Tag: 100-200

《Pseudo-5-Fold-Symmetrical Ligand Drives Geometric Frustration in Porous Metal-Organic and Hydrogen-Bonded Frameworks》 was written by Haase, Frederik; Craig, Gavin A.; Bonneau, Mickaele; Sugimoto, Kunihisa; Furukawa, Shuhei. Application In Synthesis of 2,5-Dimethoxytetrahydrofuran And the article was included in Journal of the American Chemical Society in 2020. The article conveys some information:

Reticular framework materials thrive on designability, but unexpected reaction outcomes are crucial in exploring new structures and functionalities. By combining “”incompatible”” building blocks, we employed geometric frustration in reticular materials leading to emergent structural features. The combination of a pseudo-C5-sym. organic building unit based on a pyrrole core with a C4-sym. copper paddlewheel synthon led to three distinct frameworks by tuning the synthetic conditions. The frameworks show structural features typical for geometric frustration: self-limiting assembly, internally stressed equilibrium structures, and topol. defects in the equilibrium structure, which manifested in formation of a hydrogen-bonded framework, distorted and broken secondary building units, and dangling functional groups, resp. The influence of geometric frustration on the CO2 sorption behavior and the discovery of a new secondary building unit shows geometric frustration can serve as a strategy to obtain highly complex porous frameworks.2,5-Dimethoxytetrahydrofuran(cas: 696-59-3Application In Synthesis of 2,5-Dimethoxytetrahydrofuran) was used in this study.

2,5-Dimethoxytetrahydrofuran(cas: 696-59-3) is a member of ether. Friedel Crafts reaction, for example, adds an alkyl or acyl group to aromatic ethers when they react with an alkyl or acyl halide in the presence of a Lewis acid as a catalyst.Application In Synthesis of 2,5-Dimethoxytetrahydrofuran

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Safety of 3-Hydroxydihydrofuran-2(3H)-oneOn October 7, 2019 ,《Toward Renewable-Based, Food-Applicable Prebiotics from Biomass: A One-Step, Additive-Free, Microwave-Assisted Hydrothermal Process for the Production of High Purity Xylo-oligosaccharides from Beech Wood Hemicellulose》 was published in ACS Sustainable Chemistry & Engineering. The article was written by Remon, Javier; Li, Tianzong; Chuck, Christopher J.; Matharu, Avtar S.; Clark, James H.. The article contains the following contents:

Xylooligosaccharides (XOS) produced from biomass offer a plethora of excellent physicochem. and physiol. properties to be used as natural prebiotic nutraceuticals. Herein, this work first addresses and optimizes a novel one-pot, additive-free, microwave-assisted process to produce high purity XOS from beech wood hemicellulose, studying the influence of the temperature, reaction time, and solid loading. These variables exerted a significant influence, allowing the transformation of hemicellulose into a gas (0-19%), an XOS-rich liquid product (9-80%) and a spent solid material (17-90%). The liquid phase consisted of a mixture of XOS with a d.p. (DP) DP > 6 (75-100 C-weight %) and DP 3-6 (0-10 C-weight %), together with mono/disaccharides (0-1 C-weight %), carboxylic acids (0-5 C-weight %), ketones (0-12 C-weight %) and furans (0-12 C-weight %). A good compromise between the liquid yield (81%) and XOS purity (96 C-weight %) was achieved at 172 °C using a solid loading of 5 weight % for 47 min. This time could be reduced (33 min) and the solid loading increased (25 weight %) without substantially altering the XOS (98 C-weight %) purity, although the liquid yield was reduced. The liquid yield could be increased up to 97% at the expenses of XOS purity (90 C-weight %) at 177 °C using a 5 weight % solid loading for 60 min. For these optima, the microwave production costs shifted between 1.42 and 6.50 euro/kg XOS, which is substantially lower than the XOS market price, thus highlighting the high potential of this emerging technol. Novel microwave-assisted hydrothermal process assessed and optimized for the production of food-applicable prebiotic nutraceuticals from beech wood hemicellulose.3-Hydroxydihydrofuran-2(3H)-one(cas: 19444-84-9Safety of 3-Hydroxydihydrofuran-2(3H)-one) was used in this study.

3-Hydroxydihydrofuran-2(3H)-one(cas: 19444-84-9) may be employed as starting reagent in the synthesis of series of seco-pseudonucleoside synthons via aminolysis. It may be employed as starting reagent in the synthesis of enantiomerically pure orthogonally protected δ-azaproline, via Mitsunobu reaction.Safety of 3-Hydroxydihydrofuran-2(3H)-one

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

《Discovery of Potent and Selective Inhibitors of Ataxia Telangiectasia Mutated and Rad3 Related (ATR) Protein Kinase as Potential Anticancer Agents》 was written by Charrier, Jean-Damien; Durrant, Steven J.; Golec, Julian M. C.; Kay, David P.; Knegtel, Ronald M. A.; MacCormick, Somhairle; Mortimore, Michael; O’Donnell, Michael E.; Pinder, Joanne L.; Reaper, Philip M.; Rutherford, Alistair P.; Wang, Paul S. H.; Young, Stephen C.; Pollard, John R.. Application of 918439-76-6 And the article was included in Journal of Medicinal Chemistry on April 14 ,2011. The article conveys some information:

DNA-damaging agents are among the most frequently used anticancer drugs. However, they provide only modest benefit in most cancers. This may be attributed to a genome maintenance network, the DNA damage response (DDR), that recognizes and repairs damaged DNA. ATR is a major regulator of the DDR and an attractive anticancer target. Herein, we describe the discovery of a series of aminopyrazines with potent and selective ATR inhibition. Compound (I) inhibits ATR with a Ki of 6 nM, shows >600-fold selectivity over related kinases ATM or DNA-PK, and blocks ATR signaling in cells with an IC50 of 0.42 μM. Using I, here it is shown that ATR inhibition markedly enhances death induced by DNA-damaging agents in certain cancers but not normal cells. This differential response between cancer and normal cells highlights the great potential for ATR inhibition as a novel mechanism to dramatically increase the efficacy of many established drugs and ionizing radiation. In the experimental materials used by the author, we found (S)-3-Iodotetrahydrofuran(cas: 918439-76-6Application of 918439-76-6)

(S)-3-Iodotetrahydrofuran(cas: 918439-76-6) is one of organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles.Application of 918439-76-6

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Electric Literature of C4H6O3On May 31, 2022, Polina, I. N.; Mironov, M. V.; Belyy, V. A.; Brovarova, O. V. published an article in Izvestiya Vysshikh Uchebnykh Zavedenii, Khimiya i Khimicheskaya Tekhnologiya. The article was 《Investigation of the component composition of the oxidative thermal degradation products of fuel pellets from the Heracleum sosnowskyi Manden biomass by chromatography-mass-spectrometry》. The article mentions the following:

The component composition of oxidative thermal degradation products of Heracleum sosnowskyi Manden biomass was studied by chromatog.-mass-spectrometry. The hogweed Sosnovskyi biomass was collected on the territory of the village of Vylgort in the Komi Republic, dried to an atm.-dry state, crushed to dm < 0.25 mm and pressed with a force of 10 kN. Fuel pellets were burned in the special device. The products of oxidative thermal degradation were captured and analyzed on a gas-liquid chromatog. with a mass-selective detector. As a result of mass spectrums anal., 39 low-mol.-weight products with a retention time of 6 to 79 min and a percentage content of 0.4 to 12% were identified from 47 captured compounds Qual. and quant. anal. of the component composition of the degradation products showed that their formation is directly related to the component composition of the biomass and is determined by the content of cellulose, hemicellulose and lignin. Anal. of data on retention time of the degradation products showed that cellulose and hemicellulose of the biomass sample are degraded priority, while lignin is thermally more stable due to its aromatic nature. Anal. of data on products of oxidative thermal degradation showed that in mass terms, polysaccharides and lignin are formed as a percentage 45 and 49 resp., while the composition of the products of destruction of polysaccharides is more diverse (23 and 16 names). It is shown that the list of products of oxidative thermal degradation of the Heracleum sosnowskyi Manden biomass is comparable to the products of thermal decomposition of lignocellulosic materials of other botanical origin. The results of the presented study can be used in the calculation of processes and installations for burning fuel pellets from the biomass of the Heracleum sosnowskyi Manden or a combined composition fuel pellets. As well as the results can be used to assess the complex environmental impact of the technol. of the energy use of the biomass of the hogweed Sosnowskyi on the atm. air. After reading the article, we found that the author used 3-Hydroxydihydrofuran-2(3H)-one(cas: 19444-84-9Electric Literature of C4H6O3)

3-Hydroxydihydrofuran-2(3H)-one(cas: 19444-84-9) may be employed as starting reagent in the synthesis of series of seco-pseudonucleoside synthons via aminolysis. It may be employed as starting reagent in the synthesis of enantiomerically pure orthogonally protected δ-azaproline, via Mitsunobu reaction.Electric Literature of C4H6O3

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

The author of 《Photochemical synthesis of π-extended ullazine derivatives as new electron donors for efficient conjugated D-A polymers》 were Miao, Dandan; Aumaitre, Cyril; Morin, Jean-Francois. And the article was published in Journal of Materials Chemistry C: Materials for Optical and Electronic Devices in 2019. Reference of 2,5-Dimethoxytetrahydrofuran The author mentioned the following in the article:

We report the synthesis of π-extended ullazine derivatives annulated with either electron-poor pyridine or electron-rich thiophene units through a metal-free, photochem. cyclodehydrochlorination (CDHC) reaction. The strongest electron-donor derivative, 7-tetradecylthieno[3′,2′:7,8]indolizino[6,5,4,3-ija]thieno[2,3-c]quinolone, was copolymerized with electron-deficient thienopyrroledione (TPD), isoindigo (IID), and diketopyrrolopyrrole (DPP) derivatives to provide three donor-acceptor conjugated polymers (D-A CPs). Their photophys., electrochem. and photovoltaic (PV) properties were investigated. The polymers showed broad UV-vis-NIR absorption bands with λmax values of 612 nm, 698 nm, 788 nm in chloroform and exhibited optical bandgap (Eoptg) of 1.58 eV, 1.41 eV, 1.24 eV measured as films. Inverted bulk heterojunction polymer solar cells (BHJ-PSCs) were fabricated using these polymers as host and light-harvesting materials. The device based on P3:PC70BM blends shows the best power conversion efficiency (PCE) of 2.23% (Voc = 0.55 V, Jsc = 7.86 mA cm-2, FF = 52%). These promising results demonstrate that π-extended ullazine derivatives can be used as electron-rich building blocks for the construction of D-A CPs for efficient PSCs applications. The results came from multiple reactions, including the reaction of 2,5-Dimethoxytetrahydrofuran(cas: 696-59-3Reference of 2,5-Dimethoxytetrahydrofuran)

2,5-Dimethoxytetrahydrofuran(cas: 696-59-3) is a member of ether. Friedel Crafts reaction, for example, adds an alkyl or acyl group to aromatic ethers when they react with an alkyl or acyl halide in the presence of a Lewis acid as a catalyst.Reference of 2,5-Dimethoxytetrahydrofuran

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

The author of 《Fluorinated iminophosphonates bearing stereodirecting phenylethyl group in synthesis of biorelevant scalemic aminophosphonates》 were Stanko, Oleg V.; Rassukana, Yuliya V.; Onys’ko, Petro P.. And the article was published in Phosphorus, Sulfur and Silicon and the Related Elements in 2019. Recommanded Product: 2,5-Dimethoxytetrahydrofuran The author mentioned the following in the article:

Diastereoselective reduction of α-(poly)fluoroalkylated iminophosphonates, bearing stereodirecting phenylethyl group at the nitrogen atom, produces diastereomeric N-(α-phenylethyl) polyfluoroalkylphosphonates. Separation and N-deprotection affords (S) and (R) α-amino polyfluoroalkylphosphonates. The latter react with 2,5-dimethoxytetrahydrofuran to give optically pure polyfluoroalkylphosphonates incorporating 1-pyrrolyl group in α-position. The results came from multiple reactions, including the reaction of 2,5-Dimethoxytetrahydrofuran(cas: 696-59-3Recommanded Product: 2,5-Dimethoxytetrahydrofuran)

2,5-Dimethoxytetrahydrofuran(cas: 696-59-3) is a member of ether. Friedel Crafts reaction, for example, adds an alkyl or acyl group to aromatic ethers when they react with an alkyl or acyl halide in the presence of a Lewis acid as a catalyst.Recommanded Product: 2,5-Dimethoxytetrahydrofuran

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

《Anti-quorum sensing and antibiofilm potential of 1,8-cineole derived from Musa paradisiaca against Pseudomonas aeruginosa strain PAO1》 was written by Karuppiah, Vijayakumar; Thirunanasambandham, Ramanathan; Thangaraj, Gunasekaran. Related Products of 19444-84-9 And the article was included in World Journal of Microbiology & Biotechnology on April 30 ,2021. The article conveys some information:

Abstract: Pseudomonas aeruginosa is one of the vulnerable opportunistic pathogens associated with nosocomial infections, cystic fibrosis, burn wounds and surgical site infections. Several studies have reported that quorum sensing (QS) systems are controlled the P. aeruginosa pathogenicity. Hence, the targeting of QS considered as an alternative approach to control P. aeruginosa infections. This study aimed to evaluate the anti-quorum sensing and antibiofilm inhibitory potential of Musa paradisiaca against Chromobacterium violaceum (ATCC 12472) and Pseudomonas aeruginosa. The methanol extract of M. paradisiacsa exhibits that better antibiofilm potential against P. aeruginosa. Then, the crude methanol extract was subjected to purify by column chromatog. and collected the fractions. The mass-spectrometric anal. of a methanol extract of M. paradisiaca revealed that 1,8-cineole is the major compounds 1, 8-cineole significantly inhibited the QS regulated violacein production in C. violaceum. Moreover, 1,8-cineole significantly inhibited the QS mediated virulence production and biofilm formation of P. aeruginosa without affecting their growth. The real-time PCR anal. showed the downregulation of autoinducer synthase and transcriptional regulator genes upon 1,8-cineole treatment. The findings of the present study strongly suggested that metabolite of M. paradisiaca impedes P. aeruginosa QS system and associated virulence productions. In the part of experimental materials, we found many familiar compounds, such as 3-Hydroxydihydrofuran-2(3H)-one(cas: 19444-84-9Related Products of 19444-84-9)

3-Hydroxydihydrofuran-2(3H)-one(cas: 19444-84-9) may be employed as starting reagent in the synthesis of series of seco-pseudonucleoside synthons via aminolysis. It may be employed as starting reagent in the synthesis of enantiomerically pure orthogonally protected δ-azaproline, via Mitsunobu reaction.Related Products of 19444-84-9

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Formula: C6H12O3In 2022 ,《A solvent-free manganese(II) -catalyzed Clauson-Kaas protocol for the synthesis of N-aryl pyrroles under microwave irradiation》 appeared in Journal of Heterocyclic Chemistry. The author of the article were Rohit, Kizhakkekuttu Radhakrishnan; Meera, Gopinadh; Anilkumar, Gopinathan. The article conveys some information:

The first manganese-catalyzed modified Clauson-Kaas reaction for N-substituted pyrroles I (R = Ph, 2-bromo-4-methylphenyl, 1,3-benzothiazol-2-yl, etc.) synthesis using 2,5-dimethoxytetrahydrofuran with variously substituted aromatic amines RNH2 has been developed (up to 89% yield). This interesting neat strategy is free from additives including co-catalysts, ligands, and acids. Relatively low cost, environmentally benign, and handy Mn(NO3)2.4H2O is employed as the catalyst under microwave conditions with a very short reaction time (20 min). The above qualities attest to the green nature of this reaction. In the part of experimental materials, we found many familiar compounds, such as 2,5-Dimethoxytetrahydrofuran(cas: 696-59-3Formula: C6H12O3)

2,5-Dimethoxytetrahydrofuran(cas: 696-59-3) is a member of ether. Friedel Crafts reaction, for example, adds an alkyl or acyl group to aromatic ethers when they react with an alkyl or acyl halide in the presence of a Lewis acid as a catalyst.Formula: C6H12O3

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

In 2019,Bulletin of the Chemical Society of Ethiopia included an article by Gullapelli, Kumaraswamy; Brahmeshwari, G.; Ravichander, M.. HPLC of Formula: 696-59-3. The article was titled 《A facile synthesis of 1-aryl pyrroles by Clauson-Kaas reaction using oxone as a catalyst under microwave irradiation》. The information in the text is summarized as follows:

A new and efficient methodol. to synthesize N-substituted pyrrole derivatives I (R = Ph, 4-chloro-2-nitrophenyl, benzenesulfonyl, etc.) by Clauson-Kaas reaction employing oxone as catalyst was developed. The transformation was performed in acetonitrile under microwave irradiation This procedure has several advantages such as high yield, clean product formation, and short reaction time.2,5-Dimethoxytetrahydrofuran(cas: 696-59-3HPLC of Formula: 696-59-3) was used in this study.

2,5-Dimethoxytetrahydrofuran(cas: 696-59-3) is a member of ether. When aromatic ethers are exposed to halogen in the presence or absence of a catalyst, they undergo halogenation, such as bromination.HPLC of Formula: 696-59-3

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Electric Literature of C4H6O3On September 18, 2019 ,《Enantioconvergent Alkylations of Amines by Alkyl Electrophiles: Copper-Catalyzed Nucleophilic Substitutions of Racemic α-Halolactams by Indoles》 was published in Journal of the American Chemical Society. The article was written by Bartoszewicz, Agnieszka; Matier, Carson D.; Fu, Gregory C.. The article contains the following contents:

Transition-metal catalysis has the potential to address shortcomings in the classic SN2 reaction of an amine with an alkyl electrophile, both with respect to reactivity and to enantioselectivity. The authors describe the development of a user-friendly method (reaction at room temperature, with com. available catalyst components) for the enantioconvergent nucleophilic substitution of racemic secondary alkyl halides (α-iodolactams) by indoles. Mechanistic studies are consistent with the formation of a copper(I)-indolyl complex that reacts at different rates with the two enantiomers of the electrophile, which interconvert under the reaction conditions (dynamic kinetic resolution). This study complements earlier work on photoinduced enantioconvergent N-alkylation, supporting the premise that this important challenge can be addressed by a range of strategies. The experimental part of the paper was very detailed, including the reaction process of 3-Hydroxydihydrofuran-2(3H)-one(cas: 19444-84-9Electric Literature of C4H6O3)

3-Hydroxydihydrofuran-2(3H)-one(cas: 19444-84-9) may be employed as starting reagent in the synthesis of series of seco-pseudonucleoside synthons via aminolysis. It may be employed as starting reagent in the synthesis of enantiomerically pure orthogonally protected δ-azaproline, via Mitsunobu reaction.Electric Literature of C4H6O3

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem