C26H34N4O4 [M+H]+: 467.2653; Found: 467.2652.

17347-61-4, The synthetic route of 17347-61-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Bolin, David Robert; Cheung, Adrian Wai-Hing; Hamilton, Matthew Michael; Marcopulos, Nicholas; McDermott, Lee Apostle; Qian, Yimin; US2010/113782; (2010); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

184950-35-4, (Tetrahydrofuran-3-yl)methanamine hydrochloride is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

5- (3-chloro-5-fluorobenzyloxymethyl) isoxazole-3-carboxylic acid (1.04 g, 3.6 mmol), Tetrahydrofuran-3-ylmethylamine hydrochloride (0.75 g, 5.5 mmol), Triethylamine (0.76 mL, 5.5 mmol) And 1-hydroxybenzotriazole (0.05 g, 0.4 mmol) Was added to chloroform (amylene added product) (10 mL). To the mixture, 1-Ethyl-3- (3-dimethylaminopropyl) carbodiimide hydrochloride (0.84 g, 4.4 mmol) was added at room temperature, After stirring overnight, And concentrated under reduced pressure. Dilute hydrochloric acid was added to the residue, And extracted three times with ethyl acetate.The organic layer was washed with saturated aqueous sodium hydrogen carbonate solution, Washed with saturated brine, After drying with anhydrous sodium sulfate, And concentrated under reduced pressure. The residue was subjected to silica gel column chromatography, Represented by the following equation N- (tetrahydrofuran-3-ylmethyl) -5- (3-chloro-5-fluorobenzyloxymethyl) isoxazole-3-carboxamide (Hereinafter referred to as the amide compound (268)) 0.40 g was obtained., 184950-35-4

184950-35-4 (Tetrahydrofuran-3-yl)methanamine hydrochloride 17750392, aTetrahydrofurans compound, is more and more widely used in various fields.

Reference£º
Patent; SUMITOMO CHEMICAL COMPANY LIMITED; SUMITA, YUSUKE; (264 pag.)JP2015/51963; (2015); A;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem