Tag: 100-200

Application of 696-59-3In 2019 ,《Effects of fused rings linked to the 2,5-position of pyrrole derivatives with near-infrared emission on their aggregation-enhanced emission properties》 appeared in Materials Chemistry Frontiers. The author of the article were Ren, Fei; Shi, Jianbing; Tong, Bin; Cai, Zhengxu; Dong, Yuping. The article conveys some information:

Fluorescent materials with near-IR (NIR) emission are important kinds of functional dyes for bioimaging and medical diagnosis. In this work, a type of pyrrole derivative with NIR emission was designed and synthesized through the introduction of different fused rings at the 2,5-position of pyrrole (MAP) and a furanylidene (FE) group at the 3-position of pyrrole (MAP-FE), which constructed a typical donor-π bridge-acceptor (D-π-A) structure. All MAP-FEs have shown aggregation-enhanced emission (AEE) properties. Different fused rings or different positions of substitution on the same fused ring had significant effects on the NIR photoluminescence (PL) properties. In addition, by comparison with the change in the radiative and nonradiative rates of the precursor MAPs and MAP-FEs in solution and the solid state, it can be concluded that the rings fused to the 2,5-position of pyrrole have a two-sided effect on the PL properties of organic dyes: one effect is an improvement in the quantum yield, and the other effect causes a π-π stacking interaction that is unfavorable for emission. The introduction of FE groups as acceptors in MAP-FEs not only red shifted emission wavelengths but also effectively avoided π-π stacking in the aggregated state, which are beneficial for PL properties. These results could provide general guidance for designing NIR dyes with AEE characteristics when using fused rings to improve their PL properties. In the experimental materials used by the author, we found 2,5-Dimethoxytetrahydrofuran(cas: 696-59-3Application of 696-59-3)

2,5-Dimethoxytetrahydrofuran(cas: 696-59-3) is a member of ether. Friedel Crafts reaction, for example, adds an alkyl or acyl group to aromatic ethers when they react with an alkyl or acyl halide in the presence of a Lewis acid as a catalyst.Application of 696-59-3

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Graves, Brian M.; Johnson, Tyler J.; Nishida, Robert T.; Dias, Ryan P.; Savareear, Benjamin; Harynuk, James J.; Kazemimanesh, Mohsen; Olfert, Jason S.; Boies, Adam M. published their research in Scientific Reports on December 31 ,2020. The article was titled 《Comprehensive characterization of mainstream marijuana and tobacco smoke》.Reference of 3-Hydroxydihydrofuran-2(3H)-one The article contains the following contents:

Recent increases in marijuana use and legalization without adequate knowledge of the risks necessitate the characterization of the billions of nanoparticles contained in each puff of smoke. Tobacco smoke offers a benchmark given that it has been extensively studied. Tobacco and marijuana smoke particles are quant. similar in volatility, shape, d. and number concentration, albeit with differences in size, total mass and chem. composition Particles from marijuana smoke are on average 29% larger in mobility diameter than particles from tobacco smoke and contain 3.4 times more total mass. New measurements of semivolatile fractions determined that >97% of the mass and volume of the particles from either smoke source are comprised of semivolatile compounds For tobacco smoke and marijuana smoke, resp., 4350 and 2575 different compounds are detected, of which 670 and 536 (231 in common) are tentatively identified, and of these, 173 and 110 different compounds (69 in common) are known to cause neg. health effects through carcinogenic, mutagenic, teratogenic, or other toxic mechanisms. This study demonstrates striking similarities between marijuana and tobacco smoke in terms of their phys. and chem. properties. In the experiment, the researchers used many compounds, for example, 3-Hydroxydihydrofuran-2(3H)-one(cas: 19444-84-9Reference of 3-Hydroxydihydrofuran-2(3H)-one)

3-Hydroxydihydrofuran-2(3H)-one(cas: 19444-84-9) is a 5-membered cyclic ester. It was obtained via tin-conversion of biomass-derived 1,3-dihydroxyacetone (DHA) and formaldehyde. And it may be employed as starting reagent in the synthesis of series of seco-pseudonucleoside synthons via aminolysis.Reference of 3-Hydroxydihydrofuran-2(3H)-one

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

《Synthesis and Investigation of Thermal, Optical and Electrochemical Properties of 2,4,6-Trisubstituted Pyrimidines》 was written by Slobodinyuk, Daria G.; Slobodinyuk, Alexey I.; Shklyaeva, Elena V.; Abashev, Georgii G.. Related Products of 696-59-3This research focused ontrisubstituted pyrimidine preparation UV vis spectra fluorescence redox potential. The article conveys some information:

A number of novel fluorophores have been synthesized containing an electron-withdrawing pyrimidine core and electron donating N,N-dimethylaminophenyl, 4-(9H-carbazol-9-yl)phenyl, Ph and pyrrol-1-yl fragments at positions 2, 4 and 6 of the pyrimidine ring. Thermal, optical and electrochem. properties of these substances have been studied. The structure-property dependences of substituted pyrimidines have been established. In addition to this study using 2,5-Dimethoxytetrahydrofuran, there are many other studies that have used 2,5-Dimethoxytetrahydrofuran(cas: 696-59-3Related Products of 696-59-3) was used in this study.

2,5-Dimethoxytetrahydrofuran(cas: 696-59-3) is a member of ether. Friedel Crafts reaction, for example, adds an alkyl or acyl group to aromatic ethers when they react with an alkyl or acyl halide in the presence of a Lewis acid as a catalyst.Related Products of 696-59-3

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

In 2022,Afsina, C. M. A.; Rohit, K. R.; Anilkumar, G. published an article in Results in Chemistry. The title of the article was 《A green protocol for the synthesis of N-aryl pyrroles: A modified Clauson-Kaas approach using zinc catalyst》.Synthetic Route of C6H12O3 The author mentioned the following in the article:

The first zinc-catalyzed simple and convenient protocol for the synthesis of N-substituted pyrroles I (R = H, Me, Cl, etc.; R1 = H, Me, OMe, NO2; R2 = H, OH, I, etc.; R3 = H, Me) through a modified Clauson-Kaas reaction without co-catalyst, ligand, base and solvent has been described. N-substituted pyrroles I were prepared from various aniline derivatives 2-R-3-R1-4-R2-5-R3-C6HNH2 and 2,5-dimethoxytetrahydrofuran under green condition by utilizing low cost, eco-friendly, non-toxic and easily accessible Zn(OTf)2 as catalyst. A wide variety of N-substituted pyrroles I was afforded in moderate to excellent yields from easily available starting materials at 70°C. The experimental process involved the reaction of 2,5-Dimethoxytetrahydrofuran(cas: 696-59-3Synthetic Route of C6H12O3)

2,5-Dimethoxytetrahydrofuran(cas: 696-59-3) is a member of ether. When aromatic ethers are exposed to halogen in the presence or absence of a catalyst, they undergo halogenation, such as bromination.Synthetic Route of C6H12O3

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

The author of 《Bactericidal and in vitro cytotoxicity of Moringa oleifera seed extract and its elemental analysis using laser-induced breakdown spectroscopy》 were Aldakheel, Reem K.; Rehman, Suriya; Almessiere, Munirah A.; Khan, Firdos A.; Gondal, Mohammed A.; Mostafa, Ahmed; Baykal, Abdulhadi. And the article was published in Pharmaceuticals in 2020. Category: tetrahydrofurans The author mentioned the following in the article:

In the current study, we present the correlation between the capability of laser-induced breakdown spectroscopy (LIBS) to monitor the elemental compositions of plants and their biol. effects. The selected plant, Moringa oleifera, is known to harbor various minerals and vitamins useful for human health and is a potential source for pharmaceutical interventions. From this standpoint, we assessed the antibacterial and in vitro cytotoxicity of the bioactive components present in Moringa oleifera seed (MOS) extract Detailed elemental anal. of pellets of MOSs were performed via LIBS. Furthermore, the LIBS outcome was validated using gas chromatog.-mass spectrometry (GC-MS). The LIBS signal was recorded, and the presence of the essential elements (Na, Ca, Se, K, Mg, Zn, P, S, Fe and Mn) in the MOSs were examined The bactericidal efficacy of the alc. MOS extract was examined against Escherichia coli (E. coli) and Staphylococcus aureus(S. aureus) by agar well diffusion (AWD) assays and SEM (SEM), which depicted greater inhibition against Gram-pos. bacteria. The validity and DNA nuclear morphol. of human colorectal carcinoma cells (HCT-116) cells were evaluated via an MTT assay and DAPI staining. The MTT assay results manifested a profoundly inhibitory action of MOS extract on HCT116 cell growth. Addnl., MOS extracts produced inhibitory action in colon cancer cells (HCT-116), whereas no inhibitory action was seen using the same concentrations of MOS extract on HEK-293 cells (non-cancerous cells), suggesting that MOS extracts could be non-cytotoxic to normal cells. The antibacterial and anticancer potency of these MOS extracts could be due to the presence of various bioactive chem. complexes, such as Et ester and D-allose and hexadecenoic, oleic and palmitic acids, making them an ideal candidate for pharmaceutical research and applications. The results came from multiple reactions, including the reaction of 3-Hydroxydihydrofuran-2(3H)-one(cas: 19444-84-9Category: tetrahydrofurans)

3-Hydroxydihydrofuran-2(3H)-one(cas: 19444-84-9) is a 5-membered cyclic ester. It was obtained via tin-conversion of biomass-derived 1,3-dihydroxyacetone (DHA) and formaldehyde. And it may be employed as starting reagent in the synthesis of series of seco-pseudonucleoside synthons via aminolysis.Category: tetrahydrofurans

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

《Synthesis, Stability, and Biological Studies of Fluorinated Analogues of Thromboxane A2》 was written by Jing, Changcheng; Mallah, Shahida; Kriemen, Ella; Bennett, Steven H.; Fasano, Valerio; Lennox, Alastair J. J.; Hers, Ingeborg; Aggarwal, Varinder K.. Reference of 2,5-DimethoxytetrahydrofuranThis research focused onthromboxane A2 fluorinated preparation platelet aggregation induction; hydrolysis kinetics fluorinated thromboxane A2. The article conveys some information:

Platelet activation results in the generation of thromboxane A2 (TxA2), which promotes thrombus formation by further amplifying platelet function, as well as causing vasoconstriction. Due to its role in thrombus formation and cardiovascular disease, its production is the target of antiplatelet drugs such as aspirin. However, the study of TxA2-stimulated cellular function has been limited by its instability (t1/2 = 32 s, pH = 7.4). Although more stable analogs such as U46619 and difluorinated 10,10-F2-TxA2 have been prepared, we targeted a closer mimic to TxA2 itself, monofluorinated 10-F-TxA2, since the number of fluorine atoms can affect function. Key steps in the synthesis of F-TxA2 included α-fluorination of a lactone bearing a β-alkoxy group, and a novel synthesis of the strained acetal. F-TxA2 was found to be 105 more stable than TxA2, and surprisingly was only slightly less stable than F2-TxA2. Preliminary biol. studies showed that F-TxA2 has similar potency as TxA2 toward inducing platelet aggregation but was superior to F2-TxA2 in activating integrin αIIbβ3. The synthesis is described of 10-F-thromboxane A2 I, a stable mimic of TxA2 (105 x more stable) with similar potency as TxA2 toward inducing platelet aggregation. In the experiment, the researchers used 2,5-Dimethoxytetrahydrofuran(cas: 696-59-3Reference of 2,5-Dimethoxytetrahydrofuran)

2,5-Dimethoxytetrahydrofuran(cas: 696-59-3) is a member of ether. When aromatic ethers are exposed to halogen in the presence or absence of a catalyst, they undergo halogenation, such as bromination.Reference of 2,5-Dimethoxytetrahydrofuran

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Product Details of 696-59-3In 2019 ,《Design, synthesis and antifungal activities of novel pyrrole- and pyrazole-substituted coumarin derivatives》 appeared in Molecular Diversity. The author of the article were Zhang, Shu-Guang; Liang, Chao-Gen; Sun, Yue-Qing; Teng, Peng; Wang, Jia-Qun; Zhang, Wei-Hua. The article conveys some information:

A series of novel pyrrole- and pyrazole-substituted coumarins, compounds I [R1 = H, Me, F, etc.; R2 = Me, CH2Cl, CF3, R3 = H, Me, etc.] and II [R4 = H, Me, Et, etc.; R5 = H, Me, etc.] and evaluated their antifungal activity against six phytopathogenic fungi in-vitro. The primary assay results demonstrated that some designed compounds displayed potent activities. Among them, compounds I [R1 = H, R2 = CH2Cl, R3 = Me] and II [R4 = H, Me, Et, R5 = Me; R4 = H’ R5 = CF3 R4R5 = (CH2)4]exhibited more effective control than Osthole against Cucumber anthrax and Alternaria leaf spot. Furthermore, compound I [R1 = H, R2 = CH2Cl, R3 = Me] displayed stronger antifungal activity against Rhizoctorzia solani (EC50 = 15.4 μg/mL) than pos. control Osthole (EC50 = 67.2 μg/mL). The results came from multiple reactions, including the reaction of 2,5-Dimethoxytetrahydrofuran(cas: 696-59-3Product Details of 696-59-3)

2,5-Dimethoxytetrahydrofuran(cas: 696-59-3) is a member of ether. When aromatic ethers are exposed to halogen in the presence or absence of a catalyst, they undergo halogenation, such as bromination.Product Details of 696-59-3

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

In 2019,ChemCatChem included an article by Jensen, Pernille Rose; Taarning, Esben; Meier, Sebastian. Quality Control of 3-Hydroxydihydrofuran-2(3H)-one. The article was titled 《Probing the Lewis Acid Catalyzed Acyclic Pathway of Carbohydrate Conversion in Methanol by In Situ NMR》. The information in the text is summarized as follows:

Future bioindustries will rely on the formation of diverse chems. at high yield through various reaction pathways. These pathways include reactions to a series of alpha-hydroxy esters and acids that can be formed from the conversion of C3-C6 carbohydrates by Lewis acidic catalysts in alcs. and water. Definitive kinetic and mechanistic insights to support the development of carbohydrate conversion processes are arguably less developed than for analogous biocatalytic processes. Here, we visualize acyclic pathways of carbohydrate dehydration, using the acyclic C4 carbohydrate erythrulose as a probe mol. for the conversion by homogeneous SnCl4 in methanol. In situ studies allow the detection of previously postulated intermediates, identify the branch point to competing products and provide energetic and mechanistic insight by kinetic anal. Reversibility of reactions, stereoselectivity and differential propensity for deuterium incorporation in competing pathways can be tracked by the formation of compounds with asym. mass distribution. The experimental part of the paper was very detailed, including the reaction process of 3-Hydroxydihydrofuran-2(3H)-one(cas: 19444-84-9Quality Control of 3-Hydroxydihydrofuran-2(3H)-one)

3-Hydroxydihydrofuran-2(3H)-one(cas: 19444-84-9) is a 5-membered cyclic ester. It was obtained via tin-conversion of biomass-derived 1,3-dihydroxyacetone (DHA) and formaldehyde. And it may be employed as starting reagent in the synthesis of series of seco-pseudonucleoside synthons via aminolysis.Quality Control of 3-Hydroxydihydrofuran-2(3H)-one

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

In 2019,Bioresource Technology included an article by Zhou, Haoqin; Brown, Robert C.; Wen, Zhiyou. Reference of 2,5-Dimethoxytetrahydrofuran. The article was titled 《Anaerobic digestion of aqueous phase from pyrolysis of biomass: Reducing toxicity and improving microbial tolerance》. The information in the text is summarized as follows:

Among the products of pyrolysis is an aqueous phase (AP), which contains a significant fraction of carbon but is too dilute to make recovery of this organic content cost-effectively. This study was to explore the use of AP for anaerobic digestion. Different treatment methods including overliming, Fenton’s reagent oxidation, bleaching and activated carbon adsorption were investigated to reduce toxicity of AP. Overliming treatment increased biogas production up to 32-fold compared to non-treated AP. Enhancing the tolerance of the bacterial and archaeal community to the AP toxicity was also attempted with a directed evolution method, resulting the microbes’ tolerance to AP from 5% to 14%. Directed evolution resulted a major bacterial taxa as Cloacimonetes, Firmicutes, and Chloroflexi, while shifted the predominant archaea shifted from acetoclastic to hydrogenotrophic methanogens. Collectively, the results demonstrated that combining feedstock treatment and directed evolution of the microbial community is an effective way for AP anaerobic digestion. The results came from multiple reactions, including the reaction of 2,5-Dimethoxytetrahydrofuran(cas: 696-59-3Reference of 2,5-Dimethoxytetrahydrofuran)

2,5-Dimethoxytetrahydrofuran(cas: 696-59-3) is a member of ether. When aromatic ethers are exposed to halogen in the presence or absence of a catalyst, they undergo halogenation, such as bromination.Reference of 2,5-Dimethoxytetrahydrofuran

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Thaltiri, Vikranth; Shanmugapriya, V.; Panda, Pradeepta K. published an article in 2021. The article was titled 《Efficient and Gram-Scale Synthesis of 1-Methyl-2,3,4-Trinitropyrrole: A Promising Precursor for Insensitive High Energy Melt-Castable Materials》, and you may find the article in ChemistrySelect.Computed Properties of C6H12O3 The information in the text is summarized as follows:

1-Methyl-2,3,4,5-tetranitropyrrole (NMTNP) was recently found to be a promising insensitive high energy melt-castable material. To prove its potentials further, herewith, 1-methyl-2,3,4-trinitropyrrole was established as a potent precursor for NMTNP, by developing a method for its efficient synthesis with excellent overall yield. This method involves mild nitrating conditions, easier purification (minimal chromatog.) and readily available reagents and hence can be scaled up easily. In addition, the facile synthesis of 2,3,4-trinitropyrrole during this process can lead to new class of pyrrole based high energy d. materials. In the experiment, the researchers used many compounds, for example, 2,5-Dimethoxytetrahydrofuran(cas: 696-59-3Computed Properties of C6H12O3)

2,5-Dimethoxytetrahydrofuran(cas: 696-59-3) is a member of ether. Friedel Crafts reaction, for example, adds an alkyl or acyl group to aromatic ethers when they react with an alkyl or acyl halide in the presence of a Lewis acid as a catalyst.Computed Properties of C6H12O3

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem