Heterocyclic Building Blocks-Tetrahydrofuran

Computed Properties of C6H12O3In 2020 ,《Rearrangement and cyclisation reactions on the 1-arylpyrrol-2-iminyl-2-aryliminopyrrol-1-yl radical energy surface》 appeared in ARKIVOC (Gainesville, FL, United States). The author of the article were Borthwick, Scott; Foot, Jonathan; Ieva, Maria; McNab, Hamish; McNab, Lilian; Rozgowska, Emma J.; Wright, Andrew. The article conveys some information:

Independent generation of iminyl and pyrrol-1-yl radicals by flash vacuum pyrolysis of oxime ether I (X = N; R1 = MeO; R2 = 4-MeC6H4) and imine I (X = N; R1 = 4-MeC6H4; R2 = Me2N), resp., provided two regioisomeric pyrrolo[1,2-a]quinoxalines II. This shows that radical species interconvert via spirodienyl moiety at high temperatures Corresponding generation of pyrrol-1-yl radical from I (X = CH; R1 = 4-MeC6H4; R2 = Me2N) gave single pyrrolo[1,2-α]quinoline regioisomer as the only cyclized product. In this case, DFT calculations suggested that direct cyclization of pyrrol-1-yl took place, rather than formation of spirodienyl species and exclusive migration of C-N bond. In the experimental materials used by the author, we found 2,5-Dimethoxytetrahydrofuran(cas: 696-59-3Computed Properties of C6H12O3)

2,5-Dimethoxytetrahydrofuran(cas: 696-59-3) is a member of ether. When aromatic ethers are exposed to halogen in the presence or absence of a catalyst, they undergo halogenation, such as bromination.Computed Properties of C6H12O3

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

《Comprehensive chemical characterization of the aerosol generated by a heated tobacco product by untargeted screening》 was written by Bentley, Mark C.; Almstetter, Martin; Arndt, Daniel; Knorr, Arno; Martin, Elyette; Pospisil, Pavel; Maeder, Serge. Formula: C4H6O3 And the article was included in Analytical and Bioanalytical Chemistry on April 30 ,2020. The article conveys some information:

Abstract: A suite of untargeted methods has been applied for the characterization of aerosol from the Tobacco Heating System 2.2 (THS2.2), a heated tobacco product developed by Philip Morris Products S.A. and commercialized under the brand name IQOS. A total of 529 chem. constituents, excluding water, glycerin, and nicotine, were present in the mainstream aerosol of THS2.2, generated by following the Health Canada intense smoking regimen, at concentrations ≥ 100 ng/item. The majority were present in the particulate phase (n = 402), representing more than 80% of the total mass determined by untargeted screening; a proportion were present in both particulate and gas-vapor phases (39 compounds). The identities for 80% of all chem. constituents (representing > 96% of the total determined mass) were confirmed by the use of authentic anal. reference materials. Despite the uncertainties that are recognized to be associated with aerosol-based untargeted approaches, the reported data remain indicative that the uncharacterized fraction of TPM generated by THS2.2 has been evaluated to the fullest practicable extent. To the best of our knowledge, this work represents the most comprehensive chem. characterization of a heated tobacco aerosol to date. In addition to this study using 3-Hydroxydihydrofuran-2(3H)-one, there are many other studies that have used 3-Hydroxydihydrofuran-2(3H)-one(cas: 19444-84-9Formula: C4H6O3) was used in this study.

3-Hydroxydihydrofuran-2(3H)-one(cas: 19444-84-9) may be employed as starting reagent in the synthesis of series of seco-pseudonucleoside synthons via aminolysis. It may be employed as starting reagent in the synthesis of enantiomerically pure orthogonally protected δ-azaproline, via Mitsunobu reaction.Formula: C4H6O3

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

《Synthesis, characterization and antimicrobial evaluation of some 1,2,4-triazolo-5-thione derivatives》 was written by Singh, Gurdeep; Jain, Neetesh K.; Sahu, Kiran. Recommanded Product: 696-59-3This research focused ontriazolothione preparation antibacterial activity. The article conveys some information:

In this study, substituted 1,2,4-triazolo-5-thione derivatives I (R = 4-nitro, 3-nitro; R1 = Ph, Et, Me;) were synthesized from substituted aromatic aldehydes C6H4CHO, and succinic acid and the structure of synthesized compounds were established by physicochem. (M.p., Rf value) and spectral anal. The title compounds were then evaluated for their antimicrobial activity against ciprofloxacin as a standard drug using agar plate method. The synthesized derivatives I (R = 3-nitro, R1 = Et; R = 3-nitro, R1 = Me) were found to possess very promising antimicrobial activity. In addition to this study using 2,5-Dimethoxytetrahydrofuran, there are many other studies that have used 2,5-Dimethoxytetrahydrofuran(cas: 696-59-3Recommanded Product: 696-59-3) was used in this study.

2,5-Dimethoxytetrahydrofuran(cas: 696-59-3) is a member of ether. Friedel Crafts reaction, for example, adds an alkyl or acyl group to aromatic ethers when they react with an alkyl or acyl halide in the presence of a Lewis acid as a catalyst.Recommanded Product: 696-59-3

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Related Products of 696-59-3In 2020 ,《Synthesis and characterization of some new S-substituted sulfanylpyridines, thieno[2,3-b]pyridines and related heterocycles》 was published in ARKIVOC (Gainesville, FL, United States). The article was written by Al-Taifi, Elham A.; Al-Waleedy, Safiyyah A. H.; Abbady, Mohamed S.; Abdu-Allah, Hajjaj H. M.; Marae, Islam S.; Abuelhassan, Suzan; Bakhite, Etify A.. The article contains the following contents:

Et (3-cyano-5-ethoxycarbonyl-6-methyl-4-styryl-2-pyridylsulfanyl)acetate was prepared and reacted with hydrazine hydrate in ethanol to give a mixture of (3-cyano-5-ethoxycarbonyl-6-methyl-4-styryl-2- pyridylsulfanyl)acetohydrazide and di-Et 3-amino-6-methyl-4-styrylthieno[2,3-b]pyridine-2,5-dicarboxylate. The latter compound was reacted with 2,5-dimethoxytetrahydrofuran to give 3-(1H-pyrrol-1-yl)thieno[2,3-b]pyridine analog which on treatment with hydrazine hydrate in ethanol furnished 5-ethoxycarbonyl-6- methyl-3-(1H-pyrrol-1-yl)-4-styrylthieno[2,3-b]pyridine-2-carbohydrazide. Both acetohydrazide and carbohydrazide were used as precursors for the title compounds The experimental part of the paper was very detailed, including the reaction process of 2,5-Dimethoxytetrahydrofuran(cas: 696-59-3Related Products of 696-59-3)

2,5-Dimethoxytetrahydrofuran(cas: 696-59-3) is a member of ether. Friedel Crafts reaction, for example, adds an alkyl or acyl group to aromatic ethers when they react with an alkyl or acyl halide in the presence of a Lewis acid as a catalyst.Related Products of 696-59-3

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

《Thin layer chromatography and GC-MS analysis of bioactive molecules of the Acacia ferruginea DC. thorn extract》 was published in Asian Journal of Biological and Life Sciences in 2021. These research results belong to Malathi, H.; Thamizhseran, N.. Reference of 3-Hydroxydihydrofuran-2(3H)-one The article mentions the following:

The aim of the current study is to investigate thethin layer chromatog. (TLC) and gas chromatog. and mass spectroscopy anal. (GC-MS) of methanolic extract of Acacia ferruginea thorns. The bioactive mols. were determined by qual. TLC and GC-MS method. In TLC exhibited maximum 0.6 retention factor (RF) value of the plant extract in F254 wavelength in dark blue color, F366 wave length and in visible light not shown any peaks and RF values. In the GC-MS anal., 37 bioactive mols. were exhibited and in that 10 are in higher concentration by the retention time and their % of peak and area covered in the anal. compared to other chromatograms of the fractions. Important compounds identified as Me mannose (57.14), Phenol, 2-methoxy-3-(2-propenyl)- (4.85), stigmasterol (4.65), 1-Hexacosanol (3.83), Lupeol (3.60), gamma Sitosterol (3.52), Phenol, 4-[2-(dimethylamino)ethyl]-(3.17), Ergost-5-en- 3-ol, (3.beta.)- (2.53), Oleic acid (2.44), Oleoyl chloride (1.53), Sucrose (1.82). The presence of these bioactive mols. in the plant extract may provide the scientific evidences for the cytotoxic effect, insecticidal and other biol. properties. The experimental process involved the reaction of 3-Hydroxydihydrofuran-2(3H)-one(cas: 19444-84-9Reference of 3-Hydroxydihydrofuran-2(3H)-one)

3-Hydroxydihydrofuran-2(3H)-one(cas: 19444-84-9) may be employed as starting reagent in the synthesis of series of seco-pseudonucleoside synthons via aminolysis. It may be employed as starting reagent in the synthesis of enantiomerically pure orthogonally protected δ-azaproline, via Mitsunobu reaction.Reference of 3-Hydroxydihydrofuran-2(3H)-one

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Computed Properties of C4H6O3On September 1, 2021 ,《Depsipeptide nucleic acids: Prebiotic formation, oligomerization, and self-assembly of a new proto-nucleic acid candidate》 was published in Journal of the American Chemical Society. The article was written by Fialho, David M.; Karunakaran, Suneesh C.; Greeson, Katherine W.; Martinez, Isaac; Schuster, Gary B.; Krishnamurthy, Ramanarayanan; Hud, Nicholas V.. The article contains the following contents:

The mechanism by which informational polymers first formed on the early earth is currently unknown. The RNA world hypothesis implies that RNA oligomers were produced prebiotically, before the emergence of enzymes, but the demonstration of such a process remains challenging. Alternatively, RNA may have been preceded by an earlier ancestral polymer, or proto-RNA, that had a greater propensity for self-assembly than RNA, with the eventual transition to functionally superior RNA being the result of chem. or biol. evolution. We report a new class of nucleic acid analog, depsipeptide nucleic acid (DepsiPNA), which displays several properties that are attractive as a candidate for proto-RNA. The monomers of depsipeptide nucleic acids can form under plausibly prebiotic conditions. These monomers oligomerize spontaneously when dried from aqueous solutions to form nucleobase-functionalized depsipeptides. Once formed, these DepsiPNA oligomers are capable of complementary self-assembly and are resistant to hydrolysis in the assembled state. These results suggest that the initial formation of primitive, self-assembling, informational polymers on the early earth may have been relatively facile if the constraints of an RNA-first scenario are relaxed. The experimental part of the paper was very detailed, including the reaction process of 3-Hydroxydihydrofuran-2(3H)-one(cas: 19444-84-9Computed Properties of C4H6O3)

3-Hydroxydihydrofuran-2(3H)-one(cas: 19444-84-9) may be employed as starting reagent in the synthesis of series of seco-pseudonucleoside synthons via aminolysis. It may be employed as starting reagent in the synthesis of enantiomerically pure orthogonally protected δ-azaproline, via Mitsunobu reaction.Computed Properties of C4H6O3

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

The author of 《Identification of novel 3-hydroxy-pyran-4-one derivatives as potent HIV-1 integrase inhibitors using in silico structure-based combinatorial library design approach》 were Sirous, Hajar; Chemi, Giulia; Gemma, Sandra; Butini, Stefania; Debyser, Zeger; Christ, Frauke; Saghaie, Lotfollah; Brogi, Simone; Fassihi, Afshin; Campiani, Giuseppe; Brindisi, Margherita. And the article was published in Frontiers in Chemistry (Lausanne, Switzerland) in 2019. Quality Control of 2,5-Dimethoxytetrahydrofuran The author mentioned the following in the article:

The development and exptl. validation of a computational protocol for optimizing a series of 3-hydroxy-pyran-4-one derivatives I [R = 2-(3-fluorophenyl)pyridinyl, 2-methyl-4-phenyl-1-imidazolyl, 1-phenyl-1H-pyrrolyl] as HIV integrase inhibitors (HIV INIs) was repoted. Starting from a previously developed micromolar inhibitors of HIV integrase (HIV IN), in-depth investigation based on an in silico structure-based combinatorial library designing approach was reported. This method combined a combinatorial library design and side chain hopping with Quantum Polarized Ligand Docking (QPLD) studies and mol. dynamics simulation. The resulting compounds I were assessed by the mentioned QPLD methodol. using a homol. model of full-length binary HIV IN/DNA for retrieving the best performing compounds acted as HIV INIs. Along with the prediction of physico-chem. properties, limited number of drug-like compounds were potentially displayed potent HIV IN inhibition. The compounds I were exptl. assessed in vitro for evaluating overall HIV-1 IN inhibition, HIV-1 IN strand transfer activity inhibition, HIV-1 activity inhibition and cellular toxicity. Gratifyingly, all of them showed relevant inhibitory activity in the in vitro tests along with no toxicity. Among them compound I [R = 2-(3-fluorophenyl)pyridinyl] represented the most promising compound as potential anti-HIV agent, showed inhibitory activity against HIV IN in the low nanomolar range comparable to that found for Raltegravir and relevant potency in inhibiting HIV-1 replication and HIV-1 IN strand transfer activity. The results came from multiple reactions, including the reaction of 2,5-Dimethoxytetrahydrofuran(cas: 696-59-3Quality Control of 2,5-Dimethoxytetrahydrofuran)

2,5-Dimethoxytetrahydrofuran(cas: 696-59-3) is a member of ether. When aromatic ethers are exposed to halogen in the presence or absence of a catalyst, they undergo halogenation, such as bromination.Quality Control of 2,5-Dimethoxytetrahydrofuran

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Alqahtani, Yahya S.; Kumar, S. R. Prem; Pavitra, H.; Joshi, Shrinivas D. published an article in 2021. The article was titled 《Synthesis, computational docking, and antimycobacterial study of novel N’-phenyl-4-pyrrol-1-yl-benzenesulfonamide derivatives》, and you may find the article in Indian Journal of Heterocyclic Chemistry.Safety of 2,5-Dimethoxytetrahydrofuran The information in the text is summarized as follows:

Fresh sequences of pyrrole linked N’-phenyl-4-pyrrolyl-benzenesulfonamide derivatives were synthesized by different synthetic methods. Synthesis of the N’-phenyl-4-(1H-pyrrol-1-yl) benzenesulfonamides/4-(2,5-dimethyl-1H-pyrrol-1-yl)-N’-phenylbenzenesulfonamides was achieved by refluxing 2,5-dimethoxytetrahydrofuran/hexane 2,5-dione sep. in presence of acetic acid. Further, synthesis of N-(4-(N’-phenylsulfamoyl)phenyl)-4-(1H-pyrrol-1-yl)benzamides/4-(2,5-dimethyl-1H-pyrrol-1-yl)-N-(4-(N’-phenylsulfamoyl)phenyl)benzamides was achieved by cold stirring of 4-(1H-pyrrol-1-yl)benzoic acid/4-(2,5-dimethyl-1H-pyrrol-1-yl)benzoic acid correspondingly in the presence of 2-(1H-benzotriazol-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate, N’,N’-diisopropylethylamine, and DMF. In vitro anti-tubercular study of afresh compounds has shown good min. inhibitory concentration values (0.4-12.5μg/mL) counter to Mycobacterium tuberculosis H37Rv, while the corresponding study of reported mols. for antibacterial activity disclosed considerable inhibition values (0.4-25μg/mL) counter to Escherichia coli (Gram – ve) than Staphylococcus aureus (Gram + ve). In addition to this study using 2,5-Dimethoxytetrahydrofuran, there are many other studies that have used 2,5-Dimethoxytetrahydrofuran(cas: 696-59-3Safety of 2,5-Dimethoxytetrahydrofuran) was used in this study.

2,5-Dimethoxytetrahydrofuran(cas: 696-59-3) is a member of ether. When aromatic ethers are exposed to halogen in the presence or absence of a catalyst, they undergo halogenation, such as bromination.Safety of 2,5-Dimethoxytetrahydrofuran

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Safety of 2,5-DimethoxytetrahydrofuranIn 2020 ,《Synthesis and characterization of some new pyridines, thieno[2,3-b] pyridines and pyrido[3′,2′:4,5]thieno[3,2-d]pyrimidine-4(3H)-ones bearing styryl moiety》 appeared in Journal of Heterocyclic Chemistry. The author of the article were Al-Waleedy, Safiyyah A. H.; Bakhite, Etify A.; Abbady, Mohamed S.; Abdu-Allah, Hajjaj H. M.. The article conveys some information:

Reaction of compound 3-cyano-5-ethoxycarbonyl-6-methyl-4-styrylpyridine-2(1H)-thione with some N-aryl-2-chloroacetamides, in the presence of sodium acetate, gave the corresponding 2-(N-arylcarbamoylmethylsulfanyl)-3-cyano-5-ethoxycarbonyl-6-methyl-4-styrylpyridines I [R1 = H, Me, NO2, etc.]. Reaction of compound 3-cyano-5-ethoxycarbonyl-6-methyl-4-styrylpyridine-2(1H)-thione with some N-aryl-2-chloroacetamides, in the presence of sodium acetate, gave the corresponding 2-(N-arylcarbamoylmethylsulfanyl)-3-cyano-5-ethoxycarbonyl-6-methyl-4-styrylpyridines I [R1 = H, Me, NO2, etc.]. When compounds I were subjected to Thorpe-Ziegler reaction conditions, they converted into the corresponding 3-amino-5-ethoxycarbonyl-2-(N-arylcarbamoyl)-6-methyl-4-styrylthieno[2,3-b]pyridines II [R2 = NH2]. Compounds II [R1 = H, Cl, NO2, R2 = NH2] were reacted, in turn, with 2,5-dimethoxytetrahydrofuran to furnish the corresponding 3-(pyrrol-1-yl)thieno-pyridines II [R2 = 1-pyrrolyl]. Reactions of II [R2 = NH2] with tri-Et orthoformate were also carried out to form 3-aryl-8-acetyl-7-methyl-9-styrylpyrido[3′,2′:4,5]thieno[3,2-d]pyrimidine-4(3H)-ones III [X = C]. Reactions of compounds II [R1 = OMe, Cl, R2 = NH2] with nitrous acid were also carried out to form 3-aryl-8-acetyl-7-methyl-9-styrylpyrido[3′,2′:4,5]thieno[3,2-d][1,2,3]triazine-4(3H)-ones III [X = N]. Structural formulas of all synthesized compounds I, II and III were characterized and confirmed on the basis of their elemental and spectral analyzes. The experimental part of the paper was very detailed, including the reaction process of 2,5-Dimethoxytetrahydrofuran(cas: 696-59-3Safety of 2,5-Dimethoxytetrahydrofuran)

2,5-Dimethoxytetrahydrofuran(cas: 696-59-3) is a member of ether. When aromatic ethers are exposed to halogen in the presence or absence of a catalyst, they undergo halogenation, such as bromination.Safety of 2,5-Dimethoxytetrahydrofuran

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Safety of 2,5-DimethoxytetrahydrofuranIn 2022 ,《Lactam Strategy Using Amide-Selective Nucleophilic Addition for Quick Access to Complex Amines: Unified Total Synthesis of Stemoamide-Type Alkaloids》 was published in Bulletin of the Chemical Society of Japan. The article was written by Sugiyama, Yasukazu; Soda, Yasuki; Yoritate, Makoto; Tajima, Hayato; Takahashi, Yoshito; Shibuya, Kana; Ogihara, Chisato; Yokoyama, Takashi; Oishi, Takeshi; Sato, Takaaki; Chida, Noritaka. The article contains the following contents:

In this article, the authors report full details of the unified total synthesis of stemoamide-type alkaloids by chemoselective assembly of five-membered rings based on the lactam strategy. First, the concise and gram-scale synthesis of tricyclic stemoamide was achieved by vinylogous Michael addition-reduction sequence of an unsaturated γ-lactam with an unsaturated γ-lactone, followed by N-alkylation to form the seven-membered ring. From stemoamide as a common intermediate, chemoselective nucleophilic addition of unsaturated lactone derivatives provided tetracyclic natural products. While stemonine was obtained by an Ir-catalyzed lactam-selective reductive Mannich reaction, saxorumamide and isosaxorumamide were produced through the lactone-selective nucleophilic addition of the lithiated 2-silyl furan. The developed conditions for the lactam-selective nucleophilic reactions were highly general, and were found to be applicable to the total synthesis of pentacyclic stemocochinin and isostemocochinin. The strategy enabled the concise and unified total synthesis of tricyclic, tetracyclic and pentacyclic stemoamide-type alkaloids within 12 steps from a com. available compound The experimental part of the paper was very detailed, including the reaction process of 2,5-Dimethoxytetrahydrofuran(cas: 696-59-3Safety of 2,5-Dimethoxytetrahydrofuran)

2,5-Dimethoxytetrahydrofuran(cas: 696-59-3) is a member of ether. Friedel Crafts reaction, for example, adds an alkyl or acyl group to aromatic ethers when they react with an alkyl or acyl halide in the presence of a Lewis acid as a catalyst.Safety of 2,5-Dimethoxytetrahydrofuran

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem