Tag: 100-200

《Thin layer chromatography and GC-MS analysis of bioactive molecules of the Acacia ferruginea DC. thorn extract》 was published in Asian Journal of Biological and Life Sciences in 2021. These research results belong to Malathi, H.; Thamizhseran, N.. Synthetic Route of C4H6O3 The article mentions the following:

The aim of the current study is to investigate thethin layer chromatog. (TLC) and gas chromatog. and mass spectroscopy anal. (GC-MS) of methanolic extract of Acacia ferruginea thorns. The bioactive mols. were determined by qual. TLC and GC-MS method. In TLC exhibited maximum 0.6 retention factor (RF) value of the plant extract in F254 wavelength in dark blue color, F366 wave length and in visible light not shown any peaks and RF values. In the GC-MS anal., 37 bioactive mols. were exhibited and in that 10 are in higher concentration by the retention time and their % of peak and area covered in the anal. compared to other chromatograms of the fractions. Important compounds identified as Me mannose (57.14), Phenol, 2-methoxy-3-(2-propenyl)- (4.85), stigmasterol (4.65), 1-Hexacosanol (3.83), Lupeol (3.60), gamma Sitosterol (3.52), Phenol, 4-[2-(dimethylamino)ethyl]-(3.17), Ergost-5-en- 3-ol, (3.beta.)- (2.53), Oleic acid (2.44), Oleoyl chloride (1.53), Sucrose (1.82). The presence of these bioactive mols. in the plant extract may provide the scientific evidences for the cytotoxic effect, insecticidal and other biol. properties. The experimental process involved the reaction of 3-Hydroxydihydrofuran-2(3H)-one(cas: 19444-84-9Synthetic Route of C4H6O3)

3-Hydroxydihydrofuran-2(3H)-one(cas: 19444-84-9) may be employed as starting reagent in the synthesis of series of seco-pseudonucleoside synthons via aminolysis. It may be employed as starting reagent in the synthesis of enantiomerically pure orthogonally protected δ-azaproline, via Mitsunobu reaction.Synthetic Route of C4H6O3

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Formula: C6H12O3In 2020 ,《Synthesis and characterization of some new S-substituted sulfanylpyridines, thieno[2,3-b]pyridines and related heterocycles》 was published in ARKIVOC (Gainesville, FL, United States). The article was written by Al-Taifi, Elham A.; Al-Waleedy, Safiyyah A. H.; Abbady, Mohamed S.; Abdu-Allah, Hajjaj H. M.; Marae, Islam S.; Abuelhassan, Suzan; Bakhite, Etify A.. The article contains the following contents:

Et (3-cyano-5-ethoxycarbonyl-6-methyl-4-styryl-2-pyridylsulfanyl)acetate was prepared and reacted with hydrazine hydrate in ethanol to give a mixture of (3-cyano-5-ethoxycarbonyl-6-methyl-4-styryl-2- pyridylsulfanyl)acetohydrazide and di-Et 3-amino-6-methyl-4-styrylthieno[2,3-b]pyridine-2,5-dicarboxylate. The latter compound was reacted with 2,5-dimethoxytetrahydrofuran to give 3-(1H-pyrrol-1-yl)thieno[2,3-b]pyridine analog which on treatment with hydrazine hydrate in ethanol furnished 5-ethoxycarbonyl-6- methyl-3-(1H-pyrrol-1-yl)-4-styrylthieno[2,3-b]pyridine-2-carbohydrazide. Both acetohydrazide and carbohydrazide were used as precursors for the title compounds The experimental part of the paper was very detailed, including the reaction process of 2,5-Dimethoxytetrahydrofuran(cas: 696-59-3Formula: C6H12O3)

2,5-Dimethoxytetrahydrofuran(cas: 696-59-3) is a member of ether. Friedel Crafts reaction, for example, adds an alkyl or acyl group to aromatic ethers when they react with an alkyl or acyl halide in the presence of a Lewis acid as a catalyst.Formula: C6H12O3

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

《Synthesis, characterization and antimicrobial evaluation of some 1,2,4-triazolo-5-thione derivatives》 was written by Singh, Gurdeep; Jain, Neetesh K.; Sahu, Kiran. Application of 696-59-3This research focused ontriazolothione preparation antibacterial activity. The article conveys some information:

In this study, substituted 1,2,4-triazolo-5-thione derivatives I (R = 4-nitro, 3-nitro; R1 = Ph, Et, Me;) were synthesized from substituted aromatic aldehydes C6H4CHO, and succinic acid and the structure of synthesized compounds were established by physicochem. (M.p., Rf value) and spectral anal. The title compounds were then evaluated for their antimicrobial activity against ciprofloxacin as a standard drug using agar plate method. The synthesized derivatives I (R = 3-nitro, R1 = Et; R = 3-nitro, R1 = Me) were found to possess very promising antimicrobial activity. In addition to this study using 2,5-Dimethoxytetrahydrofuran, there are many other studies that have used 2,5-Dimethoxytetrahydrofuran(cas: 696-59-3Application of 696-59-3) was used in this study.

2,5-Dimethoxytetrahydrofuran(cas: 696-59-3) is a member of ether. Friedel Crafts reaction, for example, adds an alkyl or acyl group to aromatic ethers when they react with an alkyl or acyl halide in the presence of a Lewis acid as a catalyst.Application of 696-59-3

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

《Comprehensive chemical characterization of the aerosol generated by a heated tobacco product by untargeted screening》 was written by Bentley, Mark C.; Almstetter, Martin; Arndt, Daniel; Knorr, Arno; Martin, Elyette; Pospisil, Pavel; Maeder, Serge. Application of 19444-84-9 And the article was included in Analytical and Bioanalytical Chemistry on April 30 ,2020. The article conveys some information:

Abstract: A suite of untargeted methods has been applied for the characterization of aerosol from the Tobacco Heating System 2.2 (THS2.2), a heated tobacco product developed by Philip Morris Products S.A. and commercialized under the brand name IQOS. A total of 529 chem. constituents, excluding water, glycerin, and nicotine, were present in the mainstream aerosol of THS2.2, generated by following the Health Canada intense smoking regimen, at concentrations ≥ 100 ng/item. The majority were present in the particulate phase (n = 402), representing more than 80% of the total mass determined by untargeted screening; a proportion were present in both particulate and gas-vapor phases (39 compounds). The identities for 80% of all chem. constituents (representing > 96% of the total determined mass) were confirmed by the use of authentic anal. reference materials. Despite the uncertainties that are recognized to be associated with aerosol-based untargeted approaches, the reported data remain indicative that the uncharacterized fraction of TPM generated by THS2.2 has been evaluated to the fullest practicable extent. To the best of our knowledge, this work represents the most comprehensive chem. characterization of a heated tobacco aerosol to date. In addition to this study using 3-Hydroxydihydrofuran-2(3H)-one, there are many other studies that have used 3-Hydroxydihydrofuran-2(3H)-one(cas: 19444-84-9Application of 19444-84-9) was used in this study.

3-Hydroxydihydrofuran-2(3H)-one(cas: 19444-84-9) may be employed as starting reagent in the synthesis of series of seco-pseudonucleoside synthons via aminolysis. It may be employed as starting reagent in the synthesis of enantiomerically pure orthogonally protected δ-azaproline, via Mitsunobu reaction.Application of 19444-84-9

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Product Details of 696-59-3In 2020 ,《Rearrangement and cyclisation reactions on the 1-arylpyrrol-2-iminyl-2-aryliminopyrrol-1-yl radical energy surface》 appeared in ARKIVOC (Gainesville, FL, United States). The author of the article were Borthwick, Scott; Foot, Jonathan; Ieva, Maria; McNab, Hamish; McNab, Lilian; Rozgowska, Emma J.; Wright, Andrew. The article conveys some information:

Independent generation of iminyl and pyrrol-1-yl radicals by flash vacuum pyrolysis of oxime ether I (X = N; R1 = MeO; R2 = 4-MeC6H4) and imine I (X = N; R1 = 4-MeC6H4; R2 = Me2N), resp., provided two regioisomeric pyrrolo[1,2-a]quinoxalines II. This shows that radical species interconvert via spirodienyl moiety at high temperatures Corresponding generation of pyrrol-1-yl radical from I (X = CH; R1 = 4-MeC6H4; R2 = Me2N) gave single pyrrolo[1,2-α]quinoline regioisomer as the only cyclized product. In this case, DFT calculations suggested that direct cyclization of pyrrol-1-yl took place, rather than formation of spirodienyl species and exclusive migration of C-N bond. In the experimental materials used by the author, we found 2,5-Dimethoxytetrahydrofuran(cas: 696-59-3Product Details of 696-59-3)

2,5-Dimethoxytetrahydrofuran(cas: 696-59-3) is a member of ether. When aromatic ethers are exposed to halogen in the presence or absence of a catalyst, they undergo halogenation, such as bromination.Product Details of 696-59-3

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

In 2022,EFSA Panel on Food Additives and Flavourings; Younes, Maged; Aquilina, Gabriele; Castle, Laurence; Engel, Karl-Heinz; Fowler, Paul J.; Frutos Fernandez, Maria Jose; Fuerst, Peter; Gundert-Remy, Ursula; Guertler, Rainer; Husoey, Trine; Manco, Melania; Moldeus, Peter; Passamonti, Sabina; Shah, Romina; Waalkens-Berendsen, Ine; Wolfle, Detlef; Wright, Matthew; Benigni, Romualdo; Bolognesi, Claudia; Cordelli, Eugenia; Chipman, Kevin; Degen, Gisela; Noerby, Karin; Svendsen, Camilla; Carfi, Maria; Martino, Carla; Tard, Alexandra; Vianello, Giorgia; Mennes, Wim published an article in EFSA Journal. The title of the article was 《Scientific opinion on Prosmoke BW 01》.HPLC of Formula: 696-59-3 The author mentioned the following in the article:

The EFSA Panel on Food Additives and Flavorings (FAF) was requested to evaluate the safety of Prosmoke BW 01 as a new smoke flavoring primary product, in accordance with Regulation (EC) No 2065/2003. Prosmoke BW01 is produced by pyrolysis of beechwood (Fagus sylvatica L.) sawdust. Its water content is estimated at 56 wt%, the total identified volatile fraction accounts for 28 wt% of the primary product, corresponding to 64% of the solvent-free mass, while the unidentified fraction amounts to 16 wt% of the primary product. Anal. data provided for three batches demonstrated that their batch-to-batch-variability was sufficiently low. However, for the batch used for the toxicol. studies, there were substantial deviations in the concentration of nearly all the constituents compared to the other three batches. The dietary exposure of Prosmoke BW 01 was estimated to be between 6.2 and 9.2 mg/kg body weight (bw) per day, resp., using SMK-EPIC and SMK-TAMDI. Using the FAIM tool, the 95th percentile exposure estimates ranged from 3.2 mg/kg bw per day for the elderly to 17.9 mg/kg bw per day for children. The Panel noted that furan-2(5H)-one is present in all batches of the primary product at an average concentration of 0.88 wt%. This substance was evaluated by the FAF Panel as genotoxic in vivo after oral exposure. The Panel considered that the (geno)toxicity studies available on the whole mixture were not adequate to support the safety assessment, due to limitations in these studies and because they were performed with a batch which may not be representative for the material of commerce. Considering that the exposure estimates for furan-2(5H)-one are above the TTC value of 0.0025 μg/kg bw per day (or 0.15 μg/person per day) for DNA-reactive mutagens and/or carcinogens, the Panel concluded that Prosmoke BW 01 raises a concern with respect to genotoxicity. In the experiment, the researchers used many compounds, for example, 2,5-Dimethoxytetrahydrofuran(cas: 696-59-3HPLC of Formula: 696-59-3)

2,5-Dimethoxytetrahydrofuran(cas: 696-59-3) is a member of ether. Friedel Crafts reaction, for example, adds an alkyl or acyl group to aromatic ethers when they react with an alkyl or acyl halide in the presence of a Lewis acid as a catalyst.HPLC of Formula: 696-59-3

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

In 2022,Schafer, Michael; Stuenkel, Timo; Daniliuc, Constantin G.; Gilmour, Ryan published an article in Angewandte Chemie, International Edition. The title of the article was 《Regio- and Enantioselective Intermolecular Aminofluorination of Alkenes via Iodine(I)/Iodine(III) Catalysis》.Recommanded Product: 696-59-3 The author mentioned the following in the article:

The regio- and enantio-selective, intermol. vicinal fluoroamination of α-trifluoromethyl styrenes was achieved by enantioselective II/IIII catalysis. Leveraging C2-sym. resorcinol-based aryl iodide catalysts, it was possible to intercept the transient iodonium intermediate using simple nitriles, which function as both the solvent and nucleophile. In situ Ritter reaction provides direct access to the corresponding amides (up to 89% yield, e.r. 93 : 7). This main group catalysis paradigm inverts the intrinsic regioselectivity of the uncatalyzed process, thereby providing facile access to tertiary, benzylic stereocenters bearing both CF3 and F groups. Privileged phenethylamine pharmacophores was generated in which there is complete local partial charge inversion (CF3δ-/Fδ- vs. CH3δ+/Hδ+). Crystallog. analyses of representative β-fluoroamide products reveal highly pre-organized conformations that manifest the stereoelectronic gauche effect. The experimental process involved the reaction of 2,5-Dimethoxytetrahydrofuran(cas: 696-59-3Recommanded Product: 696-59-3)

2,5-Dimethoxytetrahydrofuran(cas: 696-59-3) is a member of ether. When aromatic ethers are exposed to halogen in the presence or absence of a catalyst, they undergo halogenation, such as bromination.Recommanded Product: 696-59-3

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Li, Zhanchao; Zhang, Zhiquan; Wu, Lijie; Zhang, Hanqi; Wang, Ziming published their research in Chemical Research in Chinese Universities on February 28 ,2019. The article was titled 《Characterization of Five Kinds of Wood Vinegar Obtained from Agricultural and Forestry Wastes and Identification of Major Antioxidants in Wood Vinegar》.Application In Synthesis of 3-Hydroxydihydrofuran-2(3H)-one The article contains the following contents:

Wood vinegar(WV) has a powerful antioxidant activity, but it is unclear which components are responsi-ble for the antioxidant activity. In the present study, the double-column retention index qual. method was used for the identification of the major components in five kinds of WV. And the major antioxidants of wood vinegar were accurately identified with the aid of Pearson product-moment correlation coefficients and authentic standard samples. Our results demonstrate that phenolic compounds are mainly responsible for the powerful antioxidant activity. 2,6-Dimethoxyphenol is the most powerful antioxidant in WV. 2-Methoxyphenol and 3-methyl-1,2-cyclopentane-dione also have an important influence on the antioxidant activity of WV. Our results suggest that the contents of 2-methoxyphenol, 2,6-dimethoxyphenol and 3-methyl-1,2-cyclopentanedione should act as the criteria for evaluating the antioxidant activity of WV. Our work will provide useful information for WV’s application in the fields of food and medicine as antioxidants. In the experiment, the researchers used 3-Hydroxydihydrofuran-2(3H)-one(cas: 19444-84-9Application In Synthesis of 3-Hydroxydihydrofuran-2(3H)-one)

3-Hydroxydihydrofuran-2(3H)-one(cas: 19444-84-9) is a 5-membered cyclic ester. It was obtained via tin-conversion of biomass-derived 1,3-dihydroxyacetone (DHA) and formaldehyde. And it may be employed as starting reagent in the synthesis of series of seco-pseudonucleoside synthons via aminolysis.Application In Synthesis of 3-Hydroxydihydrofuran-2(3H)-one

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

《Hydrothermal Extraction of Valuable Components from Leaves and Petioles from Paulownia elongata x fortunei》 was written by Rodriguez-Seoane, Paula; del Pozo, Cristina; Puy, Neus; Bartroli, Jordi; Dominguez, Herminia. Application In Synthesis of 3-Hydroxydihydrofuran-2(3H)-one And the article was included in Waste and Biomass Valorization on August 31 ,2021. The article conveys some information:

Abstract: The leaves and petioles of Paulownia elongata x fortunei are residual fractions from the tree plantations com. destined to the production of wood and their valorization could contribute to the rational utilization of this resource. The saccharidic fraction is the most abundant in both parts of the plant and the sugar profile is very similar, but the ethanol extractives are more abundant in leaves. Non isothermal processing was selected since it provided better results than isothermal extraction with shorter times. For this reason, optimization of autohydrolysis under non isothermal operation (140-240°C) was performed for both materials: leaves and petioles. The final autohydrolysis temperature highly influenced the saccharidic, proteic, phenolic and volatile composition of the extracts Operating under selected conditions leaves provided extracts with more antioxidant compounds than petioles. The proposed technol. provides a variety of com. valuable components, which could contribute to the integral use of this energetic crop following a biorefinery approach. Graphic Abstract: [graphic not available: see fulltext]. In the part of experimental materials, we found many familiar compounds, such as 3-Hydroxydihydrofuran-2(3H)-one(cas: 19444-84-9Application In Synthesis of 3-Hydroxydihydrofuran-2(3H)-one)

3-Hydroxydihydrofuran-2(3H)-one(cas: 19444-84-9) may be employed as starting reagent in the synthesis of series of seco-pseudonucleoside synthons via aminolysis. It may be employed as starting reagent in the synthesis of enantiomerically pure orthogonally protected δ-azaproline, via Mitsunobu reaction.Application In Synthesis of 3-Hydroxydihydrofuran-2(3H)-one

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Product Details of 696-59-3In 2019 ,《Driving Recursive Dehydration by PIII/PV Catalysis: Annulation of Amines and Carboxylic Acids by Sequential C-N and C-C Bond Formation》 appeared in Journal of the American Chemical Society. The author of the article were Lecomte, Morgan; Lipshultz, Jeffrey M.; Kim-Lee, Shin-Ho; Li, Gen; Radosevich, Alexander T.. The article conveys some information:

Pyrrolylanilines such as I, pyrrolylbenzylamines, and arylethylamines underwent chemoselective tandem condensation and cyclocondensation reactions with carboxylic acids such as RCO2H mediated by di-Et bromomalonate or di-Et bromo(methyl)malonate and phenylsilane or diphenylsilane in the presence of a hexamethylphosphetane oxide to yield pyrroloquinoxaline such as II [R = MeOCH2, n-Pr, H2C:CHCH2CH2, Ph, 2-MeC6H4, 3-MeC6H4, 4-ClC6H4, 4-FC6H4, 4-MeOC6H4, PhCH2SCH2, TsNHCH2, Br(CH2)5, 3-chloro-1-cyclobutyl], pyrrolobenzodiazepines, a dihydro-β-carboline, and dihydroisoquinolines. The method was also used for Bischler-Napieralski cyclocondensations of aralkyl amides. A bromophosphonium bromide was generated as the key intermediate. A PIII/PV redox catalyst enabled iterative redox-neutral transformations complementary to reactions using the reductive driving force of the PIII/PV couple. In the experiment, the researchers used many compounds, for example, 2,5-Dimethoxytetrahydrofuran(cas: 696-59-3Product Details of 696-59-3)

2,5-Dimethoxytetrahydrofuran(cas: 696-59-3) is a member of ether. When aromatic ethers are exposed to halogen in the presence or absence of a catalyst, they undergo halogenation, such as bromination.Product Details of 696-59-3

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem