Properties and Exciting Facts About 5-Oxotetrahydrofuran-2-carboxylic acid

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1H and 13C NMR study of 2-hydroxyglutaric acid and its lactone

Determination of the level and absolute configuration of 2-hydroxyglutaric acid in a patient’s urine is a method of diagnosing two metabolic diseases. Such a determination can be done with the aid of NMR spectroscopic methods. In this paper the careful interpretation of 1H and 13C NMR spectra of this metabolite and its lactone measured under conditions used in biomedical assays is reported. The 1H chemical shifts and spin-spin coupling constants were derived using the total lineshape analysis method. Copyright

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Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Properties and Exciting Facts About Furan-2,4(3H,5H)-dione

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Cutting-Edge and Time-Honored Strategies for Stereoselective Construction of C-N Bonds in Total Synthesis

The main objective of this review is to provide a comprehensive survey of methods used for stereoselective construction of carbon-nitrogen bonds during the total synthesis of nitrogen-containing natural products that have appeared in the literature since 2000. The material is organized by specific reaction in order of decreasing number of applications in natural product synthesis. About 800 total syntheses of natural products with stereogenic carbon-nitrogen bonds described since 2000 have been reviewed.

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Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Properties and Exciting Facts About Ethyl 2-oxotetrahydrofuran-3-carboxylate

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Related Products of 77513-58-7, Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.77513-58-7, Name is Ethyl 2-oxotetrahydrofuran-3-carboxylate, molecular formula is C7H10O4. In a article,once mentioned of 77513-58-7

Ytterbium(III) trifluoromethanesulfonate-catalyzed homoconjugate addition reactions of beta-ketoesters with activated cyclopropane derivatives at high pressure

Ytterbium(III) triflate was found to be an effective catalyst for the homo-conjugate addition reaction of beta-ketoesters with diethyl cyclopropanedicarboxylate at high pressure.

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Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Brief introduction of 4971-56-6

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Related Products of 4971-56-6, Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.4971-56-6, Name is Furan-2,4(3H,5H)-dione, molecular formula is C4H4O3. In a article,once mentioned of 4971-56-6

A facile one pot C[sbnd]C and C[sbnd]N bond formation for the synthesis of spiro-benzodiazepines and their cytotoxicity

An efficient, multicomponent and environmentally benign protocol has been developed for the synthesis of spiro-benzodiazepines through C[sbnd]C and C[sbnd]N bond formations in a single step. This one-pot protocol proceeds via three component reaction of o-phenylenediamines, tetronic acid and isatins by using mild and inexpensive catalyst like sulphamic acid in water. A variety of spiro-benzodiazepine derivatives has been synthesized in excellent yields by using this protocol in a shorter reaction time. All the synthesized compounds were evaluated for their cytotoxic potential on different human cancer cell lines and most of the compounds exhibited moderate to good cytotoxic activity, while some of them like 4f, 4h, 4i, 4j and 4q showed promising cytotoxicity with IC50 values ranging between 1.14 and 1.69 muM.

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Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

The Absolute Best Science Experiment for (Tetrahydrofuran-3-yl)methanol

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The one-pot synthesis tetrahydrofuran – 3 – methanol new process (by machine translation)

The invention discloses adopt one-pot synthesis tetrahydrofuran – 3 – methanol of the new process, solved in the prior art reaction pressure are relatively high not only increases the cost of the device, at the same time ammonia gas and hydrogen recovery to bring difficult issues. The invention includes a A in the solvent, the reaction temperature is 100 – 130 C, 2, 5 – dihydrofuran with formaldehyde in aqueous solution under the action of the catalyst A generating 3 – hydroxymethyl – 2, 5 – dihydrofuran, the solvent evaporation A; to the generation of 3 – hydroxymethyl – 2, 5 – dihydrofuran added in the organic solvent and solvent B A, 3 – hydroxymethyl – 2, 5 – dihydrofuran B in the catalyst under the action of the reduction by the hydrogen generating 3 – tetrahydrofuran-methanol, then filtered, the solvent to dryness B, pure product obtained by rectification. The invention has the low cost of raw materials, the process is stable, it is suitable for industrial and the like. (by machine translation)

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Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Extracurricular laboratory:new discovery of 13031-04-4

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Inversion of enantioselectivity in the hydrogenation of ketopantolactone on platinum modified by ether derivatives of cinchonidine

Asymmetric hydrogenation of ketopantolactone was studied on a 5 wt% Pt/Al2O3 catalyst in the presence of cinchonidine and its O-methyl, -ethyl, -phenyl and -trimethylsilyl derivatives. Inversion of enantioselectivity with the latter two bulky substituents proved that in the enantiodifferentiating step cinchonidine adsorbs via the quinoline ring lying approximately parallel to the Pt surface. The striking nonlinear effect observed with cinchonidine-O-phenyl-cinchonidine mixtures is attributed to differences in the adsorption strength and geometry of the modifiers.

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Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Extended knowledge of (Tetrahydrofuran-3-yl)methanol

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Related Products of 15833-61-1, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.15833-61-1, Name is (Tetrahydrofuran-3-yl)methanol, molecular formula is C5H10O2. In a Patent,once mentioned of 15833-61-1

CB1 MODULATOR COMPOUNDS

Novel compounds of structural formula (I) are disclosed. As modulators of the Cannabinoid-1 (CB1) receptor, these compounds are useful in the treatment, prevention and suppression of diseases mediated by the CB1 receptor. As such, compounds of the present invention are useful as in the treatment, prevention and suppression of psychosis, memory deficits, cognitive disorders, migraine, neuropathy, neuro-inflammatory disorders (e.g., multiple sclerosis, Guillain-Barre syndrome and the inflammatory sequelae of viral encephalitis), cerebral vascular accidents, head trauma, anxiety disorders, stress, epilepsy, Parkinson’s disease, and schizophrenia. The compounds are also useful for the treatment of substance abuse disorders, particularly to opiates, alcohol, and nicotine. The compounds are also useful for the treatment of obesity or eating disorders associated with excessive food intake and complications associated therewith.

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Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

The important role of 3-Methyldihydrofuran-2(3H)-one

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Extension of the Eschenmoser sulfide contraction/iminoester cyclization method to the synthesis of tolyporphin chromophore

Tolyporphin chromophore 2 has been synthesized by performing a double-retroaldol/oxidation sequence on an octahydroporphyrin precursor 18 prepared by using the Eschenmoser sulfide-contraction/iminoester-condensation method.

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Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

The important role of 4344-84-7

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Electric Literature of 4344-84-7, Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. 4344-84-7, Name is 5-Oxotetrahydrofuran-2-carboxylic acid,introducing its new discovery.

4,1-benzoxazepin derivatives and their use

N-containing, condensed heterocyclic compounds and salts thereof are disclosed which are useful for inhibiting squalene synthetase and fungal growth, and which are useful for treating or preventing hyperlipidemia. Also disclosed is a method for producing these compounds.

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Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Final Thoughts on Chemistry for Tetrahydrofurfuryl Acetate

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Application of 637-64-9, Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In some cases, the catalyzed mechanism may include additional steps.In a article, 637-64-9, molcular formula is C7H12O3, introducing its new discovery.

Chlorotrimethylsilane catalysed acetylation of alcohols

A variety of alcohols are converted into the corresponding acetates upon treatment with acetic anhydride and catalytic amount of chlorotrimethylsilane in acetonitrile (or dichloromethane).

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Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem