Heterocyclic Building Blocks-Tetrahydrofuran

63095-51-2, (R)-4-Propyldihydrofuran-2(3H)-one is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Under nitrogen protection,willBuvacizine Intermediate III(128.1 g, 1 mol) was dissolved in 1 L of dichloromethane,Cooling to 0 ,Was added trimethylsilyl iodide (150mL),The reaction solution was stirred at 20 to 30 C for 2 hours.Followed by the addition of hydrochloric acid solution (1 M, 800 mL) and aqueous sodium thiosulfate solution (10% by mass) as the percentage of sodium thiosulfate and the total mass of sodium thiosulfate aqueous solution, 400 mL. ,The aqueous phase was extracted with 1 L of dichloromethane,The organic phase was washed twice with saturated brine,Dried over anhydrous sodium sulfate,filter,Concentration under reduced pressure gave hexanoic acid derivative IV (254.6 g, 99.5%),Yield 99.5%Purity: 95.6% (GC)., 63095-51-2

As the paragraph descriping shows that 63095-51-2 is playing an increasingly important role.

Reference£º
Patent; Shanghai Bocimed Pharmaceutical Co., Ltd.; Ying, Shuhuan; Pi, Hongjun; Chen, Jian; Zhou, Wei; Zhang, Jueming; (13 pag.)CN106588740; (2017); A;,
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88675-24-5, Tetrahydrofuran-3-amine is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

DIPEA (1 .93ml, 1 1 .1 mmol) was added to a solution of Tricyclo[3.3.1.13,7]decane-1 – carbonyl chloride (1 ) (2g, 10.1 mmol) and 3-aminotetrahydrofuran; (29)(1 .0ml, 1 1 mmol) in DCM (20ml) and the solution stirred at room temperature for 4 hours. The solution was washed with 0.1 N HCI (30ml), saturated NaHC03 (30ml), dried (Na2S04), filtered and the solvents removed to give crude product which was further purified via crystallization from 15percent EA in hexanes to give as a white solid, 88675-24-5

Big data shows that 88675-24-5 is playing an increasingly important role.

Reference£º
Patent; UNILEVER PLC; UNILEVER N.V.; CONOPCO, INC., D/B/A UNILEVER; HARICHIAN, Bijan; CLOUDSDALE, Ian Stuart; YANG, Lin; DICKSON, JR, John Kenneth; WO2014/139952; (2014); A2;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.184950-35-4,(Tetrahydrofuran-3-yl)methanamine hydrochloride,as a common compound, the synthetic route is as follows.

184950-35-4, Tetrahydrofuran-3-ylmethylamine hydrochloride (0.23 g, 1.69 mmol) And triethylamine (0.17 g, 1.69 mmol) Was added to chloroform (amylene added product) (10 mL). To the mixture, 5- (3-phenoxybenzyl) oxymethyl isoxazole-3-carboxylic acid (0.46 g, 1.41 mmol) at room temperature, 1-Hydroxybenzotriazole (0.02 g, 0.14 mmol) And 1-ethyl-3- (3-dimethylaminopropyl) carbodiimide hydrochloride (0.32 g, 1.69 mmol) were added, After stirring overnight, Dilute hydrochloric acid was added, It was extracted twice with chloroform. The organic layer was washed with saturated sodium bicarbonate water, After drying with anhydrous sodium sulfate, And concentrated under reduced pressure. The residue was subjected to silica gel column chromatography, Represented by the following equation N- (tetrahydrofuran-3-ylmethyl) -5- (3-phenoxybenzyl) oxymethyl isoxazole-3-carboxamide (Hereinafter referred to as the amide compound (11 4)) 0.54 g was obtained.

As the paragraph descriping shows that 184950-35-4 is playing an increasingly important role.

Reference£º
Patent; SUMITOMO CHEMICAL COMPANY LIMITED; SUMITA, YUSUKE; (264 pag.)JP2015/51963; (2015); A;,
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97-99-4, (Tetrahydrofuran-2-yl)methanol is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a mixture of (R)-(tetrahydrofuran-2-yl)methanol (2.0 g, 19.6 mmol) and di-tert-butyl hydrazine-1,2-dicarboxylate (4.5 g, 19.6 mmol) in anhydrous tetrahydrofuran (60 mL) was added triphenylphosphine (7.2 g, 27.4 mmol) followed by di-tert-butyl azodicarboxylate (6.3 g, 27.4 mmol) portionwise. The mixture was stirred for 16 hours, concentrated under reduced pressure and the crude residue purified by flash column chromatography using ethyl acetate, hexane (1:19 to 1:4) as an eluent to obtain the title compound (4.5 g, 72%), as a white solid, mp: 78.8-82.3 C; Rf: 0.19 (1:4 ethyl acetate, hexane); IR (vmax (neat)): 3314, 3254, 2831, 1737, 1661, 1229, 1144 cm-1; 1H NMR (300 MHz, CDCl3): delta 1.45 (18H, s), 1.78-1.99 (4H, m), 3.29-3.66 (2H, m), 3.67-3.91 (2H, m), 4.00-4.16 (1H, m), 6.58 (1H, bs) ppm; 13C NMR (75 MHz, CDCl3): delta 25.6, 28.3, 29.1, 53.3, 68.0, 74.1, 81.1, 155.4 ppm; LRMS (+ESI) m/z: 339.2 ([M+Na]+ 100%)., 97-99-4

The synthetic route of 97-99-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Moir, Michael; Boyd, Rochelle; Gunosewoyo, Hendra; Montgomery, Andrew P.; Connor, Mark; Kassiou, Michael; Tetrahedron Letters; vol. 60; 36; (2019);,
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204512-95-8, (S)-Tetrahydrofuran-3-amine hydrochloride is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

(3S)-Oxolan-3-amine hydrochloride (83 mg, 0.67 mmol) was added at room temperature to a stirred suspension of 8 -bromo- 1 -(3 ,4-dichlorob enzyl)-3 , 7-dimethyl- 1H- purine-2,6(3H,71])-dione (70 mg, 0.17 mmol) and DIEA (233 pi, 1.34 mmol) in nBuOH (5 ml). The resulting mixture was heated at 120C and stirred for 20h. Further (3S)-oxolan-3- amine hydrochloride (83 mg, 0.67 mmol) and DIEA (233 pi, 1.34 mmol) were added. The temperature was increased to 130C and stirring was continued. After 24h the solvent was removed in vacuo and the residue was purified by prep-HPLC to obtain the title compound. ?HNMR (500 MFIz, DMSO-d6) 7.55 (d, J 8.3 Hz, 1H), 7.51 (d, J 1.9 Hz, 1H), 7.25 (dd, J= 8.3, 2.0 Hz, 1H), 7.12 (d, J= 6.3 Hz, 1H), 4.98 (s, 2H), 4.47 -4.31 (m, 1H), 3.94- 3.84 (m, 2H), 3.72 (td, J= 8.1, 6.0 Hz, 1H), 3.61 (dd, J= 9.0, 4.1 Hz, 1H), 3.58 (s, 3H), 3.35 (s, 3H),2.38-2.07(m, 1H), 1.99- 1.78 (m, 1H).

204512-95-8, As the paragraph descriping shows that 204512-95-8 is playing an increasingly important role.

Reference£º
Patent; RAZE THERAPEUTICS, INC.; MAINOLFI, Nello; MOYER, Mikel, P.; SAIAH, Eddine; LECCI, Cristina; PACE, Robert, David, Matthew; TYE, Heather; VILE, Julia; (420 pag.)WO2017/106352; (2017); A1;,
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124391-75-9, (S)-(Tetrahydrofuran-3-yl)methanol is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of (tetrahydrofuran-3-yl)methanol (1.0 g, 9.8 mmol) inDCM (15 ml) was added N,N-dimethylpyridin-4-amine (122 mg, 1 mmol), TEA (2.0 g, 20mmol) and 4-methylbenzenesulfonyl chloride (1.86 g, 9.8 mmol). The reaction mixture wasstirred at rt for 3 h. The mixture was concentrated and residue was purified by columnchromatography using ethyl acetate in petroleum ether (1/4) to afford tetrahydrofuran-3-yl)methyl 4-methylbenzenesulfonate (900 mg, 36percent yield). LCMS (ESI) m/z: 257.4 (M + 1t

124391-75-9, The synthetic route of 124391-75-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED; CATALANO, John G.; DICKSON, Hamilton D.; KAZMIERSKI, Wieslaw Mieczyslaw; LEIVERS, Martin R.; WEATHERHEAD, John Gordon; (389 pag.)WO2018/154466; (2018); A1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.17347-61-4,2,2-Dimethylsuccinicanhydride,as a common compound, the synthetic route is as follows.

To a stirred solution of (1R,3aS,5aR,5bR,7aR,9S,11aR,11bR,13aR,13bR)-9-hydroxy- 5a,5b,8,8,11a-pentamethyl-N-(1-(5-phenyl-1H-imidazol-2-yl)cyclopropyl)-1-(prop-1-en-2-yl)icosahydro-3aH-cyclopenta[a]chrysene-3a-carboxamide (Step 2 Example 19, 0.2 g, 0.31 mmol) and 2,2-dimethyl succinicanhydride (0.16 g, 1.2 mmol) in toluene (7 ml), was added DMAP (0.076 g, 0.6 mmol). The reaction mixture was heated at 90 C for 12 h. After completion of the reaction (monitored by TLC), reaction mixture was concentrated under reduced pressure, cooled to 0 C, acidified to pH = 6 with IN HCl and extracted with DCM. The combined organic extracts was washed with water, brine, dried over Na2SO4 then the solvent was evaporated under reduced pressure and to the resulting solid was recrystallized from ACN to give the title compound as a white solid (0.11 g, Yield: 45.83%). 1H NMR (300 MHz, DMSO-d6): delta 12.15 (s, 1H), 11.27 (s, 1H), 8.37 (s, 1H), 7.72-7.70 (m, 2H), 7.39 (s, 1H), 7.31-7.26 (m, 2H), 7.15-7.11 (m, 1H), 4.61 (s, 1H), 4.51 (s, 1H), 4.37-4.32 (m, 1H), 3.00-2.94 (m, 1H), 2.27 (m, 1H), 1.98-1.95 (m, 1H), 1.79-1.73 (m, 1H), 1.62-1.00 (m, 32H), 0.91-0.74 (m, 19H). ESI Mass: 766.56 [M+H]+., 17347-61-4

The synthetic route of 17347-61-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; HETERO RESEARCH FOUNDATION; BANDI, Parthasaradhi Reddy; KURA, Rathnakar Reddy; GAZULA LEVI, David Krupadanam; ADULLA, Panduranga Reddy; NEELA, Sudhakar; MOGILI, Narsingam; (87 pag.)WO2017/21922; (2017); A1;,
Tetrahydrofuran – Wikipedia
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.219823-47-9,(R)-Tetrahydrofuran-3-yl 4-methylbenzenesulfonate,as a common compound, the synthetic route is as follows.

A 10-necked flask was charged with 10 (54.90 g, 100 mmol) and acetonitrile (275 mL)Add potassium carbonate(27.64 g, 200 mmol) and(3R) -tetrahydrofuran-3-p-toluenesulfonate(29.07 g, 120 mmol),Room temperature reaction overnight. The reaction was terminated by removing part of the acetonitrile, adding water (275 mL) andEthyl acetate (275 mL) and the aqueous phase was extracted again with ethyl acetate (137 mL)Combined with organic saturated brine washed twice (137mL), dried over sodium sulfate,After concentration, the crude key intermediate compound 11 (53.86 g, 87%) was re-crystallized with petroleum ether ethyl acetate.

219823-47-9, 219823-47-9 (R)-Tetrahydrofuran-3-yl 4-methylbenzenesulfonate 13837325, aTetrahydrofurans compound, is more and more widely used in various fields.

Reference£º
Patent; Hangzhou Kechao Biological Technology Co., Ltd.; Zheng Xuchun; Zhang Yiping; Wu Yihua; (18 pag.)CN107163092; (2017); A;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.453-20-3,3-Hydroxytetrahydrofuran,as a common compound, the synthetic route is as follows.

To a solution of tetrahydrofuran-3-ol (500 mg, 5.68 mmcl) and Et3N (860 mg, 8.52 mmcl) inCH2CI2 (10 mL) at 0 C was added MsCI (842 mg, 7.39 mmol) dropwise. The reaction wasstirred at room temperature for 4 hours. The reaction mixture was diluted with CH2CI2 (150mL), washed with sat. NaHCO3 (50 mL), dried over Na2SO4 and concentrated to give the title compound (700 mg, 74%) as yellow oil.1H NMR (300 MHz, CDCI3): oe 5.36-5.31 (m, IH), 4.06-3.86 (m, 4H), 3.06 (s, 3H), 2.29-2.22 (m, 2H).

453-20-3, As the paragraph descriping shows that 453-20-3 is playing an increasingly important role.

Reference£º
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED; GLAXOSMITHKLINE (CHINA) R&D COMPANY LIMITED; DING, Xiao; REN, Feng; SANG, Yingxia; XING, Weiqiang; ZHAN, Yang; ZHAO, Baowei; (357 pag.)WO2018/137593; (2018); A1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.453-20-3,3-Hydroxytetrahydrofuran,as a common compound, the synthetic route is as follows.,453-20-3

To a solution of 3-hydroxytetrahydrofuran (200 mg, 1.55 mmol) in DCM (5 mL) was added Ms20 (539 mg, 3.10 mmol) and pyridine (367 mg, 4.65 mmol) at-10 C. After stirred at room temperature overnight, the reaction mixture was diluted with DCM (10 mL), washed with saturated NaHCO3, dried over anhydrous Na2504, and evaporated to dryness under reduced pressure to afford tetrahydrofuran-3-yl methanesulfonate 35 in 89% yield (285 mg).

453-20-3 3-Hydroxytetrahydrofuran 9960, aTetrahydrofurans compound, is more and more widely used in various fields.

Reference£º
Patent; CAPELLA THERAPEUTICS, INC.; LONG, Yun; (228 pag.)WO2017/53537; (2017); A1;,
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Tetrahydrofuran | (CH2)3CH2O – PubChem