Heterocyclic Building Blocks-Tetrahydrofuran

Shao, Yuewen; Guo, Mingzhu; Wang, Junzhe; Sun, Kai; Zhang, Lijun; Zhang, Shu; Hu, Guangzhi; Xu, Leilei; Yuan, Xiangzhou; Hu, Xun published the artcile< Selective Conversion of Furfural into Diols over Co-Based Catalysts: Importance of the Coordination of Hydrogenation Sites and Basic Sites>, Category: tetrahydrofurans, the main research area is selective hydrogenation furfural diol Cobalt magnesium aluminum hydrogenation catalyst.

1,5-Pentanediol (1,5-PDO) is a feedstock for synthesis of polyesters and polyurethanes, and its selective production from furfural is a desirable route but very challenging. In this study, the production of 1,5-PDO from furfural was investigated over the Co-Mg-Al catalyst, containing abundant hydrogenation sites and basic sites. Using layered double hydroxides as the catalyst precursor benefited dispersion of metallic Co particles via preventing migration of cobalt species and developing pore structures. Furthermore, the Co-Mg-Al catalyst possessed abundant basic sites, rendering its superior catalytic activity to Co-Al or Co-Mg catalysts. In situ diffuse reflectance IR spectroscopy (DRIFTS) characterization for FA conversion demonstrated that the cooperation of abundant hydrogenation sites and basic sites facilitated a strong adsorption of C-O-C and carbon-carbon double-bond groups, which benefited the conversion of FA into diols.

Industrial & Engineering Chemistry Research published new progress about Glycols Role: SPN (Synthetic Preparation), PREP (Preparation). 97-99-4 belongs to class tetrahydrofurans, and the molecular formula is C5H10O2, Category: tetrahydrofurans.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Eckman, Mark H; Woodle, E Steve; Thakar, Charuhas V; Alloway, Rita R; Sherman, Kenneth E published the artcile< Cost-effectiveness of Using Kidneys From HCV-Viremic Donors for Transplantation Into HCV-Uninfected Recipients.>, Related Products of 58-97-9, the main research area is End-stage kidney disease (ESKD); cost-effectiveness analysis; decision analysis; direct-acting agent (DAA); glecaprevir; healthcare cost; hepatitis C; kidney transplantation; medical decision making; pibrentasvir; quality-of-life (QOL); transplant waiting list.

RATIONALE & OBJECTIVE: Less than 4% of patients with kidney failure receive kidney transplants. Although discard rates of hepatitis C virus (HCV)-viremic kidneys are declining, ~39% of HCV-viremic kidneys donated between 2018 and 2019 were discarded. Highly effective antiviral agents are now available to treat chronic HCV infection. Thus, our objective was to examine the cost-effectiveness of transplanting kidneys from HCV-viremic donors into HCV-uninfected recipients. STUDY DESIGN: Markov state transition decision model. Data sources include Medline search results, bibliographies from relevant English language articles, Scientific Registry of Transplant Recipients, and the US Renal Data System. SETTING & POPULATION: US patients receiving maintenance hemodialysis who are on kidney transplant waiting lists. INTERVENTION(S): Transplantation with an HCV-unexposed kidney versus transplantation with an HCV-viremic kidney and HCV treatment. OUTCOMES: Effectiveness measured in quality-adjusted life-years and costs measured in 2018 US dollars. MODEL, PERSPECTIVE, AND TIMEFRAME: We used a health care system perspective with a lifelong time horizon. RESULTS: In the base-case analysis, transplantation with an HCV-viremic kidney was more effective and less costly than transplantation with an HCV-unexposed kidney because of the longer waiting times for HCV-unexposed kidneys, the substantial excess mortality risk while receiving dialysis, and the high efficacy of direct-acting antiviral agents for HCV infection. Transplantation with an HCV-viremic kidney was also preferred in sensitivity analyses of multiple model parameters. The strategy remained cost-effective unless waiting list time for an HCV-viremic kidney exceeded 3.1 years compared with the base-case value of 1.56 year. LIMITATIONS: Estimates of waiting times for patients willing to accept an HCV-viremic kidney were based on data for patients who received HCV-viremic kidney transplants. CONCLUSIONS: Transplanting kidneys from HCV-viremic donors into HCV-uninfected recipients increased quality-adjusted life expectancy and reduced costs compared with a strategy of transplanting kidneys from HCV-unexposed donors.

American journal of kidney diseases : the official journal of the National Kidney Foundation published new progress about 58-97-9. 58-97-9 belongs to class tetrahydrofurans, and the molecular formula is C9H13N2O9P, Related Products of 58-97-9.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Yang, Acong; Bofill-De Ros, Xavier; Stanton, Ryan; Shao, Tie-Juan; Villanueva, Patricia; Gu, Shuo published the artcile< TENT2, TUT4, and TUT7 selectively regulate miRNA sequence and abundance>, Category: tetrahydrofurans, the main research area is .

Abstract: TENTs generate miRNA isoforms by 3′ tailing. However, little is known about how tailing regulates miRNA function. Here, we generate isogenic HEK293T cell lines in which TENT2, TUT4 and TUT7 are knocked out individually or in combination. Together with rescue experiments, we characterize TENT-specific effects by deep sequencing, Northern blot and in vitro assays. We find that 3′ tailing is not random but highly specific. In addition to its known adenylation, TENT2 contributes to guanylation and uridylation on mature miRNAs. TUT4 uridylates most miRNAs whereas TUT7 is dispensable. Removing adenylation has a marginal impact on miRNA levels. By contrast, abolishing uridylation leads to dysregulation of a set of miRNAs. Besides let-7, miR-181b and miR-222 are neg. regulated by TUT4/7 via distinct mechanisms while the miR-888 cluster is upregulated specifically by TUT7. Our results uncover the selective actions of TENTs in generating 3′ isomiRs and pave the way to investigate their functions.

Nature Communications published new progress about 58-97-9. 58-97-9 belongs to class tetrahydrofurans, and the molecular formula is C9H13N2O9P, Category: tetrahydrofurans.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Silva, Wesley R.; Matsubara, Elaine Y.; Rosolen, Jose M.; Donate, Paulo M.; Gunnella, Roberto published the artcile< Pd catalysts supported on different hydrophilic or hydrophobic carbonaceous substrate for furfural and 5-(hydroxymethyl)furfural hydrogenation in water>, Formula: C5H10O2, the main research area is palladium catalyst carbonaceous substrate furfural hydroxymethylfurfural hydrogenation water.

We hydrogenated furfural and 5-(hydroxymethyl)furfural (HMF) in water in a reaction catalyzed by Pd nanoparticles on carbonaceous materials with different morphol. and hydrophobic degree. The different Pd catalysts were prepared by dipping the carbonaceous material into a Pd0 micro-emulsion. The catalyst support affected the catalytic hydrogenation of furfural and HMF. By using micrometric active carbon (AC) combined with cup-stacked carbon nanotubes (CSCNTs) and Pd0/2+ nanoparticles (Pd), we obtained a micro/nanostructured material designated Pd/CSCNT-AC, which performed better than the other carbonaceous materials containing similar Pd nanoparticle loading. Pd/CSCNT-AC produced tetrahydrofurfuryl alc. from furfural with excellent selectivity (>99%). Unlike Pd on hybrophobic spheroid graphite or hydrophilic AC, Pd/CSCNT-AC hydrogenated both the C=O and C=C double bonds of furfural and catalyzed HMF hydrogenation at the C=O double bond more selectively: between 85% and 99% selectivity toward 2,5-dihydroxymethylfuran. We also investigated how temperature, hydrogen pressure, and reaction time affected HMF hydrogenation in water. Finally, Pd/CSCNT-AC was recycled several times without significant catalytic activity loss.

Molecular Catalysis published new progress about Carbon nanotubes. 97-99-4 belongs to class tetrahydrofurans, and the molecular formula is C5H10O2, Formula: C5H10O2.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Seleem, Mohamed M; Desoky, Esam; Abdelwahab, Khaled; Bendary, Lotfy; Elderey, Mohamed S; Eliwa, Ahmed published the artcile< Flank-Free Modified Supine vs Prone Ultra-Mini-Percutaneous Nephrolithotomy in Treatment of Medium-Sized Renal Pelvic Stone: A Randomized Clinical Trial.>, Computed Properties of 58-97-9, the main research area is modified flank free supine position; prone position; renal pelvic stone; ultra-mini-percutaneous nephrolithotomy.

Introduction and Objectives: Percutaneous nephrolithotomy (PCNL) is the standard treatment of renal stone >2 cm. Ultra-mini-percutaneous nephrolithotomy (UMP) had emerged in the past decade as a new technique in treating renal stones <2 cm. In this study we compared between the outcome of UMP in prone position with the outcome of UMP in modified flank free supine position (FFSP). Materials and Methods: A prospective randomized study was conducted between January 2016 and April 2020, including 122 patients, divided into two matched groups. Group A included 61 patients who underwent UMP in FFSP, and Group B included 61 patients who underwent UMP in a prone position. All patients had a single renal pelvic stone 1-2 cm. Patients with a single kidney, renal anomalies, body mass index ≥40 kg/m2, history of ipsilateral renal surgery, and age <18 years were excluded. In both groups, the dilatation was done up to 13F; a holmium laser was used through a 9F ureteroscope for fragmentation. Nephrostomy tube and ureteral stent were used only when indicated. Results: In total, 122 patients were divided into two groups. The mean age was 40.09 ± 13.63 and 39.67 ± 13.80 years in both groups, respectively. The operative time was 63.64 ± 9.22 and 78.48 ± 9.55 minutes in Groups A and B, respectively (p = 0.0001). The fluoroscopy time was 3.47 ± 0.56 and 4.45 ± 0.39 minutes in Groups A and B, respectively (p = 0.0001). No significant difference was shown between both groups regarding operative and postoperative complications. Shift to mini-PCNL was needed in one patient in Group A and four patients in Group B because of impaired vision. The hospital stay was 25.36 ± 4.23 and 26.13 ± 4.76 hours in both groups, respectively. The initial stone-free rate was 95.1% and 91.8% in both groups, respectively. Conclusions: UMP in modified supine position shows comparable results with UMP in the prone position regarding stone-free rate, hospital stay, and perioperative complication, with significantly shorter operative and fluoroscopy time. Journal of endourology published new progress about 58-97-9. 58-97-9 belongs to class tetrahydrofurans, and the molecular formula is C9H13N2O9P, Computed Properties of 58-97-9.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Insyani, Rizki; Barus, Amsalia Florence; Gunawan, Ricky; Park, Jaeyong; Jaya, Gladys Tiffany; Cahyadi, Handi Setiadi; Sibi, Malayil Gopalan; Kwak, Sang Kyu; Verma, Deepak; Kim, Jaehoon published the artcile< RuO2-Ru/Hβ zeolite catalyst for high-yield direct conversion of xylose to tetrahydrofurfuryl alcohol>, Application In Synthesis of 97-99-4, the main research area is RuO2 ruthenium Hbeta zeolite catalyst xylose tetrahydrofurfuryl alc.

Tetrahydrofurfuryl alc. (THFOL), a valuable biomass-derived chem., is an important precursor for producing linear diols and biodegradable solvents. Herein, we present the one-pot cascade conversion of xylose to THFOL over an Hβ zeolite-supported RuO2-Ru (RuO2-Ru/Hβ) catalyst. To elucidate the structure-property correlation of the RuO2-Ru/Hβ catalyst and achieve a high THFOL yield via sequential isomerization, dehydration, and hydrogenation, several synthesis methods, namely incipient wetness impregnation, reductive deposition, activated reductive deposition, and post-oxidative activated reductive deposition (ARD-O) were used. The best catalytic performance was obtained over the RuO2-Ru/Hβ-ARD-O catalyst. An almost complete conversion of xylose and a high THFOL yield of 61.8% were achieved after 1 h at 180°C under an initial H2 pressure of 3.0 MPa in THF. In-depth analyses of the RuO2-Ru/Hβ-ARD-O catalyst furfural (FFA)- and CO-probed diffuse reflectance IR Fourier transform spectra indicated the formation of RuO2 at the corner and edge sites of Ru nanoparticles. The direct conversion of FFA to THFOL at interfacial RuO2-Ru sites without furfuryl alc. (FOL) readsorption hindered the contact of FOL with the acidic support, which suppressed the formation of humin and other byproducts and led to a high THFOL yield.

Applied Catalysis, B: Environmental published new progress about Ammonium-exchanged zeolites, NH4-beta Role: CAT (Catalyst Use), USES (Uses). 97-99-4 belongs to class tetrahydrofurans, and the molecular formula is C5H10O2, Application In Synthesis of 97-99-4.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Islam, Mohammed J.; Granollers Mesa, Marta; Osatiashtiani, Amin; Manayil, Jinesh C.; Isaacs, Mark A.; Taylor, Martin J.; Tsatsos, Sotirios; Kyriakou, Georgios published the artcile< PdCu single atom alloys supported on alumina for the selective hydrogenation of furfural>, Product Details of C5H10O2, the main research area is palladium copper catalyst alumina support furfural hydrogenation.

Single-atom catalysts serve as a skilful control of precious metals on heterogenous catalysts where all active sites are accessible for catalytic reactions. Here we report the adoption of PdCu single-atom alloys supported on alumina for the selective hydrogenation of furfural. This is a special class of an atom efficient, single-site catalyst where trace concentrations of Pd atoms (0.0067 weight%) displace surface Cu sites on the host nanoparticle. Confirmed by EXAFS, the Pd atoms are entirely coordinated to Cu, with Pd-Cu bond lengths identical to that of a Cu-Cu bond. Selectively surface oxidized catalysts also confirm surface Pd atoms by EXAFS. These catalysts improve the conversion of furfural to furfuryl alc. compared to monometallic catalysts, as they have the advantages of Cu (high selectivity but poor activity) and Pd catalysts (superior activity but unselective) without the drawbacks, making them the optimal catalysts for green/atom efficient catalysis.

Applied Catalysis, B: Environmental published new progress about Crystallinity. 97-99-4 belongs to class tetrahydrofurans, and the molecular formula is C5H10O2, Product Details of C5H10O2.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Shao, Yuewen; Wang, Junzhe; Du, Huining; Sun, Kai; Zhang, Zhanming; Zhang, Lijun; Li, Qingyin; Zhang, Shu; Liu, Qing; Hu, Xun published the artcile< Importance of Magnesium in Cu-Based Catalysts for Selective Conversion of Biomass-Derived Furan Compounds to Diols>, Related Products of 97-99-4, the main research area is magnesium copper catalyst biomass furan diol.

Selectively hydrogenating the carbonyl of furfural and opening of the furan ring is challenging but crucial for efficient conversion of furfural to pentanediols, the valuable chems. In this study, CuMgAl catalysts with highly dispersed Cu particles and tunable basic sites were synthesized with layered double hydroxides as precursors for hydrogenation of furfural to furfuryl alc. (FA) and the subsequent hydrogenolysis of FA to 1,2-pentanediol and 1,5-pentanediol. The presence of varied content of Mg in the catalyst promoted dispersion of copper oxide and exposure of metallic copper species, weakened interaction between copper oxides and the carrier, suppressed sintering of metallic copper species, and increased abundance of the basic sites, promoting the catalytic activity/selectivity/stability. Strong chem. adsorption of the furan ring in FA on basic sites of the catalyst suppressed hydrogenation of the furan ring and facilitated opening of the furan ring in FA, the rate-determining step for formation of the diols. High yields of 1,2-pentanediol and 1,5-pentanediol are achieved over the copper-based catalyst via the hydrogenolysis of furfuryl alc.

ACS Sustainable Chemistry & Engineering published new progress about Biomass. 97-99-4 belongs to class tetrahydrofurans, and the molecular formula is C5H10O2, Related Products of 97-99-4.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem