Versatile Solid Supports for Oligonucleotide Synthesis that Incorporate Urea Bridge was written by Yagodkin, Andrey;Weisel, Janne;Azhayev, Alex. And the article was included in Nucleosides, Nucleotides & Nucleic Acids in 2011.Computed Properties of C38H34FN5O6 This article mentions the following:
The universal solid support, USIII, representing a new and improved version of com. USII, as well as 2′-deoxynucleoside and 2′-deoxy-2′-fluoronucleoside bound supports, incorporating a labile phenoxyacetyl fragment, was synthesized by an aminomethyl polystyrene carbamoylation with corresponding azides in the presence of aqueous triethylammonium bicarbonate. All three solid phases incorporate a stable urea tether, thus bridging the polymer and functional linker. These new matrixes proved to be potent solid phases for the synthesis of DNA, RNA, or modified oligonucleotides as well as randomized mixed 2′-ribo/2′-deoxy-2-fluoro-RNA libraries and/or DNA libraries, randomized with trinucleotides (codons). In the experiment, the researchers used many compounds, for example, N-(9-((2R,3R,4R,5R)-5-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3-fluoro-4-hydroxytetrahydrofuran-2-yl)-9H-purin-6-yl)benzamide (cas: 136834-21-4Computed Properties of C38H34FN5O6).
N-(9-((2R,3R,4R,5R)-5-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3-fluoro-4-hydroxytetrahydrofuran-2-yl)-9H-purin-6-yl)benzamide (cas: 136834-21-4) belongs to tetrahydrofuran derivatives. Tetrahydrofuran and dihydrofuran form the basic structural unit of many naturally occurring scaffolds like gambieric acid A and ciguatoxin, goniocin, and some biologically active molecules. Commercial tetrahydrofuran contains substantial water that must be removed for sensitive operations, e.g. those involving organometallic compounds. Although tetrahydrofuran is traditionally dried by distillation from an aggressive desiccant, molecular sieves are superior.Computed Properties of C38H34FN5O6
Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem