Some tips on 63095-51-2

As the paragraph descriping shows that 63095-51-2 is playing an increasingly important role.

63095-51-2,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.63095-51-2,(R)-4-Propyldihydrofuran-2(3H)-one,as a common compound, the synthetic route is as follows.

A solution of thionyl chloride (200 mL) anhydrous ZnCI2 (10.6 g, 0.078 mol), and the compound of formula I (bOg, 0.78mmol) was heated to 85 C. After the reaction was complete, the solvents were evaporated in vacuo. The crude product was purified by vacuum distillation to obtain the title compound X as a yellow oil. Yield 79.7%.

As the paragraph descriping shows that 63095-51-2 is playing an increasingly important role.

Reference£º
Patent; WANG, Peng; LI, Pixu; WEI, Qiang; LIU, Yuanhua; (61 pag.)WO2016/191435; (2016); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

New learning discoveries about 184950-35-4

184950-35-4, 184950-35-4 (Tetrahydrofuran-3-yl)methanamine hydrochloride 17750392, aTetrahydrofurans compound, is more and more widely used in various fields.

184950-35-4, (Tetrahydrofuran-3-yl)methanamine hydrochloride is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Production Example 151 (0471) 5-(Naphthalen-2-ylmethyl)isoxazole-3-carboxylic acid (204 mg, 0.81 mmol), tetrahydrofuran-3-ylmethylamine hydrochloride (204 mg, 1.48mmol), triethylamine (0.38 mL, 2.75 mmol) and 1-hydroxybenzotriazole (14 mg, 0.11 mmol) were added to chloroform (amylene addition product) (5 mL). 1-Ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride (264 mg, 1.38 mmol) was added to the mixture at room temperature, and the mixture was stirred overnight and then concentrated under reduced pressure. The residue was applied to a silica gel column chromatography to obtain 166 mg of N-(tetrahydrofuran-3-ylmethyl)-5-(naphthalen-2-ylmethyl)iso xazole-3-carboxamide (hereinafter, referred to as Compound of Present Invention (159)) represented by the following formula. 1H-NMR (CDCl3, TMS, delta(ppm)):1.60-1.72(m, 1H), 2.02-2.12(m, 1H), 2.52-2.61(m, 1H), 3.41-3.46(m, 2H), 3.57(dd, J=9.0, 5.3Hz, 1H), 3.72-3.79(m, 1H), 3.82-3.93(m, 2H), 4.29(s, 2H), 6.43(d, J=3. 9Hz, 1H), 6.90(brs, 1H), 7. 34-7. 38 (m, 1H), 7. 46-7. 53 (m, 2H), 7.71(s, 1H), 7.78-7.86(m, 3H)

184950-35-4, 184950-35-4 (Tetrahydrofuran-3-yl)methanamine hydrochloride 17750392, aTetrahydrofurans compound, is more and more widely used in various fields.

Reference£º
Patent; Sumitomo Chemical Company, Limited; MITSUDERA, Hiromasa; AWASAGUCHI, Kenichiro; AWANO, Tomotsugu; UJIHARA, Kazuya; EP2952096; (2015); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

Some tips on 915095-89-5

As the paragraph descriping shows that 915095-89-5 is playing an increasingly important role.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.915095-89-5,(S)-3-(4-(5-Bromo-2-chlorobenzyl)phenoxy)tetrahydrofuran,as a common compound, the synthetic route is as follows.

Take (5)-3-(4-(5-bromo-2-chlorobenzyl)phenoxy) tetrahydrofuran (91 kg), anhydrous tetrahydrofuran/toluene (200 kg (1:4)), and add it to a nitrogen-dried 2000-liter reactor. , Liquid nitrogen was cooled to -78 C, was slowly added dropwise 1. 6 mol-L” 1 n-butyllithium hexane solution 120L, maintaining the temperature stirred for 1h;A 300 kg toluene solution of 2,3,4,6-tetra-O-trimethylsilyl-D-glucono lactone (130 kg) cooled to -78C was slowly added dropwise to the above reaction solution, -78 C reaction 3 h, TLC test after the completion of the basic reaction, at this temperature was added 300kg of methanol solution of methanesulfonic acid (methanesulfonic acid 115kg + methanol 185kg); stirred at 0 C reaction 4.0h, and then heated to 40 C The reaction was stirred for 6 h. After the reaction was completed, 5 mol.I/1 aqueous sodium hydroxide solution was added to the reaction solution to adjust the pH to 7 – 8; stirred for 30 min, extracted with ethyl acetate (200 kg X 2), and the organic phase was washed with a saturated aqueous solution of sodium chloride. Neutral, then dried over anhydrous sodium sulfate, filtered, and the filtrate was concentrated to dryness to give 100 kg of pale yellow viscous oil in a yield of 84%., 915095-89-5

As the paragraph descriping shows that 915095-89-5 is playing an increasingly important role.

Reference£º
Patent; Jiangsu Engineering Polytechnic College; Feng Chengliang; Yan Bin; (12 pag.)CN107652276; (2018); A;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

Some tips on 118399-28-3

118399-28-3, The synthetic route of 118399-28-3 has been constantly updated, and we look forward to future research findings.

118399-28-3, (R)-Benzyl (5-oxotetrahydrofuran-3-yl)carbamate is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

(R)-Benzyl 5 -oxo-tetrahydrofuran-3 -ylcarbamate (24 g, 0.1 mol) was added to the solution ofMe2NH (45 g, 1 mol) in CH2Cl2 (500 ml). The mixture was stirred overnight. The solid was collected by filtration. Toluene (500 mL) was added to dissolve the solid, followed by (PhS)2 (32.7 g, 0.15 mol) and Bu3P (40 g, 0.2 mol). The mixture was heated to 80C and stirred for 18 h. The solvent was removed in vacuo. The residue was subjected to flash column chromatography on silica gel eluting with 50% EtO Ac/petroleum ether to provide 0123 (13.4 g, 35.3%). LC-MS: 373 [M+l]+. 1H NMR (CDCl3):delta 2.46 (m, 1H), 2.82 (s, 3H), 2.84 (s, 3H), 2.88 (m, 1H), 3.20 (m, 1H), 3.33 (m, 1H), 4.13 (m, 1H), 5.07 (s, 2H), 6.30 (d, J= 9.0 Hz, 1H), 7.15 (m, 1H), 7.32 (m, 9H).

118399-28-3, The synthetic route of 118399-28-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; CURIS, INC.; WO2009/36035; (2009); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

Simple exploration of 86087-24-3

As the paragraph descriping shows that 86087-24-3 is playing an increasingly important role.

86087-24-3, (R)-Tetrahydrofuran-3-ol is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

86087-24-3, Step 1: (R)-Tetrahydrofuran-3-yl-4-methylbenzenesulfonate To a solution of (R)-tetrahydrofuran-3-ol (25.4 g) in dichloromethane (250 mL) and pyridine (60 mL) is added at 0 C. N,N-dimethylaminopyridine (DMAP; 1 g) and p-toluene-sulfonylchloride (73 g) in portions. The mixture is stirred for 12 hours at room temperature, diluted with dichloromethane and washed with 1 M aqueous HCl solution and brine. After drying (MgSO4) the solvent is evaporated and the residue is chromatographed on silica gel (dichloromethane/methanol 100:0?95:5) to give the title compound. Yield: 59.5 g; Mass spectrum (ESI+): m/z=243 [M+H]+.

As the paragraph descriping shows that 86087-24-3 is playing an increasingly important role.

Reference£º
Patent; Boehringer Ingelheim International GmbH; ECKHARDT, Matthias; FRATTINI, Sara; HAMPRECHT, Dieter; HIMMELSBACH, Frank; LANGKOPF, Elke; LINGARD, Iain; PETERS, Stefan; WAGNER, Holger; US2013/252937; (2013); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

Brief introduction of 453-20-3

453-20-3, 453-20-3 3-Hydroxytetrahydrofuran 9960, aTetrahydrofurans compound, is more and more widely used in various fields.

453-20-3, 3-Hydroxytetrahydrofuran is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution oftetrahydrofuran-3-ol(0.1 g, 1.135 mmol) inacetonitrile(5 mL) was added bis(2,5-dioxopyrrolidin-1-yl) carbonate (0.436 g, 1.703 mmol) andTEA(0.237 mL, 1.703 mmol). The reaction mixture was allowed to stir at rt for 18 h. The solvent was removed and the reaction mixture was diluted with DCM, washed with 10% NaHCO3, brine, dried over Na2SO4and concentrated to afford2,5-dioxopyrrolidin-1-yl (tetrahydrofuran-3-yl) carbonate(0.08 g,0.349 mmol,30.8%yield).1H NMR (DMSO-d6, delta=2.50 ppm, 400 MHz): delta 5.44-5.38 (m, 1H), 3.88-3.65 (m, 5H), 2.82 (s, 3H), 2.31-2.21 (m, 1H), 2.07-1.98 (m, 1H).

453-20-3, 453-20-3 3-Hydroxytetrahydrofuran 9960, aTetrahydrofurans compound, is more and more widely used in various fields.

Reference£º
Patent; Hewawasam, Piyasena; Lopez, Omar D.; Tu, Yong; Wang, Alan Xiangdong; Xu, Ningning; Kadow, John F.; Meanwell, Nicholas A.; Gupta, Samayamuthula Venkata Satya Arun Kumar; Kumar, Indasi J. Gopi; Ponugupati, Suresh Kumar; Belema, Makonen; US2015/23913; (2015); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

Simple exploration of 184950-35-4

The synthetic route of 184950-35-4 has been constantly updated, and we look forward to future research findings.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.184950-35-4,(Tetrahydrofuran-3-yl)methanamine hydrochloride,as a common compound, the synthetic route is as follows.

5- (3-trifluoromethylbenzyl) isoxazole-3-carboxylic acid (242 mg, 0.89 mmol), Tetrahydrofuran-3-ylmethylamine hydrochloride (155 mg, 1.15 mmol), Triethylamine (0.32 mL, 2.30 mmol) And 1 – hydroxybenzotriazole (15 mg, 0.11 mmol) Was added to chloroform (amylen added product) (5 mL). To the mixture, 1-Ethyl-3- (3-dimethylaminopropyl) carbodiimide hydrochloride (220 mg, 1.15 mmol) was added at room temperature, After stirring overnight, it was concentrated under reduced pressure. The residue was subjected to silica gel column chromatography, Represented by the following equation N- (tetrahydrofuran-3-ylmethyl) -5- (3-trifluoromethylbenzyl) isoxazole-3-carboxamide (Hereinafter referred to as the amide compound (158)) 130 mg was obtained., 184950-35-4

The synthetic route of 184950-35-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; SUMITOMO CHEMICAL COMPANY LIMITED; SUMITA, YUSUKE; (264 pag.)JP2015/51963; (2015); A;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

New learning discoveries about 42417-39-0

The synthetic route of 42417-39-0 has been constantly updated, and we look forward to future research findings.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.42417-39-0,3-Aminodihydrofuran-2(3H)-one hydrochloride,as a common compound, the synthetic route is as follows.,42417-39-0

Dissolving 3-chloro-4-(5-(4-isopropoxy-3-cyanophenyl)-1,2,4-oxadiazol-3-yl)benzaldehyde (200 mg, 0.54 mmol) In 35 ml of dichloromethane,Add to it in orderDL-homoserine lactone hydrochloride(112mg, 0.82mmol), glacial acetic acid (0.12ml, 2.18mmol), N,N-diisopropylethylamine (0.13ml, 0.82mmol), 5ml of methanol, reacted at room temperature for 3h, then added sodium cyanoborohydride (34mg , 0.47 mmol), reacted under argon for 5 h. A saturated sodium hydrogencarbonate solution was added, and the mixture was extracted with dichloromethane (3¡Á30 mL). Concentrated and separated by column chromatography. The eluent was dichloromethane: methanol = 20:1.A white solid 154 mg was obtained in a yield of 62.5%.

The synthetic route of 42417-39-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Chinese Academy Of Medical Sciences Pharmaceutical Institute; Wang Xiaojian; Liu Tianqi; Jin Jing; Hu Jinping; Chen Xiaoguang; Yin Dali; (70 pag.)CN109956912; (2019); A;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

Analyzing the synthesis route of 88675-24-5

Big data shows that 88675-24-5 is playing an increasingly important role.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.88675-24-5,Tetrahydrofuran-3-amine,as a common compound, the synthetic route is as follows.

Example 4: 8-Chloro-7-methoxy-W-(tetrahydrofuran-3-yl)quinazolin-4-amine: To a solution of 4,8-dichloro-7-methoxyquinazoline (650 mg, 2.84 mmol) in dimethylformamide (20 mL) was added tetrahydrofuran-3-amine (297 mg, 3.41 mmol) and diisopropylethylannine (0.99 mL, 5.7 mmol). Through the mixture was bubbled N2 for 5 minutes. The reaction was then heated at 100¡ãC for 3 hrs under an atmosphere of N2. The crude mixture was concentrated and the residue was purified by flash chromatography on silica gel using a gradient of ethyl acetate and petroleum ether to give 8-chloro-7-methoxy-/V-(tetrahydrofuran-3-yl)quinazolin-4-amine 650 mg (82percent)., 88675-24-5

Big data shows that 88675-24-5 is playing an increasingly important role.

Reference£º
Patent; H. LUNDBECK A/S; KEHLER, Jan; RASMUSSEN, Lars Kyhn; LANGGARD, Morten; WO2015/150254; (2015); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

Simple exploration of 88675-24-5

As the paragraph descriping shows that 88675-24-5 is playing an increasingly important role.

88675-24-5, Tetrahydrofuran-3-amine is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of 2,4-dichloro-5-nitropyridine (386 mg, 2.0 mmol), and triethylamine (417 L, 3.0 mmol) in THF (6 mL) was added dropwise tetrahydrofuran-3-ylamine (208 mg, 2.4 mmol) and the reaction mixture was stirred for 1 h. An additional amount of tetrahydrofuran-3-ylamine (50 mg) was added and the reaction mixture was stirred for 1 h. The volatiles were removed in vacuo and the resulting residue was partitioned between water and EtOAc. The organic phase was dried (MgS04) and concentrated in vacuo to afford the title compound as a yellow solid (490 mg, quantitative). LCMS (ESI): [M+H]+ 244.2., 88675-24-5

As the paragraph descriping shows that 88675-24-5 is playing an increasingly important role.

Reference£º
Patent; GENENTECH, INC.; BRYAN, Marian C.; CHAN, Bryan; HANAN, Emily; HEFFRON, Timothy; PURKEY, Hans; ELLIOTT, Richard Leonard; HEALD, Robert; KNIGHT, Jamie; LAINCHBURY, Michael; SEWARD, Eileen M.; WO2014/81718; (2014); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem