Tag: 100-200

In 2022,Zeng, Zhenya; Zhang, Jiangbo; Jia, Miao; Wu, Bo; Cai, Xunzhi; Zhang, Xingsong; Feng, Yixiao; Ma, Youhong; Gao, Qingfu; Fei, Zonglei published an article in Organic Process Research & Development. The title of the article was 《Development of a Scalable Route with Efficient Stereoisomer Control to YZJ-1139, an Orexin Receptor Antagonist》.COA of Formula: C6H12O3 The author mentioned the following in the article:

An effort toward the synthesis and process development of the orexin receptor antagonist YZJ-1139 I was described in this article. I contains the azabicyclic nortropane structure with three chiral centers. By the original process, highly pure intermediates or API could be obtained by chromatog. with a relatively low yield. To remove the undesirable stereoisomers as early as possible, an N-(R)-α-phenethyl was synthesized by the Robinson-Schopf reaction and easily purified as its hydrochloride. The single crystal X-ray study was used to confirm the stereo configuration of I. The protecting group could be easily removed by transfer hydrogenation, resulting in an enantiomerically pure intermediate as its D-tartrate. The overall yield for preparing I was significantly increased, and this cost-efficient process might be promising in future com. productions. In the experimental materials used by the author, we found 2,5-Dimethoxytetrahydrofuran(cas: 696-59-3COA of Formula: C6H12O3)

2,5-Dimethoxytetrahydrofuran(cas: 696-59-3) is a member of ether. Friedel Crafts reaction, for example, adds an alkyl or acyl group to aromatic ethers when they react with an alkyl or acyl halide in the presence of a Lewis acid as a catalyst.COA of Formula: C6H12O3

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Muley, Arabinda; Karumban, Kalai Selvan; Gupta, Parth; Kumbhakar, Sadananda; Giri, Bishnubasu; Raut, Rajnikant; Misra, Ashish; Maji, Somnath published their research in Journal of Organometallic Chemistry in 2021. The article was titled 《Synthesis, structure, spectral, redox properties and anti-cancer activity of Ruthenium(II) Arene complexes with substituted Triazole Ligands》.Application In Synthesis of 2,5-Dimethoxytetrahydrofuran The article contains the following contents:

Three versatile half-sandwich ruthenium(II) p-cymene complexes bearing substituted triazole ligands exhibit promising cancer cell growth inhibition activity towards A549 lung adenocarcinoma and MDA-MB-231 breast adenocarcinoma cells. In this context, the triazole based phthalimide protected new ligand (2-(3, 5-di(pyridin-2-yl)-4H-1,2,4-triazol-4-yl)isoindoline-1,3-dione) (L1) was prepared Three ruthenium(II) p-cymene complexes [Ru(η6-p-cymene)(L1)Cl]Cl: [1]Cl, L1: (2-(3,5-di(pyridin-2-yl)-4H-1,2,4-triazol-4-yl)isoindoline-1,3-dione), [Ru(η6-p-cymene)(L2)Cl]Cl: [2]Cl and [Ru(η6-p-cymene)(L2)Cl](PF6): [2](PF6), L2 (2,2′-(4-(1H-pyrrol-1-yl)-4H-1,2,4-triazole-3,5-diyl)dipyridine) have been successfully synthesized and characterized by different spectral and anal. tools. Pyrrole protected substituted ruthenium complexes [2]Cl and [2](PF6) have been successfully identified structurally by single-crystal x-ray diffraction studies and confirmed the successful anion exchange. The redox properties of the ligands and the targeted metal complexes have been carefully examined Cellular staining, live-cell imaging and MTT assay have been performed for all the complexes. Authors have demonstrated that their synthesized ruthenium(II) p-cymene complexes are capable of inducing significant cytotoxicity in A549 lung cancer cell lines, with an IC50 values of 6.56 ± 0.31μM, 4.74 ± 0.2μM and 13.67 ± 0.64μM and in MDA-MB-231 breast cancer cell lines with an IC50 values of 1.13 ± 0.046μM, 0.36 ± 0.016μM and 11.32 ± 0.49μM for [1]Cl, [2]Cl and [2](PF6) resp. In the experiment, the researchers used many compounds, for example, 2,5-Dimethoxytetrahydrofuran(cas: 696-59-3Application In Synthesis of 2,5-Dimethoxytetrahydrofuran)

2,5-Dimethoxytetrahydrofuran(cas: 696-59-3) is a member of ether. When aromatic ethers are exposed to halogen in the presence or absence of a catalyst, they undergo halogenation, such as bromination.Application In Synthesis of 2,5-Dimethoxytetrahydrofuran

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Synthetic Route of C6H12O3In 2021 ,《Synthesis of Pyrrole-Based Poly(arylenevinylene)s via Co-Catalyzed Hydroarylation of Alkynes》 appeared in Macromolecular Rapid Communications. The author of the article were Iwamori, Ryota; Sato, Ryota; Kuwabara, Junpei; Yasuda, Takeshi; Kanbara, Takaki. The article conveys some information:

Polyaddition via the Co-catalyzed hydroarylation of 1-(2-pyrimidinyl)pyrrole with aromatic diynes affords poly(arylenevinylene)s under mild conditions. This reaction avoids production of stoichiometric amounts of byproducts. Although structural anal. of the obtained polymers reveals the presence of 1,1-vinylidene unit, switching the counter anion of the Co catalyst and steric hindrance of the diyne monomers improves the regioselectivity of the polymers. When a catalyst with bulky counter anions is used for the reaction of less hindered diyne monomers, 1,2-vinylene linkages are formed dominantly over 1,1-vinylidene linkages (93:7). The effect of the regioselectivity of the polymer on the optical and semiconducting properties is also evaluated. In addition to this study using 2,5-Dimethoxytetrahydrofuran, there are many other studies that have used 2,5-Dimethoxytetrahydrofuran(cas: 696-59-3Synthetic Route of C6H12O3) was used in this study.

2,5-Dimethoxytetrahydrofuran(cas: 696-59-3) is a member of ether. When aromatic ethers are exposed to halogen in the presence or absence of a catalyst, they undergo halogenation, such as bromination.Synthetic Route of C6H12O3

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Electric Literature of C4H6O3On October 11, 2019 ,《Non-targeted analysis of the particulate phase of heated tobacco product aerosol and cigarette mainstream tobacco smoke by thermal desorption comprehensive two-dimensional gas chromatography with dual flame ionisation and mass spectrometric detection》 was published in Journal of Chromatography A. The article was written by Savareear, Benjamin; Escobar-Arnanz, Juan; Brokl, Michal; Saxton, Malcolm J.; Wright, Chris; Liu, Chuan; Focant, Jean-Francois. The article contains the following contents:

An anal. methodol. based on thermal desorption and comprehensive two-dimensional gas chromatog. with dual time-of-flight mass spectrometry and flame ionization detection (TD-GC × GC-TOFMS/FID) was developed for non-target anal. of volatile organic compounds (VOCs). The technique was optimized for the measurement of the VOC content of the particulate phase (PP) fraction of aerosols produced by a tobacco heating product (THP1.0) and 3R4F mainstream tobacco smoke (MTS). The method involves sampling the PP fraction on quartz wool packed in a sorbent tube directly connected to machine-puffing, followed by a dilution through a TD recollection procedure over Tenax/Sulficarb sorbent before TD-GC × GC-TOFMS/FID anal. The comparison of the VOC content of the PP fraction of aerosols produced by THP1.0 and MTS highlighted the compositional difference between tobacco combustion (592 peaks) and tobacco heating process (160 peaks). Mass spectrometric signals were used for qual. analyses based on linear retention indexes, mass spectral matches, and GC × GC structured chromatograms, which collectively identified up to 90% of analytes detected in PP samples. FID signals were used for semi-quant. analyses based on a chem. class external calibration method. The global chem. composition of PP samples showed that hydrocarbons, oxygenated, and nitrogen-containing compounds were fewer in number and much less abundant in THP1.0 PP. Overall, 93 compounds were common to the two sample types. Excepted for a few highly volatile compounds (mainly furan family) as well as glycerin and its acetate, analyte concentrations were higher in MTS PP. The results came from multiple reactions, including the reaction of 3-Hydroxydihydrofuran-2(3H)-one(cas: 19444-84-9Electric Literature of C4H6O3)

3-Hydroxydihydrofuran-2(3H)-one(cas: 19444-84-9) may be employed as starting reagent in the synthesis of series of seco-pseudonucleoside synthons via aminolysis. It may be employed as starting reagent in the synthesis of enantiomerically pure orthogonally protected δ-azaproline, via Mitsunobu reaction.Electric Literature of C4H6O3

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

In 2022,Xi, Yang; Huang, Wenyi; Wang, Chenchen; Ding, Haojie; Xia, Tingting; Wu, Licheng; Fang, Ke; Qu, Jingping; Chen, Yifeng published an article in Journal of the American Chemical Society. The title of the article was 《Catalytic Asymmetric Diarylation of Internal Acyclic Styrenes and Enamides》.Safety of 2,5-Dimethoxytetrahydrofuran The author mentioned the following in the article:

Enantioselective transformations of olefins are among the most important strategies for the asym. synthesis of organic compounds Chemo-, diastereo-, and stereoselective control of reactions with internal acyclic alkenes for the construction of functionalized acyclic alkanes still remain a persistent challenge. Here, authors report a palladium-catalyzed asym. regiodivergent Heck-type diarylation of internal acyclic alkenes. The 1,2-diarylation of two accessible acyclic alkenes, cinnamyl carbamates and enamides with diazonium salts and aromatic boronic acids, furnishes products containing vicinal stereogenic centers via the stereospecific formation of carbonyl coordination-assisted transient palladacycles. Moreover, the asym. migratory diarylation of enamides enables the formation of incontiguous stereocenters by an interrupted diastereoselective 1,3-chain-walking process. This protocol streamlines access to highly functionalized multisubstituted enantioenriched carbamates and amine derivatives which are embedded in the key biol. active motifs. In the experiment, the researchers used 2,5-Dimethoxytetrahydrofuran(cas: 696-59-3Safety of 2,5-Dimethoxytetrahydrofuran)

2,5-Dimethoxytetrahydrofuran(cas: 696-59-3) is a member of ether. Friedel Crafts reaction, for example, adds an alkyl or acyl group to aromatic ethers when they react with an alkyl or acyl halide in the presence of a Lewis acid as a catalyst.Safety of 2,5-Dimethoxytetrahydrofuran

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

In 2022,Wu, Long; Ma, Huameng; Mei, Jingsheng; Li, Yanhua; Xu, Qing; Li, Zhanyong published an article in International Journal of Hydrogen Energy. The title of the article was 《Low energy consumption and high quality bio-fuels production via in-situ fast pyrolysis of reed straw by adding metallic particles in an induction heating reactor》.SDS of cas: 696-59-3 The author mentioned the following in the article:

An in-situ fast pyrolysis of biomass by adding metallic particles in an induction heating reactor was proposed to produce high quality bio-fuels. After adding metallic particles into biomass, the times required to reach complete pyrolysis during reed straw pyrolysis process were significantly reduced up to 28.9%. The yields of combustible gas and bio-oil products were significantly increased. Furthermore, higher-quality combustible gas and bio-oil products were obtained with the LHV of gas products and HHV of bio-oil (dry basis) increased by 14.2%-19.1% and 4.16%-16.35%, resp., under 400-600°C. The lower oxygen content and higher yields of aromatics, alkenes and alkanes contents in bio-oil were obtained after metallic particles addition More importantly, up to 26.5% of the total energy consumption during pyrolysis process was reduced after adding metallic particles into biomass in an induction heating reactor. The results indicate that adding metallic particles into biomass in an induction heating reactor can significantly enhance the heat transfer, decomposition reaction intensity and energy utilization efficiency of biomass pyrolysis process with lower energy consumption and higher-quality bio-fuel production In the experiment, the researchers used 2,5-Dimethoxytetrahydrofuran(cas: 696-59-3SDS of cas: 696-59-3)

2,5-Dimethoxytetrahydrofuran(cas: 696-59-3) is a member of ether. Friedel Crafts reaction, for example, adds an alkyl or acyl group to aromatic ethers when they react with an alkyl or acyl halide in the presence of a Lewis acid as a catalyst.SDS of cas: 696-59-3

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Wu, Zhuo; Wei, Feng; Wan, Bin; Zhang, Yanghui published an article in 2021. The article was titled 《Pd-Catalyzed ipso,meta-Dimethylation of ortho-Substituted Iodoarenes via a Base-Controlled C-H Activation Cascade with Dimethyl Carbonate as the Methyl Source》, and you may find the article in Journal of the American Chemical Society.Application In Synthesis of 2,5-Dimethoxytetrahydrofuran The information in the text is summarized as follows:

A Me group can have a profound impact on the pharmacol. properties of organic mols. Hence, developing methylation methods and methylating reagents is essential in medicinal chem. We report a palladium-catalyzed dimethylation reaction of ortho-substituted iodoarenes using di-Me carbonate as a Me source. In the presence of K2CO3 as a base, iodoarenes are dimethylated at the ipso- and meta-positions of the iodo group, which represents a novel strategy for meta-C-H methylation. With KOAc as the base, subsequent oxidative C(sp3)-H/C(sp3)-H coupling occurs; in this case, the overall transformation achieves triple C-H activation to form three new C-C bonds. These reactions allow expedient access to 2,6-dimethylated phenols, 2,3-dihydrobenzofurans, and indanes, which are ubiquitous structural motifs and essential synthetic intermediates of biol. and pharmacol. active compounds In addition to this study using 2,5-Dimethoxytetrahydrofuran, there are many other studies that have used 2,5-Dimethoxytetrahydrofuran(cas: 696-59-3Application In Synthesis of 2,5-Dimethoxytetrahydrofuran) was used in this study.

2,5-Dimethoxytetrahydrofuran(cas: 696-59-3) is a member of ether. Friedel Crafts reaction, for example, adds an alkyl or acyl group to aromatic ethers when they react with an alkyl or acyl halide in the presence of a Lewis acid as a catalyst.Application In Synthesis of 2,5-Dimethoxytetrahydrofuran

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Li, Chao; Zhang, Chenting; Zhang, Lijun; Gholizadeh, Mortaza; Hu, Xun published their research in International Journal of Energy Research in 2021. The article was titled 《Biochar catalyzing polymerization of the volatiles from pyrolysis of poplar wood》.Reference of 2,5-Dimethoxytetrahydrofuran The article contains the following contents:

In this study, the pyrolysis of poplar wood chips with biochar catalyst produced from gasification of the same poplar wood chips was conducted, aiming to probe its influence on the evolution of the pyrolysis products. From the results, it was concluded that the biochar catalyst enhanced the polymerization of the volatiles produced from the pyrolysis, and thus reduced the yields of the gaseous compounds while increased the yield of char. The carbonaceous deposit on surface of the char was oxygen-rich and more aliphatic, which decreased the thermal stability and crystallinity of the char, while made the char prone to oxidation The biochar catalyst also promoted the formation of methoxy phenols at the expense of alkyl phenols, and the formation of the phenolics with bigger π-conjugated structures. In addition, the volatile-biochar interaction removed the defective structures in the large aromatic structures in the biochar catalyst. Highlights : Biochar catalyzed polymerization, but not cracking, of volatiles in pyrolysis. Biochar catalyst enhances char formation while reduces gas formation in pyrolysis. Char in catalytic pyrolysis is more O-rich and aliphatic and low thermal stability. Biochar catalyzed condensation of volatiles to form bigger fused ring structures. Biochar-volatiles interaction removes defective structure in fused ring of biochar. The experimental part of the paper was very detailed, including the reaction process of 2,5-Dimethoxytetrahydrofuran(cas: 696-59-3Reference of 2,5-Dimethoxytetrahydrofuran)

2,5-Dimethoxytetrahydrofuran(cas: 696-59-3) is a member of ether. Friedel Crafts reaction, for example, adds an alkyl or acyl group to aromatic ethers when they react with an alkyl or acyl halide in the presence of a Lewis acid as a catalyst.Reference of 2,5-Dimethoxytetrahydrofuran

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

《KI-Mediated One-Pot Transition-Metal-Free Synthesis of 4-Phenylpyrrolo[1,2-a]quinoxalines》 was written by Li, Shichen; Xie, Caixia; Chu, Xianglong; Dai, Zhen; Feng, Lei; Ma, Chen. Related Products of 696-59-3 And the article was included in European Journal of Organic Chemistry in 2020. The article conveys some information:

An efficient and eco-friendly method for the synthesis of pyrrolo[1,2-a]quinoxalines is presented. Compared to previous methods, this protocol is transition-metal-free and only potassium iodide is required. A series of substituted 4-phenylpyrrolo[1,2-a]quinoxalines were obtained in moderate to good yields. The results came from multiple reactions, including the reaction of 2,5-Dimethoxytetrahydrofuran(cas: 696-59-3Related Products of 696-59-3)

2,5-Dimethoxytetrahydrofuran(cas: 696-59-3) is a member of ether. When aromatic ethers are exposed to halogen in the presence or absence of a catalyst, they undergo halogenation, such as bromination.Related Products of 696-59-3

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Computed Properties of C4H6O3On October 31, 2020 ,《Stability of powdered infant formula during secondary shelf-life and domestic practices》 was published in International Dairy Journal. The article was written by Condurso, Concetta; Cincotta, Fabrizio; Merlino, Maria; Stanton, Catherine; Verzera, Antonella. The article contains the following contents:

Powd. infant formula (PIF) and lactose-free PIF during secondary shelf-life (SSL) and under domestic practices was investigated to verify their stability up to the expiration date and under the label instructions for milk reconstitution. Particular attention was given to variations in Maillard reaction and lipid peroxidation products identified and quantified by HS-SPME-GC-MS. Two types of PIF: Type A based on bovine milk and Type B a lactose-free product based on glucose syrup were analyzed. The PIF were analyzed at regular time intervals beyond the labeled expiration date after opening, and reconstituted using water at 70°C, 80°C and 90°C. A large number of volatile compounds were identified and significant statistically differences resulted during SSL and water temperature used for reconstitution that were correlated to the PIF composition The study showed that water temperature for reconstitution of samples and the SSL has to be adapted to PIF composition3-Hydroxydihydrofuran-2(3H)-one(cas: 19444-84-9Computed Properties of C4H6O3) was used in this study.

3-Hydroxydihydrofuran-2(3H)-one(cas: 19444-84-9) may be employed as starting reagent in the synthesis of series of seco-pseudonucleoside synthons via aminolysis. It may be employed as starting reagent in the synthesis of enantiomerically pure orthogonally protected δ-azaproline, via Mitsunobu reaction.Computed Properties of C4H6O3

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem