Tag: M.W:100-200

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《The rearrangement of 2,4-dimethylthiazole 3-oxide with acetic anhydride》. Authors are Anderson, Hugh J.; Barnes, Douglas J.; Khan, Zahir M..The article about the compound:(2-Methylthiazol-4-yl)methanolcas:76632-23-0,SMILESS:OCC1=CSC(C)=N1).Name: (2-Methylthiazol-4-yl)methanol. Through the article, more information about this compound (cas:76632-23-0) is conveyed.

The rearrangement in Ac2O of 2,4-dimethylthiazole 3-oxide produced 2-acetoxymethyl-4-methylthiazole and 4-acetoxymethyl-2-methylthiazole in the ratio of about 4.5 to 1. The same type of rearrangement with 4-methylthiazole 3-oxide gave both 4-acetoxymethylthiazole and 2-acetoxy-4-methylthiazole, but in poor yields. The structure of the sulfate salt of 2,4-dimethylthiazole 3-oxide was established.

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Tetrahydrofuran – Wikipedia,
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Zhou, Zhenghong; Hu, Kangfei; Wang, Jiawei; Li, Zhibin; Zhang, Yan; Zha, Zhenggen; Wang, Zhiyong published the article 《Electrosynthesis of Quinazolines and Quinazolinones via an Anodic Direct Oxidation C(sp3)-H Amination/C-N Cleavage of Tertiary Amine in Aqueous Medium》. Keywords: quinazoline quinazolinone electrochem preparation green chem; tertiary amine carbonyl aniline anodic oxidation amination cleavage.They researched the compound: 2-Amino-5-chlorobenzaldehyde( cas:20028-53-9 ).Formula: C7H6ClNO. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:20028-53-9) here.

An electrochem. synthesis for quinazolines and quinazolinones was developed via a C(sp3)-H amination/C-N cleavage by virtue of the anodic oxidation The reaction can be carried out in aqueous media under mild conditions to afford the desired products with high yields. The reaction mechanism was proposed after detailed investigation.

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Reference:
Tetrahydrofuran – Wikipedia,
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In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Synthesis and cytotoxic evaluation of some structural fragments of epothilone A, published in 2002-09-30, which mentions a compound: 76632-23-0, mainly applied to epothilone A fragment preparation cytotoxicity, Recommanded Product: 76632-23-0.

The epothilones are a series of macrocyclic lactones with cytotoxic activity. Fragments of epothilone A were prepared and evaluated for cytotoxic activity in order to try to determine the active part of the epothilone structure. The fragments prepared, I [R = HOCHMe, tetrahydro-2-pyranyl, HOCHMeCH2CO2CH2, Me2CH(CH2)3CH:CH(CH2)2 (5)] and 5 diepoxide, did not display bioactivity.

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Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 2-Amino-5-chlorobenzaldehyde(SMILESS: NC1=CC=C(Cl)C=C1C=O,cas:20028-53-9) is researched.Reference of Ethyl 3,5-Dimethyl-2-pyrrolecarboxylate. The article 《Gold(I)-Catalyzed Unprecedented Rearrangement Reaction Between 2-Aminobenzaldehydes with Propargyl Amines: An Expedient Route to 3-Aminoquinolines》 in relation to this compound, is published in Chemistry – A European Journal. Let’s take a look at the latest research on this compound (cas:20028-53-9).

A gold(I)-catalyzed unprecedented rearrangement reaction between 2-aminobenzaldehydes with propargyl amine was studied. The study provided, for the first time, direct access to 3-aminoquinolines in one step starting from readily available starting materials. Elegantly designed experiments were employed to unravel the mechanism of this unprecedented rearrangement, which are corroborated by DFT calculations

There is still a lot of research devoted to this compound(SMILES：NC1=CC=C(Cl)C=C1C=O)Application In Synthesis of 2-Amino-5-chlorobenzaldehyde, and with the development of science, more effects of this compound(20028-53-9) can be discovered.

Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Formula: C7H6ClNO. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 2-Amino-5-chlorobenzaldehyde, is researched, Molecular C7H6ClNO, CAS is 20028-53-9, about Synthesis and screening of (E)-3-(2-benzylidenehydrazinyl)-5,6-diphenyl-1,2,4-triazine analogs as novel dual inhibitors of α-amylase and α-glucosidase. Author is Shamim, Shahbaz; Khan, Khalid Mohammed; Ullah, Nisar; Chigurupati, Sridevi; Wadood, Abdul; Ur Rehman, Ashfaq; Ali, Muhammad; Salar, Uzma; Alhowail, Ahmad; Taha, Muhammad; Perveen, Shahnaz.

(E)-3-(2-Benzylidenehydrazinyl)-5,6-diphenyl-1,2,4-triazine analogs I (R = 4-ClC6H4, 2-Cl-5-O2NC6H3, furan-2-yl, etc.) were synthesized by multi-step reaction scheme and subjected to in vitro inhibitory screening against α-amylase and α-glucosidase enzymes. All compounds exhibited good to moderate inhibitory potential in terms of IC50 values ranging (IC50 = 13.02 +/- 0.04-46.90 +/- 0.05μM) and (IC50 = 13.09 +/- 0.08-46.44 +/- 0.24μM) in comparison to standard acarbose (IC50 = 12.94 +/- 0.27μM and 10.95 +/- 0.08μM), for α-amylase and α-glucosidase, resp. Structure-activity relationship indicated that analogs with halogen substitution(s) were found more active as compared to compounds bearing other substituents. Kinetic studies on most active α-amylase and α-glucosidase inhibitors I (R = 4-ClC6H4, 2,4-di-ClC6H3, 4-F3CC6H4, 2-Cl-5-O2NC6H3, 3-MeO-4-F-C6H3, furan-2-yl, etc.) suggested non-competitive and competitive types of inhibition mechanism for α-amylase and α-glucosidase, resp. Mol. docking studies predicted the good protein-ligand interaction (PLI) profile with key interactions such as arene-arene, H-<, <-<, and <-H etc., against the corresponding targets. There is still a lot of research devoted to this compound(SMILES：NC1=CC=C(Cl)C=C1C=O)Formula: C7H6ClNO, and with the development of science, more effects of this compound(20028-53-9) can be discovered.

Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Rush Scaggs, W.; Scaggs, Toya D.; Snaddon, Thomas N. published an article about the compound: Methyl 2-(1-methyl-1H-pyrrol-2-yl)acetate( cas:51856-79-2,SMILESS:O=C(OC)CC1=CC=CN1C ).Safety of Methyl 2-(1-methyl-1H-pyrrol-2-yl)acetate. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:51856-79-2) through the article.

Herein we describe the direct enantioselective Lewis base/Pd catalyzed α-allylation of pyrrole acetic acid esters. This provides high isolated yields of highly enantioenriched products, e.g., I, and exhibits broad reaction scope with respect to both reaction partners. The products can be readily elaborated in a manner which points towards potential applications in target directed synthesis.

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Tetrahydrofuran – Wikipedia,
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The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: Methyl 2-(1-methyl-1H-pyrrol-2-yl)acetate( cas:51856-79-2 ) is researched.Application of 51856-79-2.Pitucha, M.; Wujec, M.; Dobosz, M. published the article 《Synthesis of 4-substituted 3-[(1-methylpyrrol-2-yl)methyl]–1,2,4-triazoline-5-thiones》 about this compound( cas:51856-79-2 ) in Annales Universitatis Mariae Curie-Sklodowska, Sectio AA: Chemia. Keywords: pyrrolylacetylthiosemicarbazide preparation heterocyclization; triazolethione pyrrolylmethyl preparation. Let’s learn more about this compound (cas:51856-79-2).

Reaction of 1-methylpyrrole-2-acetic acid hydrazide with RNCS gave thiosemicarbazides I [R = Et, cyclohexyl, (un)substituted Ph, benzyl, CH2COOEt], which were cyclized by 2% NaOH to give title compounds II (same R).

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Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Formula: C8H11NO2. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: Methyl 2-(1-methyl-1H-pyrrol-2-yl)acetate, is researched, Molecular C8H11NO2, CAS is 51856-79-2, about C-thiocarbamoylation of electron-rich heterocycles and enamines with amidophosphonium isothiocyanates. Author is Smalii, R. V.; Koidan, G. N.; Chaikovskaya, A. A.; Marchenko, A. P.; Pinchuk, A. M.; Tolmachev, A. A..

Amidophosphonium isothiocyanates can thiocarbamoylate a series of electron-rich heterocycles and enamines at the nucleophilic carbon atom to form phosphazothiocarbonyl compounds From the most active heterocycles, bis(phosphazothiocarbonyl) derivatives can be obtained.

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Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 2-Amino-5-chlorobenzaldehyde(SMILESS: NC1=CC=C(Cl)C=C1C=O,cas:20028-53-9) is researched.Related Products of 16409-43-1. The article 《Synthesis and anti-proliferation activity of Mogrol derivatives bearing quinoline and triazole moieties》 in relation to this compound, is published in Bioorganic & Medicinal Chemistry Letters. Let’s take a look at the latest research on this compound (cas:20028-53-9).

A series of novel derivatives based on Mogrol were designed and synthesized in attempt to improve anti-lung cancer activity. The cytotoxicity against human lung cancer cells including A549 and NCI-H460 were performed by Cell Counting Kit-8 (CCK8) assay in vitro. The screening result showed that compound 8f exhibited the strongest activity with an IC50 value of 4.47μM against A549 cell, and could induce the cell apoptosis in a dose-dependent manner and arrest cell cycle at G0/G1 phase. Besides, compound 8f displayed anti-proliferation effect on A549 cell through inhibiting phosphorylation of signal transducer and activator of transcription 3 (STAT3). Furthermore, compared with Mogrol, compound 10a significantly improved the cytotoxicity against NCI-H460 with the IC50 value of 17.13μM. The research stimulated the development of potential therapeutic agent for lung cancer from the natural Mogrol.

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Tetrahydrofuran – Wikipedia,
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So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Yan, Yizhe; Zhang, Yonghui; Feng, Chengtao; Zha, Zhenggen; Wang, Zhiyong researched the compound: 2-Amino-5-chlorobenzaldehyde( cas:20028-53-9 ).Formula: C7H6ClNO.They published the article 《Selective iodine-catalyzed intermolecular oxidative amination of C(sp3)-H bonds with ortho-carbonyl-substituted anilines to give quinazolines》 about this compound( cas:20028-53-9 ) in Angewandte Chemie, International Edition. Keywords: quinazoline preparation; acyl aniline DMF oxidative amination iodine catalyst. We’ll tell you more about this compound (cas:20028-53-9).

An iodine-catalyzed oxidative amination of C(sp3)-H bonds adjacent to nitrogen or oxygen atoms for the synthesis of quinazolines from o-carbonyl-substituted anilines, ammonia and solvents, such as N-alkylamides, ethers, and alcs, is reported. A wide tolerance of various functional groups, lack of transition metals, and production of alc. and water as the only waste are te major merits of this method. A series of substituted quinazoline derivatives were obtained using this strategy.

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Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem