Archives for Chemistry Experiments of 2,2-Dimethylsuccinicanhydride

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Reference of 17347-61-4, Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In some cases, the catalyzed mechanism may include additional steps.In a article, 17347-61-4, molcular formula is C6H8O3, introducing its new discovery.

Amide conjugates with four structural types of beta-amino alcohols were synthesized from 2,3-seco-18alphaH-oleananoic and 2,3-seco-lupane C-3(C-28) mono- and dicarboxylic acids. Esters were prepared by reaction of C-3-hydroxy derivatives of A-seco-triterpenoids with dicarboxylic acid anhydrides. The antiviral activity of the synthesized compounds was studied against herpes simplex virus type I. The most active amide was 5a (5.7 muM, MTC/EC 50 32.2).

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Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Can You Really Do Chemisty Experiments About (R)-(+)-2-Tetrahydrofuroic acid

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In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 87392-05-0, name is (R)-(+)-2-Tetrahydrofuroic acid, introducing its new discovery. SDS of cas: 87392-05-0

2-Amino-pyrimidine derivatives of formula I, wherein the meaning of the different substituents are those indicated in the description. These compounds are useful as histamine receptor H4antagonists.

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Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

The important role of 3-Methyldihydrofuran-2(3H)-one

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Nitroalkenes were prepared by the substitution reaction of beta-nitrovinyl sulfides and sulfoxides <1-ethylsulfinyl-2-nitrocyclohex-1-ene, -cyclohept-1-ene and (E)-2-ethylsulfinyl-1-nitroprop-1-ene> with a variety of carbon nucleophiles (i.e. alkylmetal reagents and enolates of carbonyl compounds), via an addition-elimination sequence.The sulfoxide as a leaving group was suitable for the reaction with an enolate of carbonyl compounds.This method was useful for the synthesis of nitroalkenes <2-nitrocyclohex-1-enyl(hept-1-enyl)- and 2-nitro-1-methylvinyl-substituted cyclohexanone, gamma-butyrolactones, delta-valerolactones, 2-pyrrolidinones and piperidinones>.

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Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

The important role of Furan-2,4(3H,5H)-dione

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Electric Literature of 4971-56-6, Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In some cases, the catalyzed mechanism may include additional steps.In a article, 4971-56-6, molcular formula is C4H4O3, introducing its new discovery.

2,4(3H,5H)-Furandione, 1, condenses with heteroaromatic aldehydes in the presence of concentrated hydrochloric acid to yield 3-(heteroarylmethylene)-2,4(3H,5H)-furandiones, 4.The condensation of 1 with acid sensitive aldehydes, including 2-furanacroleine and N-methylpyrrole-2-carboxaldehyde proceeded well with 1 as the sole proton source.The E/Z ratio of type 4 compounds was determined by 1H-nmr spectroscopy.

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Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Brief introduction of 87392-05-0

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The present invention, a compound having antiviral action. And 1 A 1 the, CR 1A R 1B, S or O; A 2 the, CR 2A R 2B, S or O; A 3 the, CR 3A R 3B, S or O; A 4 the, CR 4A R 4B, S or O; Here, A 1, A 2, A 3, A 4, A 1 adjacent to a nitrogen atom, and A 4 adjacent carbon atoms in the hetero atom of the number of atoms constituting, in 1 or 2 ; R 1A and R 1B is, independently, a hydrogen, halogen, alkyl, etc.; or R 2A and R 2B is, independently, a hydrogen, halogen, alkyl, etc.; or R 3A and R 3B is, independently, a hydrogen, halogen, alkyl, etc.; or R 4A and R 4B is, independently, a hydrogen, halogen, alkyl, etc.; or R 3A and R 3B together non-aromatic or non-aromatic heterocyclic ring, a carbon ring may form; The X, CH 2, S or O; R 1 is, independently, halogen or like hydroxyacid; M is an integer of 0-2 N is an integer of 1-2) (by machine translation)

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Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

A new application about 4100-80-5

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Reference of 4100-80-5, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.4100-80-5, Name is 3-Methyldihydrofuran-2,5-dione, molecular formula is C5H6O3. In a Patent,once mentioned of 4100-80-5

Provided herein are carbamate compounds which may be useful in the treatment of, for example, pain, solid tumors and/or obesity

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Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

More research is needed about 1679-47-6

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Palladium chloride catalyzed reaction < room temperature, one atmosphere > of primary, secondary, and tertiary allylic alcohols with carbon monoxide and oxygen, hydrochloric acid, and cupric chloride in tetrahydrofuran affords five-membered ring lactones.

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Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

New explortion of 52079-23-9

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In heterogeneous catalysis, the catalyst is in a different phase from the reactants. Application In Synthesis of (S)-(-)-alpha-Hydroxy-gamma-butyrolactone, At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 52079-23-9, name is (S)-(-)-alpha-Hydroxy-gamma-butyrolactone. In an article,Which mentioned a new discovery about 52079-23-9

We report the development of aryl sulfones as Bradykinin B1 receptor antagonists. Variation of the linker region identified diol 23 as a potent B1 antagonist, while modifications of the aryl moiety led to compound 26, both of which were efficacious in rabbit biochemical challenge and pain models.

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Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

More research is needed about 4971-56-6

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The synthesis of 2-(3-(4-(dimethylamino)phenyl)-2-oxoindolin-3-yl)-1H- indene-1,3(2H)-diones as new unsymmetrical oxindoles via a Friedel-Crafts type three-component reaction of 1,3-indandion, N,N-dimethylaniline and isatins in ethanol in the presence of LiClO4 is reported.

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Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Archives for Chemistry Experiments of 7175-81-7

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PB2 is an important subunit of influenza RNA-dependent RNA polymerase (RdRP) and has been recognized as a promising target for the treatment of influenza. We herein report the discovery of a new series of PB2 inhibitors containing the skeleton 5-(5-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrazin-2(1H)-one. Compound 12b is the most potent one, which showed KD values of 0.11 muM and 0.19 muM in surface plasmon resonance (SPR) and isothermal titration calorimetry (ITC) assays, respectively. In antiviral activity and cellular cytotoxicity assays, compound 12b showed an EC50 value of 1.025 muM and a CC50 value greater than 100 muM. Molecular docking was also used to predict the binding mode of 12b with PB2. Collectively, this study provides a promising lead compound for subsequent anti-influenza drug discovery targeting PB2.

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Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem