Tag: 100-200

Ren, Fei; Li, Zeshun; Li, Kai; Zheng, Xiaoyan; Shi, Jianbing; Zhang, Chen; Guo, Heng; Tong, Bin; Xi, Lei; Cai, Zhengxu; Dong, Yuping published an article in 2021. The article was titled 《Donor strategy for promoting nonradiative decay to achieve an efficient photothermal therapy for treating cancer》, and you may find the article in Science China: Chemistry.Quality Control of 2,5-Dimethoxytetrahydrofuran The information in the text is summarized as follows:

Photothermal therapy (PTT) is emerging as an effective treatment for superficial carcinoma. A key challenge to the effectiveness of PTT is to develop photosensitizers with high photothermal conversion efficiency. Aiming to address this challenge, we develop a series of multi-arylpyrrole derivatives with different donors that contain different multi-rotor structures to explore PTT photosens/itizers of high efficiency. Among these multi-arylpyrrole derivatives, MAP4-FE nanoparticles with a small size of their donor groups and better-donating ability exhibit a high photothermal conversion efficiency (up to 72%) when it is encapsulated by an amphiphilic polymer. As a result, the MAP4-FE nanoparticles have shown satisfactory PTT effects on in vivo tumor eradication under the guidance of photoacoustic signals. The findings of this study provide significant insights for the development of high-efficiency PTT photosensitizers for cancer treatment by making full use of the nonradiative decay of small size donors as rotors. After reading the article, we found that the author used 2,5-Dimethoxytetrahydrofuran(cas: 696-59-3Quality Control of 2,5-Dimethoxytetrahydrofuran)

2,5-Dimethoxytetrahydrofuran(cas: 696-59-3) is a member of ether. When aromatic ethers are exposed to halogen in the presence or absence of a catalyst, they undergo halogenation, such as bromination.Quality Control of 2,5-Dimethoxytetrahydrofuran

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

In 2019,ChemistrySelect included an article by Brites, Nathan P.; Dilelio, Marina C.; Martins, Guilherme M.; Carmo, Gabriele do; Morel, Ademir F.; Kaufman, Teodoro S.; Silveira, Claudio C.. Computed Properties of C6H12O3. The article was titled 《Synthesis and Antifungal Activity of 4- and 6-(1H-Pyrrol-1-yl) Coumarins, and their Thiocyanato Derivatives》. The information in the text is summarized as follows:

Facile and efficient syntheses of 4-(1H-pyrrol-1-yl)-coumarins and 6-(1H-pyrrol-1-yl)-coumarins from the corresponding aminocoumarins are reported. The transformations were optimized and their corresponding scope and limitations were assessed. Selected (1H-pyrrol-1-yl)-coumarins were further subjected to a mild thiocyanation, underwent selective functionalization on the pyrrole nucleus. A set of 10 differently substituted compounds was submitted to activity testing against various fungal strains. It was found that the introduction of a SCN moiety increased the antifungal activity, turning some compounds into fungicidal agents, to the point that one of the thiocyanato derivatives displayed an antifungal profile comparable to those of fluconazole and nystatin. In the experiment, the researchers used 2,5-Dimethoxytetrahydrofuran(cas: 696-59-3Computed Properties of C6H12O3)

2,5-Dimethoxytetrahydrofuran(cas: 696-59-3) is a member of ether. Friedel Crafts reaction, for example, adds an alkyl or acyl group to aromatic ethers when they react with an alkyl or acyl halide in the presence of a Lewis acid as a catalyst.Computed Properties of C6H12O3

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

COA of Formula: C6H12O3In 2022 ,《Discovery and Optimization of 6-(1-Substituted pyrrole-2-yl)-s-triazine Containing Compounds as Antibacterial Agents》 appeared in ACS Infectious Diseases. The author of the article were Green, Keith D.; Pang, Allan H.; Thamban Chandrika, Nishad; Garzan, Atefeh; Baughn, Anthony D.; Tsodikov, Oleg V.; Garneau-Tsodikova, Sylvie. The article conveys some information:

Antimicrobial drug resistance is a major health issue plaguing healthcare worldwide and leading to hundreds of thousands of deaths globally each year. Tackling this problem requires discovery and development of new antibacterial agents. In this study, we discovered novel 6-(1-substituted pyrrole-2-yl)-s-triazine containing compounds that potently inhibited the growth of Staphylococcus aureus regardless of its methicillin-resistant status, displaying min. inhibitory concentration (MIC) values as low as 1μM. The presence of a single imidazole substituent was critical to the antibacterial activity of these compounds Some of the compounds also inhibited several nontubercular mycobacteria. We have shown that these mols. are potent bacteriostatic agents and that they are nontoxic to mammalian cells at relevant concentrations Further development of these compounds as novel antimicrobial agents will be aimed at expanding our armamentarium of antibiotics. After reading the article, we found that the author used 2,5-Dimethoxytetrahydrofuran(cas: 696-59-3COA of Formula: C6H12O3)

2,5-Dimethoxytetrahydrofuran(cas: 696-59-3) is a member of ether. When aromatic ethers are exposed to halogen in the presence or absence of a catalyst, they undergo halogenation, such as bromination.COA of Formula: C6H12O3

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Product Details of 696-59-3In 2021 ,《Primary Sulfonamide Functionalization via Sulfonyl Pyrroles: Seeing the N-Ts Bond in a Different Light》 was published in Chemistry – A European Journal. The article was written by Ozaki, Tomoya; Yorimitsu, Hideki; Perry, Gregory J. P.. The article contains the following contents:

Easy-to-access arylsulfonyl pyrroles I (R = 4-MeC6H4, 4-FC6H4, etc.) as synthetic linchpins for sulfonamides RC6H4S(O)2R1 (R1 = CH3, F, 5-(trifluoromethyl)pyridin-2-yl, etc.) functionalization have been described. The versatility of the sulfonyl pyrrole unit is shown by generating a variety of products through chem., electrochem. and photochem. pathways. Preliminary results on the direct functionalization of primary sulfonamides are also provided, which may lead to new modes of activation. In the part of experimental materials, we found many familiar compounds, such as 2,5-Dimethoxytetrahydrofuran(cas: 696-59-3Product Details of 696-59-3)

2,5-Dimethoxytetrahydrofuran(cas: 696-59-3) is a member of ether. When aromatic ethers are exposed to halogen in the presence or absence of a catalyst, they undergo halogenation, such as bromination.Product Details of 696-59-3

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Ma, Kaiqing; Zhang, Mengchen; Wu, Xingkang; Yang, Peng; Yin, Caixia published their research in Bioorganic & Medicinal Chemistry in 2021. The article was titled 《Discovery of a potent β-catenin destabilizer for overcoming the resistance of 5-fluorouracil in colorectal cancer》.Application of 696-59-3 The article contains the following contents:

Wnt/β-catenin signalling is frequently activated in colorectal cancer, in which nuclear β-catenin accumulation contributes to tumor initiation and progression. However, therapeutic agents in clin. use targeting this pathway are lacking. In this report, we describe the synthesis of novel stemona alkaloid analogs and their biol. evaluation, among which compound 3 was identified to efficiently inhibit various CRC cells, including 5-fluorouracil-resistant CRC cells. Mechanistically, this study revealed that compound 3 reduced the protein level of β-catenin without affecting its mRNA level, which suggests an alternative mechanism for β-catenin degradation The expression of downstream proteins, including c-myc, survivin, and cyclin D1, was also significantly inhibited, even in Wnt-activated CRC cells. Briefly, our data highlight the potential of compound 3 as a destabilizer of β-catenin for the treatment of CRC patients. In addition to this study using 2,5-Dimethoxytetrahydrofuran, there are many other studies that have used 2,5-Dimethoxytetrahydrofuran(cas: 696-59-3Application of 696-59-3) was used in this study.

2,5-Dimethoxytetrahydrofuran(cas: 696-59-3) is a member of ether. When aromatic ethers are exposed to halogen in the presence or absence of a catalyst, they undergo halogenation, such as bromination.Application of 696-59-3

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

The author of 《Design, synthesis, and evaluation of the antimycobacterial activity of 3-mercapto-1,2,4-triazole-pyrrole hybrids》 were Roman, Gheorghe; Bostanaru, Andra-Cristina; Nastasa, Valentin; Mares, Mihai. And the article was published in Turkish Journal of Chemistry in 2019. Quality Control of 2,5-Dimethoxytetrahydrofuran The author mentioned the following in the article:

A series of 3-mercapto-1,2,4-triazole-pyrrole hybrids was designed as antimycobacterial agents by employing 5-(4-(1H-pyrrol-1-yl)phenyl)-4H-1,2,4-triazole-3-thiol as the scaffold onto which several types of moieties were introduced in the triazole ring at N-4 and N-2 and as substituents of the mercapto function. The aforementioned moieties are an allyl or a Ph moiety at N-4; an aminomethyl group at N-2; or Me, substituted benzyl, ethoxycarbonylmethyl, or substituted phenacyl at sulfur. Investigation of the compounds in the resulting library as growth inhibitors of Mycobacterium smegmatis showed that their min. inhibitory concentration was higher than 64 mg/L. The experimental process involved the reaction of 2,5-Dimethoxytetrahydrofuran(cas: 696-59-3Quality Control of 2,5-Dimethoxytetrahydrofuran)

2,5-Dimethoxytetrahydrofuran(cas: 696-59-3) is a member of ether. When aromatic ethers are exposed to halogen in the presence or absence of a catalyst, they undergo halogenation, such as bromination.Quality Control of 2,5-Dimethoxytetrahydrofuran

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

《Chemical composition and larvicidal activity of flower extracts from Clitoria ternatea against Aedes (diptera: culicidae)》 was written by Ravindran, Darvin R.; Bharathithasan, Madhuri; Ramaiah, Patmani; Rasat, Mohd Sukhairi Mat; Rajendran, Dinesh; Srikumar, Shakila; Ishak, Intan H.; Said, Abd Rahman; Ravi, Rajiv; Amin, Mohamad Faiz Mohd. HPLC of Formula: 19444-84-9 And the article was included in Journal of Chemistry in 2020. The article conveys some information:

Mosquitoes have always been a human health threat; the major global health problems caused by them are malaria, dengue fever, yellow fever, and Zika as well as several other vector-borne outbreaks. The major problems in controlling these vectors borne diseases are related to resistance to eradication measures. Different classes of insecticides used for controlling public health have raised the concern of resistant problems with mosquitoes and environmental pollution caused by the control measures. Thus, a search for alternative natural compounds is necessary for solving the insecticidal resistance problem using pesticides in the larval stage of vector development as well as creating a chem.-free environment for a healthy society. Hence, the major focus of this study is to identify the larvicidal mechanisms, metabolite, antioxidants, and chem. compounds and elucidate their structures from C. ternatea flower and to test their efficacies against early 4th instar larvae of Aedes aegypti and Aedes albopictus. Clitoria ternatea flowers were collected from the garden of the Faculty of Medicine in International Quest University, Ipoh, Perak, and thence used for crude extraction Further on, the metabolite test, antioxidant test, and chromatog. techniques were conducted to identify the chem. composition of extracts and their chem. structures were identified using GCMS-QP2010 Ultra (Shimadzu). Next, the extracts were evaluated against the early 4th instar larvae of Aedes mosquito vectors following the WHO procedures for larval bioassays. The larvicidal activity of Clitoria ternatea flower extracts evidently affected the early 4th instar larvae of Aedes mosquito vectors. The highest larvicidal activity was observed against the early 4th instar larvae of Aedes aegypti with the LC50 and LC95 values of 1056 and 2491 mg/L, resp. Meanwhile, the larvae bioassay test for Aedes albopictus recorded the LC50 and LC95 values of 1425 and 2753 mg/L. Moreover, the results for nontarget organism test on guppy fish, Poecilia reticulata, showed no mortalities with flower extracts at 2500 mg/L, hence posing no toxic effects on fish. In this study, we have found a total of 16 chem. compounds and 6 chem. compounds have been reported to possess direct insecticidal, larvicidal, and pupicidal effects. Six chems. with insecticidal properties were found to be glycerin, 2-hydroxy-gamma-butyrolactone, neophytadiene, n-hexadecanoic acid, cis-vaccenic acid, and octadecanoic acid with a total of 28.7% efficacy. Clitoria ternatea flower extracts also showed different types of phenols such as anthocyanins, flavonoids, and tannins. Our findings showed that the crude extract of Clitoria ternatea flower bioactive mols. is effective and may be developed as biolarvicide for Aedes mosquito vector control. Furthermore, this study also provided a baseline understanding for future research work in the field of applications of Clitoria ternatea flower extracts for their long-term effects on human health such as a food additive, antioxidant, and cosmetic. In addition to this study using 3-Hydroxydihydrofuran-2(3H)-one, there are many other studies that have used 3-Hydroxydihydrofuran-2(3H)-one(cas: 19444-84-9HPLC of Formula: 19444-84-9) was used in this study.

3-Hydroxydihydrofuran-2(3H)-one(cas: 19444-84-9) may be employed as starting reagent in the synthesis of series of seco-pseudonucleoside synthons via aminolysis. It may be employed as starting reagent in the synthesis of enantiomerically pure orthogonally protected δ-azaproline, via Mitsunobu reaction.HPLC of Formula: 19444-84-9

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Application In Synthesis of 2,5-DimethoxytetrahydrofuranIn 2021 ,《Functionalization of pyrrole derivatives as a way to improve their solubility in aqueous medium for applying in latent fingerprints development》 appeared in Forensic Chemistry. The author of the article were de Lyra, Ana Carolina F.; Silva, Luis P. A. da; de Lima Neto, Jorge; Costa, Cristiane V.; de Assis, Alexandro M. L.; de Freitas, Johnnatan D.; Lima, Dimas J. P.; Ribeiro, Adriana S.. The article conveys some information:

Latent fingerprints (LFPs) play an important rule for criminal investigations regarding to the identification and connection of an individual to a crime scene. Herein, we report a non-destructive method for LFPs development based on the electropolymerization of pyrrole derivatives modified with water-soluble groups on stainless steel surfaces containing fingerprint residues. The polymers, namely P1, P2, P3 and P4, and a copolymer of 4 with 3,4-ethylenedioxythiophene P(4-co-EDOT) were electrodeposited by oxidation of the monomers in aqueous LiClO4 by applying potentials (E) of 1.25-1.7 V vs. Ag/AgCl or c.d. (j) of 5.0-10 mA cm-2 for 15-240 s. The quality of the developed fingerprint images was verified by SEM, the Griaule Forensic Fingerprint software and the Bandey classification system. It was possible to observe the enhancement of the visual contrast between the surface and the fingerprint residues, providing high quality images of the developed fingerprints. In the experiment, the researchers used 2,5-Dimethoxytetrahydrofuran(cas: 696-59-3Application In Synthesis of 2,5-Dimethoxytetrahydrofuran)

2,5-Dimethoxytetrahydrofuran(cas: 696-59-3) is a member of ether. When aromatic ethers are exposed to halogen in the presence or absence of a catalyst, they undergo halogenation, such as bromination.Application In Synthesis of 2,5-Dimethoxytetrahydrofuran

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

《Interfacial Approach toward Benzene-Bridged Polypyrrole Film-Based Micro-Supercapacitors with Ultrahigh Volumetric Power Density》 was published in Advanced Functional Materials in 2020. These research results belong to Jiang, Kaiyue; Baburin, Igor A.; Han, Peng; Yang, Chongqing; Fu, Xiaobin; Yao, Yefeng; Li, Jiantong; Canovas, Enrique; Seifert, Gotthard; Chen, Jiesheng; Bonn, Mischa; Feng, Xinliang; Zhuang, Xiaodong. Application In Synthesis of 2,5-Dimethoxytetrahydrofuran The article mentions the following:

2D soft nanomaterials are an emerging research field due to their versatile chem. structures, easily tunable properties, and broad application potential. In this study, a benzene-bridged polypyrrole film with a large area, up to a few square centimeters, is synthesized through an interfacial polymerization approach. As-prepared semiconductive films exhibit a bandgap of ≈2 eV and a carrier mobility of ≈1.5 cm2 V-1 s-1, inferred from time-resolved terahertz spectroscopy. The samples are employed to fabricate in-plane micro-supercapacitors (MSCs) by laser scribing and exhibit an ultrahigh areal capacitance of 0.95 mF cm-2, using 1-ethyl-3-methylimidazolium tetrafluoroborate ([EMIM][BF4]) as an electrolyte. Importantly, the maximum energy and power densities of the developed MSCs reach values up to 50.7 mWh cm-3 and 9.6 kW cm-3, resp.; the performance surpassing most of the 2D material-based MSCs is reported to date. In the experiment, the researchers used 2,5-Dimethoxytetrahydrofuran(cas: 696-59-3Application In Synthesis of 2,5-Dimethoxytetrahydrofuran)

2,5-Dimethoxytetrahydrofuran(cas: 696-59-3) is a member of ether. When aromatic ethers are exposed to halogen in the presence or absence of a catalyst, they undergo halogenation, such as bromination.Application In Synthesis of 2,5-Dimethoxytetrahydrofuran

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

The author of 《Depolymerization of alkaline lignin over mesoporous KF/γ-Al2O3》 were Guan, Yinshuang; Zhao, Wei; Liu, Kaishuai; Guo, Tiantian; Wang, Dingkai; Cui, Mingyu; Fu, Shuiyuan; Fan, Xing; Wei, Xianyong. And the article was published in New Journal of Chemistry in 2020. SDS of cas: 19444-84-9 The author mentioned the following in the article:

As a kind of biomass resource, lignin is the only natural renewable resource that can provide abundant aromatic compounds, which is undoubtedly considered as the best candidate to produce value-added chems. by lignin depolymerization Thus, it is of great significance to develop approaches that are able to accommodate the complex structure of lignin. Herein, an efficient depolymerization method is implemented in methanol using a mesoporous solid superbase KF/γ-Al2O3 catalyst. Research shows that the depolymerization of lignin is not obvious below the critical temperature of methanol, and the conversion of lignin increases significantly above the critical temperature, which can reach 60.6% at 270°C. Phenols and methoxy-substituted monocyclic aromatic compounds are predominant in the liquid products acquired by gas chromatog./mass spectrometry. Furthermore, oligomers were analyzed by time-of-flight mass spectrometry equipped with electrospray ionization. It is found that the mol. mass of the oligomers varied between 200 and 600 Da, the degree of unsaturation is mainly 4 and 8 with 1-2 aromatic rings, and the carbon number is found to be within the range of 15-30. It is speculated that the oligomers are mainly monophenyl or biphenyl compounds containing branched chains. In the experiment, the researchers used 3-Hydroxydihydrofuran-2(3H)-one(cas: 19444-84-9SDS of cas: 19444-84-9)

3-Hydroxydihydrofuran-2(3H)-one(cas: 19444-84-9) is a 5-membered cyclic ester. It was obtained via tin-conversion of biomass-derived 1,3-dihydroxyacetone (DHA) and formaldehyde. And it may be employed as starting reagent in the synthesis of series of seco-pseudonucleoside synthons via aminolysis.SDS of cas: 19444-84-9

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem