Heterocyclic Building Blocks-Tetrahydrofuran

Chakraborty, Amit published the artcileDisulfide-based protecting groups for the cysteine side chain, Formula: C5H10OS, the publication is Organic Letters (2020), 22(24), 9644-9647, database is CAplus and MEDLINE.

Two new disulfide-based protecting groups (SIT and MOT) (I and II) are proposed for Cys thiol in the substitution of StBu, which is often difficult to remove. Both groups are based on a secondary thiol with a branched point in the β-position for an efficient modulation of its lability and/or stability. This unique structure allows them to be fully compatible with Fmoc/tBu SPPS (Fmoc = 9-fluorenylmethoxycarbonyl). At the end of the synthesis, these groups are removed in a straightforward manner with dithiothreitol with some H₂O.

Organic Letters published new progress about 57124-87-5. 57124-87-5 belongs to tetrahydrofurans, auxiliary class Tetrahydrofuran,Thiol, name is 2-Methyl-3-tetrahydrofuranthiol, and the molecular formula is C5H10OS, Formula: C5H10OS.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Niu, Ningning published the artcileBromodomain and Extra-terminal (BET) Protein Inhibitors Suppress Chondrocyte Differentiation and Restrain Bone Growth, Product Details of C28H41N7O4, the publication is Journal of Biological Chemistry (2016), 291(52), 26647-26657, database is CAplus and MEDLINE.

Small mol. inhibitors for bromodomain and extra-terminal (BET) proteins have recently emerged as potential therapeutic agents in clin. trials for various cancers. However, to date, it is unknown whether these inhibitors have side effects on bone structures. Here, we report that inhibition of BET bromodomain proteins may suppress chondrocyte differentiation and restrain bone growth. We generated a luciferase reporter system using the chondrogenic cell line ATDC5 in which the luciferase gene was driven by the promoter of Col2a1, an elementary collagen of the chondrocyte. The Col2a1-luciferase ATDC5 system was used for rapidly screening both activators and repressors of human collagen Col2a1 gene expression, and we found that BET bromodomain inhibitors reduce the Col2a1-luciferase. Consistent with the luciferase assay, BET inhibitors decrease the expression of Col2a1. Furthermore, we constructed a zebrafish line in which the enhanced green fluorescent protein (EGFP) expression was driven by col2a1 promoter. The transgenic (col2a1-EGFP) zebrafish line demonstrated that BET inhibitors I-BET151 and (+)-JQ1 may affect EGFP expression in zebrafish. Furthermore, we found that I-BET151 and (+)-JQ1 may affect chondrocyte differentiation in vitro and inhibit zebrafish growth in vivo. Mechanistic anal. revealed that BET inhibitors influenced the depletion of RNA polymerase II from the Col2a1 promoter. Collectively, these results suggest that BET bromodomain inhibition may have side effects on skeletal bone structures.

Journal of Biological Chemistry published new progress about 1338466-77-5. 1338466-77-5 belongs to tetrahydrofurans, auxiliary class Epigenetics,Histone Methyltransferase, name is 1-(3-((((2R,3S,4R,5R)-5-(4-Amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)(isopropyl)amino)propyl)-3-(4-(tert-butyl)phenyl)urea, and the molecular formula is C28H41N7O4, Product Details of C28H41N7O4.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Premkumar, Kavitha published the artcileIdentification of EPZ004777 and FG2216 as inhibitors of TGF-β1 induced Treg cells by screening a library of epigenetic compounds, Computed Properties of 1338466-77-5, the publication is Life Sciences (2022), 120643, database is CAplus and MEDLINE.

Regulatory T cells play an essential role in immune tolerance and homeostasis. Their long-term stability depends on epigenetic modifications and identification of small mol. modulators of Treg differentiation therefore has many applications. In this study, we performed a novel functional screen of an epigenetic compound library to identify compounds that can modulate generation of TGF-β1 induced T regulatory cells. A screening strategy based on IFN-γ ELISA was designed to screen epigenetic compound library. Effect of hit compounds on Treg phenotype and function was assessed by RT-PCR, flow cytometry and suppression assays. TGF-β signalling proteins were assayed by western blotting. Chromatin Immunoprecipitation (ChIP) assay was used to assess epigenetic modifications at Foxp3 gene locus. We screened 160 compounds to identify hits capable of reversing TGF-β induced inhibition of IFN-γ production in activated spleen cells and CD4+ T cells. Two compounds EPZ004777 and FG-2216 consistently reversed TGF-β1 iTregs in terms of (a) differentiation of naive T cells into CD4+CD25+Foxp3+Treg cells, (b) Foxp3 target gene expression and (c) Treg suppressive function without affecting TGF-β downstream signalling. ChIP assay revealed that the compounds were able to reverse – TGF- β mediated decrease in epigenetic marks H3K27me3 and 5-mC and an increase in epigenetic marks H3K4me3 and H3K27Ac in the promoter and conserved non coding sequence (CNS1) regions of the Foxp3 gene. EPZ004777 and FG-2216 have been identified as potent epigenetic modulators that can reverse TGF-β1 induced T regulatory cells and may be used to treat diverse immune disorders.

Life Sciences published new progress about 1338466-77-5. 1338466-77-5 belongs to tetrahydrofurans, auxiliary class Epigenetics,Histone Methyltransferase, name is 1-(3-((((2R,3S,4R,5R)-5-(4-Amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)(isopropyl)amino)propyl)-3-(4-(tert-butyl)phenyl)urea, and the molecular formula is C28H41N7O4, Computed Properties of 1338466-77-5.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Wu, Haijun published the artcileEthanol-Assisted Hydrothermal Liquefaction of Poplar Using Fe-Co/Al₂O₃ as Catalyst, Recommanded Product: 3-Hydroxydihydrofuran-2(3H)-one, the publication is Energies (Basel, Switzerland) (2022), 15(9), 3057, database is CAplus.

Although the conversion of lignocellulosic biomass into bio-oil with high yield/quality through hydrothermal liquefaction (HTL) is promising, it still faces many challenges. In this study, a Fex-Co(1-x)/Al₂O₃ catalyst was prepared with the coprecipitation method and low-content ethanol was used as the cosolvent for the HTL of poplar. The results showed that the Fex-Co(1-x)/Al₂O₃ catalyst significantly promoted the yield and energy recovery rate (ERR) of bio-oil compared with the control (10% ethanol content). At 260 °C for 30 min, 60Fe-40Co/Al₂O₃ had the best catalytic effect, achieving the highest bio-oil yield (67.35%) and ERR (93.07%). As a multifunctional bimetallic catalyst, Fex-Co(1-x)/Al₂O₃ could not only increase the degree of hydrogenation deoxidization of the product but also promote the diversity of phenolic compounds gained from lignin. The bio-oil obtained from HTL with Fex-Co(1-x)/Al₂O₃ as catalyst contained lower heterocyclic nitrogen, promoting the transfer of more bio-oil components to substances with lower b.p.

Energies (Basel, Switzerland) published new progress about 19444-84-9. 19444-84-9 belongs to tetrahydrofurans, auxiliary class Tetrahydrofuran,Ester,Alcohol, name is 3-Hydroxydihydrofuran-2(3H)-one, and the molecular formula is C22H18O2, Recommanded Product: 3-Hydroxydihydrofuran-2(3H)-one.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Wojtczak, Blaej published the artcileGeneral method for the synthesis of 2′-O-carboranyl-nucleosides, COA of Formula: C26H45N5O7Si2, the publication is Tetrahedron Letters (2005), 46(23), 3969-3972, database is CAplus.

The carboranyl cage is a new modifying entity for nucleosides, DNA oligonucleotides, and other biomols. Herein, the first reliable method for the synthesis of nucleosides modified with a carborane cluster at the 2′-position is described.

Tetrahedron Letters published new progress about 87865-78-9. 87865-78-9 belongs to tetrahydrofurans, auxiliary class Nucleosides and Nucleotides,Nucleoside Analogues, name is N-(9-((6aR,8R,9R,9aS)-9-Hydroxy-2,2,4,4-tetraisopropyltetrahydro-6H-furo[3,2-f][1,3,5,2,4]trioxadisilocin-8-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl)isobutyramide, and the molecular formula is C5H5BrN2, COA of Formula: C26H45N5O7Si2.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Deepa, J. published the artcilePreliminary phytochemical screening and GC-MS analysis of methanolic leaf extract of Drypetes sepiaria (Wight & Arn.) Pax. & Hoffim. from Silambur sacred grove, Tamilnadu, Category: tetrahydrofurans, the publication is Journal of Chemical and Pharmaceutical Research (2016), 8(8), 287-291, database is CAplus.

A valuable Indian ethnomedicinal plant, Drypetes sepiaria (Wight & Arn.) Pax. & Hoffim was investigated to determine the phytochem. constituents present in various extracts of the leaves through GC-MS (Gas Chromatog.-Mass Spectrometry) anal. Powd. leaf plant materials were subjected to successive extraction with organic solvents such as methanol by Soxhlet extraction method. In the present study, a total of 23 different compounds identified by GC-MS anal. using methanol extract, all the identified compounds were medicinally valuable for the treatment of various human ailments. In addition, all the phytochem. compounds were needed for further investigations on toxicol. aspects for the development of new lead of therapeutic interest.

Journal of Chemical and Pharmaceutical Research published new progress about 19444-84-9. 19444-84-9 belongs to tetrahydrofurans, auxiliary class Tetrahydrofuran,Ester,Alcohol, name is 3-Hydroxydihydrofuran-2(3H)-one, and the molecular formula is C4H6O3, Category: tetrahydrofurans.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Zarini, Daniele published the artcileAre In Silico Approaches Applicable As a First Step for the Prediction of e-Liquid Toxicity in e-Cigarettes?, Name: 2-Methyl-3-tetrahydrofuranthiol, the publication is Chemical Research in Toxicology (2020), 33(9), 2381-2389, database is CAplus and MEDLINE.

Recent studies have raised concerns about e-cigarette liquid inhalation toxicity by reporting the presence of chems. with European Union CLP toxicity classification. In this scenario, the regulatory context is still developing and is not yet up to date with vaping current reality. Due to the paucity of toxicol. studies, robust data regarding which components in tent. In this study we applied computational methods for studied chems. as a useful tool for predicting the acute toxicity of chems. contained in e-liquids The purpose of t the potential health concerns associated with e-liquid ingredients, (b) to prioritize e-liquid ingredients by calculating the e-tox index, and (c) to estimate acute toxicity of e-liquid mixtures QSAR models were generated using QSARINS software to fill the acute toxicity data gap of 264 e-liquid ingredients. As a second step, the potential acute toxicity of e-liquids mixtures was evaluated. Our preliminary data suggest that a computational approa serve as a roadmap to enable regulatory bodies to better regulate e-liquid composition and to contribute to consumer health protection.

Chemical Research in Toxicology published new progress about 57124-87-5. 57124-87-5 belongs to tetrahydrofurans, auxiliary class Tetrahydrofuran,Thiol, name is 2-Methyl-3-tetrahydrofuranthiol, and the molecular formula is C5H5N3S, Name: 2-Methyl-3-tetrahydrofuranthiol.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Langa-Lomba, Natalia published the artcileActivity of Anthracenediones and Flavoring Phenols in Hydromethanolic Extracts of Rubia tinctorum against Grapevine Phytopathogenic Fungi, Application In Synthesis of 19444-84-9, the publication is Plants (2021), 10(8), 1527, database is CAplus and MEDLINE.

In this work, the chem. composition of Rubia tinctorum root hydromethanolic extract was analyzed by GC-MS, and over 50 constituents were identified. The main phytochems. were alizarin-related anthraquinones and flavoring phenol compounds The antifungal activity of this extract, alone and in combination with chitosan oligomers (COS) or with stevioside, was evaluated against the pathogenic taxa Diplodia seriata, Dothiorella viticola and Neofusicoccum parvum, responsible for the so-called Botryosphaeria dieback of grapevine. In vitro mycelial growth inhibition tests showed remarkable activity for the pure extract, with EC50 and EC90 values as low as 66 and 88 μg·mL-1, resp. Nonetheless, enhanced activity was attained upon the formation of conjugate complexes with COS or with stevioside, with synergy factors of up to 5.4 and 3.3, resp., resulting in EC50 and EC90 values as low as 22 and 56 μg·mL-1, resp. The conjugate with the best performance (COS-R. tinctorum extract) was then assayed ex situ on autoclaved grapevine wood against D. seriata, confirming its antifungal behavior on this plant material. Finally, the same conjugate was evaluated in greenhouse assays on grafted grapevine plants artificially inoculated with the three aforementioned fungal species, resulting in a significant reduction in the infection rate in all cases. This natural antifungal compound represents a promising alternative for developing sustainable control methods against grapevine trunk diseases.

Plants published new progress about 19444-84-9. 19444-84-9 belongs to tetrahydrofurans, auxiliary class Tetrahydrofuran,Ester,Alcohol, name is 3-Hydroxydihydrofuran-2(3H)-one, and the molecular formula is C4H6O3, Application In Synthesis of 19444-84-9.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Bokov, D. O. published the artcileComparison of the Chemical Compositions of Galanthus woronowii Losinsk. and Galanthus nivalis L. Homeopathic Mother Tinctures by Gas Chromatography with Mass-Selective Detection, Category: tetrahydrofurans, the publication is Pharmaceutical Chemistry Journal (2017), 50(10), 659-667, database is CAplus.

The chem. compositions of homeopathic mother tinctures (HMT) from the two snowdrop species Galanthus woronowii Losinsk. and Galanthus nivalis L. were compared using gas chromatog. with mass-selective detection (GC-MS). A total of 13 compounds were identified in G. woronowii HMT; 42, in G. nivalis HMT. The common constituents of the two tinctures were ethyl-α-D-glucopyranoside, ethyl-α-D-riboside, Et linoleate, and 2,3-dihydro-3,5-dihydroxy-6-methyl-4H-pyran-4-one. The main marker compounds (galantamine and licorine) were determined Their contents were used to standardize the homeopathic drugs.

Pharmaceutical Chemistry Journal published new progress about 19444-84-9. 19444-84-9 belongs to tetrahydrofurans, auxiliary class Tetrahydrofuran,Ester,Alcohol, name is 3-Hydroxydihydrofuran-2(3H)-one, and the molecular formula is C4H6O3, Category: tetrahydrofurans.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Lackey, Jeremy G. published the artcileToward the discovery of new antifungal agents: the design and validation of a novel 2’P-RNA probe and high throughput screening assay against 2′-phosphotransferase Tpt1p, Category: tetrahydrofurans, the publication is Nucleic Acids Symposium Series (2008), 52(1), 475-476, database is CAplus and MEDLINE.

We report the solid-phase synthesis of novel 2’P-RNA probes for use in fluorescence polarization (FP) ligand binding assays that screens for inhibitors of the yeast 2′-phosphotransferase Tpt1p. The probe was synthesized by utilizing silyl phosphoramidite chem. and a phosphoramidite synthon containing an orthogonal (DMT) protecting group at its 2′-position. Regioselective removal of the 2′-DMT group and phosphitylation of the unmasked 2′-hydroxyl group afforded the desired 2’P-RNA sequence.

Nucleic Acids Symposium Series published new progress about 87865-78-9. 87865-78-9 belongs to tetrahydrofurans, auxiliary class Nucleosides and Nucleotides,Nucleoside Analogues, name is N-(9-((6aR,8R,9R,9aS)-9-Hydroxy-2,2,4,4-tetraisopropyltetrahydro-6H-furo[3,2-f][1,3,5,2,4]trioxadisilocin-8-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl)isobutyramide, and the molecular formula is C26H45N5O7Si2, Category: tetrahydrofurans.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem