Heterocyclic Building Blocks-Tetrahydrofuran

Silva, Ramon published the artcileAdvantages of using ohmic heating in Dulce de Leche manufacturing, Safety of 3-Hydroxydihydrofuran-2(3H)-one, the publication is Innovative Food Science & Emerging Technologies (2020), 102475, database is CAplus.

Ohmic heating (OH, 0, 2, 4, 6, 8, or 10 V cm-1, 72 °C/15 s, 60 Hz) at Dulce de leche processing was investigated. The equipment consisted in an ohmic heating chamber, and rectangular 316 stainless steel electrodes positioned 10 cm apart. OH-treated milk resulted in improvements in the quality parameters of Dulce de leche, with a decrease in energy expenditure (69.85-141.86 vs 1260 kJ) and hydroxymethylfurfural (HMF) levels (7.64-8.54 vs 9.53 μmol L-1), an increase in product homogeneity, and formation of volatile compounds important for the sweetness of Dulce de leche (butanoic acid and 2-furan methanol). In addition, the physicochem. composition, fatty acid profile, and health indexes (atherogenic, thrombogenic, desired fatty acids, and hypercholesterolemic saturated fatty acids) of the products remained without changes. In particular, the use of higher elec. field (> 6 V cm-1) led to a 14-78% decrease in process time, and improved volatiles profile. OH has proven to be a suitable technol. for milk treatment, resulting in improvements in the quality parameters of Dulce de leche with pos. impact at the process time and energy expenditure. The Dulce de Leche processing is characterized by long cooking times to acquire its typical characteristic color and flavor. Normally, it is used pasteurized milk as raw material. Ohmic heating decreased the total time of processing in Dulce de leche manufacturing, providing an economy at the in the energy costs without significant change at the quality parameters of the final product.

Innovative Food Science & Emerging Technologies published new progress about 19444-84-9. 19444-84-9 belongs to tetrahydrofurans, auxiliary class Tetrahydrofuran,Ester,Alcohol, name is 3-Hydroxydihydrofuran-2(3H)-one, and the molecular formula is C10H16Br3N, Safety of 3-Hydroxydihydrofuran-2(3H)-one.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Dunkel, Martin published the artcileReplacement of the phosphodiester bond between U4 and G5 in the U-turn of a chemically modified hammerhead ribozyme by an amide bond, SDS of cas: 87865-78-9, the publication is Nucleosides, Nucleotides & Nucleic Acids (2000), 19(4), 749-756, database is CAplus and MEDLINE.

The phosphodiester bond between U4 and G5 in the U-turn of a chem. modified hammerhead ribozyme was substituted by an amide backbone without compromising the ribozyme’s cleavage activity. Furthermore, the modified ribozyme proved to be completely stable against endonucleolytic digestion at this position.

Nucleosides, Nucleotides & Nucleic Acids published new progress about 87865-78-9. 87865-78-9 belongs to tetrahydrofurans, auxiliary class Nucleosides and Nucleotides,Nucleoside Analogues, name is N-(9-((6aR,8R,9R,9aS)-9-Hydroxy-2,2,4,4-tetraisopropyltetrahydro-6H-furo[3,2-f][1,3,5,2,4]trioxadisilocin-8-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl)isobutyramide, and the molecular formula is C26H45N5O7Si2, SDS of cas: 87865-78-9.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Aldakheel, Reem K. published the artcileBactericidal and in vitro cytotoxicity of Moringa oleifera seed extract and its elemental analysis using laser-induced breakdown spectroscopy, Recommanded Product: 3-Hydroxydihydrofuran-2(3H)-one, the publication is Pharmaceuticals (2020), 13(8), 193, database is CAplus and MEDLINE.

In the current study, we present the correlation between the capability of laser-induced breakdown spectroscopy (LIBS) to monitor the elemental compositions of plants and their biol. effects. The selected plant, Moringa oleifera, is known to harbor various minerals and vitamins useful for human health and is a potential source for pharmaceutical interventions. From this standpoint, we assessed the antibacterial and in vitro cytotoxicity of the bioactive components present in Moringa oleifera seed (MOS) extract Detailed elemental anal. of pellets of MOSs were performed via LIBS. Furthermore, the LIBS outcome was validated using gas chromatog.-mass spectrometry (GC-MS). The LIBS signal was recorded, and the presence of the essential elements (Na, Ca, Se, K, Mg, Zn, P, S, Fe and Mn) in the MOSs were examined The bactericidal efficacy of the alc. MOS extract was examined against Escherichia coli (E. coli) and Staphylococcus aureus(S. aureus) by agar well diffusion (AWD) assays and SEM (SEM), which depicted greater inhibition against Gram-pos. bacteria. The validity and DNA nuclear morphol. of human colorectal carcinoma cells (HCT-116) cells were evaluated via an MTT assay and DAPI staining. The MTT assay results manifested a profoundly inhibitory action of MOS extract on HCT116 cell growth. Addnl., MOS extracts produced inhibitory action in colon cancer cells (HCT-116), whereas no inhibitory action was seen using the same concentrations of MOS extract on HEK-293 cells (non-cancerous cells), suggesting that MOS extracts could be non-cytotoxic to normal cells. The antibacterial and anticancer potency of these MOS extracts could be due to the presence of various bioactive chem. complexes, such as Et ester and D-allose and hexadecenoic, oleic and palmitic acids, making them an ideal candidate for pharmaceutical research and applications.

Pharmaceuticals published new progress about 19444-84-9. 19444-84-9 belongs to tetrahydrofurans, auxiliary class Tetrahydrofuran,Ester,Alcohol, name is 3-Hydroxydihydrofuran-2(3H)-one, and the molecular formula is C4H6O3, Recommanded Product: 3-Hydroxydihydrofuran-2(3H)-one.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Khirsariya, Prashant published the artcileSynthesis and Profiling of Highly Selective Inhibitors of Methyltransferase DOT1L Based on Carbocyclic C-Nucleosides, Safety of 1-(3-((((2R,3S,4R,5R)-5-(4-Amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)(isopropyl)amino)propyl)-3-(4-(tert-butyl)phenyl)urea, the publication is Journal of Medicinal Chemistry (2022), 65(7), 5701-5723, database is CAplus and MEDLINE.

Histone methyltransferase DOT1L is an attractive therapeutic target for the treatment of hematol. malignancies. Here, we report the design, synthesis, and profiling of new DOT1L inhibitors based on nonroutine carbocyclic C-nucleoside scaffolds. The exptl. observed SAR was found to be nontrivial as seemingly minor changes of individual substituents resulted in significant changes in the affinity to DOT1L. Mol. modeling suggested that these trends could be related to significant conformational changes of the protein upon interaction with the inhibitors. The compounds 22 and (-)-53 (MU1656), carbocyclic C-nucleoside analogs of the natural nucleoside derivative EPZ004777, and the clin. candidate EPZ5676 (pinometostat) potently and selectively inhibit DOT1L in vitro as well as in the cell. The most potent compound MU1656 was found to be more metabolically stable and significantly less toxic in vivo than pinometostat itself.

Journal of Medicinal Chemistry published new progress about 1338466-77-5. 1338466-77-5 belongs to tetrahydrofurans, auxiliary class Epigenetics,Histone Methyltransferase, name is 1-(3-((((2R,3S,4R,5R)-5-(4-Amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)(isopropyl)amino)propyl)-3-(4-(tert-butyl)phenyl)urea, and the molecular formula is C28H41N7O4, Safety of 1-(3-((((2R,3S,4R,5R)-5-(4-Amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)(isopropyl)amino)propyl)-3-(4-(tert-butyl)phenyl)urea.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Zavgorodnii, S. published the artcile1-Alkylthioalkylation of nucleoside hydroxyl functions and its synthetic applications: a new versatile method in nucleoside chemistry, Synthetic Route of 87865-78-9, the publication is Tetrahedron Letters (1991), 32(51), 7593-6, database is CAplus.

Treatment of appropriately protected nucleosides I (B = Thy, BzCyt, BzAde, IbGua; R = H) with a mixture of acetic acid, acetic anhydride and dialkyl sulfoxide was shown to give O-(1-alkylthioalkylated) nucleosides I (R = CH₂SMe) that were oxidized to the corresponding sulfoxides and sulfones I [R = CH₂S(O)_nMe, n = 1, 2], or converted via O-halomethyl derivatives I (R = CH₂Br, CH₂Cl) to various O-substituted nucleosides, e.g., II, [B¹ = Thy, Cyt, Ade, Gua; R¹ = CH₂F, CH₂N₃, CH₂CN, CH₂OMe, CH₂P(O)(OH)₂].

Tetrahedron Letters published new progress about 87865-78-9. 87865-78-9 belongs to tetrahydrofurans, auxiliary class Nucleosides and Nucleotides,Nucleoside Analogues, name is N-(9-((6aR,8R,9R,9aS)-9-Hydroxy-2,2,4,4-tetraisopropyltetrahydro-6H-furo[3,2-f][1,3,5,2,4]trioxadisilocin-8-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl)isobutyramide, and the molecular formula is C12H9NO, Synthetic Route of 87865-78-9.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Yu, Tzu-Yu published the artcileSafe, Scalable, Inexpensive, and Mild Nickel-Catalyzed Migita-Like C-S Cross-Couplings in Recyclable Water, Application of 2-Methyl-3-tetrahydrofuranthiol, the publication is Angewandte Chemie, International Edition (2021), 60(7), 3708-3713, database is CAplus and MEDLINE.

A new approach to C-S couplings is reported that relies on nickel catalysis under mild conditions, enabled by micellar catalysis in recyclable water as the reaction medium. The protocol tolerates a wide range of heteroaromatic halides and thiols, including alkyl and heteroaryl thiols, leading to a variety of thioethers in good isolated yields. The method is scalable, results in low residual metal in the products, and is applicable to syntheses of targets in the pharmaceutical area. The procedure also features an associated low E Factor, suggesting a far more attractive entry than is otherwise currently available, especially those based on unsustainable loadings of Pd catalysts.

Angewandte Chemie, International Edition published new progress about 57124-87-5. 57124-87-5 belongs to tetrahydrofurans, auxiliary class Tetrahydrofuran,Thiol, name is 2-Methyl-3-tetrahydrofuranthiol, and the molecular formula is C8H8O3, Application of 2-Methyl-3-tetrahydrofuranthiol.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Chen, Jinxiang published the artcilePyrolysis volatiles and environmental impacts of printing paper in air, COA of Formula: C4H6O3, the publication is Cellulose (Dordrecht, Netherlands) (2014), 21(4), 2871-2878, database is CAplus.

Pyrolysis volatiles and the environmental impact of printing paper in an air atm. were investigated using pyrolysis-gas chromatog./mass spectrometry and SEM. CO₂ and light-pollution products were found to be the major products from pyrolysis volatiles; furthermore, because oxygen participates in the chem. reaction, many of the pyrolysis volatiles emitted during the paper printing process were different from those formed under an N₂ atmosphere. Although a small number of the volatiles were moderately toxic products, the concentrations of these volatiles were low. Heat-induced inkless eco-printing (HIEP) was found to take less time than the pyrolysis experiment in this paper and thus resulted in fewer pyrolysis volatiles. Thus, fewer pyrolysis volatiles will be emitted within the practical temperature range; in particular, no carcinogens were emitted in the pyrolysis temperature range of 250-700 °C. Therefore, HIEP was found to be an ecol. and environmentally preferable technol.

Cellulose (Dordrecht, Netherlands) published new progress about 19444-84-9. 19444-84-9 belongs to tetrahydrofurans, auxiliary class Tetrahydrofuran,Ester,Alcohol, name is 3-Hydroxydihydrofuran-2(3H)-one, and the molecular formula is C4H6O3, COA of Formula: C4H6O3.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Gibbons, Garrett S. published the artcileRegulation of Wnt Signaling Target Gene Expression by the Histone Methyltransferase DOT1L, Formula: C28H41N7O4, the publication is ACS Chemical Biology (2015), 10(1), 109-114, database is CAplus and MEDLINE.

The histone methyltransferase DOT1L, solely responsible for histone H3 lysine 79 (H3K79) methylation, is associated with gene activation. Human leukemias carrying MLL gene rearrangements aberrantly recruit DOT1L to leukemogenic genes leading to increased H3K79 methylation and their transcriptional activation. Recent studies suggest that Wnt-targeted genes also depend on H3K79 methylation. Employing a chem. biol. approach, the requirement for H3K79 methylation was investigated in Wnt pathway-inducible HEK293 cells and human colon adenocarcinoma-derived cell lines by inhibiting DOT1L with EPZ004777, a selective and potent S-adenosylmethionine competitive inhibitor. Our findings indicate that H3K79 methylation is not essential for the canonical Wnt signaling pathway, in particular for maintenance or activation of Wnt pathway target gene expression. Furthermore, H3K79 methylation is not elevated in human colon carcinoma samples in comparison with normal colon tissue. Therefore, our findings indicate that inhibition of DOT1L histone methyltransferase activity is likely not a viable therapeutic strategy in colon cancer.

ACS Chemical Biology published new progress about 1338466-77-5. 1338466-77-5 belongs to tetrahydrofurans, auxiliary class Epigenetics,Histone Methyltransferase, name is 1-(3-((((2R,3S,4R,5R)-5-(4-Amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)(isopropyl)amino)propyl)-3-(4-(tert-butyl)phenyl)urea, and the molecular formula is C28H41N7O4, Formula: C28H41N7O4.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Seow, Yi-Xin published the artcileOdor-specific loss of smell sensitivity with age as revealed by the specific sensitivity test, Synthetic Route of 57124-87-5, the publication is Chemical Senses (2016), 41(6), 487-495, database is CAplus and MEDLINE.

The perception of odor mixtures plays an important role in human food intake, behavior, and emotions. Decline of smell acuity with normal aging could impact food perception and preferences at various ages. However, since the landmark Smell Survey by National Geog., little has been elucidated on differences in the onset and extent of loss in olfactory sensitivity toward single odorants. Here, using the Specific Sensitivity test, we show the onset and extent of loss in both identification and detection thresholds of odorants with age are odorant-specific. Subjects of Chinese descent in Singapore (186 women, 95 men), aged 21-80 years, were assessed for olfactory sensitivity of 10 odorants from various odor groups. Notably, subjects in their 70s required 179 times concentration of rose-like odorant (2-phenylethanol) than subjects in the 20s, while thresholds for onion-like 2-methyloxolane-3-thiol only differed by 3 times between the age groups. In addition, identification rate for 2-phenylethanol was neg. correlated with age throughout adult life whereas mushroom-like oct-1-en-3-ol was equally identified by subjects across all ages. Our results demonstrated the girth of differentiated olfactory loss due to normal ageing, which potentially affect overall perception and preferences of odor mixtures with age.

Chemical Senses published new progress about 57124-87-5. 57124-87-5 belongs to tetrahydrofurans, auxiliary class Tetrahydrofuran,Thiol, name is 2-Methyl-3-tetrahydrofuranthiol, and the molecular formula is CBF6K, Synthetic Route of 57124-87-5.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Daigle, Scott R. published the artcileSelective Killing of Mixed Lineage Leukemia Cells by a Potent Small-Molecule DOT1L Inhibitor, Category: tetrahydrofurans, the publication is Cancer Cell (2011), 20(1), 53-65, database is CAplus and MEDLINE.

Mislocated enzymic activity of DOT1L has been proposed as a driver of leukemogenesis in mixed lineage leukemia (MLL). The characterization of EPZ004777, a potent, selective inhibitor of DOT1L is reported. Treatment of MLL cells with the compound selectively inhibits H3K79 methylation and blocks expression of leukemogenic genes. Exposure of leukemic cells to EPZ004777 results in selective killing of those cells bearing the MLL gene translocation, with little effect on non-MLL-translocated cells. Finally, in vivo administration of EPZ004777 leads to extension of survival in a mouse MLL xenograft model. These results provide compelling support for DOT1L inhibition as a basis for targeted therapeutics against MLL.

Cancer Cell published new progress about 1338466-77-5. 1338466-77-5 belongs to tetrahydrofurans, auxiliary class Epigenetics,Histone Methyltransferase, name is 1-(3-((((2R,3S,4R,5R)-5-(4-Amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)(isopropyl)amino)propyl)-3-(4-(tert-butyl)phenyl)urea, and the molecular formula is C28H41N7O4, Category: tetrahydrofurans.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem