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Pyridine-3-propanoic acids: Discovery of dual PPARalpha/gamma agonists as antidiabetic agents

A series of novel pyridine-3-propanoic acids was synthesized. A structure-activity relationship study of these compounds led to the identification of potent dual PPARalpha/gamma agonists with varied isoform selectivity. Based on the results of efficacy studies in diabetic (db/db) mice, and the desired pharmacokinetic parameters, compounds (S)-14 and (S)-19 were selected for further profiling.

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Reference£º
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Brief introduction of (S)-4-Hydroxydihydrofuran-2(3H)-one

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Reference of 7331-52-4, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.7331-52-4, Name is (S)-4-Hydroxydihydrofuran-2(3H)-one, molecular formula is C4H6O3. In a Article£¬once mentioned of 7331-52-4

Vapor-phase reaction of polyols over copper catalysts

The vapor-phase reaction of triols and diols was performed over copper metal catalysts. Triols, such as 1,2,3-propanetriol (glycerol) and 1,2,3- and 1,2,4-butanetriols, were dehydrated to afford corresponding hydroxyketones, while 1,2-propanediol was dehydrogenated to form hydroxyacetone. Supported copper as well as pure copper metal was an effective catalyst for the dehydration of glycerol to produce hydroxyacetone under inert conditions. In hydrogen flow, however, copper catalyzed the hydrogenation of hydroxyacetone as well as hydrogenolysis to produce ethylene glycol. Alumina-supported copper showed the highest catalytic activity with hydroxyacetone selectivity of >90 mol% at ambient pressure of nitrogen and 250 C. Copper metal provides an active site for the dehydration of glycerol. We propose a reaction mechanism for the dehydration of glycerol to form hydroxyacetone.

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Reference£º
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

More research is needed about Oxolane-2-carbonyl chloride

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Related Products of 52449-98-6, Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In some cases, the catalyzed mechanism may include additional steps.In a article, 52449-98-6, molcular formula is C5H7ClO2, introducing its new discovery.

Safe, selective, and high-yielding synthesis of acryloyl chloride in a continuous-flow system

Acid chlorides are an important class of compounds and their high reactivity and instability has prompted us to develop a straightforward procedure for their synthesis with ondemand and on-site synthesis possibilities. The focus of this report is acryloyl chloride, mainly important for the acrylate and polymer industry. A continuous-flow methodology was developed for the fast and selective synthesis of the otherwise highly unstable acryloyl chloride. Three routes were investigated in a microreactor setup and all three can potentially be used for its production. The methodology was further expanded to the synthesis of other unstable acid chlorides by both the thionyl chloride and the oxalyl chloride mediated processes. The most sustainable method was the oxalyl chloride mediated procedure under solvent-free conditions, in which nearequimolar amounts of carboxylic acid and oxalyl chloride were used in the presence of catalytic amounts of DMF at room temperature. Within 1 to 3 min, nearly full conversions into the acid chlorides were achieved.

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Reference£º
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

More research is needed about Oxolane-2-carbonyl chloride

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Staudinger reactions of unsymmetrical cyclic ketenes: A synthetically useful approach to spiro beta-lactams and derivatives. Reaction mechanism and theoretical studies

An efficient and operationally simple synthesis of tetrahydrofuran-derived spiro-beta-lactams using the ketene-imine cycloaddition route is described. Also the preparation of spiro-N-sulfonyl-beta-lactam derivatives, which are analogs of monobactams, is reported. As far as we know, this is the first time that an unsymmetrical cyclic ketene is used in a Staudinger-type reaction. The experimental evidence suggests the involvement of a ketene derived from the acyl chloride precursor in the reaction. High-level ab initio calculations have been performed in order to get insight into the electronic effects controlling the stereochemical outcome of the reactions.

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Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

The important role of Ethyl tetrahydrofuran-2-carboxylate

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Pyridine-3-propanoic acids: Discovery of dual PPARalpha/gamma agonists as antidiabetic agents

A series of novel pyridine-3-propanoic acids was synthesized. A structure-activity relationship study of these compounds led to the identification of potent dual PPARalpha/gamma agonists with varied isoform selectivity. Based on the results of efficacy studies in diabetic (db/db) mice, and the desired pharmacokinetic parameters, compounds (S)-14 and (S)-19 were selected for further profiling.

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Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Extracurricular laboratory:new discovery of (S)-Tetrahydrofuran-2-carboxylic acid

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Related Products of 87392-07-2, Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.87392-07-2, Name is (S)-Tetrahydrofuran-2-carboxylic acid, molecular formula is C5H8O3. In a article£¬once mentioned of 87392-07-2

QUINAZOLINES USEFUL AS MODULATOS OF ION CHANNELS

The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.

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Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Archives for Chemistry Experiments of 2,2,5,5-Tetramethyldihydrofuran-3(2H)-one

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. Computed Properties of C8H14O2, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 5455-94-7, in my other articles.

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SUBSTITUTED PYRAZOLES AS N-TYPE CALCIUM CHANNEL BLOCKERS

Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula (I) as follows: wherein R1, R2, ring A, and G are defined herein.

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Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Awesome and Easy Science Experiments about 4,4-Dimethyldihydrofuran-2,3-dione

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Electric Literature of 13031-04-4, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.13031-04-4, Name is 4,4-Dimethyldihydrofuran-2,3-dione, molecular formula is C6H8O3. In a Patent£¬once mentioned of 13031-04-4

Preparation of 4,4-dimethyltetrahydrofuran-2,3-dione

4,4-Dimethyltetrahydrofuran-2,3-dione is prepared by reacting a dimethylpyruvate (II) with formaldehyde or a formaldehyde donor at 80-150 C.

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Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Awesome Chemistry Experiments For 57203-01-7

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Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments. Product Details of 57203-01-7. Introducing a new discovery about 57203-01-7, Name is (S)-(Tetrahydrofuran-2-yl)methanol

Observations on the reactivity of thiyl radicals derived from 3,6-epidithiodiketopiperazine-2,5-diones and related congeners

A range of thiyl radicals derived from the reduced form of epidithiodiketopiperazines (ETPs) act as polarity reversal catalysts for the hydrosilylation of an enol lactone but not for H-atom abstraction from a model ribose ester.

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Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Awesome and Easy Science Experiments about Tetrahydrofuran-3-carboxylic acid

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. Safety of Tetrahydrofuran-3-carboxylic acid, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 89364-31-8, in my other articles.

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SUBSTITUTED PHTHALAZINES

Provided are compounds of formula (I), Wherein R 1, R 2, R 3, R 4, R 5 and R 6 are as defined in the specification, and pharmaceutically acceptable salts thereof, which are useful as agents in the treatment of diseases and conditions mediated and modulated by SUV402H1. Also provided are pharmaceutical compositions comprised of one or more compounds of formula (I).

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Reference£º
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem