Tag: M.W=100-150

Humbert-Voss, Emelyne published the artcileSynthesis and conformational behavior of pseudopeptides containing δ-azaproline. A cis conformational preference for Xaa₁-δ-azaPro bond, Synthetic Route of 19444-84-9, the publication is Tetrahedron (2014), 70(2), 363-370, database is CAplus.

δ-Azaproline, a new bis-nitrogen proline surrogate has been used in order to control the conformation of an AA-ΨPro bond. Conformational anal. of Xaa₁-δ-azaPro-Xaa₃ performed by NMR, IR experiments, and mol. modeling revealed a preference for a trans conformation of the Xaa₁-δ-azaPro bond when δ-azaPro is protected by a Boc group. The removal of the Boc (Boc = tert-butoxycarbonyl) protection leads to the establishment of a C₁₀ pseudocycle via a hydrogen bond network favoring the cis conformation of the Xaa₁-δ-azaPro bond.

Tetrahedron published new progress about 19444-84-9. 19444-84-9 belongs to tetrahydrofurans, auxiliary class Tetrahydrofuran,Ester,Alcohol, name is 3-Hydroxydihydrofuran-2(3H)-one, and the molecular formula is C4H6O3, Synthetic Route of 19444-84-9.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Yamaguchi, Sho published the artcileCascade approach to the synthesis of useful compounds using various natural carbon resources, Synthetic Route of 19444-84-9, the publication is Yuki Gosei Kagaku Kyokaishi (2016), 74(10), 975-983, database is CAplus.

A review. Due to the depletion of fossil fuels, natural carbon resources (i.e. biomass-derived sugars) have attracted increasing attention in recent years as an alternative carbon source. Although significant advances have been reported in the development of catalysts for the conversion of carbohydrates into key chems., only a limited range of products can be obtained. We herein describe the highly-selective cascade syntheses of a range of useful compounds using biomass-derived sugars and their decomposed oxygenates. We especially focus on the upgrade of C1 and C3 oxygenates generated from glucose, formaldehyde, and 1,3-dihydroxyacetone, resp., to yield useful compounds via C-C bond formation. The catalytic conversion reactions include (1) synthesis of α-hydroxy-γ-butyrolactone from 1,3-dihydroxyacetone and formaldehyde using tin compounds as catalysts, (2) synthesis of α-hydroxy-γ-substituted butyrolactone by cyclocondensation of 1,3-dihydroxyacetone with aldehydes in the presence of SnCl₄·5H₂O, and (3) synthesis of α-hydroxy-γ-butyrolactone from formaldehyde by formose reaction. The establishment of this novel synthetic methodol. to generate valuable chem. products from saccharides and their decomposed oxygenated materials renders carbohydrates a potential alternative carbon resource to fossil fuels.

Yuki Gosei Kagaku Kyokaishi published new progress about 19444-84-9. 19444-84-9 belongs to tetrahydrofurans, auxiliary class Tetrahydrofuran,Ester,Alcohol, name is 3-Hydroxydihydrofuran-2(3H)-one, and the molecular formula is C9H22OSi, Synthetic Route of 19444-84-9.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Furdikova, Katarina published the artcileInvestigation of volatile profile of varietal Gewurztraminer wines using two-dimensional gas chromatography, Related Products of tetrahydrofurans, the publication is Journal of Food and Nutrition Research (Bratislava, Slovakia) (2017), 56(1), 73-85, database is CAplus.

Each varietal wine has its own characteristic aroma profile, which can be described by determination of its volatile organic compounds (VOC) profile. The aim of this work was to characterize Gewiirztraminer wine using two-dimensional gas chromatog. coupled to time-of-flight mass spectrometry, preceded by solid phase microextraction of volatile compounds from headspace, and identify voe responsible for typical aroma profile of this varietal wine. In 30 wine samples, in total 288 volatiles were identified, while 153 were found in each studied sample. These common attributes creating varietal fingerprint of Gewiirztraminer wine were represented by 50 esters, 28 terpenoids and Cl3-norisoprenoids, 25 higher alcs., 23 furans, pyrans and lactones, 13 volatile acids, 10 carbonyl compounds, 3 sulfur compounds and 1 volatile phenol. Differentiation among Gewiirztraminer wines and wines of other vine varieties was mainly perceived through the following components: els-rose oxide, sulcatol, (Z)-β-ocimene, 4-vinyl-guaiacol, furan, 2$-furandicarboxaldehyde, 2(5H)-furanone, solerone, ct-angelica lactone, 2-hydroxy-y-butyrolactone, B-hydroxybutyrolactone, Me pyruvate and Me formate. Regardless of vintage and used technol., in all tested Gewiirztraminer samples, voe previously connected only with oak (maltol), botrytization (p-cymene), non-saccharomyces activity (blackberry thiophenone), insect pheromones or plants other than Vitis vinifera (isogeraniol, β-farnesene, sulcatone, sulcatol, Et 3-methylthiopropionate) were identified.

Journal of Food and Nutrition Research (Bratislava, Slovakia) published new progress about 19444-84-9. 19444-84-9 belongs to tetrahydrofurans, auxiliary class Tetrahydrofuran,Ester,Alcohol, name is 3-Hydroxydihydrofuran-2(3H)-one, and the molecular formula is C4H6O3, Related Products of tetrahydrofurans.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Verma, Manju published the artcileScreening and evaluation of bioactive components of Hedychium coronarium J. koenig in nature grown and in vitro regenerated plants by gc-ms analysis, Name: 3-Hydroxydihydrofuran-2(3H)-one, the publication is World Journal of Pharmacy and Pharmaceutical Sciences (2015), 4(4), 1729-1747, database is CAplus.

About 80% of the World’s population depends on the traditional medicines for various ailments. The yield of steam distillation of Hedychium coronarium essential oils and its physicochem. constants were determined The GC-MS anal. of nature grown and in vitro grown plant samples were carried out using GC-MS-QP 2010 Plus model with methanol as solvent. Several oil components were identified based upon comparison of their mass spectral data with those of reference compounds published in literature or stored in a computer library. The oil was found to contain monoterpenes, sesqueterpenes and diterpenes. The major components of the oil were 2-methoxy-4-vinylphenol (15.86%),.beta.-d-glucopyranoside, Me (53.06%), hexadecanoic acid (7.11%), stigmast-5-en-3-ol, (3.beta.)- (12.71%), 2-hydroxy-gamma-butyrolactone (9.42%), 2-oxabicyclo[2.2.2]octan-6-ol, 1,3,3-trimethyl- (2.91%).

World Journal of Pharmacy and Pharmaceutical Sciences published new progress about 19444-84-9. 19444-84-9 belongs to tetrahydrofurans, auxiliary class Tetrahydrofuran,Ester,Alcohol, name is 3-Hydroxydihydrofuran-2(3H)-one, and the molecular formula is C19H21N3O3S, Name: 3-Hydroxydihydrofuran-2(3H)-one.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Grover, Madhuri published the artcilePhytochemical Screening, antioxidant Assay and Cytotoxic Profile for Different Extracts of Chrysopogon zizanioides Roots, Product Details of C4H6O3, the publication is Chemistry & Biodiversity (2021), 18(8), e2100012, database is CAplus and MEDLINE.

The Chrysopogon zizanioides plant possesses multiple traditional uses, especially in therapeutics, but only a few articles have reported its biol. activity. Hence, the present study was planned to explore the phytochem. constituents, cytotoxic potential, radical scavenging activity, and GC/MS (Gas chromatog. & Mass spectrometry) anal. of the vetiver root extracts The roots extracted with different solvents exhibited more significant phytochem. constituents in polar solvents in comparison to non-polar ones, favoring the extraction of a greater number of components in highly polar solvents. All the extracts were tested for their cytotoxicity using SRB (Sulforhodamine B) assay. They confirmed ethanolic extract as a potent extract with GI₅₀ 56±0.5 μg/mL in oral cancer (SCC-29B) along with no cytotoxicity in healthy cells (Vero cells), making it a safer therapeutic option in comparison to standard Adriamycin. This extract was also analyzed for its antioxidant potential by DPPH (1,1-Diphenyl-2-picrylhydrazyl) assay with IC₅₀ value 10.73 μg/mL, which was quite comparable to Ascorbic acid having IC₅₀ value 4.61 μg/mL. The quant. anal. of ethanolic extract exhibited 107 compounds amongst which Khusenic acid, Ascorbic acid, Junipen, gamma-Himachalene, alpha-Guaiene were the majorly occurring compounds that can be explored further for their cytotoxic activity.

Chemistry & Biodiversity published new progress about 19444-84-9. 19444-84-9 belongs to tetrahydrofurans, auxiliary class Tetrahydrofuran,Ester,Alcohol, name is 3-Hydroxydihydrofuran-2(3H)-one, and the molecular formula is C4H6O3, Product Details of C4H6O3.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Anadon, Arturo published the artcileScientific opinion on Flavouring Group Evaluation 65 (FGE.65): consideration of sulfur-substituted furan derivatives used as flavouring agents evaluated by JECFA (59^thmeeting) structurally related to a subgroup of substances within the group of “furfuryl and furan derivatives with and without additional side-chain substituents and heteroatoms from chemical group 14” evaluated by EFSA in FGE.13Rev1 (2009), Application of 2-Methyl-3-tetrahydrofuranthiol, the publication is EFSA Journal (2010), 8(7), 1406, 54 pp., database is CAplus.

The Scientific Panel on Food Contact Materials, Enzymes, Flavorings and Processing Aids has been requested to consider the Joint FAO/WHO Expert Committee on Food Additives (the JECFA) evaluations of flavoring substances assessed since 2000, and to decide whether no further evaluation is necessary, as laid down in Commission Regulation (EC) No 1565/2000. The evaluation deals with 33 substances in the JECFA flavoring group of sulfur-substituted furan derivatives For 24 of the 33 JECFA evaluated sulfur-substituted furan derivatives the Panel agrees with JECFA conclusion ‘No safety concern at estimated levels of intake as flavoring substances’ based on the MSDI approach. They have reservations for nine substances: for eight substances data on the stereoisomeric composition/composition of the mixture has not been specified and for four substances addnl. toxicity data are needed.

EFSA Journal published new progress about 57124-87-5. 57124-87-5 belongs to tetrahydrofurans, auxiliary class Tetrahydrofuran,Thiol, name is 2-Methyl-3-tetrahydrofuranthiol, and the molecular formula is C5H10OS, Application of 2-Methyl-3-tetrahydrofuranthiol.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Ravindran, Darvin R. published the artcileChemical composition and larvicidal activity of flower extracts from Clitoria ternatea against Aedes (diptera: culicidae), Product Details of C4H6O3, the publication is Journal of Chemistry (2020), 3837207, database is CAplus.

Mosquitoes have always been a human health threat; the major global health problems caused by them are malaria, dengue fever, yellow fever, and Zika as well as several other vector-borne outbreaks. The major problems in controlling these vectors borne diseases are related to resistance to eradication measures. Different classes of insecticides used for controlling public health have raised the concern of resistant problems with mosquitoes and environmental pollution caused by the control measures. Thus, a search for alternative natural compounds is necessary for solving the insecticidal resistance problem using pesticides in the larval stage of vector development as well as creating a chem.-free environment for a healthy society. Hence, the major focus of this study is to identify the larvicidal mechanisms, metabolite, antioxidants, and chem. compounds and elucidate their structures from C. ternatea flower and to test their efficacies against early 4th instar larvae of Aedes aegypti and Aedes albopictus. Clitoria ternatea flowers were collected from the garden of the Faculty of Medicine in International Quest University, Ipoh, Perak, and thence used for crude extraction Further on, the metabolite test, antioxidant test, and chromatog. techniques were conducted to identify the chem. composition of extracts and their chem. structures were identified using GCMS-QP2010 Ultra (Shimadzu). Next, the extracts were evaluated against the early 4th instar larvae of Aedes mosquito vectors following the WHO procedures for larval bioassays. The larvicidal activity of Clitoria ternatea flower extracts evidently affected the early 4th instar larvae of Aedes mosquito vectors. The highest larvicidal activity was observed against the early 4th instar larvae of Aedes aegypti with the LC50 and LC95 values of 1056 and 2491 mg/L, resp. Meanwhile, the larvae bioassay test for Aedes albopictus recorded the LC50 and LC95 values of 1425 and 2753 mg/L. Moreover, the results for nontarget organism test on guppy fish, Poecilia reticulata, showed no mortalities with flower extracts at 2500 mg/L, hence posing no toxic effects on fish. In this study, we have found a total of 16 chem. compounds and 6 chem. compounds have been reported to possess direct insecticidal, larvicidal, and pupicidal effects. Six chems. with insecticidal properties were found to be glycerin, 2-hydroxy-gamma-butyrolactone, neophytadiene, n-hexadecanoic acid, cis-vaccenic acid, and octadecanoic acid with a total of 28.7% efficacy. Clitoria ternatea flower extracts also showed different types of phenols such as anthocyanins, flavonoids, and tannins. Our findings showed that the crude extract of Clitoria ternatea flower bioactive mols. is effective and may be developed as biolarvicide for Aedes mosquito vector control. Furthermore, this study also provided a baseline understanding for future research work in the field of applications of Clitoria ternatea flower extracts for their long-term effects on human health such as a food additive, antioxidant, and cosmetic.

Journal of Chemistry published new progress about 19444-84-9. 19444-84-9 belongs to tetrahydrofurans, auxiliary class Tetrahydrofuran,Ester,Alcohol, name is 3-Hydroxydihydrofuran-2(3H)-one, and the molecular formula is C4H6O3, Product Details of C4H6O3.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Sampaio, Karina L. published the artcileComparison of techniques for the isolation of volatiles from cashew apple juice, Synthetic Route of 19444-84-9, the publication is Journal of the Science of Food and Agriculture (2015), 95(2), 299-312, database is CAplus and MEDLINE.

BACKGROUND The aim of this study was to compare the performance of the following techniques on the isolation of volatiles of importance for the aroma/flavor of fresh cashew apple juice: dynamic headspace anal. using PorapakQ as trap, solvent extraction with and without further concentration of the isolate, and solid-phase microextraction (fiber DVB/CAR/PDMS). RESULTS A total of 181 compounds were identified, from which 44 were esters, 20 terpenes, 19 alcs., 17 hydrocarbons, 15 ketones, 14 aldehydes, among others. Sensory evaluation of the gas chromatog. effluents revealed esters (n = 24) and terpenes (n = 10) as the most important aroma compounds CONCLUSIONThe four techniques were efficient in isolating esters, a chem. class of high impact in the cashew aroma/flavor. However, the dynamic headspace methodol. produced an isolate in which the analytes were in greater concentration, which facilitates their identification (gas chromatog.-mass spectrometry) and sensory evaluation in the chromatog. effluents. Solvent extraction (dichloromethane) without further concentration of the isolate was the most efficient methodol. for the isolation of terpenes. Because these two techniques also isolated in greater concentration the volatiles from other chem. classes important to the cashew aroma, such as aldehydes and alcs., they were considered the most advantageous for the study of cashew aroma/flavor. © 2014 Society of Chem. Industry.

Journal of the Science of Food and Agriculture published new progress about 19444-84-9. 19444-84-9 belongs to tetrahydrofurans, auxiliary class Tetrahydrofuran,Ester,Alcohol, name is 3-Hydroxydihydrofuran-2(3H)-one, and the molecular formula is C4H6O3, Synthetic Route of 19444-84-9.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Hartman, Guy J. published the artcileVolatile products formed from the thermal degradation of thiamin at high and low moisture levels, Name: 2-Methyl-3-tetrahydrofuranthiol, the publication is Journal of Agricultural and Food Chemistry (1984), 32(5), 1015-18, database is CAplus.

Volatile products formed during the heating (135°) of thiamin  [59-43-8] in water and propylene glycol  [57-55-6] were examined Carbonyls, furans, thiophenes, thiazoles, dioxolanes, and other S-containing compounds were identified. Quant. and qual. greater amounts of compounds were identified in the water system. Qual. comparisons of systems studied were made.

Journal of Agricultural and Food Chemistry published new progress about 57124-87-5. 57124-87-5 belongs to tetrahydrofurans, auxiliary class Tetrahydrofuran,Thiol, name is 2-Methyl-3-tetrahydrofuranthiol, and the molecular formula is C5H10OS, Name: 2-Methyl-3-tetrahydrofuranthiol.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem