Heterocyclic Building Blocks-Tetrahydrofuran

Hua, Geng published the artcileOne-pot inimer promoted ROCP synthesis of branched copolyesters using α-hydroxy-γ-butyrolactone as the branching reagent, Recommanded Product: 3-Hydroxydihydrofuran-2(3H)-one, the publication is Journal of Polymer Science, Part A: Polymer Chemistry (2016), 54(13), 1908-1918, database is CAplus and MEDLINE.

An array of branched poly(ε-caprolactone)s was successfully synthesized using an one-pot inimer promoted ring-opening multibranching copolymerization (ROCP) reaction. The biorenewable, com. available yet unexploited comonomer and initiator 2-hydroxy-γ-butyrolactone was chosen as the inimer to extend the use of 5-membered lactones to branched structures and simultaneously avoiding the typical tedious work involved in the inimer preparation Reactions were carried out both in bulk and in solution using stannous octoate (Sn(Oct)₂) as the catalyst. Polymerizations with inimer equivalent varying from 0.01 to 0.2 were conducted which resulted in polymers with a degree of branching ranging from 0.049 to 0.124. Detailed ROCP kinetics of different inimer systems were compared to illustrate the branch formation mechanism. The resulting polymer structures were confirmed by ¹H, ¹³C, and ₁H-₁₃C HSQC NMR and SEC (RI detector and triple detectors). The thermal properties of polymers with different degree of branching were investigated by DSC, confirming the branch formation. Through this work, we have extended the current use of the non-homopolymerizable γ-butyrolactone to the branched polymers and thoroughly examined its behaviors in ROCP. © 2016 Wiley Periodicals, Inc.J. Polym. Sci., Part A: Polym.Chem. 2016.

Journal of Polymer Science, Part A: Polymer Chemistry published new progress about 19444-84-9. 19444-84-9 belongs to tetrahydrofurans, auxiliary class Tetrahydrofuran,Ester,Alcohol, name is 3-Hydroxydihydrofuran-2(3H)-one, and the molecular formula is C4H6O3, Recommanded Product: 3-Hydroxydihydrofuran-2(3H)-one.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Rayne, Sierra published the artcilepH dependent partitioning behaviour of food and beverage aroma compounds between air-aqueous and organic-aqueous matrices, Synthetic Route of 57124-87-5, the publication is Flavour and Fragrance Journal (2016), 31(3), 228-234, database is CAplus.

Aroma compounds in the Flavornet database were screened for ionizable functional groups such as carboxylic acids, aliphatic and aromatic amines, phenols, alcs. and thiols. Of the 738 aroma compounds listed in this database, 101 mols. have ionizable moieties with estimated monomeric aqueous pK_a values ranging between 1.75 and 10.97. pH dependent effective air/water partitioning coefficients (K_aw,eff) and n-octanol/water partitioning coefficients (D_ow) were estimated for all ionizable aroma compounds over the pH range from 0 to 14. The ionizable aroma compounds display a broad range of K_aw,eff (1.8 × 10^-23 to 6.1 atm M^-1) and log D_ow (-6.2 to +7.2 units) values. For many aroma compounds, pH dependent ionization will have a significant effect on K_aw,eff and D_ow, leading to variations in these physico-chem. properties by up to 11 orders of magnitude over the composite pH range of common foods and beverages. Changes in food and beverage pH affect not only the relative contributions of neutral vs. charged forms of ionizable aroma compounds (which directly affects analyte volatility and olfactory reception), but also partitioning between freely dissolved and sorbed forms of the analyte in solution (which indirectly affects analyte volatility). Copyright © 2015 John Wiley & Sons, Ltd.

Flavour and Fragrance Journal published new progress about 57124-87-5. 57124-87-5 belongs to tetrahydrofurans, auxiliary class Tetrahydrofuran,Thiol, name is 2-Methyl-3-tetrahydrofuranthiol, and the molecular formula is C5H10OS, Synthetic Route of 57124-87-5.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Semenyuk, Andrey published the artcileSynthesis of RNA Using 2′-O-DTM Protection, HPLC of Formula: 87865-78-9, the publication is Journal of the American Chemical Society (2006), 128(38), 12356-12357, database is CAplus and MEDLINE.

Tert-butyldithiomethyl (DTM), a novel hydroxy protecting group, cleavable under reductive conditions, was developed and applied for the protection of 2′-OH during solid-phase RNA synthesis. This function is compatible with all standard protecting groups used in oligonucleotide synthesis, and allows for fast and high-yield synthesis of RNA. Oligonucleotides containing the 2′-O-DTM groups can be easily deprotected under the mildest possible aqueous and homogeneous conditions. The preserved 5′-O-DMTr function can be used for high-throughput cartridge RNA purification

Journal of the American Chemical Society published new progress about 87865-78-9. 87865-78-9 belongs to tetrahydrofurans, auxiliary class Nucleosides and Nucleotides,Nucleoside Analogues, name is N-(9-((6aR,8R,9R,9aS)-9-Hydroxy-2,2,4,4-tetraisopropyltetrahydro-6H-furo[3,2-f][1,3,5,2,4]trioxadisilocin-8-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl)isobutyramide, and the molecular formula is C10H9IO4, HPLC of Formula: 87865-78-9.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Makibar, Jon published the artcilePerformance of a conical spouted bed pilot plant for bio-oil production by poplar flash pyrolysis, Product Details of C4H6O3, the publication is Fuel Processing Technology (2015), 283-289, database is CAplus.

Poplar (Populus nigra) flash pyrolysis has been performed at the IK4-Ikerlan 25 kg h^– 1 pilot plant equipped with a conical spouted bed reactor. Gas, bio-oil and char yields and properties have been studied in the 425-525 °C range. This reactor has been proven to be especially suitable for this process as high bio-oil yields have been obtained, with the maximum being 69 weight% at 455 °C. The bio-oil has been collected in two fractions: the lighter one, which accounts for 85 weight% of the bio-oil, has a high water content and is composed mainly of acids and ketones, whereas the heavier fraction has a lower water content and is rich in phenols. These fractions are miscible, obtaining a bio-oil with a water content lower than 25 weight% and a higher heating value in the 16-18 MJ kg^– 1 range.

Fuel Processing Technology published new progress about 19444-84-9. 19444-84-9 belongs to tetrahydrofurans, auxiliary class Tetrahydrofuran,Ester,Alcohol, name is 3-Hydroxydihydrofuran-2(3H)-one, and the molecular formula is C4H6O3, Product Details of C4H6O3.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Wang, Wenli published the artcileAnalysis of volatile compounds in Chinese dry-cured hams by comprehensive two-dimensional gas chromatography with high-resolution time-of-flight mass spectrometry, COA of Formula: C4H6O3, the publication is Meat Science (2018), 14-25, database is CAplus and MEDLINE.

A microwave assisted extraction method coupled with solvent assisted flavor evaporation (MAE-SAFE) was used to extract the volatiles from three-selected Chinese dry-cured hams (Jinhua ham, Xuanwei ham and Rugao ham). Extracts were analyzed by comprehensive two-dimensional gas chromatog. with high-resolution time-of-flight mass spectrometry (GC × GC/HR-TOFMS), gas chromatog.-mass spectrometry (GC-MS), resp. A total 165 volatile compounds were identified by GC × GC/HR-TOFMS while only 50 compounds were identified by GC-MS. Principal component anal. showed that the specific dominant volatile compounds were [S-(R*,R*)]-2,3-butanediol (26.39%) and 3-methyl-butanoic acid (7.53%) for Jinhua ham, were [R-(R*,R*)]-2,3-butanediol (16.85%) and acetic acid (8.25%) for Rugao ham and were dihydro-4-hydroxy-2(3H)-furanone (11.67%) and hexanoic acid (8.24%) for Xuanwei ham. The results not only provided a fast and mild extraction method to analyze the volatiles in non-volatile food matrixes, but also represented the detailed information of volatile profiles of Chinese dry-cured hams.

Meat Science published new progress about 19444-84-9. 19444-84-9 belongs to tetrahydrofurans, auxiliary class Tetrahydrofuran,Ester,Alcohol, name is 3-Hydroxydihydrofuran-2(3H)-one, and the molecular formula is C20H18BrN3, COA of Formula: C4H6O3.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Yi, Joanna S. published the artcileStructure-Guided DOT1L Probe Optimization by Label-Free Ligand Displacement, Safety of 1-(3-((((2R,3S,4R,5R)-5-(4-Amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)(isopropyl)amino)propyl)-3-(4-(tert-butyl)phenyl)urea, the publication is ACS Chemical Biology (2015), 10(3), 667-674, database is CAplus and MEDLINE.

The DOT1L lysine methyltransferase has emerged as a validated therapeutic target in MLL-rearranged (MLLr) acute leukemias. Although S-adenosylmethionine competitive inhibitors have demonstrated pharmacol. proof-of-principle in MLLr-leukemia, these compounds require further optimization to improve cellular potency and pharmacokinetic stability. Limiting DOT1L inhibitor discovery and ligand optimization have been complex biochem. methods often using radionucleotides and cellular methods requiring prolonged culture. The authors therefore developed a new suite of assay technologies that allows comparative assessment of chem. tools for DOT1L in a miniaturized format. Coupling these assays with structural information, the authors developed new insights into DOT1L ligand binding and identified several functionalized probes with increased cellular potency (IC₅₀ values ∼10 nM) and excellent selectivity for DOT1L. Together these assay technologies define a platform capability for discovery and optimization of small-mol. DOT1L inhibitors.

ACS Chemical Biology published new progress about 1338466-77-5. 1338466-77-5 belongs to tetrahydrofurans, auxiliary class Epigenetics,Histone Methyltransferase, name is 1-(3-((((2R,3S,4R,5R)-5-(4-Amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)(isopropyl)amino)propyl)-3-(4-(tert-butyl)phenyl)urea, and the molecular formula is C15H12O6, Safety of 1-(3-((((2R,3S,4R,5R)-5-(4-Amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)(isopropyl)amino)propyl)-3-(4-(tert-butyl)phenyl)urea.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Li, Xiaoman published the artcileCatalyst- and Metal-Free Photo-Oxidative Coupling of Thiols with BrCCl₃, HPLC of Formula: 57124-87-5, the publication is European Journal of Organic Chemistry (2022), 2022(23), e202200340, database is CAplus.

This paper reported a catalyst- and metal-free method to construct disulfide bond with BrCCl₃ under light irradiation This clean and mild reaction promoted the oxidative coupling of thiols with wide substrate scope, and was applicable to benzylic, aryl and aliphatic thiols, especially cysteine derivative The disulfides were obtained in high yields up to 98%, avoiding the use of heating, strong oxidant, metal reagent or catalyst. This facile strategy facilitated the synthesis of disulfide compounds

European Journal of Organic Chemistry published new progress about 57124-87-5. 57124-87-5 belongs to tetrahydrofurans, auxiliary class Tetrahydrofuran,Thiol, name is 2-Methyl-3-tetrahydrofuranthiol, and the molecular formula is C5H10OS, HPLC of Formula: 57124-87-5.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Savareear, Benjamin published the artcileNon-targeted analysis of the particulate phase of heated tobacco product aerosol and cigarette mainstream tobacco smoke by thermal desorption comprehensive two-dimensional gas chromatography with dual flame ionisation and mass spectrometric detection, Quality Control of 19444-84-9, the publication is Journal of Chromatography A (2019), 327-337, database is CAplus and MEDLINE.

An anal. methodol. based on thermal desorption and comprehensive two-dimensional gas chromatog. with dual time-of-flight mass spectrometry and flame ionization detection (TD-GC × GC-TOFMS/FID) was developed for non-target anal. of volatile organic compounds (VOCs). The technique was optimized for the measurement of the VOC content of the particulate phase (PP) fraction of aerosols produced by a tobacco heating product (THP1.0) and 3R4F mainstream tobacco smoke (MTS). The method involves sampling the PP fraction on quartz wool packed in a sorbent tube directly connected to machine-puffing, followed by a dilution through a TD recollection procedure over Tenax/Sulficarb sorbent before TD-GC × GC-TOFMS/FID anal. The comparison of the VOC content of the PP fraction of aerosols produced by THP1.0 and MTS highlighted the compositional difference between tobacco combustion (592 peaks) and tobacco heating process (160 peaks). Mass spectrometric signals were used for qual. analyses based on linear retention indexes, mass spectral matches, and GC × GC structured chromatograms, which collectively identified up to 90% of analytes detected in PP samples. FID signals were used for semi-quant. analyses based on a chem. class external calibration method. The global chem. composition of PP samples showed that hydrocarbons, oxygenated, and nitrogen-containing compounds were fewer in number and much less abundant in THP1.0 PP. Overall, 93 compounds were common to the two sample types. Excepted for a few highly volatile compounds (mainly furan family) as well as glycerin and its acetate, analyte concentrations were higher in MTS PP.

Journal of Chromatography A published new progress about 19444-84-9. 19444-84-9 belongs to tetrahydrofurans, auxiliary class Tetrahydrofuran,Ester,Alcohol, name is 3-Hydroxydihydrofuran-2(3H)-one, and the molecular formula is C4H6O3, Quality Control of 19444-84-9.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Efimtseva, Ekaterina V. published the artcileSynthesis of disaccharide nucleosides and their incorporation into oligonucleotides, SDS of cas: 87865-78-9, the publication is Collection of Czechoslovak Chemical Communications (1996), 61(Spec. Issue), S206-S209, database is CAplus.

A high yield synthesis of 2′-O-ribofuranosyl nucleosides has been achieved and incorporation of the cytosine analog into oligonucleotides was accomplished without difficulties. The supplementary cis diol group thus present in the middle of an oligonucleotide could be easily converted to a reactive dialdehyde moiety.

Collection of Czechoslovak Chemical Communications published new progress about 87865-78-9. 87865-78-9 belongs to tetrahydrofurans, auxiliary class Nucleosides and Nucleotides,Nucleoside Analogues, name is N-(9-((6aR,8R,9R,9aS)-9-Hydroxy-2,2,4,4-tetraisopropyltetrahydro-6H-furo[3,2-f][1,3,5,2,4]trioxadisilocin-8-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl)isobutyramide, and the molecular formula is C26H45N5O7Si2, SDS of cas: 87865-78-9.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Eltayeb, Ikram Mohamed published the artcileComparative study of chemical composition of Acacia seyal stem, stem wood and stem bark dry distillates used by sudaneses women as cosmetic and medicine, Synthetic Route of 19444-84-9, the publication is International Journal of Pharmacy and Pharmaceutical Sciences (2017), 9(11), 218-224, database is CAplus.

The content and chem. composition of dry distillates of the stem, stem wood and stem bark of Acacia seyal were investigated. The distillates are fumigants of A. seyal locally known in Sudan as Dokhan and widely used for its cosmetic, aromatic and medicinal value for the treatment of candidiasis, genital yeast infection, urinary tract infection, diarrhoea, respiratory tract infection, skin infection and with potent, antioxidant and antimicrobial activities. The dry distillates were prepared by dry distillation method from the Acacia seyal stem, stem wood and stem bark and investigated chem. by GC-MS anal. GC-MS anal. revealed the presence of one hundred and 23 constituents in the stem distillate with major constituents of solerone, furfural, catechol, syringol, allo-inositol, mequinol, furfuralc., 3-methyl-1,2-cyclopentanedione, phenol, homovanillyl alc. and 3-cresol. the wood distillate show detection of eighty compounds, with main 1, 3-dimethyl-5-methoxypyrazol, syringol, furfuralc., mequinol, 1,2-anhydro-3,4,5,6-alloinositol, 3-methyl-1,2-cyclopentanedione, catechol, 3-methoxycatechol, homovanillyl alc., homosyringic acid, 3-cresol, 3-methyl-2-cyclopentenone and 1,2-cyclopentanedione. Sixty six compounds were detected in the distillate bark and the main compounds were found to be hexadecanoic, catechol, tetrapentacontane, phenol, mequinol and 2-ethylfurane. The result concludes that the medicinal Sudanese Dokhan have good potential as sources of different bioactive compounds and antioxidants.

International Journal of Pharmacy and Pharmaceutical Sciences published new progress about 19444-84-9. 19444-84-9 belongs to tetrahydrofurans, auxiliary class Tetrahydrofuran,Ester,Alcohol, name is 3-Hydroxydihydrofuran-2(3H)-one, and the molecular formula is C4H6O3, Synthetic Route of 19444-84-9.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem