Tag: 200-300

Chemically modified guide RNAs for genome editing with Cas12b was written by Rajeev, Kallanthottathil G.; Chadwick, Alexandra; Reiss, Caroline. And the patent was published on October 14,2021.Application In Synthesis of (2R,3S,4R,5R)-2-(Hydroxymethyl)-5-(9H-purin-9-yl)tetrahydrofuran-3,4-diol The following contents are mentioned in the patent:

Provided herein are compositions related to Cas12b guide RNAs. Also provided herein are methods for modifying target polynucleotide sequences and methods of treating or preventing a condition in a subject in need thereof, such as conditions resultant from the expression of ANGPTL3 or mutations thereto. This study involved multiple reactions and reactants, such as (2R,3S,4R,5R)-2-(Hydroxymethyl)-5-(9H-purin-9-yl)tetrahydrofuran-3,4-diol (cas: 550-33-4Application In Synthesis of (2R,3S,4R,5R)-2-(Hydroxymethyl)-5-(9H-purin-9-yl)tetrahydrofuran-3,4-diol).

(2R,3S,4R,5R)-2-(Hydroxymethyl)-5-(9H-purin-9-yl)tetrahydrofuran-3,4-diol (cas: 550-33-4) belongs to tetrahydrofuran derivatives. THF (Tetrahydrofuran) is water-miscible and has a low viscosity making it a highly versatile solvent used in a variety of industries. Commercial tetrahydrofuran contains substantial water that must be removed for sensitive operations, e.g. those involving organometallic compounds. Although tetrahydrofuran is traditionally dried by distillation from an aggressive desiccant, molecular sieves are superior.Application In Synthesis of (2R,3S,4R,5R)-2-(Hydroxymethyl)-5-(9H-purin-9-yl)tetrahydrofuran-3,4-diol

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Chemically modified guide RNAs for genome editing with Cas9 was written by Chadwick, Alexandra; Rajeev, Kallanthottathil G.; Rohde, Ellen; Cheng, Christopher; Reiss, Caroline. And the patent was published on October 14,2021.Product Details of 550-33-4 The following contents are mentioned in the patent:

Provided herein are compositions for gene modification or editing and methods of using same to treat or prevent certain conditions. Specific compositions and methods capable of safely and effectively editing PCSK9 and ANGPTL3 gene targets expressed in the liver to durably lower LDL-C thereby treating a leading cause of cardiovascular disease are disclosed. This study involved multiple reactions and reactants, such as (2R,3S,4R,5R)-2-(Hydroxymethyl)-5-(9H-purin-9-yl)tetrahydrofuran-3,4-diol (cas: 550-33-4Product Details of 550-33-4).

(2R,3S,4R,5R)-2-(Hydroxymethyl)-5-(9H-purin-9-yl)tetrahydrofuran-3,4-diol (cas: 550-33-4) belongs to tetrahydrofuran derivatives.Tetrahydrofuran has many industry uses as a solvent including in natural and synthetic resins, high polymers, fat oils, rubber, polymer. Tetrahydrofuran reaction with hydrogen sulfide: In the presence of a solid acid catalyst, tetrahydrofuran reacts with hydrogen sulfide to give tetrahydrothiophene.Product Details of 550-33-4

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Enhancement of siRNA silencing activity using universal bases or mismatches in the sense strand was written by Maier, Martin; Addepalli, Haripriya; Manoharan, Muthiah. And the patent was published on January 28,2010.HPLC of Formula: 550-33-4 The following contents are mentioned in the patent:

Double-stranded nucleic acids useful as an siRNAs are provided that have a sense strand and an antisense strand relative to a target nucleic acid, where the sense strand contains one or more modified or non-natural nucleobases, or one or more mismatch base pairings with the antisense strand. A method of gene silencing comprises administering to a mammal in need thereof a therapeutically effective amount of a double-stranded oligonucleotides containing a sense strand and an antisense strand, where the sense strand contains one or more modified nucleobases or one or more mismatch base pairings with the antisense strand. The effect of mismatch base pairing and modified nucleobases on siRNA potency is dependent on the mismatched base pair and its position on the sense strand. Apparently, local destabilization in the central region of the sense strand via mismatched base pairs (position 9-12) are more effective in enhancing potency than those outside of this region. The effect of modified nucleobases (e.g., 2,4-difluorotoluyl-ribonucleotide and -deoxyribonucleotide, 5-nitroindole deoxyribonucleotide and ribonucleotide, deoxyribo- and ribonebularine,, deoxy- and riboinosine, and ribo- or deoxyribo-2-aminopurine) to enhance potency over the parent compound is particularly significant in position 10. While there is no significant correlation between activity and thermal stability at positions 9, 11, and 12, the potency of the siRNAs appears to increase with decreased thermal stability due to modifications in position 10. Further, abasic modifications in position 10 and 12 particularly enhance potency over the parent compound This study involved multiple reactions and reactants, such as (2R,3S,4R,5R)-2-(Hydroxymethyl)-5-(9H-purin-9-yl)tetrahydrofuran-3,4-diol (cas: 550-33-4HPLC of Formula: 550-33-4).

(2R,3S,4R,5R)-2-(Hydroxymethyl)-5-(9H-purin-9-yl)tetrahydrofuran-3,4-diol (cas: 550-33-4) belongs to tetrahydrofuran derivatives. THF (Tetrahydrofuran) is water-miscible and has a low viscosity making it a highly versatile solvent used in a variety of industries. It is more basic than diethyl ether and forms stronger complexes with Li+, Mg2+, and boranes. It is a popular solvent for hydroboration reactions and for organometallic compounds such as organolithium and Grignard reagents.HPLC of Formula: 550-33-4

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Anti-inflammatory and anti-allergy extracts from nettle was written by Alberte, Randall S.; Roschek, William P., Jr.; Li, Dan. And the patent was published on January 14,2010.Electric Literature of C10H12N4O4   The following contents are mentioned in the patent:

The present invention relates in part to nettle extracts comprising at least one compound useful for treating or preventing seasonal allergies, allergic rhinitis, and other inflammatory conditions. The nettle extracts showed inhibitory activities against COX-1, COX-2, 5-lipoxygenase, and tryptase, as well as H1 antagonistic activity. This study involved multiple reactions and reactants, such as (2R,3S,4R,5R)-2-(Hydroxymethyl)-5-(9H-purin-9-yl)tetrahydrofuran-3,4-diol (cas: 550-33-4Electric Literature of C10H12N4O4  ).

(2R,3S,4R,5R)-2-(Hydroxymethyl)-5-(9H-purin-9-yl)tetrahydrofuran-3,4-diol (cas: 550-33-4) belongs to tetrahydrofuran derivatives. Solid acid catalysis, and the advantages often associated with their use, have been proved equally efficient for the synthesis of tetrahydrofurans or furans. Tetrahydrofuran (THF) is primarily used as a precursor to polymers including for surface coating, adhesives, and printing inks.Electric Literature of C10H12N4O4  

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Convertible nucleic acid adapters was written by Gloekler, Joern; Frohme, Marcus. And the patent was published on March 15,2018.Related Products of 550-33-4 The following contents are mentioned in the patent:

The invention relates to a method and a kit comprising single or at least partially double-stranded adapters comprising sequences with base modifications that are ligated to nucleic acid fragments and converted to generate asym. ends for specific recognition. The method is based on two main sequence conversion mechanisms, a direct conversion of specific bases and an indirect conversion by copying, wherein both mechanisms may be combined. This study involved multiple reactions and reactants, such as (2R,3S,4R,5R)-2-(Hydroxymethyl)-5-(9H-purin-9-yl)tetrahydrofuran-3,4-diol (cas: 550-33-4Related Products of 550-33-4).

(2R,3S,4R,5R)-2-(Hydroxymethyl)-5-(9H-purin-9-yl)tetrahydrofuran-3,4-diol (cas: 550-33-4) belongs to tetrahydrofuran derivatives. Tetrahydrofurans and furans are important oxygen-containing heterocycles that often exhibit interesting properties for biological applications or applications in the cosmetic industry. Oxidations have also proved to be valuable and efficient approaches to chiral tetrahydrofuran derivatives.Related Products of 550-33-4

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

HPLC of Formula: 160709-02-4On March 15, 2015, Jin, Feng-min; Zhang, Jing published an article in Zhongguo Xinyao Zazhi. The article was 《Synthesis of posaconazole》. The article mentions the following:

Objective: To improve the synthesis process of posaconazole. Methods: Posaconazole was synthesized from 1-(1-bromomethyl-vinyl)-2,4-difluoro-benzene by several reactions such as esterification, reduction and enzymic acetylation. Results: The overall yield was 27.7%. Conclusion: This synthetic process had the advantages of simpler purifying operation, lower cost and mild condition, so it could be used in industrial manufacturing In the experiment, the researchers used many compounds, for example, ((3R,5R)-5-((1H-1,2,4-Triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methanol(cas: 160709-02-4HPLC of Formula: 160709-02-4)

((3R,5R)-5-((1H-1,2,4-Triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methanol(cas: 160709-02-4) is a member of aromaticfluorinated building blocks. Depending on which substituents are present, fluoroaromatic intermediates can be converted into fluorinated or fluorine-free commercial end products.Fluorine-containing aromatics have been incorporated into drugs (hypnotics, tranquilizers, antiinflammatory agents, analgesics, antibacterials).HPLC of Formula: 160709-02-4

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Recommanded Product: 160709-02-4On March 13, 1995, Saksena, Anil K.; Girijavallabhan, Viyyoor M.; Lovey, Raymond G.; Pike, Russell E.; Wang, Haiyan; Ganguly, Ashit K.; Morgan, Brian; Zaks, Alesey; Puar, Mohinder S. published an article in Tetrahedron Letters. The article was 《Highly stereoselective access to novel 2,2,4-trisubstituted tetrahydrofurans by halocyclization: practical chemoenzymic synthesis of SCH 51048, a broad-spectrum orally active antifungal agent》. The article mentions the following:

A convenient synthesis of (-)-(2R)-cis-tosylate I is reported via stereoselective 5-exo-iodocyclization of the optically active 2,2-disubstituted olefin II. Enzymic desymmetrization of the homoallylic diol III with Novo SP435 allowed optimal pro(S) selectivity to provide the desired (-)-monoacetate II. Under the irreversible reaction conditions, the presence of a bulky aryl substituent on the 2,2-disubstituted olefin seems to determine stereochem. outcome of these halocyclizations. The experimental part of the paper was very detailed, including the reaction process of ((3R,5R)-5-((1H-1,2,4-Triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methanol(cas: 160709-02-4Recommanded Product: 160709-02-4)

((3R,5R)-5-((1H-1,2,4-Triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methanol(cas: 160709-02-4) is a member of aromaticfluorinated building blocks. Depending on which substituents are present, fluoroaromatic intermediates can be converted into fluorinated or fluorine-free commercial end products.Fluorine-containing aromatics have been incorporated into drugs (hypnotics, tranquilizers, antiinflammatory agents, analgesics, antibacterials).Recommanded Product: 160709-02-4

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Lovey, Raymond G.; Saksena, Anil K.; Girijavallabhan, Vlyyoor M. published their research in Tetrahedron Letters on August 15 ,1994. The article was titled 《PPL-catalyzed enzymic asymmetrization of a 2-substituted prochiral 1,3-diol with remote chiral functionality: improvements toward synthesis of the eutomers of SCH 45012》.Recommanded Product: 160709-02-4 The article contains the following contents:

Porcine pancreatic lipase catalysis has been used to establish both stereocenters of (tetrahydrofuranylmethyl)tosylate I. In addition to the enzymic differentiation of the hydroxyl groups of the pro-chiral 1,3-diol segment of triol (R)-II [R1 = CH(CH2OH)2], successful enzymic resolution of the racemic diol II (R1 = OH) provided an alternate route to the important precursor diol (R)-II (R1 = OH). In the experiment, the researchers used many compounds, for example, ((3R,5R)-5-((1H-1,2,4-Triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methanol(cas: 160709-02-4Recommanded Product: 160709-02-4)

((3R,5R)-5-((1H-1,2,4-Triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methanol(cas: 160709-02-4) is a member of aromaticfluorinated building blocks. Depending on which substituents are present, fluoroaromatic intermediates can be converted into fluorinated or fluorine-free commercial end products.Fluorine-containing aromatics have been incorporated into drugs (hypnotics, tranquilizers, antiinflammatory agents, analgesics, antibacterials).Recommanded Product: 160709-02-4

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Saksena, Anil K.; Girijavallabhan, Viyyoor M.; Wang, Haiyan; Liu, Yi-Tsung; Pike, Russell E.; Ganguly, Ashit K. published their research in Tetrahedron Letters on August 5 ,1996. The article was titled 《Concise asymmetric routes to 2,2,4-trisubstituted tetrahydrofurans via chiral titanium imide enolates: key intermediates towards synthesis of highly active azole antifungals Sch 51048 and Sch 56592》.Application of 160709-02-4 The article contains the following contents:

Two complimentary approaches to the key (-)-(2R)-cis-tosylate I and its (+)-(2S)-enantiomer via generation of chiral imide enolates having a 2,2-disubstituted olefin functionality in the β-position, are described. In a “”protecting group free”” sequence, reaction of the titanium enolate generated from (4R)-benzyl-2-oxazolidinone derived imide II with s-trioxane provided a convenient oxazolidinone intermediate III which could be directly subjected to 2,4-diastereoselective iodocycln. In the experimental materials used by the author, we found ((3R,5R)-5-((1H-1,2,4-Triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methanol(cas: 160709-02-4Application of 160709-02-4)

((3R,5R)-5-((1H-1,2,4-Triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methanol(cas: 160709-02-4) is a member of aromaticfluorinated building blocks. Depending on which substituents are present, fluoroaromatic intermediates can be converted into fluorinated or fluorine-free commercial end products.Fluorine-containing aromatics have been incorporated into drugs (hypnotics, tranquilizers, antiinflammatory agents, analgesics, antibacterials).Application of 160709-02-4

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

In 2019,Chinese Journal of Structural Chemistry included an article by Han, Hao; Zhang, Zhi-Fang; Zhang, Jun-Fei; Zhang, Bin. Product Details of 160709-02-4. The article was titled 《Synthesis, crystal structure and anti-breast cancer activity of ((3S,5R)-5-((1H-1,2,4-triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methyl 4-methylbenzenesulfonate》. The information in the text is summarized as follows:

The new heterocycle compound ((3S,5R)-5-((1H-1,2,4-triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methyl 4-methylbenzenesulfonate (1), designed using ((3R,5S)-5-(2,4-difluorophenyl)-5-iodotetrahydrofuran-3-yl)methyl isobutyrate (2) as the start material, was successfully obtained via multiple synthesis route and finally characterized by IR, 1H NMR, and single-crystal X-ray crystallog. In addition, the in vitro anticancer activities of the newly synthesized complex 1 have been emulated against three human breast cancer cell lines BT474, MCF7 and MB. The experimental part of the paper was very detailed, including the reaction process of ((3R,5R)-5-((1H-1,2,4-Triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methanol(cas: 160709-02-4Product Details of 160709-02-4)

((3R,5R)-5-((1H-1,2,4-Triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methanol(cas: 160709-02-4) is a member of aromaticfluorinated building blocks. Depending on which substituents are present, fluoroaromatic intermediates can be converted into fluorinated or fluorine-free commercial end products.Fluorine-containing aromatics have been incorporated into drugs (hypnotics, tranquilizers, antiinflammatory agents, analgesics, antibacterials).Product Details of 160709-02-4

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem