Heterocyclic Building Blocks-Tetrahydrofuran

Garavagno, Maria de los A.; Hernandez, Federico J.; Jara-Toro, Rafael A.; Mahecha, Genesys; Barrera, Javier A.; Taccone, Raul A.; Pino, Gustavo A. published the artcile< Rate coefficient and mechanism of the OH-initiated degradation of cyclobutanol: A combined experimental and theoretical study>, Safety of (Tetrahydrofuran-2-yl)methanol, the main research area is cyclobutanol OH initiated degradation rate coefficient exptl theor study.

The degradation process of cyclobutanol (cButOH) by hydroxyl radical (OH), under atm. conditions, (750 ± 10) Torr of air and (296 ± 2) K, has been studied. The rate coefficient for the title reaction (k296K = (7.3 ± 0.6) x 10-12 cm3 mol.-1 s-1) was determined at 296 K by the conventional relative-rate method. Electronic structure calculations with uCCSD(T)/uBHandHLYP/aug-cc-PVDZ were conducted to study the reaction mechanism. The global rate coefficient was also calculated using the transition state theory with tunneling corrections, obtaining a value of 5.4 x 10-12 cm3 mol.-1 s-1 in agreement with the exptl. determination Addnl., reaction products identification in clean and NOx-contaminated atmospheres was performed for the first time. The identified reaction products and their corresponding yields (YP) depend on the environment composition in which the reaction is studied. In the absence of NOx, cyclobutanone (cButanone) was the only identified product, with YcButanone = (0.66 ± 0.08). In NOx-contaminated atmospheres, in addition to cButanone, THF (THF), 2-nitro-1-butanol (2N1B), 3-nitro-2-butanol (3N2B) and 2-methyl-2-nitro-1-propanol (2M2N1P), were also identified as primary reaction products. Under this condition, we were able to determine only the yields of cButanone and THF (YcButanone = 0.38 ± 0.05 and YTHF = 0.28 ± 0.02). A likely reaction mechanism for the observed products is proposed and the atm. implications are discussed.

Atmospheric Environmentpublished new progress about Alcohols, nitro Role: POL (Pollutant), OCCU (Occurrence). 97-99-4 belongs to class tetrahydrofurans, and the molecular formula is C5H10O2, Safety of (Tetrahydrofuran-2-yl)methanol.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Harrison, Carrie-Ann; Jackson, P. Mark; Moody, Christopher J.; Williams, Jonathan M. J. published the artcile< Cyclopenta[b]indoles. Part 2. Model studies towards the tremorgenic mycotoxins>, Product Details of C8H14O2, the main research area is cyclopentaindole; tremorgenic mycotoxin cyclopentindole.

The 7-bromocyclopenta[b]indole I has been converted into the hydroxybutenyl derivatives and a tetrahydrofuranylidene derivative in model studies towards the elaboration of paspalitrem and lolitrem type side chains. In a parallel approach, the cyclopentapyrrole II was converted into the fused α-pyrone III which acted as a pyrrole-2,3-quinodimethane, and underwent Diels-Alder reaction to give, after loss of carbon dioxide, the cyclopentaindoles, e.g. IV.

Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistrypublished new progress about Indole alkaloids Role: SPN (Synthetic Preparation), PREP (Preparation). 5455-94-7 belongs to class tetrahydrofurans, and the molecular formula is C8H14O2, Product Details of C8H14O2.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Ishii, Hidenori; Tetsutani, Hisashi; Nagi, Tatsuya published the artcile< Improving liquid crystal alignment ability and UV sensitivity in photodecomposition polyimide film>, SDS of cas: 4415-87-6, the main research area is carboxylic dianhydride liquid crystal UV sensitivity photodecomposition.

A liquid crystal alignment film with fewer processes capable of imparting anisotropy was developed using a polyimide, which utilized the cleavage of a cyclobutane ring by irradiation of polarized UV light at 254 nm. When an aromatic diamine with alkylene in the mol. center was used, an even methylene number of diamines showed superior liquid crystal alignment ability compared with diamines with an odd methylene number Addnl., a diamine containing a mol. structure with a pre-imidized imide group adjoined to a cyclobutane ring was extremely effective in improving liquid crystal alignment ability and sensitivity to polarized UV light.

Journal of Photopolymer Science and Technologypublished new progress about Anisotropy. 4415-87-6 belongs to class tetrahydrofurans, and the molecular formula is C8H4O6, SDS of cas: 4415-87-6.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Li, Feng; Jiang, Shanshan; Huang, Jin; Wang, Yue; Lu, Shiyu; Li, Cuiqin published the artcile< Catalytic transfer hydrogenation of furfural to furfuryl alcohol over a magnetic Fe3O4@C catalyst>, Recommanded Product: (Tetrahydrofuran-2-yl)methanol, the main research area is catalytic transfer hydrogenation furfural furfuryl alc catalyst.

Carbon-encapsulated Fe3O4 (Fe3O4@C) catalysts were prepared by a solvothermal method using glucose as the carbon source and their physicochem. properties were characterized via various anal. techniques. Catalytic transfer hydrogenation of furfural over Fe3O4@C catalysts was investigated with isopropanol as the solvent and hydrogen donor. The Fe3O4@C catalysts exhibited high catalytic furfural transfer hydrogenation activity, selectivity of furfuryl alc., and high reusability. The mechanism of catalytic transfer hydrogenation of furfural by Fe3O4@C obeys the Meerwein-Ponndorf-Verley reduction on a Lewis acid site (Fe3O4).

New Journal of Chemistrypublished new progress about Meerwein-Ponndorf-Verley reduction. 97-99-4 belongs to class tetrahydrofurans, and the molecular formula is C5H10O2, Recommanded Product: (Tetrahydrofuran-2-yl)methanol.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Bakharev, Vladimir V.; Gidaspov, Alexander A.; Zalomlenkov, Vladimir A.; Parfenov, Victor E.; Golovina, Olga V.; Slepukhin, Pavel A. published the artcile< Opening of the 1,3,5-triazine ring in 3-methyl-5-(trinitromethyl)tetrazolo[1,5-a][1,3,5]triazin-7-one by the action of alcohols>, COA of Formula: C5H10O2, the main research area is tetrazolotriazinone ring opening alc.

It was shown for the first time that in the reaction of 3-methyl-5-(trinitromethyl)tetrazolo[1,5-a][1,3,5]triazin-7-one with alcs. in the presence of bases, along with the expected substitution of the trinitromethyl group, opening of the 1,3,5-triazine ring with the addition of an alc. at the site of the C-N bond cleavage takes place. It was found that in the absence of bases only opening of the 1,3,5-triazine ring occurs with the formation of alkyl esters of {1-[(1-methyl-1H-tetrazol-5-yl)imino]-2,2,2-trinitroethyl}carbamic acid, and the trinitromethyl group retains high reactivity and can be substituted by the action of alcs. in the presence of a base.

Chemistry of Heterocyclic Compounds (New York, NY, United States)published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 97-99-4 belongs to class tetrahydrofurans, and the molecular formula is C5H10O2, COA of Formula: C5H10O2.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Feliu, Catherine; Peyret, Helene; Vautier, Damien; Djerada, Zoubir published the artcile< Simultaneous quantification of 8 nucleotides and adenosine in cells and their medium using UHPLC-HRMS>, Quality Control of 58-97-9, the main research area is nucleotide adenosine UHPLC HRMS; Adenosine; Extracellular; High-resolution mass spectrometry; Intracellular; Nucleotides; Quantification.

Purinergic signaling is involved in physiol. processes, particularly during ischemia-reperfusion injuries for which it has a protective effect. The purpose of this work was to develop a method for simultaneous quantification of eight nucleotides and adenosine in biol. matrixes by liquid chromatog. coupled with high-resolution mass spectrometry. A method was developed that was sufficiently robust to quantify the targeted analytes in 20 min with good sensitivity. Anal. of extracellular media from cultured endothelial cells detected the release of nucleotides and adenosine during 2 h of hypoxia. The quantification of cylic adenosine monophosphate (cAMP) allowed to establish a dose-response curve after receptor stimulation. Therefore, the authors′ method allows the authors to study the involvement of nucleotides in various processes in both the intracellular and extracellular compartment.

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciencespublished new progress about Cardiomyocyte. 58-97-9 belongs to class tetrahydrofurans, and the molecular formula is C9H13N2O9P, Quality Control of 58-97-9.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Liu, Qianhe; Liu, Qing; Hu, Xun published the artcile< Selective conversion of furfural into value-added chemical commodity in successive fixed-bed reactors>, Product Details of C5H10O2, the main research area is furfural commodity successive fixed bed reactor.

Successive hydrogenation of furfural in two fixed-bed reactors connected in tandem with Cu/SiO2 and Ni/SiO2 as the catalysts was achieved under atm. pressure. Various targeting products including furfuryl alc. (yield: 98.8%), 2-methylfuran (yield: 95.1%), 2-methyltetrahydrofuran (yield: 96.2%) and tetrahydrofurfuryl alc. (yield: 78.2%) could be obtained by variation of the reactor configurations.

Catalysis Communicationspublished new progress about Fixed-bed catalytic reactors. 97-99-4 belongs to class tetrahydrofurans, and the molecular formula is C5H10O2, Product Details of C5H10O2.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Zhu, Yanru; Zhao, Wenfang; Zhang, Jian; An, Zhe; Ma, Xiaodan; Zhang, Zhijun; Jiang, Yitao; Zheng, Lirong; Shu, Xin; Song, Hongyan; Xiang, Xu; He, Jing published the artcile< Selective activation of C-OH, C-O-C, or C=C in furfuryl alcohol by engineered Pt Sites supported on layered double oxides>, Name: (Tetrahydrofuran-2-yl)methanol, the main research area is selective activation carbon OH oxygen furfuryl alc engineered.

The selective activation of targeted bonds in biomass-derived furfural or furfuryl alc. with complex chem. linkages (C-C/C-H/C-O, C=C/C=O, or C-O-H/C-O-C) is of great challenge for biomass upgrading, expecting well-defined catalyst and definite catalytically active sites. This work demonstrates an efficient targeted activation to C-OH, C-O-C, or C=C by engineering the structure of catalytic Pt sites, affording 2-methylfuran (2-MF), tetrahydrofurfuryl alc. (THFA), or 1,2-pentanediol (1,2-PeD) as product in the hydroconversion of furfuryl alc. The catalytic Pt sites have been engineered as at. Pt, coordination unsaturated Pt-Pt in atom-thick dispersion, or coordination unsaturated 3D Pt-Pt by tailoring the Pt dispersion (single atom, 2D cluster, or 3D cluster) on Mg and Al-containing layered double oxide (Mg(Al)O) support. The selective activation of C-OH, C-O-C, or C=C has been traced with the FT-IR spectra recorded surface reaction. On at. Pt, C-O-H is easily activated, with the assistance of Mg(Al)O support, with O-terminal adsorption without affecting furan C-O and C=C. However, C=C in the furan ring is easier to be activated on coordination-unsaturated Pt-Pt in atom-thick dispersion, resulting in a step-by-step hydrogenation to generate THFA. On coordination-unsaturated 3D Pt-Pt, the hydrogenolysis of furan ring is favored, resulting in the cleavage of furan C-O to produce 1,2-PeD. Also, the Mg(Al)O supports derived from Mg and Al layered double hydroxides (LDHs) here also play a key role in promoting the selectivity to 1,2-PeD by providing basic sites.

ACS Catalysispublished new progress about Hydrogenation. 97-99-4 belongs to class tetrahydrofurans, and the molecular formula is C5H10O2, Name: (Tetrahydrofuran-2-yl)methanol.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Vega, Ana D.; Hynicka, Lauren M.; Claeys, Kimberly; Chua, Joel V.; Heil, Emily L. published the artcile< Effectiveness of 8 weeks of ledipasvir/sofosbuvir for hepatitis C in HCV-HIV-coinfected patients>, Application In Synthesis of 58-97-9, the main research area is ledipasvir sofosbuvir antiviral agent hepatitis C virus HIV.

Background: Data is limited on the use of 8 wk of therapy with ledipasvir/sofosbuvir (LDV/SOF) for special populations such as HCV-HIV-coinfected patients. The primary objective of this anal. was to compare sustained virol. response at 12 wk after end of therapy (SVR12) rates among HCV-monoinfected and HCV-HIV-coinfected patients in a real-world clin. setting. Addnl., we compared SVR12 rates among patients receiving 8 vs. 12 wk of therapy. Methods: This was a single-center, retrospective study of HCV-infected patients prescribed LDV/SOF at ambulatory clinics associated with the University of Maryland Medical Center (UMMC) from May 2015 to May 2016. Data were obtained from UMMC electronic medical records and outpatient pharmacy claims database. Comparisons between groups were made using χ2 or Fisher’s exact test for categorical variables and Student’s t-test or Wilcoxon rank-sum for continuous variables. All analyses were per-protocol; patients missing SVR12 data (25.2%) could not be evaluated for our stated objectives. Results: A total of 274 patients were included. Median age was 58 years; 62.8% were male; 82.5% were Black. SVR12 data was available for 65 HCV-HIV-coinfected patients, of which 62 (95.4%) achieved SVR12. There was no difference in SVR12 rate between HCV-HIV-coinfected patients and HCV-monoinfected patients (86/90; 95.6%; P=0.959). Addnl., there was no difference in SVR12 attainment between HIV-HCV-coinfected patients who received 8 vs. 12 wk of therapy (P=0.101). Conclusions: 8 wk of LDV/SOF was effective for treatment-naive, non-cirrhotic, HCV genotype-1 patients in this real-world setting, regardless of HIV status. Increased uptake of the 8-wk regimen can decrease costs for patients and payers without compromising outcomes.

Antiviral Therapypublished new progress about Antiviral agents. 58-97-9 belongs to class tetrahydrofurans, and the molecular formula is C9H13N2O9P, Application In Synthesis of 58-97-9.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Taylor, Martin J.; Beaumont, Simon K.; Islam, Mohammed J.; Tsatsos, Sotirios; Parlett, Christopher A. M.; Issacs, Mark A.; Kyriakou, Georgios published the artcile< Atom efficient PtCu bimetallic catalysts and ultra dilute alloys for the selective hydrogenation of furfural>, Category: tetrahydrofurans, the main research area is atom PtCu bimetallic catalyst dilute alloy hydrogenation furfural.

A range of Pt:Cu bimetallic nanoparticles were investigated for the liquid-phase selective hydrogenation of furfural, an important platform biomass feedstock. Alloying of the two metals had a profound effect on the overall catalytic activity, providing superior rates of reaction and achieving the needed high selectivity towards furfuryl alc. Furthermore, we investigated the catalytic activity of an Ultra Dilute Alloy (UDA) formed via the galvanic replacement of Cu atoms by Pt atoms on dispersed host Cu nanoparticles (at. ratio Pt:Cu 1:20). This UDA, after overcoming an induction period, exhibits exceptionally high initial rates of hydrogenation under modest hydrogen pressures of 10 and 20 bar, rivalling the catalytic turnover for the monometallic Pt (containing 12 times more Pt), and outdoing the pure Cu or other compositions of bimetallic nanoparticle alloy catalysts. These atom efficient catalysts are ideal candidates for the valorization of furfural due to their activity and vastly greater economic viability.

Applied Catalysis, B: Environmentalpublished new progress about Hydrogenation catalysts. 97-99-4 belongs to class tetrahydrofurans, and the molecular formula is C5H10O2, Category: tetrahydrofurans.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem