Tag: M.W=100-150

Modelska, Magdalena; Binczarski, Michal J.; Dziugan, Piotr; Nowak, Szymon; Romanowska-Duda, Zdzislawa; Sadowski, Adam; Witonska, Izabela A. published the artcile< Potential of waste biomass from the sugar industry as a source of furfural and its derivatives for use as fuel additives in Poland>, Related Products of 97-99-4, the main research area is furfural biomass lignocellulosic waste fuel additive.

Poland is one of the leading producers of sugar from sugar beet in Europe. However, the production of sugar generates large amounts of lignocellulosic waste, in the form of beet pulp and leaves. Currently, this waste is not reutilized in the chem. industry, but is only used as food for farm animals. This paper assesses the potential of using bio-waste from the sugar industry as a raw material for the production of furfurals via acid hydrolysis. Further processing of furfural into derivatives such as furfuryl alc. (FA) or tetrahydrofurfuryl alc. (THFA) could increase the economic profitability of the initiative. Furfuryl alc. can be used as a fuel additive in sugar factories. Tetrahydrofurfuryl alc. can be used as a component in agricultural fertilizers, increasing the yield of sugar beet. This approach reduces the amount of post-production waste and brings the sugar industry closer to the concept of a circular economy.

Energies (Basel, Switzerland) published new progress about Beta vulgaris saccharifera, pulp, silage. 97-99-4 belongs to class tetrahydrofurans, and the molecular formula is C5H10O2, Related Products of 97-99-4.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Chen, Lifang; Ye, Jingyun; Yang, Yusen; Yin, Pan; Feng, Haisong; Chen, Chunyuan; Zhang, Xin; Wei, Min; Truhlar, Donald G. published the artcile< Catalytic Conversion Furfuryl Alcohol to Tetrahydrofurfuryl Alcohol and 2-Methylfuran at Terrace, Step, and Corner Sites on Ni>, Formula: C5H10O2, the main research area is nickel catalytic conversion furfuryl alc tetrahydrofurfuryl alc methylfuran.

The surface structures at catalytic sites are critical factors for determining catalytic selectivity. Here, we use periodic d. functional theory and microkinetic modeling to systematically investigate the effect of surface structures on the conversion of furfuryl alc. (FA). We consider nine surface terminations of Ni with various coordination numbers representing terrace, step, and corner sites. We study three reaction paths for FA conversion on various surfaces and find that the surface structure impacts the adsorption configuration and causes significant differences in selectivity. Barrier height anal. shows that terrace sites favor hydrogenation to tetrahydrofurfuryl alc. (THFA), whereas corner sites favor C-OH bond scission to produce 2-methylfuran (2-MF); step sites show similar barriers for the two reactions. We explain this by identifying three characteristics of the reactant adsorption structures that have a significant effect on selectivity, namely, that a shorter distance between the adsorbed hydrogen atom and the C3 carbon of FA favors hydrogenation to produce THFA, and more neg. charge transfer to Oalcohol and a longer C-Oalcohol bond length favor C-Oalcohol bond scission to produce 2-MF. Since the reactions have similar barriers at a step site, microkinetic calculations are employed to calculate the product selectivity on a step site under exptl. conditions. At lower temperatures and higher generalized coordination number (CN), THFA is the most favorable product, while the selectivity to 2-MF is higher at lower CN and at higher temperature This work provides guidance for the rational design catalysts to control the product distribution of FA conversion.

ACS Catalysis published new progress about Adsorption. 97-99-4 belongs to class tetrahydrofurans, and the molecular formula is C5H10O2, Formula: C5H10O2.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Qin, Yaqiong; Wang, Bing; Liu, Shaofeng; Pan, Lining; Chen, Mantang; Cui, Huapeng; Liu, Ruihong; Jia, Yunzhen; Cai, Junlan; Liu, Kejian; Wang, Xiaoyu; Xie, Fuwei published the artcile< Robust, comprehensive, sensitive analysis of flavour additives with carboxyl and hydroxyl groups in cigarette smoke combining silylation and gas chromatography-tandem mass spectrometry with an improved backflushing system>, Application In Synthesis of 97-99-4, the main research area is silylation GC MS backflushing system flavor additives; Backflushing; Cigarette smoke; Derivatization; Flavour additives; GC-MS/MS.

Flavor additives with carboxyl and hydroxyl groups (FACHs), the key ingredients in characteristic flavours, are frequently detected in cigarette smoke. They are attracting increasing attention in regulating the flavor additives used in tobacco to curb youth tobacco use and prevent the use of additives that are harmful. In this study, a highly robust, sensitive, and precise method based on silylation and GC-MS/MS with an improved backflushing system was developed for the simultaneous anal. of 171 FACHs in cigarette smoke. Silylation has been shown to have advantages in terms of high selectivity and sensitivity to chems. with carboxyl and hydroxyl groups, especially when combined with GC-MS/MS. The extraction and silylation conditions were optimized. Dichloromethane was used as the extraction agent. BSTFA in combination with 1% TMCS and 0.2% TMSI was selected as silylating agent for high silylation efficiency, particularly for hindered analytes. The method has been validated. The limit of detection (LOD) ranged from 0.6 to 332.3 ng/mL. 91.1% out of the analytes in QC samples had precisions lower than 10% during one month run. The improved backflushing system with a fused silica splitter was shown to be crucial in the excellent long-term robustness of the method. The developed method was used to determine flavor additives in 270 practical cigarette smoke samples with reliable results. A total of 154 FACHs were identified with wide-range levels among different cigarette brands.

Journal of Chromatography A published new progress about Food additives (flavor). 97-99-4 belongs to class tetrahydrofurans, and the molecular formula is C5H10O2, Application In Synthesis of 97-99-4.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Jurutka, Peter W.; Kaneko, Ichiro; Yang, Joanna; Bhogal, Jaskaran S.; Swierski, Johnathon C.; Tabacaru, Christa R.; Montano, Luis A.; Huynh, Chanh C.; Jama, Rabia A.; Mahelona, Ryan D.; Sarnowski, Joseph T.; Marcus, Lisa M.; Quezada, Alexis; Lemming, Brittney; Tedesco, Maria A.; Fischer, Audra J.; Mohamed, Said A.; Ziller, Joseph W.; Ma, Ning; Gray, Geoffrey M.; van der Vaart, Arjan; Marshall, Pamela A.; Wagner, Carl E. published the artcile< Modeling, Synthesis, and Biological Evaluation of Potential Retinoid X Receptor (RXR) Selective Agonists: Novel Analogues of 4-[1-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)ethynyl|benzoic Acid (Bexarotene) and (E)-3-(3-(1,2,3,4-tetrahydro-1,1,4,4,6-pentamethylnaphthalen-7-yl)-4-hydroxyphenyl)acrylic Acid (CD3254)>, Electric Literature of 5455-94-7, the main research area is bexarotene methylnaphthylhydroxyphenylacrylic acid preparation retinoic X receptor agonist; structure bexarotene methylnaphthylhydroxyphenylacrylate analog retinoid X receptor agonist activity; mutagenicity vitamin D3 receptor agonism apoptosis bexarotene analog; antitumor activity bexarotene methylnaphthylhydroxyphenylacrylic acid RXR agonist analog; methylnaphthylcyclopropyl pyrimidinecarboxylic acid mol crystal structure.

Analogs of the retinoid X receptor (RXR) agonists bexarotene I (X = CH) and of pentamethylnaphthylhydroxyphenylacrylic acid II such as I (X = N) were prepared as potential antitumor agents and tested for their abilities to act as RXR agonists, to initiate apoptosis in human cancer cells, to modulate transcription mediated by the vitamin D3 receptor, and their mutagenicity in Saccharomyces cerevisiae. Seven of the compounds including I (X = N) stimulate RXR-regulated transcription in mammalian two-hybrid and RXRE-mediated assays, possessed comparable or elevated biol. activity based on EC50 profiles, and retained similar or improved apoptotic activity in CTCL assays compared to bexarotene. The novel compounds demonstrated selectivity for RXR and minimal crossover onto the retinoic acid receptor (RAR) compared to all-trans-retinoic acid, with select analogs also reducing inhibition of other RXR-dependent pathways (e.g., VDR-RXR). The structure of a pentamethylnaphthylcyclopropyl pyrimidinecarboxylic acid RXR agonist was determined by X-ray crystallog.

Journal of Medicinal Chemistry published new progress about Antitumor agents. 5455-94-7 belongs to class tetrahydrofurans, and the molecular formula is C8H14O2, Electric Literature of 5455-94-7.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Mironenko, Roman M.; Belskaya, Olga B.; Likholobov, Vladimir A. published the artcile< Approaches to the synthesis of Pd/C catalysts with controllable activity and selectivity in hydrogenation reactions>, Quality Control of 97-99-4, the main research area is review palladium carbon hydrogenation catalyst.

A review. C-supported Pd catalysts are widely used for hydrogenation of various organic compounds in the fine chem. industry. The nanoscale geometry and electronic structure of supported Pd nanoparticles play a crucial role in providing the necessary catalytic properties. To improve catalytic activity and selectivity of Pd nanoparticles, it is possible to fine tune their intrinsic properties (e.g., size and oxidation state) by controlling the chem. transformations at different stages of catalyst preparation Recent years have seen considerable advancement in developing new catalyst preparation techniques as well as in understanding the mechanism of active site formation. This review summarizes some of the existing approaches to regulating the catalytic properties of C-supported Pd by variation of the C support, the composition of Pd precursor and its reduction conditions, as well as the addition of a 2nd active metal. The data presented may be useful for researchers developing efficient Pd/C catalysts for hydrogenation of polyfunctional organic compounds

Catalysis Today published new progress about Carbon nanofibers Role: CAT (Catalyst Use), NAN (Nanomaterial), PEP (Physical, Engineering or Chemical Process), PRP (Properties), TEM (Technical or Engineered Material Use), USES (Uses), PROC (Process). 97-99-4 belongs to class tetrahydrofurans, and the molecular formula is C5H10O2, Quality Control of 97-99-4.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Deng, Qiang; Gao, Rui; Li, Xiang; Wang, Jun; Zeng, Zheling; Zou, Ji-Jun; Deng, Shuguang published the artcile< Hydrogenative Ring-Rearrangement of Biobased Furanic Aldehydes to Cyclopentanone Compounds over Pd/Pyrochlore by Introducing Oxygen Vacancies>, Application In Synthesis of 97-99-4, the main research area is hydrogenative ring rearrangement biobased furanic aldehyde cyclopentanone.

Upgrading furanic aldehydes (such as furfural or 5-hydroxymethyl furfural) to cyclopentanone compounds (such as cyclopentanone or 3-hydroxymethyl cyclopentanone) is of great significance for the synthesis of high-value chems. and biomass utilization. Developing an efficient reduced metal/acidic support with Lewis acidity is the key to facilitating the carbonyl hydrogenation and hydrolysis steps in the hydrogenative ring-rearrangement reaction. Herein, three pure Lewis acidic pyrochlore supports of the form A2B2O7 (La2Sn2O7, Y2Sn2O7, and Y2(Sn0.7Ce0.3)2O7-δ) with the same crystal structures and different metals are synthesized. The Lewis acidity and the surface properties of the pyrochlore can be tuned by inserting different kinds of A and B site metals. After impregnation, Pd nanoparticles with appropriate particle sizes are uniformly loaded on the surface of pyrochlore. For the reaction of the furanic aldehydes, all of these pyrochlore-based catalysts exhibit hydrogenation and hydrolysis rates that are both faster than those of traditional support-based catalysts due to the oxygen vacancy and pure Lewis acidity of the support. Among these pyrochlore-based catalysts, Pd/Y2Sn2O7 exhibits activity and selectivity that are higher than those of Pd/La2Sn2O7. Moreover, the Y2Sn2O7-based catalyst partially substituted by Ce3+ ions at the B site is more efficient, with the highest cyclopentanone yield and 3-hydroxymethyl cyclopentanone yield of 95.0% and 92.5%, resp. Furthermore, the catalyst can still maintain an effective activity and stability after 4 runs. This study not only presents an efficient biobased route for the production of cyclopentanone compounds but also focuses on the acid catalytic performance of pyrochlore based on its pure Lewis acidity.

ACS Catalysis published new progress about Crystal structure. 97-99-4 belongs to class tetrahydrofurans, and the molecular formula is C5H10O2, Application In Synthesis of 97-99-4.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Xia, Haihong; Chen, Changzhou; Liu, Peng; Zhou, Minghao; Jiang, Jianchun published the artcile< Selective hydrogenation of furfural for high-value chemicals: effect of catalysts and temperature>, Electric Literature of 97-99-4, the main research area is furfural selective hydrogenation bimetallic catalyst temperature effect.

Transformation of furfural (FFA), a typical representative of furan platform chems. derived from the acid hydrolysis of hemicellulose to the high value chems. tetrahydrofurfuryl alc. (THFOL) and cyclopentanol (CPL), has drawn great attention. In this study, we report an efficient NiCo bimetallic catalyst with highly dispersed NiCo-based metals on a porous carbon matrix for FFA hydrogenation. For different FFA conversion reactions of the bimetallic catalysts, the tetrahydrofurfuryl (THFOL) yield was up to 95% over the Ni3Co1@C catalyst at 80°C. Furthermore, cyclopentanol (CPL) could also be obtained with a yield of 95% with Ni1Co1@C as the catalyst at 160°C in an aqueous medium. The detailed physicochem. characterization was carried out by means of XRD, SEM, BET, ICP, XPS, NH3-TPD and Raman anal. With the addition of Co in the bimetallic catalysts, the average particle size decreased obviously to around 5.7 nm in NixCoy/C catalysts with different Ni/Co ratios, which increased the dispersion and improved the catalytic activity of FFA hydrogenation. The NixCoy@C catalysts could be recovered and efficiently applied in the next run for four consecutive recycling tests in FFA hydrogenation to the corresponding target products under different reaction conditions. The results suggested that the NixCoy@C catalyst appeared to increasingly favor the formation of Ni-Co alloys and suggested a metallic active site in FFA hydrogenation with the addition of the Co element. Mechanistic study indicated that temperature was a key factor contributing to the formation of different desired products (THFOL and CPL). Furthermore, water was another essential factor, which was responsible for the arrangement of the furan compound

Sustainable Energy & Fuels published new progress about Acidity. 97-99-4 belongs to class tetrahydrofurans, and the molecular formula is C5H10O2, Electric Literature of 97-99-4.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Kuronen, Pirjo; Laitalainen, Tarja published the artcile< Crystal and molecular structure and spectra of 2',2',5,5,5',5',7,7-octamethyl-2',5,5',7-tetrahydrofuro[3,4-d]-1-oxa-3,4-diselenin-2-spiro-3'-furan-4'(3'H)-one from selenium dioxide oxidation of 2,2,5,5-tetramethyltetrahydrofuran-3-one. A novel six-membered heterocyclic ring system in the chalcogen series>, Synthetic Route of 5455-94-7, the main research area is tetramethyltetrahydrofuranone oxidation selenium dioxide; tetrahydrofurandione tetramethyl; crystal structure octamethyltetrahydrofurooxadiseleninspirofuranone; spirofuranone octamethyltetrahydrofurooxadiselenin crystal mol structure; furanone octamethyltetrahydrofurooxadiseleninspiro crystal mol structure; mol structure octamethyltetrahydrofurooxadiseleninspirofuranone.

When 2,2,5,5-tetramethyltetrahydrofuran-3-one 1 was oxidized with selenium dioxide in ethanol, the title heterocycle I was formed along with 2,2,5,5-tetramethyltetrahydro-3,4-furandione 2. The diselenide I represents a novel six-membered heterocycle in the chalcogen series.

Journal of Heterocyclic Chemistry published new progress about Crystal structure. 5455-94-7 belongs to class tetrahydrofurans, and the molecular formula is C8H14O2, Synthetic Route of 5455-94-7.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Rodina, Liudmila L.; Galkina, Olesia S.; Maas, Gerhard; Platz, Matthew S.; Nikolaev, Valerij A. published the artcile< A New Method for C-H Functionalization of Aliphatic Compounds by an Unusual Photochemical Reaction of Diazoketones without Elimination of Nitrogen>, Category: tetrahydrofurans, the main research area is diazotetrahydrofuranone aliphatic compound Wolff rearrangement photochem; hydrazone diazotetrahydrofuranyl preparation; aliphatic compound diazotetrahydrofuranone Wolff rearrangement photochem; bisfuranylhydrazonoethane preparation.

Benzophenone-sensitized reactions of 4-diazotetrahydrofuran-3(2H)-ones with H-donors such as THF, 1,4-dioxane, cyclohexane and di-Et ether, occur without elimination of nitrogen and give rise to the corresponding N-substituted hydrazones or bis-hydrazonoethanes due to a formal insertion of the terminal N atom of diazo group into α-C-H bonds of ethers and aliphatic hydrocarbons, with yields of up to 78 %. Long-wavelength UV irradiation (λ>310 nm) was most suitable for this process, whereas oxygen mols. adequately quench the triplet excited state of the diazoketone and reduce the preparative yields of C-H-insertion products. Hence this photochem. reaction of diazoketones could be used for C-H functionalization of different aliphatic compounds

Asian Journal of Organic Chemistry published new progress about Aliphatic hydrocarbons Role: RCT (Reactant), RACT (Reactant or Reagent). 5455-94-7 belongs to class tetrahydrofurans, and the molecular formula is C8H14O2, Category: tetrahydrofurans.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Qian, Yang; Li, Ze-Jun; Du, Xian-Long; Zhang, Qi; Zhao, Yi; Liu, Yong-Mei; Cao, Yong published the artcile< Total hydrogenation of bio-derived furans over supported Ru subnanoclusters prepared via amino acid-assisted deposition>, Formula: C5H10O2, the main research area is titania supported lysine assisted ruthenium catalyst total hydrogenation furan.

Development of a highly efficient and robust catalyst with reduced usage of noble metals is extremely desirable for selective hydrogenations of furan-containing bio-based feedstocks, which represents an attractive and sustainable alternative to petrochem. resources. Herein, we describe a new type of well-dispersed Ru subnanoclusters (ca. 0.50 wt%) supported on com. P25 TiO2 material obtained from a facile and effective amino acid-assisted deposition-precipitation strategy. The as-synthesized catalyst exhibits superior catalytic activity and selectivity for direct hydrogenation of industrially important furfural as well as a range of structurally diverse bio-based furanic compounds to their corresponding fully hydrogenated derivatives An average turnover frequency (ATOF) value as high as 367 h-1 at 80°C and 4 MPa H2 is obtained, which is the highest reported value. This catalyst also shows stable furfural total hydrogenation in 5 reaction cycles conducted at 80°C (52 mmol-scale, turnover number up to 12 500). In terms of the kinetic and structural characterizations, the key performances of the ultrasmall Ru clusters are proposed to mainly originate from an enhanced number of unsaturated surface Ru atoms and change in local coordination environment. Our work highlights the importance of the subnanometric size of Ru clusters in the advancement of efficient and affordable approaches towards bio-based chem. production

Green Chemistry published new progress about Hydrogenation. 97-99-4 belongs to class tetrahydrofurans, and the molecular formula is C5H10O2, Formula: C5H10O2.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem