Tag: M.W:100-200

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5061-21-2,2-Bromo-4-butanolide,as a common compound, the synthetic route is as follows.

5061-21-2, General procedure: To a stirred mixture of thiols 12a-12k (100 mmol) and K2CO3(27.64 g, 200 mmol) in DMF (120 mL) at room temperaturewas added alpha-bromobutyrolactone (10, 14.85 g, 90 mmol), andthe resulting mixture was stirred at room temperature until thecompletion of reaction as indicated by TLC analysis (typicallywithin 12 h).The reaction mixture was poured into ice-water (400 mL),and the mixture thus obtained was extracted with CH2Cl2 (3 ¡Á100 mL). The combined extracts were washed successively with10% aqueous Na2CO3 (2 ¡Á 100 mL) and 5% brine (3 ¡Á 100 mL),dried over anhydrous Na2SO4 and evaporated on a rotary evaporator to aord a residue, which was purifed by columnchromatography to yield 13a-13k after trituration withEtOAc/n-hexane if the product was a solid.

As the paragraph descriping shows that 5061-21-2 is playing an increasingly important role.

Reference£º
Article; Zhang, Xiansheng; Wu, Jingwei; Liu, Yuqiang; Xie, Yafei; Liu, Changying; Wang, Jianwu; Zhao, Guilong; Phosphorus, Sulfur and Silicon and the Related Elements; vol. 192; 7; (2017); p. 799 – 811;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5061-21-2,2-Bromo-4-butanolide,as a common compound, the synthetic route is as follows.

5061-21-2, To a solution of 4-bromophenol (13.9 g, 0.078 mol) in 75 mL of DMF was added cesium carbonate(38 g, 1.5 eq.). It was then cooled to 0 C and ct-Bromo-y-butyrolactone (18 g, 1.4 eq.) was added.After the addition was completed, the mixture was stirred at RT overnight. It was quenched withwater and extracted with EtOAc (3x). The combined organic layer was washed with water (2x),brine and dried (Na2504). The residue after concentration was purified on a Biotage column using 5-50% EtOAc in hexane to give 3-(4-bromophenoxy)dihydrofuran-2(3H)-one (17 g, 85%).

The synthetic route of 5061-21-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; THE BRIGHAM AND WOMEN’S HOSPITAL, INC.; THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES; LEE, Arthur; MCKEW, John, C.; PATEL, Paresma, R.; YU, Paul, B.; MOHEDAS, Agustin, H.; SANDERSON, Philip, E.; ZHENG, Wei; HUANG, Xiuli; UNIVERSITY OF HOUSTON SYSTEM; CUNY, Gregory, D.; (304 pag.)WO2016/11019; (2016); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.52079-23-9,(S)-(-)-alpha-Hydroxy-gamma-butyrolactone,as a common compound, the synthetic route is as follows.,52079-23-9

5- (2-aminoethoxy)-N- [3-chloro-4- (pyridin-2-ylmethoxy) phenyl] quinazolin-4-amine (obtained as described in Example 2.6, preparation of starting materials, 0.5 g, 1.19 mmol) was heated to 130C in xylene (20 ml) until it had dissolved. (S)- (-)-a-hydroxy-y- butyrolactone (0.10 ml, 1.31 mmol) was added and the mixture was stirred at 130C for 3 hours. More (S)-(-)-oc-hydroxy-y-butyrolactone (0.05 ml, 0.66 mmol) was added and the mixture was heated for a further 2 hours. The resultant precipitate was filtered off while the mixture was hot, washed with diethyl ether (3 x 10 ml) and dried to give the title compound as a solid (430 mg, 69%) ; NMR spectrum (DMSO-d6) 1.38-1. 55 (m, 1H), 1.69-1. 85 (m, 1H), 3.37-3. 50 (m, 2H), 3.61-3. 77 (m, 2H), 3.89-4. 00 (m, 1H), 4. 28-4. 45 (m, 3H), 5.29 (s, 2H), 5.51 (d, 1H), 7.13 (d, 1H), 7.22 (d, 1H), 7.28-7. 41 (m, 2H), 7.49-7. 62 (m, 2H), 7.71 (t, 1H), 8.01 (d, 1H), 8.14-8. 25 (m, 1H), 8.45 (s, 1H), 8. 59 (d, 1H), 9. 82 (s, 1H) ; Mass spectrum MU 523.9

As the paragraph descriping shows that 52079-23-9 is playing an increasingly important role.

Reference£º
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2005/51923; (2005); A1;,
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Tetrahydrofuran | (CH2)3CH2O – PubChem

1679-47-6, 3-Methyldihydrofuran-2(3H)-one is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

2 wt. % MGBL in 60 mL H2O, 1.0 g 5 wt. % Ru/C, 140 bar. Data reported at time of maximum MBDO selectivity: 80 C. (71 h-did not reach maximum), 100 C. (6.3 h), 120 C. (3.5 h), 140 C. (1.8 h), 160 C. (0.3 h), 200 C. (0.3 h). Pd/C (1.5 h), Pt/C (1.5 h).

1679-47-6, The synthetic route of 1679-47-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; REGENTS OF THE UNIVERSITY OF MINNESOTA; Dauenhauer, Paul J.; Spanjers, Charles; Zhang, Kechun; (37 pag.)US2017/297983; (2017); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

5061-21-2,5061-21-2, 2-Bromo-4-butanolide is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: A mixture of 41 (1 equiv), K2CO3 (3 equiv), and halogenated compounds (2 equiv) in DMF (5 mL) was stirred for 45 min at room temperature. After filtering the mixture and removing the solvent in vacuo, the residue was purified by column chromatography (eluent: hexane/EtOAc 95:5) to afford the desired compounds (42a-d) as white solids in 73-82% yields.

As the paragraph descriping shows that 5061-21-2 is playing an increasingly important role.

Reference£º
Article; Chen, Ying; Cheng, Ming; Liu, Fa-Qiang; Xia, Peng; Qian, Keduo; Yu, Donglei; Xia, Yi; Yang, Zheng-Yu; Chen, Chin-Ho; Morris-Natschke, Susan L.; Lee, Kuo-Hsiung; European Journal of Medicinal Chemistry; vol. 46; 10; (2011); p. 4924 – 4936;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.63095-51-2,(R)-4-Propyldihydrofuran-2(3H)-one,as a common compound, the synthetic route is as follows.

63095-51-2, (R)-4-propyl-dihydrofuran-2-one 10.0 g (78.1 mmol)Dissolved in 100 mL DMF, followed by the addition of potassium carbonate 11.9 g (85.9 mmol).(S)-2-aminobutyric acid 8.9 g (86.4 mmol), warmed to 50 C,Stir the reaction for 15h, the temperature of the reaction solution dropped to 0-5 C, diluted with water,Adjust the pH to 3 with 2N hydrochloric acid solution and extract three times with dichloromethane.The organic phases were combined, dried and concentrated to give 16.2 g of Intermediate II.The yield was 90.0%.

As the paragraph descriping shows that 63095-51-2 is playing an increasingly important role.

Reference£º
Patent; Beijing Wanquan De Zhong Pharmaceutical Biological Co., Ltd.; Ma Xiang; Zhao Guolei; Zhao Yunping; (7 pag.)CN108947883; (2018); A;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.16874-33-2,Tetrahydrofuran-2-carboxylic acid,as a common compound, the synthetic route is as follows.

4 Under dry conditions, 66.6 g (0.616 mol) of thionyl chloride was added dropwise to tetrahydrofurancarboxylic acid, and the temperature was controlled at 35 C for 3 hours to obtain tetrahydrofuroyl chloride, and then the temperature was controlled at 5 to 15 C, tetrahydrofuroyl chloride was added dropwise to 56.7 g (0.56 mol) of the acid-binding agent triethylamine, the organic solvent dichloroethane and N-methyl-N-benzyl-3-aminopropyldiamine 99 g ( 0.56mol) of the mixed solution, dripping, temperature control 35 C, reaction for 3 hours, adjusted to pH 8 with sodium bicarbonate solution, extracted with organic solvent, spin dry to obtain N-methyl-N-benzyl-3-acryl-tetrahydrofurancarboxamide crude product 128g, after purification to obtain refined product 101g, the yield is 65.8%, 16874-33-2

The synthetic route of 16874-33-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Liaoning Ke Ji Pharmaceutical Co., Ltd.; Wang Haiyan; Luo Wengong; Zhang Lulu; (9 pag.)CN108003141; (2018); A;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

97-99-4, (Tetrahydrofuran-2-yl)methanol is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

97-99-4, Example 22CN-[(2Z)-5-tert-butyl-3-[2R)-tetrahydrofuran-2-ylmethyl]-1,3-thiazol-2(3H)-ylidene]-2-[(2R)-tetrahydrofuran-2-ylmethoxy]-5-(trifluoromethyl)benzamideIn a 50 mL round-bottomed flask, (R)-(tetrahydrofuran-2-yl)methanol (176 mg, 1.74 mmol) was dissolved in tetrahydrofuran (8 ml). Sodium t-butoxide (176 mg, 1.83 mmol) was added and stirred at room temperature for 20 min before Example 22B (375 mg, 0.87 mmol) in tetrahydrofuran (5 mL) was added and stirred for 2 hours. The reaction was quenched with saturated ammonium chloride solution and extracted with ethyl acetate (3¡Á20 ml). The organics were combined, washed with brine, dried with sodium sulfate, filtered, and concentrated in vacuo. The residue was purified by Analogix Intelliflash280 (SiO2, 0-30% hexanes in ethyl acetate) to afford the title compound (210 mg, 47% yield). 1H NMR (300 MHz, DMSO-d6) delta ppm 1.32 (s, 9H) 1.59-1.68 (m, 1H) 1.75-2.00 (m, 7H) 3.60-3.69 (m, 2H) 3.70-3.82 (m, 2H) 4.04-4.10 (m, 2H) 4.11-4.24 (m, 3H) 4.25-4.32 (m, 1H) 7.25 (s, 1H) 7.28 (d, J=8.82 Hz, 1H) 7.73 (dd, J=8.65, 1.87 Hz, 1H) 7.94 (d, J=2.37 Hz, 1H); MS (DCI/NH3) m/z 513 (M+H)+. Anal. calcd C25H31F3N2O4S: C, 58.58; H, 6.1; N, 5.47. Found: C, 58.34; H, 6.22; N, 5.28.

97-99-4 (Tetrahydrofuran-2-yl)methanol 7360, aTetrahydrofurans compound, is more and more widely used in various fields.

Reference£º
Patent; ABBOTT LABORATORIES; US2010/63022; (2010); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.184950-35-4,(Tetrahydrofuran-3-yl)methanamine hydrochloride,as a common compound, the synthetic route is as follows.

Tetrahydrofuran-3-ylmethylamine hydrochloride (0.55 g, 3.97 mmol) And triethylamine (0.40 g, 3.97 mmol) Was added to chloroform (amylene added product) (15 mL). To the mixture, At room temperature 5- (5,6,7,8-tetrahydronaphthalen-2-ylmethyl) oxymethyl isoxazole-3-carboxylic acid (0.76 g, 2.65 mmol) 1-Hydroxybenzotriazole (0.04 g, 0.26 mmol) And 1-ethyl-3- (3-dimethylaminopropyl) carbodiimide hydrochloride (0. 76 g, 3.97 mmol) After stirring at room temperature for 5 hours, Dilute hydrochloric acid was added, It was extracted twice with chloroform. The organic layer was washed with saturated sodium bicarbonate water, After drying with anhydrous sodium sulfate, And concentrated under reduced pressure. The residue was subjected to silica gel column chromatography, The following equationIndicated by N- (tetrahydrofuran-3-ylmethyl) -5- (5,6,7,8-tetrahydronaphthalen-2-ylmethyl) oxymethyl isoxazole-3-carboxyamide (Hereinafter referred to as present amide compound (119)) 0.80 g was obtained., 184950-35-4

184950-35-4 (Tetrahydrofuran-3-yl)methanamine hydrochloride 17750392, aTetrahydrofurans compound, is more and more widely used in various fields.

Reference£º
Patent; SUMITOMO CHEMICAL COMPANY LIMITED; SUMITA, YUSUKE; (264 pag.)JP2015/51963; (2015); A;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

16874-33-2, Tetrahydrofuran-2-carboxylic acid is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Stage II: Preparation of N-[3-[(4-amino-6,7-dimethoxy-2-quinazolinyl) methylamino]propyl]tetrahydrofuran-2-carboxamide (Alfuzosin); Ethyl chloroformate (22.35 g, 0.206 mol) was added to a mixture of tetrahydrofuran-2- carboxylic acid (23.90 g, 0.206 mol), and triethylamine (20.80 g, 0.206 mol) in methylene dichloride (300 ml) at 0-50C. The stirring was continued for 30 min at 0-50C to complete the formation of mixed anhydride. To this, mixture of N]-(4-amino-6,7- dimethoxyquinazolin-2-yl)-Ni-methylpropane-l,3-diamine (50 g, 0.172 mol) in methylene dichloride (200 ml) was added at 0-50C and stirring was continued for additional 1 hr at 0-50C to complete the reaction. Thereafter, water was added to the reaction mass and pH was adjusted to 4.0-4.5. The organic layer was discarded and the pH of the aqueous layer was raised to 10-10.5 with aqueous sodium hydroxide. The aqueous layer was extracted with methylene dichloride and the organic extract was concentrated to remove methylene dichloride. The concentrated mass was stirred with acetone to afford Alfuzosin. The product was filtered and dried under vacuum. Yield: 50 g (75percent of theory). HPLC purity: 99.97percent.

16874-33-2, As the paragraph descriping shows that 16874-33-2 is playing an increasingly important role.

Reference£º
Patent; AUROBINDO PHARMA LIMITED; WO2007/74364; (2007); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem