Tag: M.W:100-200

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.19311-37-6,3-Bromotetrahydrofuran,as a common compound, the synthetic route is as follows.

Example 57: 5-methyl-2-{3-i4-(methylsulfonyl)phenoxy1-5-(tetrahvdrofuran- 3-yloxy)phenyl}pyrimidin-4(3H)-oneA mixture of 5-(4-(4-methoxybenzyloxy)-5-methylpyrimidin-2-yl)benzene-1 ,3- diol (125 mg, 0.369 mmol), 3-bromotetrahydrofuran (55 mg, 0.369 mmol) and potassium carbonate (102 mg, 0.738 mmol) in N,N-dimethylformamide (1 ml_) was stirred at 80C overnight. The reaction mixture was cooled to room temperature. 4-Fluorophenylmethylsulfone (65 mg, 0.369 mmol) and additional potassium carbonate (102 mg, 0.738 mmol) were then added to the reaction. The reaction mixture was stirred at 80C for 2 days. The cooled reaction mixture was treated with trifluoroacetic acid (0.75 ml_) for 3 hours, then diluted with EtOAc and washed with saturated aqueous sodium bicarbonate solution, dried over sodium sulfate and purified by HPLC to afford the title compound (11.3 mg, 19%). MS (M+1): 443.1. Column:Waters Atlantis C184.6mm x 50 mm, 5 muetaeta; Modifier: TFA 0.05%; Gradient: 95% H20 / 5% MeCN linear to 5% H20 / 95% MeCN over 4.0 minutes HOLD at 5% H20 / 95% MeCN to 5.0 minutes. Flow: 2.0 mL / min.; RT: 2.43 min., 19311-37-6

As the paragraph descriping shows that 19311-37-6 is playing an increasingly important role.

Reference£º
Patent; PFIZER INC.; ASPNES, Gary Erik; DIDIUK, Mary Theresa; GUZMAN-PEREZ, Angel; MAGUIRE, Robert John; WO2011/158149; (2011); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

184950-35-4, (Tetrahydrofuran-3-yl)methanamine hydrochloride is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Production Example 51 (0366) Tetrahydrofuran-3-ylmethylamine hydrochloride (0.38 g, 2.75 mmol) and triethylamine (0.28 g, 2.75 mmol) were added to chloroform (amylene addition product) (8 mL). 2-Butyl-2H-tetrazole-5-carboxylic acid (0.39 g, 2.29 mmol), 1-hydroxybenzotriazole (0.03 g, 0.23 mmol) and 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride (0.53g, 2. 75 mmol) were added to the mixture at room temperature, and the mixture was stirred overnight. Then, dilute hydrochloric acid was added thereto, and the mixture was extracted twice with chloroform. The organic layer was washed with a saturated aqueous sodium bicarbonate solution, dried over anhydrous magnesium sulfate, and then concentrated under reduced pressure. The residue was applied to a silica gel column chromatography to obtain 0.51 g of N-(tetrahydrofuran-3-ylmethyl)-2-butyl-2H-tetrazole-5-carbo xamide (hereinafter, referred to as Compound of Present Invention (56)) represented by the following formula. 1H-NMR(CDCl3, TMS, delta(ppm)):0.97(3H, t), 1.32-1.41(2H, m), 1.66-1.75(1H, m), 2.01-2.13(3H, m), 2.58-2.68(1H, m), 3.53-3.56(2H, m), 3.61-3.64(1H, m), 3.75-3.80(1H, m), 3.85-3.96(2H, m), 4.69(2H, t), 7.31(1H, br s)

184950-35-4, 184950-35-4 (Tetrahydrofuran-3-yl)methanamine hydrochloride 17750392, aTetrahydrofurans compound, is more and more widely used in various fields.

Reference£º
Patent; Sumitomo Chemical Company, Limited; MITSUDERA, Hiromasa; AWASAGUCHI, Kenichiro; AWANO, Tomotsugu; UJIHARA, Kazuya; EP2952096; (2015); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.165253-29-2,3-(Bromomethyl)tetrahydrofuran,as a common compound, the synthetic route is as follows.

Step 3: 3-((4-Bromo-3,5-dimethylphenoxy)methyl)tetrahydrofuran To a solution of 4-bromo-3,5-dimethylphenol (1.5 g) and K2CO3 (3.2 g) in N,N-dimethylformamide (12 mL) is added 3-(bromomethyl)tetrahydrofuran (3.6 g). The mixture is stirred for 16 hours at 80¡ã C. and then partitioned between water and ethyl acetate. The organic phase is washed with brine and dried (MgSO4). The solvent is evaporated and the residue is chromatographed on silica gel (cyclohexane/ethyl acetate 99:1?70:30) to give the title compound. Yield: 1.72 g; LC (method 1): tR=1.37 min; Mass spectrum (ESI+): m/z=285 [M+H]+., 165253-29-2

As the paragraph descriping shows that 165253-29-2 is playing an increasingly important role.

Reference£º
Patent; Boehringer Ingelheim International GmbH; ECKHARDT, Matthias; FRATTINI, Sara; HAMPRECHT, Dieter; HIMMELSBACH, Frank; LANGKOPF, Elke; LINGARD, Iain; PETERS, Stefan; WAGNER, Holger; US2013/252937; (2013); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

17347-61-4, 2,2-Dimethylsuccinicanhydride is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

17347-61-4, Example 15: Preparation of 2,2-dimethyl-4-oxo-4-(((lR,3aS,5aR,5bR,7aR,9S,l laR,l lbR, 13aR,13bR)-5a,5b,8,8,l la-pentamethyl-3a-((S)-2-(l-methyl-4-phenyl-lH-imidazol-2-yl) pyrrolidine- l-carbonyl)-l-(prop-l-en-2-yl)icosahydro-lH-cyclopentaralchrysen-9-yl)oxy) butanoic acid:2,2-Dimethylsuccinic anhydride (385 mg, 3.0 mmol) was added to a stirred solution of ((lR,3aS,5aR,5bR,7aR,9S,l laR,l lbR,13aR,13bR)-9-hydroxy-5a,5b,8,8,l la-pentamethyl- l-(prop-l-en-2-yl)icosahydro-3aH-cyclopenta[a]chrysen-3a-yl)((S)-2-(l-methyl-4-phenyl- lH-imidazol-2-yl)pyrrolidin-l-yl)methanone (Example 1-step 2, 500 mg, 0.75 mmol) and DMAP (183 mg, 1.49 mmol) in pyridine (8 ml) at room temperature and heated at 90¡ãC for about 24 hours. After completion of the reaction (monitored by TLC), the reaction mixture was diluted with dichloromethane, washed with 20percent HCl and brine solution. The residue was dried over Na2S04, filtered, the solvent was evaporated under reduced pressure and purified on silica gel column (100-200 mesh, elution 36-40percent ethyl acetate/hexanes) to afford the title compound (240 mg, Yield: 40percent) as an off white solid. H1 NMR (DMSO-D6, 300 MHz): delta 12.15 (s, 1H), 7.64 (d, J = 7.5 Hz, 2H), 7.42 (s, 1H), 7.27 (t, J = 7.5 Hz, 2H), 7.11 (t, J = 7.5, 1H), 5.11 (m, 1H), 4.50 (s, 1H), 4.43 (s, 1H), 4.35 (m, 1H), 3.85 (m, 1H), 3.68 (s, 3H), 3.65 (m, 1H), 2.75 (m, 1H), 2.10-2.60 (m, 6H), 0.70-2.0 (m, 48H); Mass (ESI): 794.55 [M+H]+; HPLC: 92.60percent.

As the paragraph descriping shows that 17347-61-4 is playing an increasingly important role.

Reference£º
Patent; HETERO RESEARCH FOUNDATION; BANDI, Parthasaradhi Reddy; KURA, Rathnakar Reddy; ADULLA, Panduranga Reddy; GAZULA LEVI, David Krupadanam; BAMMIDI, Eswara Rao; KOTHAKAPU, Ranga Reddy; (78 pag.)WO2016/1820; (2016); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.184950-35-4,(Tetrahydrofuran-3-yl)methanamine hydrochloride,as a common compound, the synthetic route is as follows.

Tetrahydrofuran-3-ylmethylamine hydrochloride (1.71 g, 12.4 mmol) and triethylamine (1.89 g, 18.7 mmol) were added to tetrahydrofuran (10 mL). To the mixture solution was added (E)-2-octenoic acid chloride (1.00 g, 6.22 mmol) under ice cooling, then the mixture was stirred at room temperature for 4 hours. Thereafter, water was added to the reaction mixture, and the mixture was extracted twice with ethyl acetate. The organic layer was washed with an aqueous solution of sodium bicarbonate, and dried over anhydrous sodium sulfate, then filtered, and the filtrate was concentrated under reduced pressure. The residue was applied to a silica gel column chromatography, to obtain 1.25 g of (E)-N-(tetrahydrofuran-3-ylmethyl)-2-octenamide (hereinafter, described as Compound (1) of the present invention) represented by the following formula.1H-NMR (CDCl3, TMS) delta (ppm): 0.88 (t, 3H), 1.22-1.38 (m, 4H), 1.40-1.48 (m, 2H), 1.58-1.68 (m, 1H), 2.00-2.09 (m, 1H), 2.17 (dq, 2H), 2.46-2.57 (m, 1H), 3.30-3.38 (m, 2H), 3.55 (dd, 1H), 3.74 (dd, 1H), 3.82 (dd, 1H), 3.89 (td, 1H), 5.65 (br s, 1H), 5.75 (dt, 1H), 6.84 (dt, 1H)

184950-35-4, As the paragraph descriping shows that 184950-35-4 is playing an increasingly important role.

Reference£º
Patent; Sumitomo Chemical Company Limited; IHARA, Hideki; AWANO, Tomotsugu; OHSHITA, Jun; MATSUO, Noritada; EP2813493; (2014); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.42417-39-0,3-Aminodihydrofuran-2(3H)-one hydrochloride,as a common compound, the synthetic route is as follows.,42417-39-0

The reactor was charged with 1 g of HSL ¡¤ HCl, 40 g of methanol and 0.05 g of Pt (5) / Ac, followed by NO / N2 (15 atm, 1: 1 (v / v) As above, additional H2 (6.5 atm) was added and the desmethylation reaction of HSL.HCl was performed. The product was partially recovered and the components were analyzed. The results are shown in Table 8 below.

As the paragraph descriping shows that 42417-39-0 is playing an increasingly important role.

Reference£º
Patent; CJ CHEILJEDANG CORPORATION; KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY; YANG, YOUNG RYEOL; KIM, BYUNG SIK; KIM, JEONG HYUN; LEE, JUNG HO; SHIN, HYUN KWAN; KIM, JU NAM; CHO, KYUNG HO; (40 pag.)KR2015/118287; (2015); A;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

184950-35-4, (Tetrahydrofuran-3-yl)methanamine hydrochloride is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

5- [3- (4-chlorophenyl) propyl] isoxazole-3-carboxylic acid (0.7 8 g, 2.9 mmol) Tetrahydrofuran-3-ylmethylamine hydrochloride (0.60 g, 4.4 mmol), Triethylamine (0.44 g, 4.4 mmol) And 1-hydroxybenzotriazole (0.04 g, 0.3 mmol) Was added to a mixed solvent of chloroform (amylene addition product) (4 mL) and tetrahydrofuran (4 mL). To the mixture, 1-Ethyl-3- (3-dimethylaminopropyl) carbodiimide hydrochloride (0.67 g, 3.5 mmol) was added at room temperature, After stirring overnight at room temperature, And concentrated under reduced pressure. Dilute hydrochloric acid was added to the residue, And extracted three times with ethyl acetate. The organic layer was washed with saturated aqueous sodium hydrogen carbonate solution, Washed with saturated brine, After drying with anhydrous sodium sulfate, And concentrated under reduced pressure. The residue was subjected to silica gel column chromatography, The following equation Indicated by N- (tetrahydrofuran-3-ylmethyl) -5- (3- (4-chlorophenyl) propyl) isoxazole-3-carboxamide (Hereinafter referred to as the amide compound (25 2)) 0.78 g was obtained.

184950-35-4, 184950-35-4 (Tetrahydrofuran-3-yl)methanamine hydrochloride 17750392, aTetrahydrofurans compound, is more and more widely used in various fields.

Reference£º
Patent; SUMITOMO CHEMICAL COMPANY LIMITED; SUMITA, YUSUKE; (264 pag.)JP2015/51963; (2015); A;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.112372-15-3,Furo[2,3-c]pyridine-2-carboxylic acid,as a common compound, the synthetic route is as follows.

A solution of tert-butyl 4-[6- (aminomethyl)pyridine-3 -sulfonyl]piperidine-1-carboxylate (90 mg, 0 25 mmol), furo[2,3-c]pyridine-2-carboxylic acid (49.5 mg, 0.30 mmol, 1 .20 equiv), EDCI (96 mg, 0.49 mmol), HOBt (5 1 mg, 0.37 mmol), and triethylamine (77 mg, 0.75 mmol, 3.01 equiv, 98%) in DMF (1 mL) was stirred overnight at rt. The reaction was then quenched by the addition of 1 0 mL of water and the resulting solution was extracted with 3×20 mL of ethyl acetate. The combined organic layers was washed with 2×20 mL of water, dried over anhydrous sodium sulfate, and concentrated under vacuum to give 1 04 mg (84%) of tert-butyl 4-[6-([furo[2,3-c]pyridin-2- ylformamido]methyl)pyridine-3-sulfonyl]piperidine-1-carboxylate as a yellow oil. LC MS (Method F, ESI): RT = 1 . 1 5 min, w z = 501 .0 [M+H], 112372-15-3

As the paragraph descriping shows that 112372-15-3 is playing an increasingly important role.

Reference£º
Patent; GENENTECH, INC.; FORMA TM, LLC; BAIR, Kenneth W.; BAUMEISTER, Timm R.; DRAGOVICH, Peter; GOSSELIN, Francis; YUEN, Po-Wai; ZAK, Mark; ZHENG, Xiaozhang; WO2013/127267; (2013); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.124391-75-9,(S)-(Tetrahydrofuran-3-yl)methanol,as a common compound, the synthetic route is as follows.

TETRAHYDRO-3-FURAN methanol 65 (0.50 g, 4.9 mmol) was dissolved in dry DCM (30 mL) and triethylamine (1.06 mL, 8.8 mmol, 1.8 equiv) was added to the solution via syringe under N2 with stirring. The solution was cooled to 0 ¡ãC and METLIANESULFONYL chloride 63 (0.68 mL, 8.8 mmol, 1.8 equiv) added dropwise via syringe. The resultant solution was allowed to warm to RT and stirred at RT for 36 h. The solvent was then removed in vacuo. The residue was dissolved in fresh DCM and water (25 mL) added to the solution. The solution was then extracted with DCM. The DCM extracts were washed with brine, and the brine back-extracted with DCM. The combined DCM extracts were then reduced in vacuo to yield a yellow oil (66,0. 88 g, quantitative)., 124391-75-9

As the paragraph descriping shows that 124391-75-9 is playing an increasingly important role.

Reference£º
Patent; UNIVERSITY COLLEGE CARDIFF CONSULTANTS LIMITED; REGA FOUNDATION; WO2004/96813; (2004); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.184950-35-4,(Tetrahydrofuran-3-yl)methanamine hydrochloride,as a common compound, the synthetic route is as follows.

Tetrahydrofuran-3-ylmethylamine hydrochloride (0.24 g, 1.75 mmol) And triethylamine (0.18 g, 1.75 mmol) Was added to chloroform (amylene added product) (8 mL). To the mixture, 5- (5,6,7,8-tetrahydronaphthalen-2-yl) oxymethyl isoxazole-3-carboxylic acid (0.40 g, 1.46 mmol) at room temperature, 1-Hydroxybenzotriazole (0.02 g, 0.18 mmol) And 1-ethyl-3- (3-dimethylaminopropyl) carbodiimide hydrochloride (0.34 g, 1.75 mmol) After stirring for 5 hours, Dilute hydrochloric acid was added, It was extracted twice with chloroform. The organic layer was washed with saturated sodium bicarbonate water, After drying with anhydrous sodium sulfate, And concentrated under reduced pressure. The residue was subjected to silica gel column chromatography to obtain the compound represented by the following formula Indicated by N- (tetrahydrofuran-3-ylmethyl) -5- (5,6,7,8-tetrahydronaphthalen-2-yl) oxymethyl isoxazole-3-carboxamide (Hereinafter referred to as present amide compound (239)) 0.40 g was obtained., 184950-35-4

As the paragraph descriping shows that 184950-35-4 is playing an increasingly important role.

Reference£º
Patent; SUMITOMO CHEMICAL COMPANY LIMITED; SUMITA, YUSUKE; (264 pag.)JP2015/51963; (2015); A;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem