Tag: 100-200

Product Details of 19444-84-9On September 30, 2021 ,《Antidiabetic and antilipidemic effect of Clerodendrum paniculatum flower ethanolic extract. An in vivo investigation in Albino Wistar rats》 was published in Biocatalysis and Agricultural Biotechnology. The article was written by Varghese, Sincy; Kannappan, Poornima; Kanakasabapathi, Devaki; Madathil, SriRashmy; Perumalsamy, Muneeswari. The article contains the following contents:

The goal was to evaluate the effects of ethanolic extract of Clerodendrum paniculatum flower (CPF) on antidiabetic and antilipidemic tests indexes of exptl.-induced hyperglycemic rats. High Fat Diet (HFD) treated Streptozotocin (STZ) induced diabetic rats were used for this study. The acute toxicity of ethanolic extract of C. paniculatum flower (2000 mg/kg body weight) and antidiabetic effect of CPF (200 mg/kg body weight)were studied in rats. Glibenclamide (1.25 mg/kg body weight) was used as a reference drug. For antihyperglycemic evaluation, glucose, C-peptide, Insulin, Hb and glycosylated Hb(HbA1c) levels were analyzed. Low d. lipoprotein (LDL), High d. lipoprotein(HDL), triglycerides and total cholesterol were analyzed in rats. The enzymic antioxidant activity (super oxide dismutase(SOD), glutathione peroxidase(GPx), glutathione S transferase (GST) and Catalase) and non-enzymic antioxidant activity(vitamin C, vitamin E and reduced glutathione) of C. Paniculatum flower were evaluated. Important carbohydrate metabolizing enzymes like Glucose 6-phosphatase, Fructose 1and 6 diphosphatase and hexokinase were determined in exptl. rats. After the oral administration of CPF extract significantly reduced glucose levels and cholesterol values. Extract improved enzymic and non enzymic antioxidant levels. CPF extract is useful in controlling blood glucose level as well as improving lipid metabolism and body weight in rats with induced diabetic rats. The results came from multiple reactions, including the reaction of 3-Hydroxydihydrofuran-2(3H)-one(cas: 19444-84-9Product Details of 19444-84-9)

3-Hydroxydihydrofuran-2(3H)-one(cas: 19444-84-9) may be employed as starting reagent in the synthesis of series of seco-pseudonucleoside synthons via aminolysis. It may be employed as starting reagent in the synthesis of enantiomerically pure orthogonally protected δ-azaproline, via Mitsunobu reaction.Product Details of 19444-84-9

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

《Visualization of Pathway Usage in an Extended Carbohydrate Conversion Network Reveals the Impact of Solvent-Enabled Proton Transfer》 was written by Jensen, Pernille R.; Knudsen, Rikke K.; Meier, Sebastian. Formula: C4H6O3 And the article was included in ACS Sustainable Chemistry & Engineering on August 17 ,2020. The article conveys some information:

Bio-sourced mols. should increasingly contribute to meeting societal demands for energy and chems., while reducing net carbon dioxide release and the dependence on fossil resources. Especially oxygenated chems. can be derived from carbohydrates, and the conversion of carbohydrates in protic and nonprotic solvents has attracted considerable interest. Here, we probe chemocatalytic carbohydrate conversion in a time-resolved manner using quant. in situ NMR spectroscopy. A core reaction network in the carbohydrate conversion by Sn(IV) in nonprotic solvents is followed by identifying and quant. tracking 10 chems. with more than 70 at. sites. In situ anal. yields nine rate constants and shows that (co)solvents with labile protons strongly affect tautomerization kinetics and product distributions at an upstream branch point of the reaction network. Solvent-enabled tautomerization and the ensuing accumulation of reactive 1,2-dicarbonyl compounds can thus be key factors influencing reaction kinetics and atom economy in carbohydrate conversion. A reaction network for carbohydrate valorization was observed, revealing the impact of solvent protons on the desired process and on aggregation and degradation reactions. In the experimental materials used by the author, we found 3-Hydroxydihydrofuran-2(3H)-one(cas: 19444-84-9Formula: C4H6O3)

3-Hydroxydihydrofuran-2(3H)-one(cas: 19444-84-9) may be employed as starting reagent in the synthesis of series of seco-pseudonucleoside synthons via aminolysis. It may be employed as starting reagent in the synthesis of enantiomerically pure orthogonally protected δ-azaproline, via Mitsunobu reaction.Formula: C4H6O3

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

In 2022,Current Issues in Molecular Biology included an article by Kiddane, Anley Teferra; Kang, Min-Jae; Ho, Truc Cong; Getachew, Adane Tilahun; Patil, Maheshkumar Prakash; Chun, Byung-Soo; Kim, Gun-Do. Recommanded Product: 3-Hydroxydihydrofuran-2(3H)-one. The article was titled 《Anticancer and Apoptotic Activity in Cervical Adenocarcinoma HeLa Using Crude Extract of Ganoderma applanatum》. The information in the text is summarized as follows:

Cancer is currently one of the foremost health challenges and a leading cause of death worldwide. Cervical cancer is caused by cofactors, including oral contraceptive use, smoking, multiparity, and HIV infection. One of the major and considerable etiologies is the persistent infection of the oncogenic human papilloma virus. G. applanatum is a valuable medicinal mushroom that has been widely used as a folk medicine for the treatment and prevention of various diseases. In this study, we obtained crude extract from G. applanatum mushroom with a subcritical water extraction method; cell viability assay was carried out and the crude extract showed an antiproliferative effect in HeLa cells with IC50 of 1.55 ± 0.01 mg/mL; however, it did not show any sign of toxicity in HaCaT. Protein expression was detected by Western blot, stability of IκBα and downregulation of NFκB, IKKα, IKKβ, p-NFκB-65(Ser 536) and p-IKKα/β(Ser 176/180), suggesting loss of survival in a dose-dependent manner. RT-qPCR revealed RNA/mRNA expression; fold changes of gene expression in Apaf-1, caspase-3, cytochrome-c, caspase-9, Bax and Bak were increased, which implies apoptosis, and NFκB was decreased in a dose-dependent manner. DNA fragmentation was seen in the treatment groups as compared to the control group using gel electrophoresis. Identification and quantification of compounds were carried out by GC-MS and HPLC, resp.; 2(5H)furanone with IC50 of 1.99 ± 0.01 μg/mL could be the responsible anticancer compound In conclusion, these findings suggest the potential use of the crude extract of G. applanatum as a natural source with anticancer activity against cervical cancer. In addition to this study using 3-Hydroxydihydrofuran-2(3H)-one, there are many other studies that have used 3-Hydroxydihydrofuran-2(3H)-one(cas: 19444-84-9Recommanded Product: 3-Hydroxydihydrofuran-2(3H)-one) was used in this study.

3-Hydroxydihydrofuran-2(3H)-one(cas: 19444-84-9) is a 5-membered cyclic ester. It was obtained via tin-conversion of biomass-derived 1,3-dihydroxyacetone (DHA) and formaldehyde. And it may be employed as starting reagent in the synthesis of series of seco-pseudonucleoside synthons via aminolysis.Recommanded Product: 3-Hydroxydihydrofuran-2(3H)-one

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

In 2021,World News of Natural Sciences included an article by James-Okoro, Paula-Peace O.; Iheagwam, Franklyn N.; Sholeye, Mariam I.; Umoren, Itoroobong A.; Adetuyi, Babatunde O.; Ogundipe, Adebanke E.; Braimah, Adefoyeke A.; Adekunbi, Tobi S.; Ogunlana, Oluseyi E.; Ogunlana, Olubanke O.. Category: tetrahydrofurans. The article was titled 《Phytochemical and in vitro antioxidant assessment of Yoyo bitters》. The information in the text is summarized as follows:

In this paper, herbal bitters are widely used due to their numerous acclaimed health benefits in many Nigerian homes; however, many have not been subjected to scientific scrutiny. The aim of this study was to determine the phytochem. composition and antioxidant capacity of a non-alc. polyherbal formulation, Yoyo bitters, towards validating its broad pharmacol. claims. The phytochem. components of Yoyo bitters were ascertained by phytochem. screening assays and gas chromatog.-mass spectrometry (GC-MS). The antioxidant activity was investigated in vitro using 2,2-diphenyl-1-picryhydrazyl (DPPH) radical, hydrogen peroxide (H2O2) scavenging activity, total antioxidant capacity (TAC) and ferric reducing antioxidant power (FRAP) assays. Qual. phytochem. anal. of Yoyo bitters showed the presence of saponins, tannins, flavonoids, terpenoids, cardiac glycosides and anthocyanins. The total phenols, flavonoids, flavanols, tannins and carotenoids content were 14.741 ± 0.64 mg GAE/mL, 0.152 ± 0.01 mg RE/mL, 0.437 ± 0.02 mg RE/mL, 0.368 ± 0.04 mg TAE/mL and 0.016 ± 0.00 mg CAE/mL resp. GC-MS chromatogram revealed the presence of forty-three (43) phytochem. compounds with D-allose (41.81%), 1,6-anhydro-beta-D-glucofuranose (24.15%), 5-hydroxymethylfurfural (8.02%) and Z-6-pentadecen-1-ol acetate (3.50%) as the most abundant constituents. Yoyo bitters demonstrated effective antioxidant activity against DPPH and H2O2 with IC50 values of 0.492 mg/mL and 0.629 mg/mL resp. compared to ascorbic acid of 0.161 mg/mL and 0.130 mg/mL resp. Total antioxidant capacity and ferric reducing antioxidant power of Yoyo bitters were 0.432 mg AAE/mL and 2.236 mg AAE/mL resp. This study validates the antioxidant capacity of Yoyo bitters and provides chem. basis for its acclaimed pharmacol. actions.3-Hydroxydihydrofuran-2(3H)-one(cas: 19444-84-9Category: tetrahydrofurans) was used in this study.

3-Hydroxydihydrofuran-2(3H)-one(cas: 19444-84-9) is a 5-membered cyclic ester. It was obtained via tin-conversion of biomass-derived 1,3-dihydroxyacetone (DHA) and formaldehyde. And it may be employed as starting reagent in the synthesis of series of seco-pseudonucleoside synthons via aminolysis.Category: tetrahydrofurans

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

In 2022,EL-Mahdy, Ahmed F. M.; Bakhite, Etify A.; Abdel-Hafez, Shams H.; Ibrahim, Omaima F.; Abdu-Allah, Hajjaj H. M.; Marae, Islam S. published an article in Journal of Heterocyclic Chemistry. The title of the article was 《Synthesis, characterization, and photophysical properties of some new thieno[2,3-b]pyridines bearing phenylethenyl moiety》.Synthetic Route of C6H12O3 The author mentioned the following in the article:

The 5-acetyl-3-cyano-6-methyl-4-(2-phenylethenyl)pyridine-2(1H)-thione was synthesized by interaction of cinnamylidene-2-cyanothioacetamide and acetylacetone or via one-pot reaction of E-cinnamaldehyde, 2-cyanothioacetamide, and acetylacetone. Reaction of 5-acetyl-3-cyano-6-methyl-4-(2-phenylethenyl)pyridine-2(1H)-thione with Et iodide or N-chloroacetyl derivative of aromatic amines RC6H4NHC(O)CH2Cl (R = Me, OMe, acetyl, Cl) in boiling ethanol containing sodium ethoxide gave the 5-acetyl-3-cyano-2-ethylsulfanyl-6-methyl-4-(2-phenylethenyl)pyridine and 5-acetyl-3-amino-2-(N-arylcarbamoyl)-6-methyl-4-(2-phenylethenyl)thieno[2,3-b]pyridines I, resp. Compound I (R = Cl) was reacted with 2,5-dimethoxytetrahydrofuran or tri-Et orthoformate to furnish 5-acetyl-2-[N-(4-chlorophenyl)carbamoyl]-6-methyl-4-(2-phenylethenyl)-3-(1H-pyrrol-1-yl)- thieno[2,3-b]pyridine or 8-acetyl-3-(4-chlorophenyl)-7-methyl-9-(2-phenylethenyl)pyrido [3′,2′:4,5]thieno[3,2-d]pyrimidine-4(3H)-one, resp. The photophys. properties of I (Me, OMe, Cl), and 8-acetyl-3-(4-chlorophenyl)-7-methyl-9-(2-phenylethenyl)pyrido [3′,2′:4,5]thieno[3,2-d]pyrimidine-4(3H)-one were fully studied and the obtained results included herein. The fluorescence data confirmed that compounds I (Me, OMe, Cl), and 8-acetyl-3-(4-chlorophenyl)-7-methyl-9-(2-phenylethenyl)pyrido [3′,2′:4,5]thieno[3,2-d]pyrimidine-4(3H)-one exhibit aggregation-induced emission behavior with high absolute quantum yields. In the experimental materials used by the author, we found 2,5-Dimethoxytetrahydrofuran(cas: 696-59-3Synthetic Route of C6H12O3)

2,5-Dimethoxytetrahydrofuran(cas: 696-59-3) is a member of ether. Friedel Crafts reaction, for example, adds an alkyl or acyl group to aromatic ethers when they react with an alkyl or acyl halide in the presence of a Lewis acid as a catalyst.Synthetic Route of C6H12O3

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

《Formal enantioselective total synthesis of bisdehydroneostemoninine》 was published in Journal of Asian Natural Products Research in 2020. These research results belong to Ma, Kai-Qing; Ren, Hu-Bin; Chao, Jian-Bin; Qin, Xue-Mei. Application of 696-59-3 The article mentions the following:

A formal enantioselective total synthesis of bisdehydroneostemoninine I employing L-glutamic acid as the chiral pool is described. The key features of the synthesis include regioselective and enantioselective opening of the chiral epoxide, (2R)-2-[3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]propyl]oxirane with dimethylsulfonium methylide and tandem Friedel-Crafts cyclization followed by lactonization to form a 5-7-5 tricyclic core of the target stemona alkaloids I. The synthetic route provides opportunities to explore the biol. behavior of enantiopure compound I.2,5-Dimethoxytetrahydrofuran(cas: 696-59-3Application of 696-59-3) was used in this study.

2,5-Dimethoxytetrahydrofuran(cas: 696-59-3) is a member of ether. Friedel Crafts reaction, for example, adds an alkyl or acyl group to aromatic ethers when they react with an alkyl or acyl halide in the presence of a Lewis acid as a catalyst.Application of 696-59-3

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Quality Control of 3-Hydroxydihydrofuran-2(3H)-oneOn June 1, 2022, Wurzler, Gleicielle Tozzi; da Silva, Victor Teixeira; de Almeida Azevedo, Debora; Ana da Silva, Ayla Sant’; Noronha, Fabio Bellot published an article in Fuel Processing Technology. The article was 《Integrating bio-oil and carbohydrate valorization on the fractionation of sugarcane bagasse via Organosolv process using Mo2C-based catalysts》. The article mentions the following:

This work studied the fractionation of sugarcane bagasse via Organosolv treatment using isopropanol/water in the presence of Raney-Ni and molybdenum carbide catalysts (Bulk Mo2C and Mo2C supported on activated carbon (AC) or Al2O3). The degree of delignification, the bio-oil and solid residue composition depended on the type of catalyst. A partial extraction of hemicellulose occurred followed by depolymerization, resulting in a product distribution that depended on the catalyst. Raney-Ni catalyst promoted the formation of diols and triols, while xylose, furfural, and furan were mainly produced by Mo2C based-catalysts. The Organosolv treatment without catalyst and in the presence of bulk Mo2C produced a bio-oil containing mainly 2,3-dihydrobenzofuran. Mo2C/AC and Mo2C/Al2O3 are promising catalysts for the fractionation of sugarcane bagasse that produced a bio-oil with higher yield to substituted methoxyphenols and a solid residue more easily hydrolyzed by cellulases, producing higher yield to glucose than Raney-Ni catalyst. In the experiment, the researchers used 3-Hydroxydihydrofuran-2(3H)-one(cas: 19444-84-9Quality Control of 3-Hydroxydihydrofuran-2(3H)-one)

3-Hydroxydihydrofuran-2(3H)-one(cas: 19444-84-9) may be employed as starting reagent in the synthesis of series of seco-pseudonucleoside synthons via aminolysis. It may be employed as starting reagent in the synthesis of enantiomerically pure orthogonally protected δ-azaproline, via Mitsunobu reaction.Quality Control of 3-Hydroxydihydrofuran-2(3H)-one

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Category: tetrahydrofuransIn 2020 ,《Towards the template synthesis of conjugated pyrrole based oligo-heteroaryls》 was published in Journal of the Indian Chemical Society. The article was written by Panda, Biswajit. The article contains the following contents:

Synthesis of polymers and Oligomers with various interesting phys. properties is a rewarding task for the chemist. oligoheteroaryls are a significant class of organic compounds due to their wide applicability in various fields. Here, in this article, the synthetic studies directed for the preparation of conjugated pyrrole based oligo-heteroaryls was reported. The successful synthesis of double stranded polymeric ladderphane using ring opening metathesis polymerizations (ROMP) and palladium catalyzed Suzuki coupling were the key feature of this work. Hydrolysis of the double stranded polymer was unsuccessful due to its insoluble nature. The effort to increase the solubility of the double stranded polymers by the incorporation of long-chain aliphatic counterpart is underway in our laboratory In the part of experimental materials, we found many familiar compounds, such as 2,5-Dimethoxytetrahydrofuran(cas: 696-59-3Category: tetrahydrofurans)

2,5-Dimethoxytetrahydrofuran(cas: 696-59-3) is a member of ether. When aromatic ethers are exposed to halogen in the presence or absence of a catalyst, they undergo halogenation, such as bromination.Category: tetrahydrofurans

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

In 2022,Li, Guangchen; Xing, Yangyang; Zhao, Hui; Zhang, Jin; Hong, Xin; Szostak, Michal published an article in Angewandte Chemie, International Edition. The title of the article was 《Chemoselective Transamidation of Thioamides by Transition-Metal-Free N-C(S) Transacylation》.Related Products of 696-59-3 The author mentioned the following in the article:

The first general, mild and highly chemoselective method for transamidation of thio-amides by NC(S) transacylation using non-nucleophilic anilines was reported. The method was broadly compatible with N-Ar tertiary thioamides and N-thioacyl-azoles as selective N-thioacyl transfer reagents. DFT studies that provided insight into the chemoselectivity of this new transamidation method and provided guidelines for the development of future transamidation methods of the thioamide bond.2,5-Dimethoxytetrahydrofuran(cas: 696-59-3Related Products of 696-59-3) was used in this study.

2,5-Dimethoxytetrahydrofuran(cas: 696-59-3) is a member of ether. Friedel Crafts reaction, for example, adds an alkyl or acyl group to aromatic ethers when they react with an alkyl or acyl halide in the presence of a Lewis acid as a catalyst.Related Products of 696-59-3

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Product Details of 19444-84-9On March 10, 2021, Li, Zijian; Sun, Wenxuan; Wang, Xianxu; Li, Luyang; Zhang, Yong; Li, Chao published an article in Journal of the American Chemical Society. The article was 《Electrochemically Enabled, Nickel-Catalyzed Dehydroxylative Cross-Coupling of Alcohols with Aryl Halides》. The article mentions the following:

As alcs. are ubiquitous throughout chem. science, this functional group represents a highly attractive starting material for forging new C-C bonds. Here, it is demonstrated that the combination of anodic preparation of alkoxy triphenylphosphonium ion and nickel catalyzed cathodic reductive cross-coupling provides an efficient method to construct C(sp2)-C(sp3) bonds, in which free alcs. and aryl bromides e.g., bromobenzene-both readily available chems. can be directly used as coupling partners yielding arene derivative e.g., I. This nickel catalyzed paired electrolysis reaction features a broad substrate scope bearing a wide gamut of functionalities, which was illustrated by the late-stage arylation of several structurally complex natural products and pharmaceuticals. In addition to this study using 3-Hydroxydihydrofuran-2(3H)-one, there are many other studies that have used 3-Hydroxydihydrofuran-2(3H)-one(cas: 19444-84-9Product Details of 19444-84-9) was used in this study.

3-Hydroxydihydrofuran-2(3H)-one(cas: 19444-84-9) may be employed as starting reagent in the synthesis of series of seco-pseudonucleoside synthons via aminolysis. It may be employed as starting reagent in the synthesis of enantiomerically pure orthogonally protected δ-azaproline, via Mitsunobu reaction.Product Details of 19444-84-9

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem