Some scientific research about Ethyl tetrahydrofuran-2-carboxylate

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Pyridine-2-propanoic acids: Discovery of dual PPARalpha/gamma agonists as antidiabetic agents

A series of novel pyridine-2-propanoic acids was synthesized. A structure-activity relationship study of these compounds led to the identification of potent dual PPARalpha/gamma agonists with varied isoform selectivity. Based on the results of efficacy studies in diabetic (db/db) mice, and the desired pharmacokinetic parameters, compound (S)-13 was selected for further profiling.

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Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Brief introduction of 3-Methyldihydrofuran-2(3H)-one

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Reactions of lactones with tropospheric oxidants: A kinetics and products study

Tropospheric lifetimes of two lactones, gamma-valerolactone (GVL) and alpha-methyl gamma-butyrolactone (AMGBL) in terms of their reactions with two important tropospheric oxidants- OH and Cl – are estimated, after determining the respective rate coefficients of their reactions in the gas phase using relative rate method. Values of the rate coefficients of the reactions of GVL (kOH?= (1.95?¡À?0.58) x 10?12; kCl?=?2.26?¡À?0.53?¡Á?10?11 cm3molecule?1s?1) and AMGBL (kOH?=?1.81?¡À?0.43?¡Á?10?12; kCl?=?3.42?¡À?0.63?¡Á?10?11 cm3molecule?1s?1) at 298?K imply that reaction with OH is the dominant reaction in the ambient conditions, and that reaction with Cl atom becomes relevant under marine boundary layer (MBL) conditions, reducing the tropospheric lifetimes to almost half. The tropospheric life times of GVL and AMGBL based on their reaction with OH under ambient conditions are comparable, 71.2 and 76.7?h respectively. However, the products of the reactions are found to be different. In GVL, a promising second generation biofuel component, only ring opening reactions are important, acetic acid and CO2 being the only observed volatile products. In AMGBL, additional ring oxidized products are also formed, of which 3,4-dihydro-3-methyl-2,5-furandione is the most dominant one. The absence of such ring oxidized products in GVL is assigned to the difference in the preferred position of H atom abstraction, based on the computed rate coefficients of individual channels reported in the literature. This suggests that the impact in terms of aerosol generation in the troposphere may also be different for GVL and AMGBL, which differ only in the position of methyl substitution.

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Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Extended knowledge of 3-Methyldihydrofuran-2(3H)-one

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Selective Mono-methylation of Arylacetonitriles and Methyl Arylacetates by Dimethyl Carbonate

Both arylacetonitriles and methyl arylacetates react with dimethyl carbonate (DMC) (20 molar excess) at 180 – 200 deg C in the presence of K2CO3 to produce monomethylated 2-arylpropionitriles and methyl 2-arylpropionates, respectively, with a selectivity >99.5percent.The reaction, with wide application, proceeds by DMC acting as a methoxycarbonylating agent towards the ArCH-X anion (X = CN, CO2Me) and as a methylating agent to ArC-(CO2Me)X.DMC also proved to be the best solvent for such reactions.

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Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Brief introduction of 52449-98-6

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Synthetic Route of 52449-98-6, Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.52449-98-6, Name is Oxolane-2-carbonyl chloride, molecular formula is C5H7ClO2. In a article£¬once mentioned of 52449-98-6

Tricyclic diazepine vasopressin antagonists and oxytocin antagonists

Tricyclic diazepines of the formula: STR1 wherein A, B, D, E, F, Y and Z are defined in the specification which compounds have vasopressin and oxytocin antagonist activity.

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Tetrahydrofuran – Wikipedia,
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Extracurricular laboratory:new discovery of 89364-31-8

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Evaluation of a 3-amino-8-azabicyclo[3.2.1]octane replacement in the CCR5 antagonist maraviroc

The bicyclic 5-amino-3-azabicyclo[3.3.0]octanes were shown to be effective replacements for the 3-amino-8-azabicyclo[3.2.1]octane found in the CCR5 antagonist maraviroc.

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Tetrahydrofuran – Wikipedia,
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Some scientific research about 52079-23-9

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In heterogeneous catalysis, the catalyst is in a different phase from the reactants. Safety of (S)-(-)-alpha-Hydroxy-gamma-butyrolactone, At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 52079-23-9, name is (S)-(-)-alpha-Hydroxy-gamma-butyrolactone. In an article£¬Which mentioned a new discovery about 52079-23-9

Synthesis of 1alpha,25-dihydroxy-24R-fluorocholecalciferol and 1alpha,25-dihydroxy-24S-fluorocholecalciferol

1alpha,25-Dihydroxy-24R-fluorocholecalciferol and 1alpha,25-dihydroxy-24S-fluorocholecalciferol, analogs of 1alpha,25-dihydroxy-cholecalciferol which is physiologically the most active metabolite of vitamin D3, are synthesized in a multistep process from the known substance 1alpha,3beta-dihydroxyandrost-5-en-17-one. The new analogs are characterized by the ability to increase intestinal calcium transport, increase serum calcium and phosphate concentrations and to increase the deposition of these minerals in bones. These compounds will find a ready application as substitutes for natural 1alpha,25-dihydroxycholecalciferol in the treatment of disease states characterized by metabolic calcium and phosphate deficiencies. Exemplary of such disease states are the following: osteosclerosis, anticonvulsant treatment, osteopenia, fibrogenesis-imperfecta ossium, secondary hyperparathyrodism, hypoparathyroidism, hyperparathyroidism, cirrhosis, obstructive jaundice, drug induced metabolism, medullary carcinoma, chronic renal disease, hypophosphatemic VDRR, vitamin D-dependent rickets, sarcoidosis, glucocorticoid antagonism, malabsorption syndrome, steatorrhea, tropical sprue, idiopathic hypercalcemia and milk fever.

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Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Simple exploration of 3-Methyldihydrofuran-2,5-dione

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Investigation on the structural features of Zhundong subbituminous coal through ruthenium ion-catalyzed oxidation

The structural features of Zhundong subbituminous coal (ZSBC) were investigated by ruthenium ion-catalyzed oxidation (RICO) and subsequent analyses with a gas chromatograph/mass spectrometer and an atmospheric-pressure solid analysis probe/time of flight-mass spectrometer (ASAP/TOF-MS). The results suggest that condensed aromatic rings linked by short polymethylene bridged linkages, long side chains, and oxygen-containing groups are predominant in ZSBC. Aliphatic bridged linkages connecting 3 aromatic rings also exist in ZSBC. Several heterocyclic carboxylic acids were produced from RICO of ZSBC. The heterocyclic moieties include tetrahydrofuran, pyridine, pyrazole, benzo[b]thiophene, and dithiole rings, suggesting the existence of oxygen-, nitrogen-, and sulfur-containing building blocks in ZSBC. According to analysis with ASAP/TOF-MS, a series of heavier arenecarboxylic acids were detected in the products from RICO of ZSBC and aromatic rings of the heavier arenepolycarboxylic acids include naphthalene, biphenyl, anthracene, phenylnaphthalene, and methyl(phenyl)tetrahydroanthracene, implying that ZSBC contains highly condensed aromatic rings. The existence of chlorine- and bromine-containing moieties was confirmed by the identification of chlorine- and bromine-containing species produced from RICO of ZSBC.

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Archives for Chemistry Experiments of 89364-31-8

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Synthetic Route of 89364-31-8, A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 89364-31-8, Name is Tetrahydrofuran-3-carboxylic acid, molecular formula is C5H8O3. In a Article£¬once mentioned of 89364-31-8

An improved and practical sharpless oxidation of primary alcohols to the carboxylic acids

An improved and practical procedure for the oxidation of primary alcohols to the carboxylic acids under Sharpless’s conditions (NaIO4/RuCl3.H2O/water/acetonitrile) using ethyl acetate as the solvent, in place of toxic and ecologically undesirable carbon tetrachloride, is described.

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Tetrahydrofuran – Wikipedia,
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Top Picks: new discover of 1679-47-6

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A study of the degradation of ester-modified epoxy resins obtained by cationic copolymerization of DGEBA with gamma-lactones initiated by rare earth triflates

The thermal degradation of new thermosetting materials prepared by cationic copolymerization of mixtures with different proportions of diglycidylether of bisphenol A (DGEBA) with gamma-valerolactone (gamma-VL) or alpha-methyl-gamma-butyrolactone (gamma-MBL) initiated by scandium, ytterbium or lanthanum triflate and a complex of boron trifluoride was investigated. To study the thermal degradation thermogravimetry (TGA) was used. The materials are more degradable than conventional epoxy resins due to the presence of ester groups in the polymer chain, which are broken at the beginning of degradation. The degradability increased with the proportion of linear ester groups and the Lewis acidity of the initiator used in the polymerization and when the proportion of lactone in the initial mixture increased. The kinetic parameters of the degradation were calculated from TGA data by applying isoconversional procedures.

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Tetrahydrofuran – Wikipedia,
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Discovery of (Tetrahydrofuran-3-yl)methanol

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Electric Literature of 15833-61-1, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.15833-61-1, Name is (Tetrahydrofuran-3-yl)methanol, molecular formula is C5H10O2. In a Patent£¬once mentioned of 15833-61-1

NEW INDANYLOXYDIHYDROBENZOFURANYLACETIC ACIDS

The present invention relates to compounds of general for-mula I, wherein the groups R1, R2 and m are defined as in claim 1, which have valuable pharmacological properties, in particu-lar bind to the GPR40 receptor and modulate its activity. The compounds are suitable for treatment and prevention of dis-eases which can be influenced by this receptor, such as meta-bolic diseases, in particular diabetes type 2

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Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem