Heterocyclic Building Blocks-Tetrahydrofuran

Guan, Yinshuang published the artcileDepolymerization of alkaline lignin over mesoporous KF/γ-Al₂O₃, COA of Formula: C4H6O3, the publication is New Journal of Chemistry (2020), 44(34), 14411-14420, database is CAplus.

As a kind of biomass resource, lignin is the only natural renewable resource that can provide abundant aromatic compounds, which is undoubtedly considered as the best candidate to produce value-added chems. by lignin depolymerization Thus, it is of great significance to develop approaches that are able to accommodate the complex structure of lignin. Herein, an efficient depolymerization method is implemented in methanol using a mesoporous solid superbase KF/γ-Al₂O₃ catalyst. Research shows that the depolymerization of lignin is not obvious below the critical temperature of methanol, and the conversion of lignin increases significantly above the critical temperature, which can reach 60.6% at 270°C. Phenols and methoxy-substituted monocyclic aromatic compounds are predominant in the liquid products acquired by gas chromatog./mass spectrometry. Furthermore, oligomers were analyzed by time-of-flight mass spectrometry equipped with electrospray ionization. It is found that the mol. mass of the oligomers varied between 200 and 600 Da, the degree of unsaturation is mainly 4 and 8 with 1-2 aromatic rings, and the carbon number is found to be within the range of 15-30. It is speculated that the oligomers are mainly monophenyl or biphenyl compounds containing branched chains.

New Journal of Chemistry published new progress about 19444-84-9. 19444-84-9 belongs to tetrahydrofurans, auxiliary class Tetrahydrofuran,Ester,Alcohol, name is 3-Hydroxydihydrofuran-2(3H)-one, and the molecular formula is C4H6O3, COA of Formula: C4H6O3.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Zhao, Yang published the artcileA XEN-like state bridges somatic cells to pluripotency during chemical reprogramming, Recommanded Product: 1-(3-((((2R,3S,4R,5R)-5-(4-Amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)(isopropyl)amino)propyl)-3-(4-(tert-butyl)phenyl)urea, the publication is Cell (Cambridge, MA, United States) (2015), 163(7), 1678-1691, database is CAplus and MEDLINE.

Somatic cells can be reprogrammed into pluripotent stem cells (PSCs) by using pure chems., providing a different paradigm to study somatic reprogramming. However, the cell fate dynamics and mol. events that occur during the chem. reprogramming process remain unclear. Here, the authors show that the chem. reprogramming process requires the early formation of extra-embryonic endoderm (XEN)-like cells and a late transition from XEN-like cells to chem.-induced (Ci)PSCs, a unique route that fundamentally differs from the pathway of transcription factor-induced reprogramming. Moreover, precise manipulation of the cell fate transition in a step-wise manner through the XEN-like state allowed the authors to identify small-mol. boosters and establish a robust chem. reprogramming system with a yield up to 1000-fold greater than that of the previously reported protocol. These findings demonstrate that chem. reprogramming is a promising approach to manipulate cell fates.

Cell (Cambridge, MA, United States) published new progress about 1338466-77-5. 1338466-77-5 belongs to tetrahydrofurans, auxiliary class Epigenetics,Histone Methyltransferase, name is 1-(3-((((2R,3S,4R,5R)-5-(4-Amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)(isopropyl)amino)propyl)-3-(4-(tert-butyl)phenyl)urea, and the molecular formula is C24H20Ge, Recommanded Product: 1-(3-((((2R,3S,4R,5R)-5-(4-Amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)(isopropyl)amino)propyl)-3-(4-(tert-butyl)phenyl)urea.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Li, Zhanchao published the artcilePreparation and characterization of two wood vinegars obtained from hull of spina date seed and shell of peanut, Recommanded Product: 3-Hydroxydihydrofuran-2(3H)-one, the publication is Chemical Research in Chinese Universities (2017), 33(3), 348-353, database is CAplus.

Two new kind of wood vinegars(WVs) from the hull of spina date seed(HSDS) and the shell of peanut(PS) were prepared 32 Major components in the two kind of WVs were identified and determined by gas chromato-graph-mass spectrometery. The total phenolic content was determined and the antioxidant activity of the WV was measured. The total phenolic contents of PSWV and HSDSWV were 75.9 and 98.1 mg/L, resp., when they were expressed as catechol equivalent In 1,1-diphenyl-2-picrylhydrazyl assay, free radical scavenging activity of HSDSWV was also superior than that of PSWV. In addition, the antioxidant activities of the two kind of WVs exhi-bited a good pos. correlation with total phenolic content, and the linear correlation coefficients ranged from 0.9594 to 0.9970. The two kind of WVs could be used in the fields of food and medicine due to their powerful anti-oxidant activities.

Chemical Research in Chinese Universities published new progress about 19444-84-9. 19444-84-9 belongs to tetrahydrofurans, auxiliary class Tetrahydrofuran,Ester,Alcohol, name is 3-Hydroxydihydrofuran-2(3H)-one, and the molecular formula is C4H6O3, Recommanded Product: 3-Hydroxydihydrofuran-2(3H)-one.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Li, Zhanchao published the artcileCharacterization of Five Kinds of Wood Vinegar Obtained from Agricultural and Forestry Wastes and Identification of Major Antioxidants in Wood Vinegar, Product Details of C4H6O3, the publication is Chemical Research in Chinese Universities (2019), 35(1), 12-20, database is CAplus.

Wood vinegar(WV) has a powerful antioxidant activity, but it is unclear which components are responsi-ble for the antioxidant activity. In the present study, the double-column retention index qual. method was used for the identification of the major components in five kinds of WV. And the major antioxidants of wood vinegar were accurately identified with the aid of Pearson product-moment correlation coefficients and authentic standard samples. Our results demonstrate that phenolic compounds are mainly responsible for the powerful antioxidant activity. 2,6-Dimethoxyphenol is the most powerful antioxidant in WV. 2-Methoxyphenol and 3-methyl-1,2-cyclopentane-dione also have an important influence on the antioxidant activity of WV. Our results suggest that the contents of 2-methoxyphenol, 2,6-dimethoxyphenol and 3-methyl-1,2-cyclopentanedione should act as the criteria for evaluating the antioxidant activity of WV. Our work will provide useful information for WV’s application in the fields of food and medicine as antioxidants.

Chemical Research in Chinese Universities published new progress about 19444-84-9. 19444-84-9 belongs to tetrahydrofurans, auxiliary class Tetrahydrofuran,Ester,Alcohol, name is 3-Hydroxydihydrofuran-2(3H)-one, and the molecular formula is C4H6O3, Product Details of C4H6O3.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Kang, Wenyue published the artcileSelective production of acetic acid via catalytic fast pyrolysis of hexoses over potassium salts, Formula: C4H6O3, the publication is Catalysts (2020), 10(5), 502, database is CAplus.

Glucose and fructose are widely available and renewable resources. They were used to prepare acetic acid (AA) under the catalysis of potassium acetate (KAc) by thermogravimetric anal. and pyrolysis coupled with gas chromatog. and mass spectrometry. The TGA result showed that the KAc addition lowered the glucose’s thermal decomposition temperatures (about 30°C for initial decomposition temperature and 40°C for maximum mass loss rate temperature), implying its promotion of glucose’s decomposition The Py-GC/MS tests illustrated that the KAc addition significantly altered the composition and distribution of hexose pyrolysis products. The maximum yield of AA was 52.1% for the in situ catalytic pyrolysis of glucose/KAc (1:0.25 wt/wt) mixtures at 350°C for 30 s. Under the same conditions, the AA yield obtained from fructose was 48% and it increased with the increasing amount of KAc. When the ratio reached to 1:1, the yield was 53.6%. In comparison, a study of in situ and online catalytic methods showed that KAc can not only catalyze the primary cracking of glucose, but also catalyze the cracking of a secondary pyrolysis stream. KAc plays roles in both phys. heat transfer and chem. catalysis.

Catalysts published new progress about 19444-84-9. 19444-84-9 belongs to tetrahydrofurans, auxiliary class Tetrahydrofuran,Ester,Alcohol, name is 3-Hydroxydihydrofuran-2(3H)-one, and the molecular formula is C4H6O3, Formula: C4H6O3.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Tao, Jia published the artcileDOT1L inhibitor improves early development of porcine somatic cell nuclear transfer embryos, Recommanded Product: 1-(3-((((2R,3S,4R,5R)-5-(4-Amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)(isopropyl)amino)propyl)-3-(4-(tert-butyl)phenyl)urea, the publication is PLoS One (2017), 12(6), e0179436/1-e0179436/12, database is CAplus and MEDLINE.

Incomplete epigenetic reprogramming of the genome of donor cells causes poor early and full-term developmental efficiency of somatic cell nuclear transfer (SCNT) embryos. Previous research indicate that inhibition of the histone H3 K79 methyltransferase DOT1L, using a selective pharmacol. inhibitor EPZ004777 (EPZ), significantly improved reprogramming efficiency during the generation of mouse induced pluripotent stem cells. However, the roles of DOT1L in porcine nuclear transfer-mediated cellular reprogramming are not yet known. Here we showed that DOT1L inhibition via 0.5 nM EPZ treatment for 12 or 24 h significantly enhanced the blastocyst rate of SCNT embryos and dramatically reduced the level of H3K79me2 during SCNT 1-cell embryonic development. Addnl., H3K79me2 level in the EPZ-treated SCNT embryos was similar to that in in vitro fertilized embryos, suggesting that DOT1L-mediated H3K79me2 is a reprogramming barrier to early development of porcine SCNT embryos. qRT-PCR anal. further demonstrated that DOT1L inactivation did not change the expression levels of DOT1L itself but increased the expression levels of POU5F1, LIN28, SOX2, CDX2 and GATA4 associated with pluripotency and early cell differentiation. In conclusion, DOT1L inhibitor improved early developmental efficiency of porcine SCNT embryos probably via inducing the increased expression of genes important for pluripotency and lineage specification.

PLoS One published new progress about 1338466-77-5. 1338466-77-5 belongs to tetrahydrofurans, auxiliary class Epigenetics,Histone Methyltransferase, name is 1-(3-((((2R,3S,4R,5R)-5-(4-Amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)(isopropyl)amino)propyl)-3-(4-(tert-butyl)phenyl)urea, and the molecular formula is C13H9FO2, Recommanded Product: 1-(3-((((2R,3S,4R,5R)-5-(4-Amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)(isopropyl)amino)propyl)-3-(4-(tert-butyl)phenyl)urea.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Ding, Kunshan published the artcileEasily encodable/decodable digital polymers linked by dithiosuccinimide motif, Synthetic Route of 57124-87-5, the publication is European Polymer Journal (2019), 421-425, database is CAplus.

Digital polymers with precise arrangements of units acting as the 0- or 1-bit, have shown bright promise for the data storage media. The easiness of encoding and decoding these polymers is essential when putting them into practical applications. Herein, the concept of utilizing sequence building block and sequencing indicator to generate easily encodable and decodable digital polymers is proposed. With the thiol-maleimide Michael coupling for digital chain growth, the dithiosuccinimide (DTS) motifs generated from the succinimide thioether linkages are used as the sequence building block. The DTS can be equipped with different groups, thus greatly enabling the modular encoding process. Importantly, the tandem mass spectrometry (MS/MS) results unveil the relatively abundant DTS-induced MS signal, which facilitates the decoding process with DTS acting as the sequencing indicator. The synergetic MS/MS induced cleavages of the two C-S bonds on DTS are responsible for the relatively abundant MS signal. Finally, the work exemplifies the quant. decoding of a digital polymer with DTS as the sequence building block and sequencing indicator. This study demonstrates the concept of sequence building block and sequencing indicator, which advances the digital polymers for practical applications.

European Polymer Journal published new progress about 57124-87-5. 57124-87-5 belongs to tetrahydrofurans, auxiliary class Tetrahydrofuran,Thiol, name is 2-Methyl-3-tetrahydrofuranthiol, and the molecular formula is C5H10OS, Synthetic Route of 57124-87-5.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Li, Qingyin published the artcileCo-hydrothermal carbonization of swine and chicken manure: Influence of cross-interaction on hydrochar and liquid characteristics, Quality Control of 19444-84-9, the publication is Science of the Total Environment (2021), 147381, database is CAplus and MEDLINE.

Swine and chicken manures are abundant solid wastes that can be converted into carbonaceous materials through hydrothermal carbonization (HTC). Owing to their unique biochem. compositions, co-HTC of these two types of manures may have significant implications for the generated products. We investigated the co-HTC of swine manure and chicken manure to understand the influence of the interaction between contrasting manures on the properties of the derived products. The results indicated that co-HTC treatment enhanced the formation of solid product and improved the C and N contents, heating value, and energy yield of the resulting hydrochar. Regarding the ignition temperature and comprehensive combustion index, the combustion properties of the hydrochar were enhanced owing to the mutual effect of the HTC intermediates. Addnl., the interaction of the intermediates significantly impacted the transfer of nitrogenous species and generation of organic acids and organic polymers with fused-ring structures. Therefore, co-HTC processing of animal manures could potentially provide a sustainable pathway for the conversion of animal waste into solid products with improved characteristics compared to those produced by treating the two feedstocks sep.

Science of the Total Environment published new progress about 19444-84-9. 19444-84-9 belongs to tetrahydrofurans, auxiliary class Tetrahydrofuran,Ester,Alcohol, name is 3-Hydroxydihydrofuran-2(3H)-one, and the molecular formula is C4H6O3, Quality Control of 19444-84-9.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Chen, Hai-tao published the artcileBlending of Yueshengzhai spiced beef-like liquid flavor, Recommanded Product: 2-Methyl-3-tetrahydrofuranthiol, the publication is Beijing Gongshang Daxue Xuebao, Ziran Kexueban (2011), 29(4), 24-27, database is CAplus.

The previous anal. of volatile flavor compounds of spiced beef was reviewed. The commonly used spices for beef flavor were listed, and the liquid essence formula of Yueshengzhai spiced beef consisted of 36 flavor compounds was given based on the laboratory results.

Beijing Gongshang Daxue Xuebao, Ziran Kexueban published new progress about 57124-87-5. 57124-87-5 belongs to tetrahydrofurans, auxiliary class Tetrahydrofuran,Thiol, name is 2-Methyl-3-tetrahydrofuranthiol, and the molecular formula is C5H10OS, Recommanded Product: 2-Methyl-3-tetrahydrofuranthiol.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Xiao, Qian published the artcileDirecting-Group-Assisted Markovnikov-Selective Hydrothiolation of Styrenes with Thiols by Photoredox/Cobalt Catalysis, Safety of 2-Methyl-3-tetrahydrofuranthiol, the publication is Organic Letters (2021), 23(9), 3604-3609, database is CAplus and MEDLINE.

In contrast with the well-developed radical thiol-ene reaction to access anti-Markovnikov-type products, the research on the catalytic Markovnikov-selective hydrothiolation of alkenes is very restricted. Because of the catalyst poisoning of metal catalysts by organosulfur compounds, limited examples of transition-metal-catalyzed thiol-ene reactions have been reported. However, in this work, a directing-group-assisted hydrothiolation of styrenes with thiols by photoredox/cobalt catalysis is found to proceed smoothly to afford Markovnikov-type sulfides with excellent regioselectivity.

Organic Letters published new progress about 57124-87-5. 57124-87-5 belongs to tetrahydrofurans, auxiliary class Tetrahydrofuran,Thiol, name is 2-Methyl-3-tetrahydrofuranthiol, and the molecular formula is C8H10S, Safety of 2-Methyl-3-tetrahydrofuranthiol.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem