A new application about Furan-2,4(3H,5H)-dione

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A Novel and Highly Stereoselective Approach to Aza-Spirocycles. A Short Total Synthesis of 2-epi-(¡À)-Perhydrohistrionicotoxin and an Unprecedented Decarboxylation of 2-Pyrones

(Matrix Presented) A novel and highly stereoselective synthesis of aza-spirocycles is described. An application of this methodology is illustrated as a short and concise total synthesis of 2-epi-(¡À)-perhydrohistrionicotoxin with high diastereomeric control at the aza-spirocenter. An unprecedented decarboxylation of the 2-pyrone ring is observed in this total synthesis effort.

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Reference£º
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Discovery of 3-Methyldihydrofuran-2,5-dione

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In heterogeneous catalysis, the catalyst is in a different phase from the reactants. Safety of 3-Methyldihydrofuran-2,5-dione, At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 4100-80-5, name is 3-Methyldihydrofuran-2,5-dione. In an article£¬Which mentioned a new discovery about 4100-80-5

Reactions of Trialkylsilyl Trifluoromethanesulfonates, VIII. – Synthesis of O-(Trimethylsilyl)ketene O,N-Acetals, 2,5-Bis(trimethylsiloxy)pyrroles, -furans, and -thiophenes

Ketene O,N-acetals 3, 4, 6, 8 are obtained from N,N-diarylcarboxamides and N-acetylheterocycles 5, 7 by silylation with trimethylsilyl triflate (2) in the presence of triethylamine.Analogous reactions of carboxamides 9 and N-acyllactams 11 yield the ketene O,N-acetals 10, 12.Succinimides 13, succinic anhydrides 20, and succinic thioanhydrides 22 are doubly silylated by 2 to give the 2,5-bis(trimethylsiloxy)heterocycles 14, 21, 23. 2,5-Bis(trimethylsiloxy)furan (21a) reacts with aldehyde acetals and orthoesters 24 catalyzed by 2 to yield 2,3-disubstituted succinic anhydrides 25.

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Reference£º
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

A new application about Furan-2,4(3H,5H)-dione

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4971-56-6, Name is Furan-2,4(3H,5H)-dione, belongs to Tetrahydrofurans compound, is a common compound. Quality Control of Furan-2,4(3H,5H)-dioneIn an article, once mentioned the new application about 4971-56-6.

Synthesis and anticancer activity of 4-aza-daurinol derivatives

Daurinol, a natural aryl naphthalene lactone, has been reported to have antiproliferative activity against various cell lines, and has also been shown to be efficacious in an in vivo xenograft mouse model. In this study, we tried to discover a new scaffold that enables both rapid structure-activity relationship study of daurinol and scalable synthesis of active compounds. 4-Aza-daurinol, a bioisosterism-based scaffold of daurinol, was designed and 17 analogues were synthesized and evaluated against five representative cancer cell lines. Among them, the 2,3-dihydrobenzo[b][1,4]dioxinyl derivative was found to be the most potent and showed similar activity and tendency as daurinol.

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Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

The Absolute Best Science Experiment for 165253-31-6

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Reference of 165253-31-6, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.165253-31-6, Name is (Tetrahydrofuran-3-yl)methanamine, molecular formula is C5H11NO. In a Patent£¬once mentioned of 165253-31-6

BENZIMIDAZOLE DERIVATIVES AS BROMODOMAIN INHIBITORS

Compounds of formula (I) and salts thereof: wherein R1, R2, R3, R4 are defined herein. Compounds of formula (I) and salts thereof have been found to inhibit the binding of the BET family of bromodomain proteins to, for example, acetylated lysine residues and thus may have use in therapy, for example in the treatment of autoimmune and inflammatory diseases, such as rheumatoid arthritis; and cancers.

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Reference£º
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Final Thoughts on Chemistry for (Tetrahydrofuran-3-yl)methanamine

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3 – Amino methyl tetrahydrofuran synthetic method (by machine translation)

The invention discloses a 3 – amino methyl tetrahydrofuran synthetic method. The method in order to maleic acid diester as the starting material, by Michael addition, metal borohydride reduction, dehydration cyclization and catalytic hydrogenation reduction of four-step reaction for the synthesis of 3 – amino methyl tetrahydrofuran. The invention synthetic method of mild reaction conditions, high product yield, less pollution emission, simple process operation, is suitable for industrial production. (by machine translation)

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Reference£º
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Some scientific research about 87392-07-2

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TRICYCLIC INHIBITORS OF HEPATITIS B VIRUS

The present invention relates to compounds that are inhibitors of hepatitis B virus (HBV). Compounds of this invention are useful alone or in combination with other agents for treating, ameliorating, preventing or curing HBV infection and related conditions. The present invention also relates to pharmaceutical compositions containing said compounds.

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Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Top Picks: new discover of (Tetrahydrofuran-3-yl)methanol

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15833-61-1, Name is (Tetrahydrofuran-3-yl)methanol, belongs to Tetrahydrofurans compound, is a common compound. Product Details of 15833-61-1In an article, once mentioned the new application about 15833-61-1.

Through the Prins reaction to synthesize 3 – tetrahydrofuran methanol new process (by machine translation)

The invention discloses through Prins reaction to synthesize 3 – tetrahydrofuran-methanol of the new process, solved in the prior art in a manufacturing process, the raw materials are not only expensive, raising the production cost, but also the production process would release a large amount of heat and flammable and explosive gas hydrogen, will be brought to the production the security risk. The invention comprises (1) in the organic solvent, 2, 5 – dihydrofuran catalyst under the action of the A poly formaldehyde and hydrogen chloride reaction, to obtain the methyl – 2, 5 – dihydrofuran; (2) methyl 2, 5 – dihydrofuran in the sodium hydroxide solution is hydrolyzed to hydroxymethyl – 2, 5 – dihydrofuran, distilled to obtain crude; (3) crude hydroxy methyl – 2, 5 – dihydrofuran B under the action of the catalyst by the hydrogen reduction to obtain 3 – tetrahydrofuran methanol, filtering, rectifying the filtrate to obtain the pure product. The invention has the low cost of raw materials, little three-waste discharge, simple process and the like. (by machine translation)

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Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Some scientific research about 57203-01-7

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Electric Literature of 57203-01-7, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.57203-01-7, Name is (S)-(Tetrahydrofuran-2-yl)methanol, molecular formula is C5H10O2. In a Patent£¬once mentioned of 57203-01-7

NOVEL COMPOUNDS AS CANNABINOID RECEPTOR LIGANDS

The present application relates to cannabinoid receptor ligands of formula (I) wherein X1, A1, Rx, R2, R3, R4, and z are as defined in the specification. The present application also relates to compositions comprising such compounds, and methods for treating conditions and disorders using such compounds and compositions

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Reference£º
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

A new application about 3-Methyldihydrofuran-2,5-dione

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Related Products of 4100-80-5, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.4100-80-5, Name is 3-Methyldihydrofuran-2,5-dione, molecular formula is C5H6O3. In a Article£¬once mentioned of 4100-80-5

Application of a double Mannich reaction using bis(aminol) ethers in the synthesis of AE ring analogues of methyl lycaconitine

An efficient method for the construction of azabicyclo[3.3.1]nonanes and azabicyclo[3.2.1]octanes is reported via double Mannich reaction of cyclic ketoesters with bis(aminol) ethers. This method is applied to the synthesis of AE ring analogues of methyl lycaconitine.

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Reference£º
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

A new application about 89364-31-8

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Synthetic Route of 89364-31-8, Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics.In a document type is Patent, and a compound is mentioned, 89364-31-8, Tetrahydrofuran-3-carboxylic acid, introducing its new discovery.

Synthesis of combinatorial libraries of compounds reminiscent of natural products

The present invention provides complex compounds reminiscent of natural products and libraries thereof, as well as methods for their production. The inventive compounds and libraries of compounds are reminiscent of natural products in that they contain one or more stereocenters, and a high density and diversity of functionality. In general, the inventive libraries are synthesized from diversifiable scaffold structures, which are synthesized from readily available or easily synthesizable template structures. In certain embodiments, the inventive compounds and libraries are generated from diversifiable scaffolds synthesized from a shikimic acid based epoxyol template. In other embodiments, the inventive compounds and libraries are generated from diversifiable scaffolds synthesized from the pyridine-based template isonicotinamide. The present invention also provides a novel ortho-nitrobenzyl photolinker and a method for its synthesis. Furthermore, the present invention provides methods and kits for determining one or more biological activities of members of the inventive libraries. Additionally, the present invention provides pharmaceutical compositions containing one or more library members.

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Reference£º
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem