Synthesis and evaluation of acyl protein thioesterase 1 (APT1) inhibitors was written by Biel, Markus;Deck, Patrick;Giannis, Athanassios;Waldmann, Herbert. And the article was included in Chemistry – A European Journal in 2006.HPLC of Formula: 40856-59-5 This article mentions the following:
Lipid-modified proteins play decisive roles in important biol. processes such as signal transduction, organization of the cytoskeleton and vesicular transport. Lipidation of these proteins is essential for correct biol. function. Among the modifications with lipids, prenylation and myristoylation are well understood. However, the machinery of palmitoylation is still under investigation. Recently, an enzyme, acyl protein thioesterase 1 (APT1), that may play a regulatory role in the palmitoylation cycle of H-Ras and G-protein α subunits, was purified. Motivated by this work, several lipopeptide inhibitors of APT1 were designed, synthesized and biol. evaluated to be highly active compounds In the experiment, the researchers used many compounds, for example, Boc-L-Homoserine lactone (cas: 40856-59-5HPLC of Formula: 40856-59-5).
Boc-L-Homoserine lactone (cas: 40856-59-5) belongs to tetrahydrofuran derivatives. Solid acid catalysis, and the advantages often associated with their use, have been proved equally efficient for the synthesis of tetrahydrofurans or furans. Tetrahydrofuran reaction with hydrogen sulfide: In the presence of a solid acid catalyst, tetrahydrofuran reacts with hydrogen sulfide to give tetrahydrothiophene.HPLC of Formula: 40856-59-5
Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem