Heterocyclic Building Blocks-Tetrahydrofuran

Gao, Rui; Li, Xiang; Guo, Lingyun; Tong, Zhikun; Deng, Qiang; Wang, Jun; Zeng, Zheling; Zou, Ji-Jun; Deng, Shuguang published the artcile< Pyrochlore/Al2O3 composites supported Pd for the selective synthesis of cyclopentanones from biobased furfurals>, Application of C5H10O2, the main research area is pyrochlore alumina supported palladium catalyst cyclopentanones biobased furfural.

Designing a bifunctional catalyst with both highly selective C=O hydrogenation ability and Lewis acid-catalyzed ring-rearrangement ability is highly important for the synthesis of the cyclopentanone motifs from furfural derivatives Herein, a class of pyrochlore/Al2O3 composites (2.68 wt%Y2(Sn0.65Al0.35)2O7-δ/Al2O3, 7.74 wt%Y2(Sn0.65Al0.35)2O7-δ/Al2O3) with a onefold Lewis acidity and rich oxygen defects were synthesized via a dissolution-precipitation method. After the impregnation by Pd nanoparticles, the oxygen defect of pyrochlore/Al2O3 shows a bifunctional effect: they can adsorb C=O, promoting the selective C=O hydrogenation step and can enhance the accessibility of coordinatively unsaturated metal ions, providing Lewis acidic sites for the ring-rearrangement step. The composite-based catalysts show noticeably higher hydrogenation and hydrolysis rates than their corresponding single metal oxide-based catalysts (Pd/Al2O3, Pd/Y2Sn2O7). Finally, 7.74 wt%Y2(Sn0.65Al0.35)2O7-δ/Al2O3 shows a cyclopentanone yield of 98.1% and a 3-hydroxymethyl cyclopentanone yield of 90.6%. ATR-IR results verify the catalytic mechanism and emphasize the importance of oxygen defects.

Applied Catalysis, A: General published new progress about Acidity. 97-99-4 belongs to class tetrahydrofurans, and the molecular formula is C5H10O2, Application of C5H10O2.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Rhee, Sung W.; DeGraw, Joseph I.; Kaegi, Heinz H. published the artcile< Synthesis of a new class of retinoid, tritium-labeled TTNPB [(E)-4-[2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl]benzoic acid] with a high specific activity>, SDS of cas: 5455-94-7, the main research area is retinoidal benzoic acid tritium labeled; naphthalenylpropenylbenzoic acid retinoid tritium labeled.

The labeled retinoidal benzoic acid I was prepared starting with C6H6 and furanone II via catalytic tritiation of dihydronaphthalene III.

Journal of Labelled Compounds and Radiopharmaceuticals published new progress about 5455-94-7. 5455-94-7 belongs to class tetrahydrofurans, and the molecular formula is C8H14O2, SDS of cas: 5455-94-7.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Kuang, Bifeng; Zhang, Qian; Fang, Yanxiong; Bai, Yong; Qiu, Songbai; Wu, Ping; Qin, Yanlin; Wang, Tiejun published the artcile< Ring Opening of Cyclic Ether for Selective Synthesis of Renewable 1,5-Pentanediol over Pt/WO3@SiO2 Catalysts>, HPLC of Formula: 97-99-4, the main research area is ring opening catalyst cyclic ether renewable pentanediol.

In this paper, the WO3-embedded in mesoporous SiO2 framework (WO3@SiO2) was developed using facile modified sol-gel, and was further applied as the support of Pt/WO3@SiO2 catalysts during impregnation. The ring-opening of cyclic ether such as biomass-derived tetrahydrofurfuryl alc. (THFA), for selective synthesis of renewable 1, 5-pentanediol (1, 5-PeD), was efficiently accomplished over Pt/WO3@SiO2 catalysts. This special nanocomposite structure provided both abundant active sites and strong synergetic coupling, thus significantly boosting the catalytic performances. The effects of reaction parameters were also investigated on the catalytic performances, including W/Si molar ratio, reaction time, reaction temperature and reduction temperature The high THFA conversion of 82.9% and 1, 5-PeD selectivity of 72.9% were achieved under the optimized reaction conditions. The preliminary characterization results suggested that the Bronsted acid sites of HxWO3 species with proper acid amounts played an important role in controlling the selective ring-opening of THFA cyclic ether towards 1, 5-PeD.

Industrial & Engineering Chemistry Research published new progress about Biomass. 97-99-4 belongs to class tetrahydrofurans, and the molecular formula is C5H10O2, HPLC of Formula: 97-99-4.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Shen, Su; Zhang, Xing; Li, Zhimin published the artcile< Development of an engineered carbamoyl phosphate synthetase with released sensitivity to feedback inhibition by site-directed mutation and casting error-prone PCR>, Product Details of C9H13N2O9P, the main research area is Carbamoyl phosphate synthase; Feedback inhibition; Intermolecular interaction; Molecular docking; Protein engineering.

Carbamoyl phosphate synthetase (CPS) is a key enzyme in both pyrimidine and arginine biosynthesis. However, it is inhibited strongly by uridine monophosphate (UMP), which is an intermediate of the de-novo synthesis of pyrimidine nucleoside. In this study, the native carbamoyl phosphate synthetase, from Escherichia coli, was evolved by site-directed mutation and casting error-prone PCR. Compared with the wild-type, the variant N1015 F had released sensitivity to UMP and exhibited 100% of the initial activity in the presence of UMP. Variant K1006A exhibited 0.14-fold improvement in initial activity and kept above 65% of relative activity under the saturated concentration of inhibitor. Structure anal. of variants demonstrated that the reduced sensitivity to inhibitor was largely attributed to the decreased hydrogen bonds, which could reduce the binding affinity with UMP. Also, Phe with large side chain could narrow the binding pocket and generate more steric hindrance. Based on the results in this study, N1015F was an ideal alternative catalyst for the wild-type CPS for pyrimidine biosynthesis.

Enzyme and Microbial Technology published new progress about 58-97-9. 58-97-9 belongs to class tetrahydrofurans, and the molecular formula is C9H13N2O9P, Product Details of C9H13N2O9P.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Rymen, Daisy; Lindhout, Martijn; Spanou, Maria; Ashrafzadeh, Farah; Benkel, Ira; Betzler, Cornelia; Coubes, Christine; Hartmann, Hans; Kaplan, Julie D.; Ballhausen, Diana; Koch, Johannes; Lotte, Jan; Mohammadi, Mohammad Hasan; Rohrbach, Marianne; Dinopoulos, Argirios; Wermuth, Marieke; Willis, Daniel; Brugger, Karin; Wevers, Ron A.; Boltshauser, Eugen; Bierau, Jorgen; Mayr, Johannes A.; Wortmann, Saskia B. published the artcile< Expanding the clinical and genetic spectrum of CAD deficiency: an epileptic encephalopathy treatable with uridine supplementation>, Formula: C9H13N2O9P, the main research area is anemia epilepticus dyserythropoietic infantile encephalopathy; EIEE; anemia; developmental delay; early infantile epileptic encephalopathy-50; epilepsy.

Abstract: Purpose: Biallelic CAD variants underlie CAD deficiency (or early infantile epileptic encephalopathy-50, [EIEE-50]), an error of pyrimidine de novo biosynthesis amenable to treatment via the uridine salvage pathway. We further define the genotype and phenotype with a focus on treatment. Methods: Retrospective case series of 20 patients. Results: Our study confirms CAD defici. as a progressive EIEE with recurrent status epilepticus, loss of skills, and dyserythropoietic anemia. We further refine the phenotype by reporting a movement disorder as a frequent feature, and add that milder courses with isolated developn. delay/intellectual disability can occur as well as onset with neonatal seizures. With no biomarker availa., the diagnosis relies on genetic testing and functional validation in patient-derived fibroblasts. Underlying pathogenic variants are often rated as variants of unknown significance, which could lead to underrecognition of this treatable disorder. Supplemen. with uridine, uridine monophosphate, or uridine triacetate in 10 patients was safe and led to significant clin. improvn. in most patients. Conclusion: We advise a trial with uridine in all patients with developmental delay/intellectual disability, epilepsy, and anemia; all patients with status epilepticus; and all patients with neonatal seizures until (genetically) proven otherwise or proven unsuccessful after 6 mo. CAD defici. might represent a condition for genetic newborn screening.

Genetics in Medicine published new progress about Anemia. 58-97-9 belongs to class tetrahydrofurans, and the molecular formula is C9H13N2O9P, Formula: C9H13N2O9P.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Zhou, Dong-Dong; Zhang, Hao; Zhang, Qian; Qian, Zheng-Ming; Li, Wen-Jia; Li, Chun-Hong; Yang, Feng-Qing; Chen, Hua published the artcile< Preparation of titanium ion functionalized polydopamine coated ferroferric oxide core-shell magnetic particles for selective extraction of nucleotides from Cordyceps and Lentinus edodes>, Safety of ((2R,3S,4R,5R)-5-(2,4-Dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl dihydrogen phosphate, the main research area is titanium polydopamine ferroferric oxide magnetic particle nucleotide Cordyceps Lentinus; Cordyceps; Lentinus edodes; Magnetic solid phase extraction; Nucleotides; Selective extraction.

In this study, a titanium ion (Ti4+) functionalized polydopamine coated ferroferric oxide (Fe3O4@PDA@Ti4+) core-shell magnetic particle was prepared for the selective extraction of nucleotides. Firstly, different metal ions including Ti4+, Zr4+, Fe3+, Al3+, Cu2+, Zn2+, Ni2+ and Mg2+ were resp. immobilized onto Fe3O4@PDA particles and their extraction efficiency for five nucleotides [cytidine-5′-monophosphate (CMP), uridine-5′-monophosphate (UMP), guanosine-5′-monophosphate (GMP), thymidine-5′-monophosphate (TMP) and adenosine-5′-monophosphate (AMP)] were compared. Among these prepared materials, Fe3O4@PDA@Ti4+, which exhibited the highest extraction efficiency for nucleotides, was further characterized by Fourier transform IR spectroscopy, SEM, TEM and energy dispersive x-ray spectroscopy. After being optimized of the extraction parameters including adsorbent amounts, extraction time, extraction temperature, type and concentration of the eluent, the prepared Fe3O4@PDA@Ti4+ magnetic particles were successfully applied for the selective extraction and determination of CMP, UMP, GMP, TMP and AMP in Cordyceps and Lentinus edodes. Good linearity (varying from 0.063 to 19.000 μg/mL, R2 > 0.999) and low limit of detection (LODs) (ranging between 0.0047 and 0.0141 μg/mL) for target analytes were achieved. These results demonstrated that the synthesized material in this study had potential for selective extraction of phosphorylated small mol. compounds in complicated matrix.

Journal of Chromatography A published new progress about Cordyceps. 58-97-9 belongs to class tetrahydrofurans, and the molecular formula is C9H13N2O9P, Safety of ((2R,3S,4R,5R)-5-(2,4-Dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl dihydrogen phosphate.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Anteunis, M.; Vandewalle, M. published the artcile< Long-range phenomena. XII. Organic mass spectrometry. VII. Enolization in 3-oxotetrahydrofuran. PMR and MS study>, Electric Literature of 5455-94-7, the main research area is PMR oxotetrahydrofuran enolization; mass spectra oxotetrahydrofuran enolization.

A PMR study shows extensive enolization in the 3-oxotetrahydrofurans with branched substitution at C-5. Next to classical M-mode long range couplings, non-planar (non-classical) long range couplings, J(2,4) and J(2,5) are common features. The 3-oxotetrahydrofuran ring is easily changed conformationally, which is reflected by changes in vicinal and long range coupling values. The mass spectra of the keto- and enol mols. show different fragmentation patterns. The expulsion of an alkane moiety, directly from the molecular ion (M+), is observed for the enol form. Mass spectrometry allows easy characterization of C-2 or C-5-substituted 3-oxotetrahydrofurans.

Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy published new progress about Mass spectra. 5455-94-7 belongs to class tetrahydrofurans, and the molecular formula is C8H14O2, Electric Literature of 5455-94-7.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Chen, Jianzhong; Zhang, Zhenfeng; Li, Bowen; Li, Feilong; Wang, Yulin; Zhao, Min; Gridnev, Ilya D.; Imamoto, Tsuneo; Zhang, Wanbin published the artcile< Pd(OAc)2-catalyzed asymmetric hydrogenation of sterically hindered N-tosylimines>, Recommanded Product: 2,2,5,5-Tetramethyldihydrofuran-3(2H)-one, the main research area is tosylamine preparation enantioselective; tosylimine preparation hydrogenation palladium catalyst.

An efficient palladium acetate (an inexpensive Pd salt with low toxicity) catalyzed asym. hydrogenation of sterically hindered N-tosylimines RC(R1)=NS(O)2R2 (R = t-Bu, 1-methoxycyclohexyl, adamantan-1-yl, etc.; R1 = Ph, 2H-1,3-benzodioxol-5-yl, Me, etc.; R2 = Ph, Me, 4-FC6H4, etc.), (E)-N-(2,2-Dimethylcyclopentylidene)-4-methylbenzenesulfonamide and (E)-4-Methyl-N-(2,2,5,5-tetramethyldihydrofuran-3(2H)-ylidene)benzenesulfonamide is realized with high catalytic activities (S/C up to 5000) and excellent enantioselectivities (ee up to 99.9%). Quantum chem. calculations suggest that uniformly high enantioselectivities are observed due to the structurally different S- and R-reaction pathways.

Nature Communications published new progress about Amines, chiral Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation) (tosyl). 5455-94-7 belongs to class tetrahydrofurans, and the molecular formula is C8H14O2, Recommanded Product: 2,2,5,5-Tetramethyldihydrofuran-3(2H)-one.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Zhang, Lin; Badea, Beth Ann; Enyeart, Debra; Berger, Elaine M.; Mais, Dale E.; Boehm, Marcus F. published the artcile< Synthesis of isotopically labeled 4-[1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)ethenyl]benzoic acid (LGD1069), a potent retinoid X receptor-selective Ligand>, Reference of 5455-94-7, the main research area is isotopically labeled retinoid preparation binding receptor; benzoic acid naphthylethenyl preparation binding receptor; naphthylethenylbenzoic acid preparation binding receptor.

LGD1069, 4-[1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)ethenyl]benzoic acid, is the first retinoid X receptor (RXR)-selective retinoid to enter clin. trials for treatment of dermatol. diseases and cancer. In order to exam. biol. properties such as receptor binding, metabolism and bioavailability, [13C]-, [14C]-, and [3H]-labeled LGD1069 is required. Herein, the authors describe synthetic methods for preparing isotopically labeled homologs of LGD1069 and [3H]-9-cis-retinoic acid with RXR active retinoids. The final radiolabeled products, [6,7-3H]-LGD1069 and 3-[14C]-LGD1069 have specific activities of 56 Ci/mmol and 49 mCi/mmol, resp. Radiochem. purities are 99.5% for [6,7-3H]-LGD1069 and 99.0% for 3-[14C]-LGD1069. The chem. purity is 99.0% for 3-[13CD3]-LGD1069. Competition binding studies with known retinoids show similar Kd values when either [6,7-32H]-LGD1069 or [3H]-9-cis-retinoic acid as the radioligand.

Journal of Labelled Compounds & Radiopharmaceuticals published new progress about Receptors Role: BSU (Biological Study, Unclassified), BUU (Biological Use, Unclassified), BIOL (Biological Study), USES (Uses). 5455-94-7 belongs to class tetrahydrofurans, and the molecular formula is C8H14O2, Reference of 5455-94-7.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Wang, Yongxing; Lu, Yaowei; Cao, Qiue; Fang, Wenhao published the artcile< A magnetic CoRu-CoOX nanocomposite efficiently hydrogenates furfural to furfuryl alcohol at ambient H2 pressure in water>, Computed Properties of 97-99-4, the main research area is ruthenium cobalt oxide magnetic nanocomposite hydrogenation catalyst; hydrogenation catalyst furfural furfuryl alc.

A one-pot synthesized CoRu-CoOX nanocomposite was reported as a magnetically recoverable catalyst for selective hydrogenation of furfural to furfuryl alc. in water at ambient H2 pressure.

Chemical Communications (Cambridge, United Kingdom) published new progress about Adsorption. 97-99-4 belongs to class tetrahydrofurans, and the molecular formula is C5H10O2, Computed Properties of 97-99-4.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem