Heterocyclic Building Blocks-Tetrahydrofuran

Zhang, Mei; Liu, Weili; Gao, Xia; Cui, Peng; Zou, Tao; Hu, Guanghui; Tao, Liming; Zhai, Lei published the artcile< Preparation and characterization of semi-alicyclic polyimides containing trifluoromethyl groups for optoelectronic application>, Electric Literature of 4415-87-6, the main research area is polyimide trifluoromethyl group optoelectronic application; alicyclic structure; polyimide; structure–property relationship; transparency; trifluoromethyl.

Transparent polyimides (PI) films with outstanding overall performance are attractive for next generation optoelectronic and microelectronic applications. Semi-alicyclic PIs derived from alicyclic dianhydrides and aromatic diamines have proved effective to prepare transparent PIs with high transmittance. To optimize the combined properties of semi-alicyclic PIs, incorporating bulky trifluoromethyl groups into the backbones is regarded as a powerful tool. However, the lack of fundamental understanding of structure-property relationships of fluorinated semi-alicyclic PIs constrains the design and engineering of advanced films for such challenging applications. Herein, a series of semi-alicyclic PIs derived from alicyclic dianhydrides and trifluoromethyl-containing aromatic diamines was synthesized by solution polycondensation at high temperature The effects of alicyclic structures and bulky trifluoromethyl groups on thermal, dielec. and optical properties of PIs were investigated systematically. These PI films had excellent solubility, low water absorption and good mech. property. They showed high heat resistance with Tg in the range of 294-390 °C. It is noted that tensile strength and thermal stability were greatly affected by the rigid linkages and alicyclic moieties, resp. These films exhibited obviously low refractive indexes and significantly reduced dielec. constants from 2.61 to 2.76, together with low optical birefringence and dielec. anisotropy. Highly transparent films exhibited cutoff wavelength even as low as 298 nm and transmittance at 500 nm over 85%, displaying almost colorless appearance with yellowness index (b*) below 4.2. The remarkable optical improvement should be mainly ascribed to both weak electron-accepting alicyclic units and bulky electron-withdrawing trifluoromethyl or sulfone groups. The present work provides an effective strategy to design mol. structures of optically transparent PIs for a trade-off between solution-processability, low water uptake, good toughness, high heat resistance, low dielec. constant and excellent optical transparency.

Polymers (Basel, Switzerland) published new progress about Absorption. 4415-87-6 belongs to class tetrahydrofurans, and the molecular formula is C8H4O6, Electric Literature of 4415-87-6.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Kiani, Salma; Staples, Richard J.; Ted Treves, S.; Packard, Alan B. published the artcile< Synthesis and characterization of a tetramethyl furanone functionalized diiminedioxime, a potential ligand for 64Cu radiopharmaceuticals, and its copper(II) and nickel(II) complexes>, Recommanded Product: 2,2,5,5-Tetramethyldihydrofuran-3(2H)-one, the main research area is copper nickel furanone functionalized imineoxime preparation structure; crystal structure copper nickel furanone functionalized imineoxime; furanone functionalized imineoxime preparation potential radiopharmaceutical imaging ligand.

As part of the authors’ on-going effort to develop 64Cu-based radiopharmaceuticals for PET (positron emission tomog.) imaging of multidrug resistance in cancer, the authors prepared a tetramethylfuranone-functionalized diiminedioxime ligand, TMFPreH (TMFPreH = 4-[3-(4-hydroxyimino-2,2,5,5-dimethyl-dihydro-furan-3-ylideneamino)-propylimino]-2,2,5,5-tetramethyl-dihydrofuran-3(2H)-one oxime) and its Cu(II) and Ni(II) complexes. When the Cu(II) complex was prepared from Cu(ClO4)2 in EtOH, it was isolated as a Cu(II)-bridged dimer, but when it was prepared from Cu(OAc)2 and heated in acetone, an unusual example of an acetone adduct of the ligand is formed by reduction of one of the imine double bonds by the solvent. The Ni(II) complex is square planar with the perchlorate counterion not bonded.

Polyhedron published new progress about Crystal structure. 5455-94-7 belongs to class tetrahydrofurans, and the molecular formula is C8H14O2, Recommanded Product: 2,2,5,5-Tetramethyldihydrofuran-3(2H)-one.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Chuseang, Jirawat; Nakwachara, Rapeepong; Kalong, Munsuree; Ratchahat, Sakhon; Koo-amornpattana, Wanida; Klysubun, Wantana; Khemthong, Pongtanawat; Faungnawakij, Kajornsak; Assabumrungrat, Suttichai; Itthibenchapong, Vorranutch; Srifa, Atthapon published the artcile< Selective hydrogenolysis of furfural into fuel-additive 2-methylfuran over a rhenium-promoted copper catalyst>, SDS of cas: 97-99-4, the main research area is furfural hydrogenation methylfuran rhenium copper catalyst phys chem property.

The effect of Re promoter on Cu/γ-Al2O3 catalysts with various Cu : Re molar ratios was comprehensively investigated in comparison to the monometallic Cu/γ-Al2O3 and Re/γ-Al2O3 catalysts. The combination of Re and Cu resulted in a difficulty in reduction behavior of the Cu species, as detected using hydrogen temperature-programmed reduction, indicating that the Re promoter had stronger metal-support interactions. The acidity, as confirmed by ammonia temperature-programmed desorption, increased with the Re loading. X-ray diffraction and X-ray absorption near edge structure measurements of the spent CuRe catalyst revealed the existence of metallic Cu, Cu2O, CuO, amorphous CuAl2O4, ReO3, and NH4ReO4. The as-synthesized catalysts without reduction were directly utilized for the hydrogenolysis of furfural (FAL) into the fuel additive 2-methylfuran (2-MF). The highest 2-MF yield (86.4%) was accompanied by a 10.4% 2-methyltetrahydrofuran (2-MTHF) yield using the optimal Cu1Re0.14 catalyst under the investigated conditions (200°C, 6 h, and 20 bar H2). The kinetic study using furfuryl alc. (FOL), a primary intermediate, revealed that the rate of 2-MF production for the optimal Cu1Re0.14 catalyst was faster than that of the Cu benchmark. These results indicated that a small amount of oxophilic Re species could promote the hydrogenolysis of the C-OH bond in FOL to form 2-MF due to the synergistic effect between the Cu and Re active species. In addition, the activity of the Cu1Re0.14 catalyst remained highly stable through four consecutive experiments

Sustainable Energy & Fuels published new progress about Adsorption. 97-99-4 belongs to class tetrahydrofurans, and the molecular formula is C5H10O2, SDS of cas: 97-99-4.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Vlasova, Nataliya; Markitan, Olga published the artcile< Phosphate-nucleotide-nucleic acid: Adsorption onto nanocrystalline ceria surface>, Computed Properties of 58-97-9, the main research area is cerium dioxide deoxyribonucleic acid phosphate nucleotide.

The adsorption of DNA (DNA) and its constituents – phosphate and nucleotides on the surface of nanocrystalline cerium dioxide (pHpzc = 6.3) in NaCl solutions was investigated using multi batch adsorption experiments over a wide range pH. The adsorption data of inorganic phosphate, and nucleotides were interpreted as a formation of outer and inner sphere surface complexes in term of the Basic Stern surface complexation model. The comparison of adsorptions of DNA, phosphate and nucleotides has revealed that double-stranded DNA is mainly adsorbed with the participation of phosphate backbone of its mol. The approach of DNA to the oxide surface due to the electrostatic attraction promotes other types of interaction, e.g. dispersion interaction and hydrogen bonding.

Colloids and Surfaces, A: Physicochemical and Engineering Aspects published new progress about DNA Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 58-97-9 belongs to class tetrahydrofurans, and the molecular formula is C9H13N2O9P, Computed Properties of 58-97-9.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Feliu, Catherine; Peyret, Helene; Vautier, Damien; Djerada, Zoubir published the artcile< Simultaneous quantification of 8 nucleotides and adenosine in cells and their medium using UHPLC-HRMS>, Recommanded Product: ((2R,3S,4R,5R)-5-(2,4-Dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl dihydrogen phosphate, the main research area is nucleotide adenosine UHPLC HRMS; Adenosine; Extracellular; High-resolution mass spectrometry; Intracellular; Nucleotides; Quantification.

Purinergic signaling is involved in physiol. processes, particularly during ischemia-reperfusion injuries for which it has a protective effect. The purpose of this work was to develop a method for simultaneous quantification of eight nucleotides and adenosine in biol. matrixes by liquid chromatog. coupled with high-resolution mass spectrometry. A method was developed that was sufficiently robust to quantify the targeted analytes in 20 min with good sensitivity. Anal. of extracellular media from cultured endothelial cells detected the release of nucleotides and adenosine during 2 h of hypoxia. The quantification of cylic adenosine monophosphate (cAMP) allowed to establish a dose-response curve after receptor stimulation. Therefore, the authors′ method allows the authors to study the involvement of nucleotides in various processes in both the intracellular and extracellular compartment.

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences published new progress about Cardiomyocyte. 58-97-9 belongs to class tetrahydrofurans, and the molecular formula is C9H13N2O9P, Recommanded Product: ((2R,3S,4R,5R)-5-(2,4-Dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl dihydrogen phosphate.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Li, Feng; Jiang, Shanshan; Zhu, Tianhan; Wang, Yue; Huang, Tao; Li, Cuiqin published the artcile< Organodiphosphonate Metal-Organic Frameworks Derived Ni-P@C Catalyst for Hydrogenation of Furfural>, Electric Literature of 97-99-4, the main research area is organodiphosphonate metal organic framework furfural hydrogenation.

Tetra-Et p-xylenediphosphate is used as the organic ligand to prepare the Ni-P-MOFs material belonging to the category of organic phosphoric acids, through pyrolysis and in-situ reduction reaction of Ni-P-MOFs material during the high-temperature carbonization process, Ni-P@C catalyst with graphitized carbon-covering Ni2P particles is prepared Compared with Ni-P catalyst prepared through coprecipitation method, Ni-P@C catalyst prepared with Ni-P-MOFs material can obviously decrease the formation temperature of Ni2P active phase and retain the schistose morphol. of the Ni-P-MOFs material, which is of high specific area, and meanwhile effectively suppresses the agglomeration of Ni2P particles. It is indicated by research on furfural hydrogenation performance that, Ni-P@C catalyst presents a high activity and stability in furfural hydrogenation. Products of furfural hydrogenation catalyzed by Ni-P@C catalyst mainly contain furfuryl alc., 2-methylfuran and 2-methyltetra hydrofuran, and the reaction temperature and reaction time have great influence on the distribution of products. The carbon-covering structure of Ni-P@C catalyst can effectively protect the active components of Ni2P, thus presenting a high stability and good reusability.

ChemistrySelect published new progress about Crystallinity. 97-99-4 belongs to class tetrahydrofurans, and the molecular formula is C5H10O2, Electric Literature of 97-99-4.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Szubiakiewicz, Elzbieta; Modelska, Magdalena; Brzezinska, Magdalena; Binczarski, Michal J.; Severino, Courtney J.; Stanishevsky, Andrei; Witonska, Izabela published the artcile< Influence of modification of supported palladium systems by polymers: PVP, AMPS and AcrAMPS on their catalytic properties in the reaction of transformation of biomass into fuel bio-components>, Synthetic Route of 97-99-4, the main research area is acidic hydrolysis waste biomass furfural reduction palladium polymer catalyst.

Catalytic systems based on highly dispersed Pd nanoparticles deposited on SiO2 modified with PVP, AMPS and AcrAMPS were prepared and used in the hydrogenation of furfural obtained by the aqueous phase acidic hydrolysis of waste biomass (sugar beet pulp, sugar beet leaves, and brewing grain) from the food industry. Pd/PVP/SiO2 catalysts containing 50 g of Pd per 1 kg of catalyst were characterized by high activity in studied process, but lower selectivity to THFA in comparison to Pd/AMPS-SiO2 or Pd/AcrAMPS-SiO2 catalysts. The modification of SiO2 by PVP followed by the palladium catalyst loading, limited the adsorption of furfural by carbonyl group which probably leads to the improvement in THFA formation, which was confirmed by FTIR studies. The physico-chem. properties of the obtained palladium catalysts were investigated by XRD, CO chemisorption, TPR H2, TG-DTA-MS and BET techniques. The ICP-AES indicated no leaching of metal into the environment during furfural reduction, which confirms the stability of the Pd/PVP/SiO2, Pd/AMPS-SiO2 and Pd/AcrAMPS-SiO2 systems in the studied process.

Fuel published new progress about Acid hydrolysis. 97-99-4 belongs to class tetrahydrofurans, and the molecular formula is C5H10O2, Synthetic Route of 97-99-4.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Seifert, Roland; Schirmer, Bastian published the artcile< cCMP and cUMP come into the spotlight, finally>, Reference of 58-97-9, the main research area is cytidylyl uridylyl cyclase identification; base-specificity; cCMP; cUMP; cytidylyl cyclase; second messenger; uridylyl cyclase.

cCMP and cUMP have been identified in numerous biol. systems and proposed to serve as second messengers. However, this proposal remained controversial because of the base-promiscuity of generators, effectors, phosphodiesterases, and bacterial toxins. With the identification of specific cytidylyl and uridylyl cyclases, cCMP and cUMP research enters a new era.

Trends in Biochemical Sciences published new progress about Enzymes Role: BSU (Biological Study, Unclassified), BIOL (Biological Study) (Uridylyl cyclase). 58-97-9 belongs to class tetrahydrofurans, and the molecular formula is C9H13N2O9P, Reference of 58-97-9.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Wang, Zhuangqing; Wang, Xinchao; Zhang, Chao; Arai, Masahiko; Zhou, Leilei; Zhao, Fengyu published the artcile< Selective hydrogenation of furfural to furfuryl alcohol over Pd/TiH2 catalyst>, Recommanded Product: (Tetrahydrofuran-2-yl)methanol, the main research area is palladium titanium hydride catalyst furfural hydrogenation furfuryl alc.

In this work, the selective hydrogenation of furfural to furfuryl alc. has been studied over Pd/TiH2 catalysts. The catalytic performances of several catalysts with different Pd loading (0.2-3% in weight) were discussed, among which a higher selectivity to furfuryl alc. was obtained over 0.5Pd/TiH2 and it gave rise to a 73% furfural alc. selectivity at complete conversion at 60°C. The physicochem. properties of catalysts were well characterized by TEM, XRD, XPS, Raman, TPR and TPD, as well as in-situ DRIFT for the adsorption of the reactant. The size and the electronic state of Pd particles, and the surface defects of catalysts presented significant influence on the catalytic performance. The furfural is preferentially adsorbed with its C = O bond on the boundary of Pd particle and TiH2 support, leading to the high selectivity to furfuryl alc.

Molecular Catalysis published new progress about Adsorption. 97-99-4 belongs to class tetrahydrofurans, and the molecular formula is C5H10O2, Recommanded Product: (Tetrahydrofuran-2-yl)methanol.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Beaver, Matthew G.; Zhang, En-xuan; Liu, Zhi-qing; Zheng, Song-yuan; Wang, Bin; Lu, Jiang-ping; Tao, Jian; Gonzalez, Miguel; Jones, Sian; Tedrow, Jason S. published the artcile< Development and Execution of a Production-Scale Continuous [2 + 2] Photocycloaddition>, Recommanded Product: Cyclobuta[1,2-c:3,4-c’]difuran-1,3,4,6(3aH,3bH,6aH,6bH)-tetraone, the main research area is continuous photocycloaddition maleic anhydride ethylene cyclobutane.

This article details the approach to large-scale production of cyclobutane 2 by the continuous-flow [2 + 2] photocycloaddition of maleic anhydride and ethylene, including (1) focused reaction optimization and development of a robust isolation protocol, (2) the approach to equipment design and process safety, and (3) the results of commissioning tests and production runs delivering the target compound at throughputs exceeding 5 kg/day.

Organic Process Research & Development published new progress about Photocycloaddition reaction. 4415-87-6 belongs to class tetrahydrofurans, and the molecular formula is C8H4O6, Recommanded Product: Cyclobuta[1,2-c:3,4-c’]difuran-1,3,4,6(3aH,3bH,6aH,6bH)-tetraone.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem