Heterocyclic Building Blocks-Tetrahydrofuran

Singh, Sandip K. published the artcileLignin Conversion Using Catalytic Ionic Liquids: Understanding the Role of Cations, Anions, and Hammett Acidity Functions, Product Details of C4H6O3, the publication is Industrial & Engineering Chemistry Research (2019), 58(47), 21273-21284, database is CAplus.

Because it is undisputable that lignin depolymerization is a must to make the biorefinery concept economically feasible, several efforts are put toward it; however, a lot of catalyst designing is required to achieve efficient depolymerization activities. In this work, we show a systematic approach in the synthesis and characterization of ionic liquids (ILs) with varying combinations of cations (imidazole, benzimidazole, phosphonium, and ammonium) and anions (HSO₄, PTS (p-toluenesulfonate), Cl, H₂PO₄, SnCl₃, FeCl₄, and CuCl₃) for the depolymerization of lignin into low-mol. weight aromatic fractions (<220 g/mol) under mild reaction conditions (120 °C, 1 h, ambient pressure). In a methodical approach, effects of various reaction parameters such as temperature (70-170 °C), time (15-360 min), pressure (N₂, 0.5-3 MPa), solvents and substrate, and so forth were studied to achieve best activity. Among all the catalysts, IL with the imidazolium cation and HSO₄ as the anion showed best activity (78% yield). Subsequent to depolymerization, three aromatic monomers (5 wt % pure vanillin) were isolated using flash column chromatog. These aromatic monomers were characterized using gas chromatog. (GC), GC-mass spectrometry, and NMR techniques for their purity. Hammett acidity functions (H₀) of ILs were measured using UV-vis photo-spectroscopy, and values are correlated with lignin depolymerization results. Lignin and tetrahydrofuran-soluble products were thoroughly characterized using assorted physicochem. techniques such as NMR (¹H and ¹³C), gel permittivity chromatog., thermogravimetric anal., and so forth. The catalyst was recycled up to six runs and showed similar results in consecutive reactions.

Industrial & Engineering Chemistry Research published new progress about 19444-84-9. 19444-84-9 belongs to tetrahydrofurans, auxiliary class Tetrahydrofuran,Ester,Alcohol, name is 3-Hydroxydihydrofuran-2(3H)-one, and the molecular formula is C17H14O5, Product Details of C4H6O3.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Chen, L. published the artcileAbrogation of MLL-AF10 and CALM-AF10-mediated transformation through genetic inactivation or pharmacological inhibition of the H3K79 methyltransferase Dot1l, Application of 1-(3-((((2R,3S,4R,5R)-5-(4-Amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)(isopropyl)amino)propyl)-3-(4-(tert-butyl)phenyl)urea, the publication is Leukemia (2013), 27(4), 813-822, database is CAplus and MEDLINE.

The t(10;11)(p12;q23) translocation and the t(10;11)(p12;q14) translocation, which encode the MLL (mixed lineage leukemia)-AF10 and CALM (clathrin assembly lymphoid myeloid leukemia)-AF10 fusion oncoproteins, resp., are two recurrent chromosomal rearrangements observed in patients with acute myeloid leukemia and acute lymphoblastic leukemia. Here, we demonstrate that MLL-AF10 and CALM-AF10-mediated transformation is dependent on the H3K79 methyltransferase Dot1l using genetic and pharmacol. approaches in mouse models. Targeted disruption of Dot1l using a conditional knockout mouse model abolished in vitro transformation of murine bone marrow cells and in vivo initiation and maintenance of MLL-AF10 or CALM-AF10 leukemia. The treatment of MLL-AF10 and CALM-AF10 transformed cells with EPZ004777, a specific small-mol. inhibitor of Dot1l, suppressed expression of leukemogenic genes such as Hoxa cluster genes and Meis1, and selectively impaired proliferation of MLL-AF10 and CALM-AF10 transformed cells. Pretreatment with EPZ004777 profoundly decreased the in vivo spleen-colony-forming ability of MLL-AF10 or CALM-AF10 transformed bone marrow cells. These results show that patients with leukemia-bearing chromosomal translocations that involve the AF10 gene may benefit from small-mol. therapeutics that inhibit H3K79 methylation. Leukemia (2013) 27, 813-822; doi:10.1038/leu.2012.327; published online 4 Dec. 2012.

Leukemia published new progress about 1338466-77-5. 1338466-77-5 belongs to tetrahydrofurans, auxiliary class Epigenetics,Histone Methyltransferase, name is 1-(3-((((2R,3S,4R,5R)-5-(4-Amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)(isopropyl)amino)propyl)-3-(4-(tert-butyl)phenyl)urea, and the molecular formula is C28H41N7O4, Application of 1-(3-((((2R,3S,4R,5R)-5-(4-Amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)(isopropyl)amino)propyl)-3-(4-(tert-butyl)phenyl)urea.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Rodriguez-Seoane, Paula published the artcileHydrothermal Extraction of Valuable Components from Leaves and Petioles from Paulownia elongata x fortunei, Quality Control of 19444-84-9, the publication is Waste and Biomass Valorization (2021), 12(8), 4525-4535, database is CAplus.

Abstract: The leaves and petioles of Paulownia elongata x fortunei are residual fractions from the tree plantations com. destined to the production of wood and their valorization could contribute to the rational utilization of this resource. The saccharidic fraction is the most abundant in both parts of the plant and the sugar profile is very similar, but the ethanol extractives are more abundant in leaves. Non isothermal processing was selected since it provided better results than isothermal extraction with shorter times. For this reason, optimization of autohydrolysis under non isothermal operation (140-240°C) was performed for both materials: leaves and petioles. The final autohydrolysis temperature highly influenced the saccharidic, proteic, phenolic and volatile composition of the extracts Operating under selected conditions leaves provided extracts with more antioxidant compounds than petioles. The proposed technol. provides a variety of com. valuable components, which could contribute to the integral use of this energetic crop following a biorefinery approach. Graphic Abstract: [graphic not available: see fulltext].

Waste and Biomass Valorization published new progress about 19444-84-9. 19444-84-9 belongs to tetrahydrofurans, auxiliary class Tetrahydrofuran,Ester,Alcohol, name is 3-Hydroxydihydrofuran-2(3H)-one, and the molecular formula is C4H6O3, Quality Control of 19444-84-9.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Yamaguchi, Sho published the artcileMechanistic Insight into Biomass Conversion to Five-membered Lactone Based on Computational and Experimental Analysis, Computed Properties of 19444-84-9, the publication is ChemistrySelect (2017), 2(2), 591-597, database is CAplus.

We investigated the mechanism of a cascade coupling reaction between 1,3-dihydroxyacetone (DHA) and formaldehyde using d. functional theory (DFT) calculations Based on our exptl. results, and in contrast to the previously proposed reaction pathway, we propose the following pathway: (i) the isomerization and dehydration of DHA to an enolate, (ii) an aldol reaction between the enolate and formaldehyde, (iii) the formation of a five-membered ring, and (iv) a proton transfer to form α-hydroxy-γ-butyrolactone (HBL). Consideration of the thermodn. stability of each substrate enabled us to suggest the most likely pathway, and the construction of a transition state model helped us to clarify the origin of the observed product selectivity.

ChemistrySelect published new progress about 19444-84-9. 19444-84-9 belongs to tetrahydrofurans, auxiliary class Tetrahydrofuran,Ester,Alcohol, name is 3-Hydroxydihydrofuran-2(3H)-one, and the molecular formula is C11H15NO2, Computed Properties of 19444-84-9.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Torres-Pacheco, Luis J. published the artcileSorbitol electro-oxidation reaction on sub<10 nm PtAu bimetallic nanoparticles, Quality Control of 19444-84-9, the publication is Electrochimica Acta (2020), 136593, database is CAplus.

Sorbitol is a highly available and functionalized polyalc., with vast industrial usages and with great potential for fuel cells application. However, few studies were done regarding its electrochem. oxidation Monometallic Au, Pt and PtAu with different compositions from Pt-rich (such as Pt₈₅Au₁₅) to Au-rich (Pt₁₀Au₉₀) nanomaterials were synthesized. Several parameters like sorbitol and KOH concentration, scan rate, charge-transfer resistance, and temperature were tested. According with the physicochem. characterization, average particle sizes from 5.6 to 6.5 nm were found for all electrocatalysts, while Pt at. percentages of 85, 60, 40, and 10% were obtained. XPS revealed shifts in Pt 4f and Au 4f core-levels related to electron d. changes by the interaction between these elements and as a result, the electrocatalytic properties for the sorbitol electrooxidation reaction (SOR) were modified. The PtAu nanomaterials presented an increase of the c.d. with the raise of the KOH and sorbitol concentrations, being Pt₄₀Au₆₀/C the most active electrocatalyst displaying 40 mA mg^-1 at 0.1M sorbitol in 2 M KOH with an onset potential of -0.50 V vs. normal H electrode. This onset potential value was more neg. to that typically reported for other polyols like glycerol and ethylene glycol. The reaction pathway of Pt/C, Au/C and Pt₄₀Au₆₀/C was followed by chromatog. and spectroscopic techniques, finding that the complex surfaces of these electrocatalysts were capable to carry the SOR via several electrons (from 2 to 24 e^–). In this manner, the high electrocatalytic activity of Pt₄₀Au₆₀/C was attributed to the electron d. changes that promote a higher electron transfer forming shorter-chain byproducts.

Electrochimica Acta published new progress about 19444-84-9. 19444-84-9 belongs to tetrahydrofurans, auxiliary class Tetrahydrofuran,Ester,Alcohol, name is 3-Hydroxydihydrofuran-2(3H)-one, and the molecular formula is C16H24BF4Ir, Quality Control of 19444-84-9.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Ozpinar, H. published the artcileAlleophatic effects of benzoic acid, salicylic acid and leaf extract of Persica vulgaris Mill. (Rosaceae), COA of Formula: C4H6O3, the publication is South African Journal of Botany (2017), 102-109, database is CAplus.

Secondary compounds in higher plants have great diversity in terms of biol. activity. Most of them are used for the defense by plants. This study aims to investigate the effects of benzoic acid, salicylic acid, and Persica vulgaris Mill. (Peach) on the germination of the seeds of cultivated plants such as Triticum aestivum L. (wheat), Zea mays L. (corn), Cicer arietinum L. (chickpea), as well as weeds such as Lepidium campestre (L.) R.Br. and Convolvulus arvensis L. Method 1, in which benzoic acid, salicylic acid, and Persica vulgaris Mill. are added to the germination environment at different doses, and Method 2, in which they are mixed with the irrigation water at the specified doses, have been employed in this study. As a result of this study, it has been determined that the leaf extract of P. vulgaris Mill., Benzoic acid, and salicylic acid prevent the growth of the root and stem in all seeds at high doses in both methods, and they increase the growth at low doses. According to the GC-MS results of the leaf extract of P. vulgaris Mill., benzoic acid has been determined to be at the highest rate. No difference has been found between months as a result of the HPLC anal. of the amounts of benzoic acid. The determination of neg. effects of benzoic acid, salicylic acid, and peach leaf extract both on cultivated plants and weeds at high doses will repress the development of cultivated plants as well as weeds. Growing cultivated plants in places with peach trees may decrease the yield. The leaves should not be let decompose on the soil in defoliation season, and fallen leaves should be collected. Not collecting all of the leaves and leaving some of them may increase the development of weeds in the surrounding area since it may cause a low dose effect.

South African Journal of Botany published new progress about 19444-84-9. 19444-84-9 belongs to tetrahydrofurans, auxiliary class Tetrahydrofuran,Ester,Alcohol, name is 3-Hydroxydihydrofuran-2(3H)-one, and the molecular formula is C4H6O3, COA of Formula: C4H6O3.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Wurzler, Gleicielle Tozzi published the artcileIntegrating bio-oil and carbohydrate valorization on the fractionation of sugarcane bagasse via Organosolv process using Mo₂C-based catalysts, Safety of 3-Hydroxydihydrofuran-2(3H)-one, the publication is Fuel Processing Technology (2022), 107208, database is CAplus.

This work studied the fractionation of sugarcane bagasse via Organosolv treatment using isopropanol/water in the presence of Raney-Ni and molybdenum carbide catalysts (Bulk Mo₂C and Mo2C supported on activated carbon (AC) or Al₂O₃). The degree of delignification, the bio-oil and solid residue composition depended on the type of catalyst. A partial extraction of hemicellulose occurred followed by depolymerization, resulting in a product distribution that depended on the catalyst. Raney-Ni catalyst promoted the formation of diols and triols, while xylose, furfural, and furan were mainly produced by Mo₂C based-catalysts. The Organosolv treatment without catalyst and in the presence of bulk Mo₂C produced a bio-oil containing mainly 2,3-dihydrobenzofuran. Mo₂C/AC and Mo₂C/Al₂O₃ are promising catalysts for the fractionation of sugarcane bagasse that produced a bio-oil with higher yield to substituted methoxyphenols and a solid residue more easily hydrolyzed by cellulases, producing higher yield to glucose than Raney-Ni catalyst.

Fuel Processing Technology published new progress about 19444-84-9. 19444-84-9 belongs to tetrahydrofurans, auxiliary class Tetrahydrofuran,Ester,Alcohol, name is 3-Hydroxydihydrofuran-2(3H)-one, and the molecular formula is C10H10N2, Safety of 3-Hydroxydihydrofuran-2(3H)-one.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Silveira, Marcello R. published the artcileGuava-flavored whey beverage processed by cold plasma technology: Bioactive compounds, fatty acid profile and volatile compounds, Quality Control of 19444-84-9, the publication is Food Chemistry (2019), 120-127, database is CAplus and MEDLINE.

The effect of cold plasma processing time and gas flow on bioactive compounds such as vitamin C, carotenoids and phenolic compounds, DPPH, angiotensin-converting-enzyme (ACE) inhibitory activity, fatty acids profile, and volatile compounds of guava-flavored whey beverage was investigated. For comparative purposes, a pasteurized beverage was also manufactured Cold plasma increased the concentration of bioactive and volatile compounds, and proportionated changes in the fatty acids profile. The milder conditions like lower flow rate and processing time, resulted in higher vitamin C and volatile compounds levels, and higher antioxidant activity, but with a lower carotenoids content and a less favorable fatty acids profile. More drastic conditions like higher flow rate and processing time resulted in products with lower vitamin C and volatile compounds levels, but with higher carotenoids content and ACE inhibitory activity. It can be concluded that the cold plasma processing can improve the properties of the guava-flavored whey beverages (increased concentration of bioactive and volatile compounds), while the effect on the fatty acid profile and ACE inhibitory activity is dependent on the process parameters (processing time and flow rate).

Food Chemistry published new progress about 19444-84-9. 19444-84-9 belongs to tetrahydrofurans, auxiliary class Tetrahydrofuran,Ester,Alcohol, name is 3-Hydroxydihydrofuran-2(3H)-one, and the molecular formula is C10H16Br3N, Quality Control of 19444-84-9.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Braun, Theodore P. published the artcileCombined inhibition of JAK/STAT pathway and lysine-specific demethylase 1 as a therapeutic strategy in CSF3R/CEBPA mutant acute myeloid leukemia, Related Products of tetrahydrofurans, the publication is Proceedings of the National Academy of Sciences of the United States of America (2020), 117(24), 13670-13679, database is CAplus and MEDLINE.

Acute myeloid leukemia (AML) is a deadly hematol. malignancy with poor prognosis, particularly in the elderly. Even among individuals with favorable-risk disease, approx. half will relapse with conventional therapy. In this clin. circumstance, the determinants of relapse are unclear, and there are no therapeutic interventions that can prevent recurrent disease. Mutations in the transcription factor CEBPA are associated with favorable risk in AML. However, mutations in the growth factor receptor CSF3R are commonly co-occurrent in CEBPA mutant AML and are associated with an increased risk of relapse. To develop therapeutic strategies for this disease subset, we performed medium-throughput drug screening on CEBPA/CSF3R mutant leukemia cells and identified sensitivity to inhibitors of lysine-specific demethylase 1 (LSD1). Treatment of CSF3R/CEBPA mutant leukemia cells with LSD1 inhibitors reactivates differentiation-associated enhancers driving immunophenotypic and morphol. differentiation. LSD1 inhibition is ineffective as monotherapy but demonstrates synergy with inhibitors of JAK/STAT signaling, doubling median survival in vivo. These results demonstrate that combined inhibition of JAK/STAT signaling and LSD1 is a promising therapeutic strategy for CEBPA/CSF3R mutant AML.

Proceedings of the National Academy of Sciences of the United States of America published new progress about 1338466-77-5. 1338466-77-5 belongs to tetrahydrofurans, auxiliary class Epigenetics,Histone Methyltransferase, name is 1-(3-((((2R,3S,4R,5R)-5-(4-Amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)(isopropyl)amino)propyl)-3-(4-(tert-butyl)phenyl)urea, and the molecular formula is C28H41N7O4, Related Products of tetrahydrofurans.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Spanik, Ivan published the artcileClassification of wine distillates using multivariate statistical methods based on their direct GC-MS analysis, Recommanded Product: 3-Hydroxydihydrofuran-2(3H)-one, the publication is Chemical Papers (2015), 69(3), 395-401, database is CAplus.

This work describes a novel methodol. for the recognition of brandies based on direct injection of a raw sample followed by GC-MS anal. Direct injection was chosen for its simplicity and the fact that the composition of the samples analyzed remains unchanged compared to original brandy. The repeatability of the anal. procedure was evaluated by a comparison of the peak areas for randomly selected compounds obtained from 10 parallel measurements. A novel chemometric procedure was investigated in order to sep. the samples studied on the basis of their geog. origin, processing technol. or maturation time. In this procedure, a principal component anal. was applied to full chromatograms to select the time interval that shows the significant differences between the samples studied. It was shown that the chromatogram recorded at 36-39 min bore the maximal differences, hence it could be used to classify the brandy samples. The chromatog. peaks found within this time interval were identified and their peak areas determined These compounds could be used as specific markers for determining geog. origin or processing technol.

Chemical Papers published new progress about 19444-84-9. 19444-84-9 belongs to tetrahydrofurans, auxiliary class Tetrahydrofuran,Ester,Alcohol, name is 3-Hydroxydihydrofuran-2(3H)-one, and the molecular formula is C8H17Br, Recommanded Product: 3-Hydroxydihydrofuran-2(3H)-one.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem