Heterocyclic Building Blocks-Tetrahydrofuran

Condurso, Concetta published the artcileStability of powdered infant formula during secondary shelf-life and domestic practices, SDS of cas: 19444-84-9, the publication is International Dairy Journal (2020), 104761, database is CAplus.

Powd. infant formula (PIF) and lactose-free PIF during secondary shelf-life (SSL) and under domestic practices was investigated to verify their stability up to the expiration date and under the label instructions for milk reconstitution. Particular attention was given to variations in Maillard reaction and lipid peroxidation products identified and quantified by HS-SPME-GC-MS. Two types of PIF: Type A based on bovine milk and Type B a lactose-free product based on glucose syrup were analyzed. The PIF were analyzed at regular time intervals beyond the labeled expiration date after opening, and reconstituted using water at 70°C, 80°C and 90°C. A large number of volatile compounds were identified and significant statistically differences resulted during SSL and water temperature used for reconstitution that were correlated to the PIF composition The study showed that water temperature for reconstitution of samples and the SSL has to be adapted to PIF composition

International Dairy Journal published new progress about 19444-84-9. 19444-84-9 belongs to tetrahydrofurans, auxiliary class Tetrahydrofuran,Ester,Alcohol, name is 3-Hydroxydihydrofuran-2(3H)-one, and the molecular formula is C4H6O3, SDS of cas: 19444-84-9.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Sarkaria, S. M. published the artcilePrimary acute myeloid leukemia cells with IDH1 or IDH2 mutations respond to a DOT1L inhibitor in vitro, Related Products of tetrahydrofurans, the publication is Leukemia (2014), 28(12), 2403-2406, database is CAplus and MEDLINE.

The aim was to test the effects of DOT1Linhibition against a set of cryopreserved, genomically characterized de novo AML patient samples, collected through a study approved by the Human Research Protection Office at Washington University School of Medicine after patients provided informed consent.

Leukemia published new progress about 1338466-77-5. 1338466-77-5 belongs to tetrahydrofurans, auxiliary class Epigenetics,Histone Methyltransferase, name is 1-(3-((((2R,3S,4R,5R)-5-(4-Amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)(isopropyl)amino)propyl)-3-(4-(tert-butyl)phenyl)urea, and the molecular formula is C28H41N7O4, Related Products of tetrahydrofurans.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Yu, Wenyu published the artcileCatalytic site remodelling of the DOT1L methyltransferase by selective inhibitors, Computed Properties of 1338466-77-5, the publication is Nature Communications (2012), 3(Dec.), 2304/1-2304/11, database is CAplus and MEDLINE.

Selective inhibition of protein methyltransferases is a promising new approach to drug discovery. An attractive strategy towards this goal is the development of compounds that selectively inhibit binding of the cofactor, S-adenosylmethionine, within specific protein methyltransferases. Here we report the three-dimensional structure of the protein methyltransferase DOT1L bound to EPZ004777, the first S-adenosylmethionine-competitive inhibitor of a protein methyltransferase with in vivo efficacy. This structure and those of four new analogs reveal remodelling of the catalytic site. EPZ004777 and a brominated analog, SGC0946, inhibit DOT1L in vitro and selectively kill mixed lineage leukemia cells, in which DOT1L is aberrantly localized via interaction with an oncogenic MLL fusion protein. These data provide important new insight into mechanisms of cell-active S-adenosylmethionine-competitive protein methyltransferase inhibitors, and establish a foundation for the further development of drug-like inhibitors of DOT1L for cancer therapy.

Nature Communications published new progress about 1338466-77-5. 1338466-77-5 belongs to tetrahydrofurans, auxiliary class Epigenetics,Histone Methyltransferase, name is 1-(3-((((2R,3S,4R,5R)-5-(4-Amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)(isopropyl)amino)propyl)-3-(4-(tert-butyl)phenyl)urea, and the molecular formula is C4H10O2, Computed Properties of 1338466-77-5.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Choi, Jae-Wook published the artcileFeasibility of Laminaria japonica as a feedstock for fast pyrolysis in a bubbling fluidized-bed reactor, Recommanded Product: 3-Hydroxydihydrofuran-2(3H)-one, the publication is Journal of Analytical and Applied Pyrolysis (2015), 141-149, database is CAplus.

Laminaria japonica, brown algae, was used as a feedstock for fast pyrolysis in a bubbling fluidized-bed (BFB) reactor by manipulating the pyrolysis temperature, feeding rate, and ratio of the fluidizing velocity to the min. fluidizing velocity (U/U_mf), which exhibited optimum operating conditions of a feeding rate of 600 g/h, a U/U_mf of 18.3 and a pyrolysis temperature of 425°C. The maximum yield of L. japonica-derived bio-oil (approx. 35 weight %) was lower than that of lignocellulose. When fractionated, the L. japonica-derived bio-oil was found to be composed of several major compounds, including cyclic aliphatic compounds, which were very different from aromatic mols., the major compounds of lignocellulose-derived bio-oil.

Journal of Analytical and Applied Pyrolysis published new progress about 19444-84-9. 19444-84-9 belongs to tetrahydrofurans, auxiliary class Tetrahydrofuran,Ester,Alcohol, name is 3-Hydroxydihydrofuran-2(3H)-one, and the molecular formula is C4H6O3, Recommanded Product: 3-Hydroxydihydrofuran-2(3H)-one.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Kim, Kee-Pyo published the artcilePermissive epigenomes endow reprogramming competence to transcriptional regulators, Recommanded Product: 1-(3-((((2R,3S,4R,5R)-5-(4-Amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)(isopropyl)amino)propyl)-3-(4-(tert-butyl)phenyl)urea, the publication is Nature Chemical Biology (2021), 17(1), 47-56, database is CAplus and MEDLINE.

Abstract: Identifying mol. and cellular processes that regulate reprogramming competence of transcription factors broadens our understanding of reprogramming mechanisms. In the present study, by a chem. screen targeting major epigenetic pathways in human reprogramming, we discovered that inhibiting specific epigenetic roadblocks including disruptor of telomeric silencing 1-like (DOT1L)-mediated H3K79/K27 methylation, but also other epigenetic pathways, catalyzed by lysine-specific histone demethylase 1A, DNA methyltransferases and histone deacetylases, allows induced pluripotent stem cell generation with almost all OCT factors. We found that simultaneous inhibition of these pathways not only dramatically enhances reprogramming competence of most OCT factors, but in fact enables dismantling of species-dependent reprogramming competence of OCT6, NR5A1, NR5A2, TET1 and GATA3. Harnessing these induced permissive epigenetic states, we performed an addnl. screen with 98 candidate genes. Thereby, we identified 25 transcriptional regulators (OTX2, SIX3, and so on) that can functionally replace OCT4 in inducing pluripotency. Our findings provide a conceptual framework for understanding how transcription factors elicit reprogramming in dependency of the donor cell epigenome that differs across species.

Nature Chemical Biology published new progress about 1338466-77-5. 1338466-77-5 belongs to tetrahydrofurans, auxiliary class Epigenetics,Histone Methyltransferase, name is 1-(3-((((2R,3S,4R,5R)-5-(4-Amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)(isopropyl)amino)propyl)-3-(4-(tert-butyl)phenyl)urea, and the molecular formula is C28H41N7O4, Recommanded Product: 1-(3-((((2R,3S,4R,5R)-5-(4-Amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)(isopropyl)amino)propyl)-3-(4-(tert-butyl)phenyl)urea.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Zhu, Jiayi published the artcileNiSO₄-catalyzed C-H activation/C-S cross-coupling of 1,2,3-triazole N-oxides with thiols, Computed Properties of 57124-87-5, the publication is Organic & Biomolecular Chemistry (2015), 13(12), 3711-3720, database is CAplus and MEDLINE.

An efficient nickel-catalyzed protocol for C-S cross-coupling through the direct functionalization of 2-aryl-1,2,3-triazole N-oxide C-H bonds with aryl or alkyl thiols, or di-Ph disulfide has been developed. The targeted N⁺-O^– bond cleavage can be observed during the reaction, and thus obviates the need to use an addnl. deoxygenation step. This new protocol for the preparation of thiolated 2-aryl-1,2,3-triazoles, e.g., I, appears to offer good yields with high regioselectivity, mild conditions, and a wide substrate scope.

Organic & Biomolecular Chemistry published new progress about 57124-87-5. 57124-87-5 belongs to tetrahydrofurans, auxiliary class Tetrahydrofuran,Thiol, name is 2-Methyl-3-tetrahydrofuranthiol, and the molecular formula is C18H26ClN3O, Computed Properties of 57124-87-5.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Xie, Long-Yong published the artcileVisible-light-promoted direct C-H/S-H cross-coupling of quinoxalin-2(1H)-ones with thiols leading to 3-sulfenylated quinoxalin-2(1H)-ones in air, Category: tetrahydrofurans, the publication is Organic Chemistry Frontiers (2019), 6(24), 3950-3955, database is CAplus.

A new and efficient visible-light-mediated strategy was developed for the synthesis of 3-sulfenylated quinoxalin-2(1H)-ones via direct C-H sulfenylation of quinoxalin-2(1H)-ones with thiols in air at room temperature Through this photochem. reaction, various 3-sulfenylated quinoxalin-2(1H)-ones were be efficiently and conveniently obtained in excellent yields with good functional group tolerance by simple use of rhodamine B as the cheap photocatalyst and air as the green oxidant.

Organic Chemistry Frontiers published new progress about 57124-87-5. 57124-87-5 belongs to tetrahydrofurans, auxiliary class Tetrahydrofuran,Thiol, name is 2-Methyl-3-tetrahydrofuranthiol, and the molecular formula is C7H7ClN2S, Category: tetrahydrofurans.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Liang, Jiajin published the artcileComprehensive insights into xylan structure evolution via multi-perspective analysis during slow pyrolysis process, Synthetic Route of 19444-84-9, the publication is Fuel Processing Technology (2019), 1-7, database is CAplus.

Comprehension in hemicellulose pyrolysis is critical to generate renewable fuel and valuable chem. Herein, a self-designed tubular reactor was applied to observe the appearance alteration and chem. structure evolution during the whole xylan pyrolysis process. Before 200°C, it was free moisture removal stage without significant chem. structure alteration. Xylan began to depolymerize at 200°C corresponding with the appearance change from its original state to dark brown, cleavage of branched-chain and primary product acids & ketones generation. The main chain of xylan was completely broken at 250-350°C via β-1,4-glycosidic bond cleavage, dehydration, decarboxylation, and decarbonylation reaction. Acids were mainly originated from hemicellulose pyrolysis. The typical signals from FTIR, ¹³C CP/MAS NMR were disappeared at 350°C. In the carbonation stage, the C/H and C/O ratio reached 2.01 and 4.54, leading to the aromaticity enhancement of char and formation of carbon-centered radicals.

Fuel Processing Technology published new progress about 19444-84-9. 19444-84-9 belongs to tetrahydrofurans, auxiliary class Tetrahydrofuran,Ester,Alcohol, name is 3-Hydroxydihydrofuran-2(3H)-one, and the molecular formula is C4H6O3, Synthetic Route of 19444-84-9.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Liu, Yuping published the artcileSynthesis and odor evaluation of five new sulfur-containing ester flavor compounds from 4-ethyloctanoic acid, Category: tetrahydrofurans, the publication is Molecules (2010), 5104-5111, database is CAplus and MEDLINE.

Five sulfur-containing flavor compounds were designed. and the synthesis of the target compounds was achieved using 4-ethyloctanoyl chloride and thiols and alcs. as starting materials. The products thus obtained [i.e., 4-ethyloctanoic acid 3-(methylthio)propyl ester, 4-ethyloctanethioic acid S-(2-furanylmethyl) ester, 4-ethyloctanethioic acid S-(2-methyl-3-furanyl) ester, 4-ethyloctanoic acid 2-(4-methyl-5-thiazolyl)ethyl ester, 4-ethyloctanethioic acid S-(tetrahydro-2-methyl-3-furanyl) ester] are synthetic sulfur-containing ester flavor compounds which all possess a meaty odor and might be used in foods if approved for this purpose.

Molecules published new progress about 57124-87-5. 57124-87-5 belongs to tetrahydrofurans, auxiliary class Tetrahydrofuran,Thiol, name is 2-Methyl-3-tetrahydrofuranthiol, and the molecular formula is C5H10OS, Category: tetrahydrofurans.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Hartman, Guy J. published the artcileVolatile products formed from the thermal degradation of thiamin at high and low moisture levels, Name: 2-Methyl-3-tetrahydrofuranthiol, the publication is Journal of Agricultural and Food Chemistry (1984), 32(5), 1015-18, database is CAplus.

Volatile products formed during the heating (135°) of thiamin  [59-43-8] in water and propylene glycol  [57-55-6] were examined Carbonyls, furans, thiophenes, thiazoles, dioxolanes, and other S-containing compounds were identified. Quant. and qual. greater amounts of compounds were identified in the water system. Qual. comparisons of systems studied were made.

Journal of Agricultural and Food Chemistry published new progress about 57124-87-5. 57124-87-5 belongs to tetrahydrofurans, auxiliary class Tetrahydrofuran,Thiol, name is 2-Methyl-3-tetrahydrofuranthiol, and the molecular formula is C5H10OS, Name: 2-Methyl-3-tetrahydrofuranthiol.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem