Heterocyclic Building Blocks-Tetrahydrofuran

Ni, Zhi-Jing published the artcileAnalysis of key precursor peptides and flavor components of flaxseed derived Maillard reaction products based on iBAQ mass spectrometry and molecular sensory science, Recommanded Product: 2-Methyl-3-tetrahydrofuranthiol, the publication is Food Chemistry: X (2022), 100224, database is CAplus and MEDLINE.

Flaxseed derived Maillard reaction products (MRPs) have typical meaty flavor, but there is no report on comparison of their amino acids and peptides reactivity. The peptides and amino acids of flaxseed protein hydrolyzates were sep. collected by G-15 gel chromatog. Taste dilution anal. (TDA) showed that peptides-MRPs had high umami, mouthfulness, and continuity enhancement. Further, LC-MS/MS revealed that flaxseed protein hydrolyzates consumed 41 peptides after Maillard reaction. Particularly, DLSFIP (Asp-Leu-Ser-Phe-Ile-Pro) and ELPGSP (Glu-Leu-Pro-Gly-Ser-Pro) accounted for 42.22% and 20.41% of total consumption, resp. Aroma extract dilution anal. (AEDA) indicated that formation of sulfur-containing flavors was dependent on cysteine, while peptides were more reactive than amino acids for nitrogen-containing heterocycles. On the other hand, 11 flavor compounds with flavor dilution (FD) ≥ 64 were identified for flaxseed derived MRPs, such as 2-methylthiophene, 2-methyl-3-furanthiol, furfural, 2-furfurylthiol, 3-thiophenethiol, thieno[3,2-b] thiophene, 2,5-thiophenedicarboxaldehyde, 2-methylthieno[2,3-b] thiophene, 1-(2-methyl-3-furylthio)-ethanethiol, 2-methylthieno[3,2-b] thiophene, and bis(2-methyl-3-furyl)-disulfide. In addition, we further demonstrated the flavors formation mechanism of flaxseed derived MRPs.

Food Chemistry: X published new progress about 57124-87-5. 57124-87-5 belongs to tetrahydrofurans, auxiliary class Tetrahydrofuran,Thiol, name is 2-Methyl-3-tetrahydrofuranthiol, and the molecular formula is C5H10OS, Recommanded Product: 2-Methyl-3-tetrahydrofuranthiol.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Wang, Wen-peng published the artcileIsolation and identification of three anaerobic bacteria strains in Luzhou-flavor liquor and metabolites analysis, HPLC of Formula: 19444-84-9, the publication is Shipin Keji (2018), 43(2), 15-20, database is CAplus.

In this experiment, anaerobic bacteria were isolated from pit mud under anaerobic condition, and the metabolites were analyzed by GC-MS and through colony morphol. observation, Gram staining, spore staining, biochem. test, phospholipid fatty acid anal. and 16S rDNA identification. Three strains of bacteria were screened, resp. named as SJ-1, SJ-2 and SJ-3. It was obtained from the anal. and identification that SJ-1 is Bacillus liciusiformis, SJ-2 is Bacillus aerius, and SJ-3 is Clostridium butyricum subsp. The results of the fermentation products showed that the main products of the three strains such as butyric acid, n-butanol, acetic acid, 2,3-butanediol that are the skeletal components in the micro components of Luzhou-flavor liquor, Strain SJ-3 had good performance, and its yield of butyric acid was 202.56 mg/mL, indicating that the three strains play a pos. role in the production of flavor substances in the Luzhou-flavor liquor.

Shipin Keji published new progress about 19444-84-9. 19444-84-9 belongs to tetrahydrofurans, auxiliary class Tetrahydrofuran,Ester,Alcohol, name is 3-Hydroxydihydrofuran-2(3H)-one, and the molecular formula is C13H11NO, HPLC of Formula: 19444-84-9.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Chen, Zhuo published the artcileAcenaphtho[1,2-b]pyrrole-Based Selective Fibroblast Growth Factor Receptors 1 (FGFR1) Inhibitors: Design, Synthesis, and Biological Activity, Application of 2-Methyl-3-tetrahydrofuranthiol, the publication is Journal of Medicinal Chemistry (2011), 54(11), 3732-3745, database is CAplus and MEDLINE.

A novel series of acenaphtho[1,2-b]pyrrole derivatives as potent and selective inhibitors of fibroblast growth factor receptor 1 (FGFR1) were designed and synthesized. In silico target prediction revealed that tyrosine kinases might be the potential targets of the representative compound I, which was subsequently validated by ELISA for its selective and active FGFR1 inhibition of various tyrosine kinases. The structure-activity relationship (SAR) anal. aided by mol. docking simulation in the ATP-binding site demonstrated that acenaphtho[1,2-b]pyrrolecarboxylic acid esters are potent inhibitors of FGFR1 with IC₅₀ values ranging from 19 to 77 nM. Furthermore, these compounds exhibited favorable growth inhibition property against FGFR-expressing cancer cell lines with IC₅₀ values ranging from micromolar to submicromolar. Western blotting anal. showed that three of these compounds inhibited activation of FGFR1 and extracellular-signal regulated kinase 1/2 (Erk1/2).

Journal of Medicinal Chemistry published new progress about 57124-87-5. 57124-87-5 belongs to tetrahydrofurans, auxiliary class Tetrahydrofuran,Thiol, name is 2-Methyl-3-tetrahydrofuranthiol, and the molecular formula is C5H10OS, Application of 2-Methyl-3-tetrahydrofuranthiol.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Spanik, I. published the artcileA comparative study of various sample preparation procedures for characterization of organic compounds in brandy, SDS of cas: 19444-84-9, the publication is Uchenye Zapiski Kazanskogo Universiteta, Seriya Estestvennye Nauki (2014), 156(4), 8-28, database is CAplus.

This paper describes the composition of volatile compounds in 19 different wine distillates was studied by gas chromatog. (GC) coupled with flame ionization (FID) or mass-spectrometric (MS) detector. The studied samples were divided into two groups depending on the way of their production and geog. region. The effect of various sample treatment procedures on final composition of volatiles was investigated in details. The effectiveness of direct injection, headspace, solid phase extraction (SPE), solid phase microextraction (SPME) and liquid-liquid extraction (LLE) was compared. Moreover, the effect of exptl. conditions of preconcentration methods such as type of sorbent, temperature, time or solvent removal procedure was studied in details. The repeatability of particular sample preparation procedure was evaluated by comparison of peak areas for randomly selected compounds obtained from 4 parallel measurements. It was shown that the most suitable sample treatment procedure in terms of repeatability is SPE followed by direct injection and headspace. LLE and SPME provide higher variability of peak areas, thus utilization of internal standard for quantification is recommended. On the contrary, the most suitable sample treatment procedure in terms of the number of different type of compounds is liquid-liquid extraction into CH₂Cl₂. By this method, more than 240 compounds have been extracted from wine distillates produced by classical technol. Furthermore, SPME has shown different selectivity which allows one to determine compounds that could not be extracted by other studied sample preparation methods.

Uchenye Zapiski Kazanskogo Universiteta, Seriya Estestvennye Nauki published new progress about 19444-84-9. 19444-84-9 belongs to tetrahydrofurans, auxiliary class Tetrahydrofuran,Ester,Alcohol, name is 3-Hydroxydihydrofuran-2(3H)-one, and the molecular formula is C30H24BrCuN2P, SDS of cas: 19444-84-9.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Binh, Nguyen Tan published the artcileBioactive compounds from marine fungus penicillium citrinum strain ND7c by gas chromatography-mass spectrometry, Quality Control of 19444-84-9, the publication is Pharmaceutical and Chemical Journal (2018), 5(1), 211-224, database is CAplus.

The objectives of this study were anal. of the secondary metabolite products from extract of marine Penicillium citrinum strain ND7a which isolated from sponges at Ha Tien Sea, Kien Giang province, Vietnam. Sixteen bioactive compounds were identified in the organic solvent hexan-aceton and aceton-methanol. The identification of bioactive chem. compounds is based on the peak area, retention time, mol. weight and mol. formular. GC-MS anal. of Penicillium citrinum strain ND7a revealed the existence of the 9-Hexadecenoic acid, Hexadecane, n-Hexadecanoic acid, Heptacosane, Octadecane, 3-ethyl-5-(2-ethylbutyl), Tri-Bu acetylcitrate, 17-Pentatriacontene, Hexanedioic acid, bis(2-ethylhexyl) ester, Bis(2-ethylhexyl) phthalate (in organic solvent hexan-aceton) and Oxime-, methoxy-Ph, 2-Hydroxy-gamma-butyrolactone, 7,9-Di-tert-butyl-1-oxaspiro(4,5)deca-6,9-diene-2,8-dione, Pentadecanoic acid, 14-methyl-, Me ester, Hexadecanoic acid, 1-(hydroxymethyl)-1,2-ethanediyl ester, Stigmasterol, γ-Sitosterol (in organic solvent aceton-methanol).

Pharmaceutical and Chemical Journal published new progress about 19444-84-9. 19444-84-9 belongs to tetrahydrofurans, auxiliary class Tetrahydrofuran,Ester,Alcohol, name is 3-Hydroxydihydrofuran-2(3H)-one, and the molecular formula is C4H6O3, Quality Control of 19444-84-9.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Li, Yuehui published the artcileLewis Acid Promoted Ruthenium(II)-Catalyzed Etherifications by Selective Hydrogenation of Carboxylic Acids/Esters, Recommanded Product: 3-Hydroxydihydrofuran-2(3H)-one, the publication is Angewandte Chemie, International Edition (2015), 54(17), 5196-5200, database is CAplus and MEDLINE.

Ethers are of fundamental importance in organic chem. and they are an integral part of valuable flavors, fragrances, and numerous bioactive compounds In general, the reduction of esters constitutes the most straightforward preparation of ethers. Unfortunately, this transformation requires large amounts of metal hydrides. Presented herein is a bifunctional catalyst system, consisting of Ru/phosphine complex and aluminum triflate, which allows selective synthesis of ethers by hydrogenation of esters or carboxylic acids. Different lactones were reduced in good yields to the desired products. Even challenging aromatic and aliphatic esters were reduced to the desired products. Notably, the in situ formed catalyst can be reused several times without any significant loss of activity.

Angewandte Chemie, International Edition published new progress about 19444-84-9. 19444-84-9 belongs to tetrahydrofurans, auxiliary class Tetrahydrofuran,Ester,Alcohol, name is 3-Hydroxydihydrofuran-2(3H)-one, and the molecular formula is C4H6O3, Recommanded Product: 3-Hydroxydihydrofuran-2(3H)-one.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Dellinger, Douglas J. published the artcileStreamlined Process for the Chemical Synthesis of RNA Using 2′-O-Thionocarbamate-Protected Nucleoside Phosphoramidites in the Solid Phase, Product Details of C26H45N5O7Si2, the publication is Journal of the American Chemical Society (2011), 133(30), 11540-11556, database is CAplus and MEDLINE.

An improved method for the chem. synthesis of RNA was developed utilizing a streamlined method for the preparation of phosphoramidite monomers and a single-step deprotection of the resulting oligoribonucleotide product using 1,2-diamines under anhydrous conditions. The process is compatible with most standard hetero-base protection and employs a 2′-O-(1,1-dioxo-1λ⁶-thio-morpholine-4-carbo-thioate) as a unique 2′-hydroxyl protective group. Using this approach, it was demonstrated that the chem. synthesis of RNA can be as simple and robust as the chem. synthesis of DNA.

Journal of the American Chemical Society published new progress about 87865-78-9. 87865-78-9 belongs to tetrahydrofurans, auxiliary class Nucleosides and Nucleotides,Nucleoside Analogues, name is N-(9-((6aR,8R,9R,9aS)-9-Hydroxy-2,2,4,4-tetraisopropyltetrahydro-6H-furo[3,2-f][1,3,5,2,4]trioxadisilocin-8-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl)isobutyramide, and the molecular formula is C26H45N5O7Si2, Product Details of C26H45N5O7Si2.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Karuppiah, Vijayakumar published the artcileAnti-quorum sensing and antibiofilm potential of 1,8-cineole derived from Musa paradisiaca against Pseudomonas aeruginosa strain PAO1, Name: 3-Hydroxydihydrofuran-2(3H)-one, the publication is World Journal of Microbiology & Biotechnology (2021), 37(4), 66, database is CAplus and MEDLINE.

Abstract: Pseudomonas aeruginosa is one of the vulnerable opportunistic pathogens associated with nosocomial infections, cystic fibrosis, burn wounds and surgical site infections. Several studies have reported that quorum sensing (QS) systems are controlled the P. aeruginosa pathogenicity. Hence, the targeting of QS considered as an alternative approach to control P. aeruginosa infections. This study aimed to evaluate the anti-quorum sensing and antibiofilm inhibitory potential of Musa paradisiaca against Chromobacterium violaceum (ATCC 12472) and Pseudomonas aeruginosa. The methanol extract of M. paradisiacsa exhibits that better antibiofilm potential against P. aeruginosa. Then, the crude methanol extract was subjected to purify by column chromatog. and collected the fractions. The mass-spectrometric anal. of a methanol extract of M. paradisiaca revealed that 1,8-cineole is the major compounds 1, 8-cineole significantly inhibited the QS regulated violacein production in C. violaceum. Moreover, 1,8-cineole significantly inhibited the QS mediated virulence production and biofilm formation of P. aeruginosa without affecting their growth. The real-time PCR anal. showed the downregulation of autoinducer synthase and transcriptional regulator genes upon 1,8-cineole treatment. The findings of the present study strongly suggested that metabolite of M. paradisiaca impedes P. aeruginosa QS system and associated virulence productions.

World Journal of Microbiology & Biotechnology published new progress about 19444-84-9. 19444-84-9 belongs to tetrahydrofurans, auxiliary class Tetrahydrofuran,Ester,Alcohol, name is 3-Hydroxydihydrofuran-2(3H)-one, and the molecular formula is C4H6O3, Name: 3-Hydroxydihydrofuran-2(3H)-one.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Malathi, H. published the artcileThin layer chromatography and GC-MS analysis of bioactive molecules of the Acacia ferruginea DC. thorn extract, Related Products of tetrahydrofurans, the publication is Asian Journal of Biological and Life Sciences (2021), 10(1), 110-117, database is CAplus.

The aim of the current study is to investigate thethin layer chromatog. (TLC) and gas chromatog. and mass spectroscopy anal. (GC-MS) of methanolic extract of Acacia ferruginea thorns. The bioactive mols. were determined by qual. TLC and GC-MS method. In TLC exhibited maximum 0.6 retention factor (RF) value of the plant extract in F254 wavelength in dark blue color, F366 wave length and in visible light not shown any peaks and RF values. In the GC-MS anal., 37 bioactive mols. were exhibited and in that 10 are in higher concentration by the retention time and their % of peak and area covered in the anal. compared to other chromatograms of the fractions. Important compounds identified as Me mannose (57.14), Phenol, 2-methoxy-3-(2-propenyl)- (4.85), stigmasterol (4.65), 1-Hexacosanol (3.83), Lupeol (3.60), gamma Sitosterol (3.52), Phenol, 4-[2-(dimethylamino)ethyl]-(3.17), Ergost-5-en- 3-ol, (3.beta.)- (2.53), Oleic acid (2.44), Oleoyl chloride (1.53), Sucrose (1.82). The presence of these bioactive mols. in the plant extract may provide the scientific evidences for the cytotoxic effect, insecticidal and other biol. properties.

Asian Journal of Biological and Life Sciences published new progress about 19444-84-9. 19444-84-9 belongs to tetrahydrofurans, auxiliary class Tetrahydrofuran,Ester,Alcohol, name is 3-Hydroxydihydrofuran-2(3H)-one, and the molecular formula is C4H6O3, Related Products of tetrahydrofurans.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Peng, Yuhan published the artcileAnalysis of pyrolysis behaviors of biomass extractives via non-linear stepwise heating program based on Gaussian multi-peak fitting of differential thermogravimetric curve, Quality Control of 19444-84-9, the publication is Thermochimica Acta (2021), 178976, database is CAplus.

The thermal decomposition of extractives can yield addnl. products, resulting in a different final product distribution of bio-oil, especially for extractives-rich biomass. However, the thermal decomposition behavior of extractives themselves has long been ignored, but deserves deep investigation. Herein, the non-linear stepwise heating program based on Gaussian multi-peak fitting of differential thermogravimetric curve for biomass extractives was designed. Using this stepwise heating program, the pyrolysis process of different chem. substances in biomass extractives was effectively decoupled and systematically studied. As for water-soluble extractives, the evaporation of volatile substances, the thermal decomposition of water-soluble carbohydrates, phenolic substances, and nitrogenous substances proceed in sequence with the increase of temperature during the pyrolysis process. With regard to liposol. extractives, the pyrolysis included the volatilization of endogenous substances and the thermal decomposition of different lipids into olefins. This work provides a systematic understanding of thermal decomposition process in the extractives of lignocellulosic biomass.

Thermochimica Acta published new progress about 19444-84-9. 19444-84-9 belongs to tetrahydrofurans, auxiliary class Tetrahydrofuran,Ester,Alcohol, name is 3-Hydroxydihydrofuran-2(3H)-one, and the molecular formula is C4H6O3, Quality Control of 19444-84-9.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem