Tag: M.W:100-200

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, Formula: C5H8O3, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 87392-07-2, Name is (S)-Tetrahydrofuran-2-carboxylic acid, molecular formula is C5H8O3

The synthesis and pharmacological activities of the four stereoisomers of methyl tetrahydrofuran-2-ylmethyl 2,6-dimethyl-4-(2′-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate (furnidipine) are reported.The four isomers were synthesized by a modified Hantzsch synthesis by reaction of (-)- or (+)-tetrahydrofuran-2-ylmethyl 3-aminocrotonate and methyl 2-<(2'-nitrophenyl)methylene>acetoacetate or, alternatively, by reaction of (-)- or (+)-tetrahydrofuran-2-ylmethyl 2-<(2'-nitrophenyl)methylene>acetoacetate and methyl 3-aminocrotonate.The 1:1 diasteromeric mixture thus obtained were separated by chromatography, using poly(D-phenylglycine) as the chiral stationary phase.The enantiomeric purity of the stereoisomers was determined by high-performance liquid chromatography-chiral stationary phase technique (HPLC-CSP).Attempts to obtain crystals of a single stereoisomer failed in different solvent, while methanol crystallization of the product obtained from (+/-)-tetrahydrofuran-2-ylmethyl 2-<(2'-nitrophenyl)methylene>acetoacetate and methyl 3-aminocrotonate yielded good-quality crystals of the most insoluble racemate which proved to be a mixture of the (SS)/(RR) enantiomers by X-ray crystaloography.Conformational analysis of the stereoisomers, assuming rotation of the aryl substituent and ester groups, shows small energy differences (about 4 kcal*mol-1) between the most and the least favorable conformations.Binding studies were performed using <3H>isradipine as a reference ligand.The results showed stereospecificity of the furnidipine isomers in brain, ileum, and cardiac tissues, the (SS) and (SR)-isomers clearly being more potent than their (RR)- and (RS)-enantiomers.The (SS)- and (SR)-isomers were also more selective on cerebral tissue when compared with ileal and cardiac preparations.

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Reference：
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, Quality Control of (cis-Tetrahydrofuran-2,5-diyl)dimethanol, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 2144-40-3, Name is (cis-Tetrahydrofuran-2,5-diyl)dimethanol, molecular formula is C6H12O3

Cellulose-derived tetrahydrofuran-dimethanol (THFDM) can be converted over Pt-WOx/TiO2 catalysts to 1,6-hexanediol (1,6-HDO) with up to 70% yield. This reaction involves ring-opening of THFDM to 1,2,6-hexanetriol (HTO) and then hydrogenolysis of HTO to 1,6-HDO. Hydrogen atoms spill over from Pt sites onto WOx/TiO2 to reduce the W=O functional group and create Br°nsted acid sites. Similar catalytic activity for THFDM conversion can be been obtained with a physical mixture of Pt/TiO2 and WOx/TiO2 due to hydrogen spillover over spatially separate Pt and WOx when a reducible support (TiO2) is used.

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Reference：
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Synthetic Route of 53558-93-3, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.53558-93-3, Name is (R)-(-)-5-Oxotetrahydrofuran-2-carboxylicacid, molecular formula is C5H6O4. In a Article，once mentioned of 53558-93-3

Glutamic acid is a promising renewable platform molecule which is abundantly available in biomass waste streams; it is also efficiently manufactured by fermentation. Here we report the reductive deamination of glutamic acid to bio-based dimethyl glutarate and methylamines. In order to recycle nitrogen in an industrially relevant co-product, glutamic acid was modified to N,N-dimethylglutamic acid by a mild reductive alkylation with Pd/C. Subsequently, selective C-N hydrogenolysis in methanol resulted in dimethyl glutarate and trimethylamine. A wide screening of transition metals (Pt, Pd, Rh and Ru) immobilized on various supports showed that the highest yields of dimethyl glutarate were obtained with Pt/TiO2. An FTIR study and kinetic experiments on metal-loaded and unloaded supports demonstrate that the interplay between the metal and the moderate acidity of the support results in the excellent C-N hydrogenolysis activity and selectivity. Finally, reaction parameter optimization resulted in 81% yield of dimethyl glutarate with 1 wt% Pt/TiO2 at 225 C, 30 bar H2 after 8 h.

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Reference：
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Reference of 13031-04-4, Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics.In a document type is Article, and a compound is mentioned, 13031-04-4, 4,4-Dimethyldihydrofuran-2,3-dione, introducing its new discovery.

(3-tert-Butyl-7-(5-methylisoxazol-3-yl)-2-(1-methyl-1H-1,2, 4-triazol-5-ylmethoxy)pyrazolo[1,5-d][1,2,4]triazine (1) was recently identified as a functionally selective, inverse agonist at the benzodiazepine site of GABAA alpha5 receptors and enhances performance in animal models of cognition. The routes of metabolism of this compound in vivo in rat have been well characterised, the identities of the major metabolites are confirmed by synthesis and their biological profiles were evaluated. An unusual oxidation of the pyrazolo[1,5-d][1,2,4]triazine core to the corresponding pyrazolo[1,5-d][1,2,4]triazin-4(5H)-one scaffold by aldehyde oxidase has been observed.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Reference of 13031-04-4. In my other articles, you can also check out more blogs about 13031-04-4

Reference：
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 17347-61-4, name is 2,2-Dimethylsuccinicanhydride, introducing its new discovery. Safety of 2,2-Dimethylsuccinicanhydride

Betulinic acid (BA) derivatives with a side chain at C-3 can inhibit HIV-1 maturation. On the other hand, BA derivatives with a side chain at C-28 can block HIV-1 entry. In order to combine the anti-maturation and anti-entry activities in a single molecule, new bi-functional BA derivatives containing side chains at C-3 and C-28 have been synthesized. The most potent compound ([[N-[3beta-O-(3?,3?-dimethylsuccinyl)-lup-20(29)-en-28-oyl] -7-aminoheptyl]-carbamoyl]methane) inhibited HIV-1 at an EC50 of 0.0026 muM and was at least 20 times more potent than either the anti-maturation lead compound DSB or the anti-entry lead compound IC9564. This bi-functional BA derivative was active against both HIV entry and maturation. These results suggest that bi-functional BA derivatives with dual mechanisms of action have the potential to become clinically useful for AIDS therapy.

We’ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, the role of 17347-61-4, and how the biochemistry of the body works.Safety of 2,2-Dimethylsuccinicanhydride

Reference：
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

4971-56-6, Name is Furan-2,4(3H,5H)-dione, belongs to tetrahydrofurans compound, is a common compound. Product Details of 4971-56-6In an article, once mentioned the new application about 4971-56-6.

Background: 1,4-Diazepines are two nitrogen containing seven membered heterocyclic compounds and associated with a wide range of biological activities. Due to its medicinal importance, scientists are actively involved in the synthesis, reactions and biological evaluation of 1,4-diazepines since number of decades. Objective: The primary purpose of this review is to discuss the synthetic schemes and reactivity of 1,4-diazepines. This article also describes biological aspects of 1,4-diazepine derivatives, that can be usefully exploited for the pharmaceutical sector. Conclusion: This review summarizes the abundant literature on synthetic routes, chemical reactions and biological attributes of 1,4-diazepine derivatives. We concluded that 1,4-diazepines have significant importance due to their biological activities like antipsychotic, anxiolytic, anthelmintic, anticonvulsant, antibacterial, antifungal and anticancer. 1,4-diazepine derivatives with significant biological activities could be explored for potential use in the pharmaceutical industries.

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Reference：
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Reference of 4971-56-6, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.4971-56-6, Name is Furan-2,4(3H,5H)-dione, molecular formula is C4H4O3. In a Article，once mentioned of 4971-56-6

A green and highly efficient method for the synthesis of polyfunctionalized indoline-spiro fused pyran derivatives has been established. This reaction was conducted by reacting readily available and inexpensive starting materials, such as isatins, cyclic-1,3-dicarbonyl compounds, and malononitrile in aqueous media without any catalysts under microwave irradiation. The present green synthesis shows fascinating properties such as the use of water as the reaction solution, concise one-pot conditions, short reaction periods (8-14 min), and easy purifications. The synthesis could also set a good example to GAP (Group-Assistant-Purification) chemistry in which purification via chromatography can be avoided and the pure products can be easily acquired only by washing the crude products with 95% EtOH.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 4971-56-6

Reference：
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Electric Literature of 1679-47-6, A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 1679-47-6, Name is 3-Methyldihydrofuran-2(3H)-one, molecular formula is C5H8O2. In a Article，once mentioned of 1679-47-6

A holistic investigation considering the sugarcane bagasse characterization, fast pyrolysis and upgrading of bio-oil applying two nickel-based catalysts is presented. The bio-oil composition is correlated to the bagasse building blocks, and the hydrotreatment reaction pathways are identified. Despite the high ash content of 6.75 wt%, 60.1 wt% of bio-oil was obtained by fast pyrolysis, attributed to low concentration of potassium (0.08 wt%) and low humidity (2.80 wt%) observed in the bagasse. Upgraded bio-oil with 60.3% less water and 43.3% less oxygen were obtained with Ni/SiO2, resulting in an HHV 63% higher compared to bagasse. Ni-Cr/SiO2 showed the highest hydrogenation activity and the highest conversion of acids, converting 25.7% of acetic acid and 14.95% of propionic acid while Ni/SiO2 was more active for conversion of compounds containing aromatic groups. The higher viscosity of upgraded oils in comparison to the fast pyrolysis bio-oil indicates that the stabilization during the heating ramp can be improved to suppress polymerization. Hence, sugarcane bagasse is an attractive feedstock with an overall final yield of 30.5 wt% of the upgraded product.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Electric Literature of 1679-47-6. In my other articles, you can also check out more blogs about 1679-47-6

Reference：
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

In heterogeneous catalysis, the catalyst is in a different phase from the reactants. category: Tetrahydrofurans, At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 4100-80-5, name is 3-Methyldihydrofuran-2,5-dione. In an article，Which mentioned a new discovery about 4100-80-5

On the basis of the electron-impact mass spectra of a series of 1-diazo-4-methoxycarbonyl-2-butanones, the data from high-resolution mass spectrometry, and the spectrum of the deuterated analog it was shown that the +. ions formed at the first stage in the fragmentation of the molecular ions of these compounds are partly stabilized with the formation of pseudomolecular ions of oxolanones.The molecular ions of the diazo ketones themselves can dissociate in various directions.The many-path dissociation makes it possible to suppose that the yield of oxolanones formed during cyclization in solution under the influence of acidic agents is small.

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Reference：
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, Recommanded Product: 4100-80-5, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 4100-80-5, Name is 3-Methyldihydrofuran-2,5-dione, molecular formula is C5H6O3

The pure rotational spectra of succinic, itaconic, and methylsuccinic anhydrides were collected in the region of 7?18 GHz using Fourier transform microwave spectroscopy. Each molecule shows varying degrees of puckering, demonstrating the effects of substitution on torsional and bond angle strain. The spectra of all three molecules exhibit perturbations consistent with internal motion; succinic and itaconic anhydride display pseudorotational motion (DeltaE = 0.1 cm?1 and 0.2 cm?1, respectively), while methylsuccinic anhydride shows two uncoupled vibrations (DeltaE01 = 0.4 cm?1 and DeltaE02 = 1.2 cm?1). Analyses of similar five-membered rings demonstrate the relationship between the planarity of the ring and the barrier to pseudorotation.

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Reference：
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem