Heterocyclic Building Blocks-Tetrahydrofuran

de la Lande, Aurelien; Denisov, Sergey; Mostafavi, Mehran published the artcile< The mystery of sub-picosecond charge transfer following irradiation of hydrated uridine monophosphate>, Application In Synthesis of 58-97-9, the main research area is uridine monophosphate electron transfer mechanism kinetics free energy.

The early mechanisms by which ionizing rays damage biol. structures by so-called direct effects are largely elusive. In a recent picosecond pulse radiolysis study of concentrated uridine monophosphate solutions [J. Ma, S. A. Denisov, J.-L. Marignier, P. Pernot, A. Adhikary, S. Seki and M. Mostafavi, J. Phys. Chem. Lett., 2018, 9, 5105], unexpected results were found regarding the oxidation of the nucleobase. The signature of the oxidized nucleobase could not be detected 5 ps after the electron pulse, but only the oxidized phosphate, raising intriguing questions about the identity of charge-transfer mechanisms that could explain the absence of U+. We address here this question by means of advanced first-principles atomistic simulations of solvated uridine monophosphate, combining D. Functional Theory (DFT) with polarizable embedding schemes. We contrast three very distinct mechanisms of charge transfer covering the atto-, femto- and pico-second timescales. We first investigate the ionization mechanism and subsequent hole/charge migrations on a timescale of attoseconds to a few femtoseconds under the frozen nuclei approximation We then consider a nuclear-driven phosphate-to-oxidized-nucleobase electron transfer, showing that it is an uncompetitive reaction channel on the sub-picosecond timescale, despite its high exothermicity and significant electronic coupling. Finally, we show that non-adiabatic charge transfer is enabled by femtosecond nuclear relaxation after ionization. We show that electronic decoherence and the electronic coupling strength are the key parameters that determine the hopping probabilities. Our results provide important insight into the interplay between electronics and nuclear motions in the early stages of the multiscale responses of biol. matter subjected to ionizing radiation.

Physical Chemistry Chemical Physics published new progress about Band gap. 58-97-9 belongs to class tetrahydrofurans, and the molecular formula is C9H13N2O9P, Application In Synthesis of 58-97-9.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Bratkovic, Tomaz; Bozic, Janja; Rogelj, Boris published the artcile< Functional diversity of small nucleolar RNAs>, Safety of ((2R,3S,4R,5R)-5-(2,4-Dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl dihydrogen phosphate, the main research area is review snoRNA posttranscription processing.

A review. Small nucleolar RNAs (snoRNAs) are short non-protein-coding RNAs with a long-recognized role in tuning ribosomal and spliceosomal function by guiding ribose methylation and pseudouridylation at targeted nucleotide residues of ribosomal and small nuclear RNAs, resp. SnoRNAs are increasingly being implicated in regulation of new types of post-transcriptional processes, for example rRNA acetylation, modulation of splicing patterns, control of mRNA abundance and translational efficiency, or they themselves are processed to shorter stable RNA species that seem to be the principal or alternative bioactive isoform. Intriguingly, some display unusual cellular localization under exogenous stimuli, or tissue-specific distribution. Here, we discuss the new and unforeseen roles attributed to snoRNAs, focusing on the presumed mechanisms of action. Furthermore, we review the exptl. approaches to study snoRNA function, including high resolution RNA:protein and RNA:RNA interaction mapping, techniques for analyzing modifications on targeted RNAs, and cellular and animal models used in snoRNA biol. research.

Nucleic Acids Research published new progress about Acetylation. 58-97-9 belongs to class tetrahydrofurans, and the molecular formula is C9H13N2O9P, Safety of ((2R,3S,4R,5R)-5-(2,4-Dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl dihydrogen phosphate.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Xu, Jiamin; Cui, Qianqian; Xue, Teng; Guan, Yejun; Wu, Peng published the artcile< Total Hydrogenation of Furfural under Mild Conditions over a Durable Ni/TiO2-SiO2 Catalyst with Amorphous TiO2 Species>, Reference of 97-99-4, the main research area is total hydrogenation furfural mild condition durable nickel titania silica.

One-step total hydrogenation of furfural (FAL) toward tetrahydrofurfuryl alc. in continuous flow using cheap transition metals still remains a great challenge. We herein reported the total hydrogenation of FAL over Ni (~5 nm) nanoparticles loaded on TiO2-SiO2 composites with long-term stability. The TiO2-SiO2 composites comprise amorphous TiOx which was grafted on the silica aerogel by acetyl acetone-aided controlled hydrolysis of tetra-Bu titanate. The catalysts were characterized by several techniques including Brunauer-Emmett-Teller, X-ray diffraction, transmission electron microscopy, H2-temperature-programmed reduction, and H2-temperature-programmed desorption. The hydrogenation performances were systematically explored in terms of TiO2 content, Ni loading, liquid hour space velocity, and so forth. Ni nanoparticles in contact with amorphous TiOx showed strengthened interaction with the C=O bond of FAL as well as enhanced hydrogen dissociation and desorption ability, hence benefiting the overall hydrogenation process.

ACS Omega published new progress about Adsorption. 97-99-4 belongs to class tetrahydrofurans, and the molecular formula is C5H10O2, Reference of 97-99-4.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Bellin, Leo; Del Cano-Ochoa, Francisco; Velazquez-Campoy, Adrian; Moehlmann, Torsten; Ramon-Maiques, Santiago published the artcile< Mechanisms of feedback inhibition and sequential firing of active sites in plant aspartate transcarbamoylase>, Recommanded Product: ((2R,3S,4R,5R)-5-(2,4-Dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl dihydrogen phosphate, the main research area is .

Abstract: Aspartate transcarbamoylase (ATC), an essential enzyme for de novo pyrimidine biosynthesis, is uniquely regulated in plants by feedback inhibition of uridine 5-monophosphate (UMP). Despite its importance in plant growth, the structure of this UMP-controlled ATC and the regulatory mechanism remain unknown. Here, we report the crystal structures of Arabidopsis ATC trimer free and bound to UMP, complexed to a transition-state analog or bearing a mutation that turns the enzyme insensitive to UMP. We found that UMP binds and blocks the ATC active site, directly competing with the binding of the substrates. We also prove that UMP recognition relies on a loop exclusively conserved in plants that is also responsible for the sequential firing of the active sites. In this work, we describe unique regulatory and catalytic properties of plant ATCs that could be exploited to modulate de novo pyrimidine synthesis and plant growth.

Nature Communications published new progress about 58-97-9. 58-97-9 belongs to class tetrahydrofurans, and the molecular formula is C9H13N2O9P, Recommanded Product: ((2R,3S,4R,5R)-5-(2,4-Dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl dihydrogen phosphate.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Li, Pengfei; Lan, Hongling; Chen, Kuo; Ma, Xiupeng; Wei, Bingxin; Wang, Ming; Li, Peng; Hou, Yingfei; Jason Niu, Q. published the artcile< Novel high-flux positively charged aliphatic polyamide nanofiltration membrane for selective removal of heavy metals>, Quality Control of 4415-87-6, the main research area is aliphatic polyamide nanofiltration membrane heavy metal removal separation.

The toxic heavy metals produced by the discharge of industrial wastewater pose a serious threat to the ecol. environment and human health. Nanofiltration (NF) membrane separation technol. is widely used in fields such as water softening, heavy metal removal and dye separation due to its environmental friendliness and low cost. Herein, a novel pos. charged aliphatic polyamide NF membrane (PEI-BTC) has been developed by using 1,2,3,4-cyclobutane tetracarboxylic acid chloride (BTC) monomer bearing a stereoscopic structure which undergoes classic interfacial polymerization (IP) with polyethyleneimine (PEI) on the Polyether sulfone (PES) support membrane. The physicochem. properties revealed that the PEI-BTC membrane had a larger mean effective pore size (0.285 nm), a thinner separation layer (40 nm) and a stronger pos. charged membrane surface (IEP = 7.25) than the traditional PEI-TMC membrane. Compared with previously reported PEI-based and com. NF membranes, the optimized PEI-BTC membrane exhibits a higher MgCl2 (2000 ppm) rejection of 97.53% and pure water flux of 156.85 kg·m-2·h-1 at 1.0 MPa. Moreover, the prepared PEI-BTC NF membrane shows excellent toxic heavy metal (1000 ppm) removal efficiency in the order of Mn (98.78%) > Zn (98.32%) > Ni (97.74%) > Cu (95.67%) > Cd (90.49%). The results demonstrate that the prepared pos. charged aliphatic polyamide NF membrane (PEI-BTC) has a unique industrial production potential for water softening and heavy metal removal.

Separation and Purification Technology published new progress about Contact angle. 4415-87-6 belongs to class tetrahydrofurans, and the molecular formula is C8H4O6, Quality Control of 4415-87-6.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Pirmoradi, Maryam; Janulaitis, Nida; Gulotty, Robert J.; Kastner, James R. published the artcile< Continuous Hydrogenation of Aqueous Furfural Using a Metal-Supported Activated Carbon Monolith>, Formula: C5H10O2, the main research area is continuous hydrogenation aqueous furfural palladium activated carbon.

Continuous hydrogenation of aqueous furfural (4.5%) was studied using a monolith form (ACM) of an activated carbon Pd catalyst (~1.2% Pd). A sequential reaction pathway was observed, with ACM achieving high selectivity and space time yields (STYs) for furfuryl alc. (~25%, 60-70 g/L-cat/h, 7-15 1/h liquid hourly space velocity, LHSV), 2-methylfuran (~25%, 45-50 g/L-cat/h, 7-15 1/h LHSV), and tetrahydrofurfuryl alc. (~20-60%, 10-50 g/L-cat/h, <7 1/h LHSV). ACM showed a low loss of activity and metal leaching over the course of the reactions and was not limited by H2 external mass transfer resistance. Acetic acid (1%) did not significantly affect furfural conversion and product yields using ACM, suggesting Pd/ACM's potential for conversion of crude furfural. Limited metal leaching combined with high metal dispersion and H2 mass transfer rates in the composite carbon catalyst (ACM) provides possible advantages over granular and powd. forms in continuous processing. ACS Omega published new progress about Crystallites. 97-99-4 belongs to class tetrahydrofurans, and the molecular formula is C5H10O2, Formula: C5H10O2.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Audemar, Maite; Wang, Yantao; Zhao, Deyang; Royer, Sebastien; Jerome, Francois; Len, Christophe; De Oliveira Vigier, Karine published the artcile< Synthesis of furfuryl alcohol from furfural: a comparison between batch and continuous flow reactors>, Related Products of 97-99-4, the main research area is cobalt silica catalyst furfural hydrogenation furfuryl alc; continuous flow batch reactor.

Furfural is a platform mol. obtained from hemicellulose. Among the products that can be produced from furfural, furfuryl alc. is one of the most extensively studied. It is synthesized at an industrial scale in the presence of CuCr catalyst, but this process suffers from an environmental neg. impact. Here, we demonstrate that a non-noble metal catalyst (Co/SiO2) was active (100% conversion of furfural) and selective (100% selectivity to furfuryl alc.) in the hydrogenation of furfural to furfuryl alc. at 150°C under 20 bar of hydrogen. This catalyst was recyclable up to 3 cycles, and then the activity decreased. Thus, a comparison between batch and continuous flow reactors shows that changing the reactor type helps to increase the stability of the catalyst and the space-time yield. This study shows that using a continuous flow reactor can be a solution to the catalyst suffering from a lack of stability in the batch process.

Energies (Basel, Switzerland) published new progress about Batch bioreactors. 97-99-4 belongs to class tetrahydrofurans, and the molecular formula is C5H10O2, Related Products of 97-99-4.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Li, Lei; Huang, Kai-Lieh; Gao, Yipeng; Cui, Ya; Wang, Gao; Elrod, Nathan D.; Li, Yumei; Chen, Yiling Elaine; Ji, Ping; Peng, Fanglue; Russell, William K.; Wagner, Eric J.; Li, Wei published the artcile< An atlas of alternative polyadenylation quantitative trait loci contributing to complex trait and disease heritability>, Recommanded Product: ((2R,3S,4R,5R)-5-(2,4-Dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl dihydrogen phosphate, the main research area is human alternative polyadenylation QTL linkage mapping disease heritability.

Genome-wide association studies have identified thousands of noncoding variants associated with human traits and diseases. However, the functional interpretation of these variants is a major challenge. Here, we constructed a multi-tissue atlas of human 3’UTR alternative polyadenylation (APA) quant. trait loci (3’aQTLs), containing approx. 0.4 million common genetic variants associated with the APA of target genes, identified in 46 tissues isolated from 467 individuals (Genotype-Tissue Expression Project). Mechanistically, 3’aQTLs can alter poly(A) motifs, RNA secondary structure and RNA-binding protein-binding sites, leading to thousands of APA changes. Our CRISPR-based experiments indicate that such 3’aQTLs can alter APA regulation. Furthermore, we demonstrate that mapping 3’aQTLs can identify APA regulators, such as La-related protein 4. Finally, 3’aQTLs are colocalized with approx. 16.1% of trait-associated variants and are largely distinct from other QTLs, such as expression QTLs. Together, our findings show that 3’aQTLs contribute substantially to the mol. mechanisms underlying human complex traits and diseases.

Nature Genetics published new progress about 3′-Untranslated region Role: BSU (Biological Study, Unclassified), PRP (Properties), BIOL (Biological Study). 58-97-9 belongs to class tetrahydrofurans, and the molecular formula is C9H13N2O9P, Recommanded Product: ((2R,3S,4R,5R)-5-(2,4-Dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl dihydrogen phosphate.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Goryanova, Bogdana; Amyes, Tina L.; Richard, John P. published the artcile< Role of the Carboxylate in Enzyme-Catalyzed Decarboxylation of Orotidine 5'-Monophosphate: Transition State Stabilization Dominates Over Ground State Destabilization>, Product Details of C9H13N2O9P, the main research area is decarboxylation orotidine monophosphate decarboxylase transition state stabilization.

Kinetic parameters kex (s-1) and kex/Kd (M-1s-1) are reported for exchange for deuterium in D2O of the C-6 hydrogen of 5-fluororotidine 5′-monophosphate (FUMP) catalyzed by the Q215A, Y217F, and Q215A/Y217F variants of yeast orotidine 5′-monophosphate decarboxylase (ScOMPDC) at pD 8.1, and by the Q215A variant at pD 7.1-9.3. The pD rate profiles for wildtype ScOMPDC and the Q215A variant are identical, except for a 2.5 log unit downward displacement in the profile for the Q215A variant. The Q215A, Y217F and Q215A/Y217F substitutions cause 1.3-2.0 kcal/mol larger increases in the activation barrier for wildtype ScOMPDC-catalyzed deuterium exchange compared with decarboxylation, because of the stronger apparent side chain interaction with the transition state for the deuterium exchange reaction. The stabilization of the transition state for the OMPDC-catalyzed deuterium exchange reaction of FUMP is ca. 19 kcal/mol smaller than the transition state for decarboxylation of OMP, and ca. 8 kcal/mol smaller than for OMPDC-catalyzed deprotonation of FUMP to form the vinyl carbanion intermediate common to OMPDC-catalyzed reactions OMP/FOMP and UMP/FUMP. We propose that ScOMPDC shows similar stabilizing interactions with the common portions of decarboxylation and deprotonation transition states that lead to formation of this vinyl carbanion intermediate, and that there is a large ca. (19-8) = 11 kcal/mol stabilization of the former transition state from interactions with the nascent CO2 of product. The effects of Q215A and Y217F substitutions on kcat/Km for decarboxylation of OMP are expressed mainly as an increase in Km for the reactions catalyzed by the variant enzymes, while the effects on kex/Kd for deuterium exchange are expressed mainly as an increase in kex. This shows that the Q215 and Y217 side chains stabilize the Michaelis complex to OMP for the decarboxylation reaction, compared with the complex to FUMP for the deuterium exchange reaction. These results provide strong support for the conclusion that interactions which stabilize the transition state for ScOMPDC-catalyzed decarboxylation at a nonpolar enzyme active site dominate over interactions that destabilize the ground-state Michaelis complex.

Journal of the American Chemical Society published new progress about Enzyme functional sites, active. 58-97-9 belongs to class tetrahydrofurans, and the molecular formula is C9H13N2O9P, Product Details of C9H13N2O9P.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Kato, Shunsuke; Yusof, Fitri Adila Amat; Harimoto, Toyohiro; Takada, Kenji; Kaneko, Tatsuo; Kawai, Mika; Mitsumata, Tetsu published the artcile< Electric volume resistivity for biopolyimide using 4,4'-diamino-α-truxillic acid and 1,2,3,4-cyclobutanetetracarboxylic dianhydride>, Safety of Cyclobuta[1,2-c:3,4-c’]difuran-1,3,4,6(3aH,3bH,6aH,6bH)-tetraone, the main research area is biopolyimide film volume resistivity elec insulation property; biopolyimide; biopolymer; electric resistivity; polyimide.

Biopolyimides poly(ATA-CBDA), made from of 4,4′-diamino-α-truxillic acid di-Me ester (ATA) and 1,2,3,4-cyclobutanetetracarboxylic dianhydride (CBDA), is synthesized and measured its elec. volume resistivity at various exptl. conditions. The effects of film size, thickness, drying time, and the elec. field strength on elec. resistivity are investigated and compared with polyimide (Kapton). The elec. resistivity for all polyimide and biopolyimide are distributed in the range of 1015-1016 Ωcm, which shows that biopolyimide has high elec. insulation as well as polyimide. The elec. resistivity strongly depends on film thickness, which suggests that elec. resistivity is a function of elec. field strength. The critical elec. field for polyimide and biopolyimide films are determined to be 5.8 x 107 V/m and 3.2 x 107 V/m, resp. Humidity was found to strongly affect the elec. resistivity; ~1016 Ωcm at 34% RH and ~1013 Ωcm at 60% RH for both polyimide and biopolyimide films.

Polymers (Basel, Switzerland) published new progress about Electric breakdown. 4415-87-6 belongs to class tetrahydrofurans, and the molecular formula is C8H4O6, Safety of Cyclobuta[1,2-c:3,4-c’]difuran-1,3,4,6(3aH,3bH,6aH,6bH)-tetraone.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem