The important role of 3-Methyldihydrofuran-2,5-dione

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6-Phenyl-1,2,4-triazolo[4,3-b]pyridazine hypotensive agents

This disclosure describes novel substituted 6-phenyl-1,2,4-triazolo[4,3-b]pyridazines useful as hypotensive agents.

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Reference£º
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

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Application of 89364-31-8, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.89364-31-8, Name is Tetrahydrofuran-3-carboxylic acid, molecular formula is C5H8O3. In a Patent£¬once mentioned of 89364-31-8

THIAZOLOPYRIMIDINONE DERIVATIVES AS PI3 KINASE INHIBITORS

This invention relates to the use of thiazolopyrimidinone derivatives for the modulation, notably the inhibition of the activity or function of the phosphoinositide 3? OH kinase family (hereinafter PI3 kinases), suitably, PI3Kalpha, PI3Kdelta, PI3Kbeta, and/or PI3Kgamma. Suitably, the present invention relates to the use of thiazolopyrimidinones in the treatment of one or more disease states selected from: autoimmune disorders, inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, allergy, asthma, pancreatitis, multiorgan failure, kidney diseases, platelet aggregation, cancer, sperm motility, transplantation rejection, graft rejection and lung injuries. More suitably, the present invention relates to PI3Kbeta selective thiazolopyrimidinones compounds for treating cancer

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Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Extended knowledge of 4,4-Dimethyldihydrofuran-2,3-dione

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. Formula: C6H8O3, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 13031-04-4, in my other articles.

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Enantioselective hydrogenation of alpha-ketoesters over alkaloid-modified platinum nanowires

A green process for enantioselective hydrogenation of alpha-ketoesters over cinchona alkaloid-modified platinum (Pt) nanowires has been developed. Pt nanowires with a diameter of ?1 nm were successfully synthesized, and used for the asymmetric hydrogenation of alpha-ketoesters in the presence of cinchona alkaloids under a low pressure at room temperature in water. Quantitative yields and excellent enantioselectivity of up to 78% were achieved. The catalyst along with the modifier was recycled multiple times without any significant loss in activity or selectivity. To our knowledge, such a catalyst system is unprecedented for asymmetric hydrogenation of alpha-ketoesters. The Royal Society of Chemistry.

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Reference£º
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

New explortion of 3-Methyldihydrofuran-2(3H)-one

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Application of 1679-47-6, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.1679-47-6, Name is 3-Methyldihydrofuran-2(3H)-one, molecular formula is C5H8O2. In a Patent£¬once mentioned of 1679-47-6

ALPHA7 NICOTINIC ACETYLCHOLINE RECEPTOR INHIBITORS

The present invention provides compounds and compositions, methods of making them, and methods of using them to modulate alpha7 nicotinic acetylcholine receptors and/or to treat any of a variety of disorders, diseases, and conditions. Provided compounds can affect, among other things, neurological, psychiatric and/or inflammatory systems.

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Reference£º
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

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First total synthesis of prionoid E, A bioactive rearranged secoabietane diterpene quinone from Salvia prionitis

The first total synthesis of prionoid E (1), a rearranged secoabietane diterpene quinone isolated from Salvia prionitis, was achieved efficiently by means of Wacker oxidation (Scheme 5) and aldol condensation (Scheme 7) as the key steps in the synthetic sequence. Thus 1 was prepared in 15 steps in 3.7% yield starting on one hand from anisole (=methoxybenzene) and methylsuccinic anhydride (=dihydro-3-methylfuran-2,5-dione) via 4 (Scheme 3 and 5), and on the other hand from 2-hydroxy-2-methylpropanoic acid via 5 (Scheme 6). Copyright

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Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Extended knowledge of 3-Iodotetrahydrofuran

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121138-01-0, Name is 3-Iodotetrahydrofuran, belongs to Tetrahydrofurans compound, is a common compound. HPLC of Formula: C4H7IOIn an article, once mentioned the new application about 121138-01-0.

Visible-Light-Initiated Manganese Catalysis for C?H Alkylation of Heteroarenes: Applications and Mechanistic Studies

A visible-light-driven Minisci protocol that employs an inexpensive earth-abundant metal catalyst, decacarbonyldimanganese Mn2(CO)10, to generate alkyl radicals from alkyl iodides has been developed. This Minisci protocol is compatible with a wide array of sensitive functional groups, including oxetanes, sugar moieties, azetidines, tert-butyl carbamates (Boc-group), cyclobutanes, and spirocycles. The robustness of this protocol is demonstrated on the late-stage functionalization of complex nitrogen-containing drugs. Photophysical and DFT studies indicate a light-initiated chain reaction mechanism propagated by .Mn(CO)5. The rate-limiting step is the iodine abstraction from an alkyl iodide by .Mn(CO)5.

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Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

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INDOLOBENZAZEPINE HCV NS5B INHIBITORS

The invention encompasses compounds and salts of Formulas I, II, III, and IV as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV.

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Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Some scientific research about Furan-2,4(3H,5H)-dione

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Catalytic processes in vitamins synthesis and production

Water- and fat-soluble vitamins are essential for human and animal nutrition. Several of them are produced in amounts of well above 1000 t annually worldwide. In this highly competitive field, catalytic methods represent ideal tools to lower production costs, and consequently gain an economical advantage, by the application of environmentally benign processes. Examples of industrially important transformations given in this review are grouped by reaction types, e.g. hydrogenation, oxidation and various alkylation, rearrangement, cycloaddition, and esterification reactions.

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Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Extended knowledge of 105-21-5

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Related Products of 105-21-5, Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics.In a document type is Article, and a compound is mentioned, 105-21-5, Gamma-heptalactone, introducing its new discovery.

Hydrodeoxygenation Model Compounds gamma-Heptalactone and gamma-Nonalactone: Density from 293 to 473 K and H2 Solubility from 479 to 582 K

Determining the H2 solubility in model compounds that represent lignocellulose derivatives is valuable for the study of upgrading processes such as hydrodeoxygenation. In this work, gamma-heptalactone and gamma-nonalactone are studied as model compounds at conditions relevant to hydrodeoxygenation. The solubility of H2 in the lactones was determined in the range of 479 to 582 K and 3 to 10 MPa. The solubility measurements were performed in a continuous flow setup based on the visual observation of the bubble point. Furthermore, the densities of the lactones were measured in order to provide the necessary data for the solubility calculations. The density measurements were performed from 293 to 373 K and from 0.16 to 9.9 MPa in a vibrating tube density meter. Using the measurements, a model of the density as a function of temperature and pressure was developed, obtaining average relative deviations on the order of 0.1%. Similarly, the Peng-Robinson equation of state with the Boston-Mathias modification was used to predict the H2 solubility in the lactones. A temperature-dependent model of the symmetric binary parameter of the equation of state was regressed from the data in order to improve the predictions.

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Tetrahydrofuran – Wikipedia,
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Synthesis of probes for the active site of leucine dehydrogenase

A series of novel 3-substituted 2-oxobutanoic acids were prepared and incubated with leucine dehydrogenase giving in one case both a kinetic resolution at C-3 and reductive amination of the ketone. This is the first example of an amino acid dehydrogenase catalysed kinetic resolution and reductive amination.

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Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem