Tag: 138498-97-2

138498-97-2, 2-(Tetrahydrofuran-3-yl)acetic acid is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a mixture of A-2 (100.00 mg, 691.75 mmol), PYBOP (539.97 mg, 1.04 mmol) in DCM (10.00 mL) was added 2-tetrahydrofuran-3-ylacetic acid (90.02 mg, 691.75 mmol) and DIPEA (362.44 _, 2.08 mmol), and the mixture was stirred at 25 C for 1 hour. The mixture was concentrated to give crude A-11 (800.00 mg), which was used directly without any further purification. LCMS Rt = 0.18 min using Method B, MS ESI calcd. For C10H14CIN4O2 [M+H]+ 257.1, found 257.0.

The synthetic route of 138498-97-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; PRAXIS PRECISION MEDICINES, INC.; REDDY, Kiran; MARTINEZ BOTELLA, Gabriel; GRIFFIN, Andrew, Mark; MARRON, Brian, Edward; (364 pag.)WO2018/98499; (2018); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.138498-97-2,2-(Tetrahydrofuran-3-yl)acetic acid,as a common compound, the synthetic route is as follows.

To a solution of 1-iodobutane (12.4 g, 67.9 mmol) in acetonitrile (100 mL) was added 1,8-diazabicyclo[5.4.0]undec-7-ene (9.36 g, 61.1 mmol), followed by (tetrahydro-furan-3-yl)-acetic acid (8.0 g, 61.1 mmol) at 0 C. The resulting mixture was stirred at 25 C. for 12 h and poured into water (100 mL). The mixture was extracted with ethyl acetate (2*100 mL). The combined organic layers were washed with brine (50 mL), dried over anhydrous sodium sulfate and concentrated under reduced pressure to give crude butyl 2-tetrahydrofuran-3-ylacetate (11.0 g, 96%) as a yellow oil, used as is in the next step.

As the paragraph descriping shows that 138498-97-2 is playing an increasingly important role.

Reference£º
Patent; Genentech, Inc.; Patel, Snahel; Hamilton, Gregory; (73 pag.)US2018/170927; (2018); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem