Heterocyclic Building Blocks-Tetrahydrofuran

Shibutani, Shotaro; Kodo, Taiga; Takeda, Mitsutaka; Nagao, Kazunori; Tokunaga, Norihito; Sasaki, Yusuke; Ohmiya, Hirohisa published the artcile< Organophotoredox-Catalyzed Decarboxylative C(sp3)-O Bond Formation>, Electric Literature of 97-99-4, the main research area is ether secondary amine thioether preparation; alc amine thiol dioxoisoindolinyl carboxylate photoredox decarboxylative coupling.

This manuscript reports a visible-light-mediated organosulfide catalysis that enables the decarboxylative coupling between simple aliphatic alc. and tertiary or secondary alkyl carboxylic acid-derived redox active esters to produce a C(sp3)-O-C(sp3) fragment. Results of the coupling using other heteroatom nucleophiles such as water, amides, and thiols are also described.

Journal of the American Chemical Society published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 97-99-4 belongs to class tetrahydrofurans, and the molecular formula is C5H10O2, Electric Literature of 97-99-4.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Guerra Romero, Adriana R; Pérez Figueras, Manuel; Alonso López, Sonia published the artcile< Successful evolution of morphea after hepatitis C virus eradication with direct-acting antiviral agent treatment.>, Category: tetrahydrofurans, the main research area is .

Hepatitis C virus infection has been associated with many dermatologic conditions such as lichen planus, porphyria cutanea tarda, and cryoglobulinemia. Recently, an association of HCV with systemic sclerosis has been reported. However, there are few reports of the association of localized scleroderma or morphea with Hepatitis C Virus infection. We describe the case of a 36 years old female patient suffering from prolonged morphea with difficult management, who was recently diagnosed of Hepatitis C Virus and received direct-acting antiviral agents treatment with Hepatitis C Virus clearance. Skin lesion faded away in a short period after successful therapy.

Revista espanola de enfermedades digestivas : organo oficial de la Sociedad Espanola de Patologia Digestiva published new progress about 58-97-9. 58-97-9 belongs to class tetrahydrofurans, and the molecular formula is C9H13N2O9P, Category: tetrahydrofurans.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Takada, Kenji; Shinagawa, Hiromasa; Morita, Yuki; Grewal, Manjit S.; Taya, Kazuya; Kumar, Amit; Kaneko, Tatsuo published the artcile< Syntheses of Soluble Biopolyimides Using 4-Aminophenylalanine>, Electric Literature of 4415-87-6, the main research area is aminophenylalanine tetracarboxylic dianhydride polyamic acid thermal imidization biopolyimide.

4-Aminophenylalanine (4APhe), an exotic amino acid which is obtained as a microorganism metabolite of glucose, is polycondensed with various tetracarboxylic dianhydrides as a diamine monomer to obtain poly(amic acid)s. Subsequent thermal imidization of poly(amic acid)s is made at 220°C with stepwise heating from 100°C. Some of the obtained polyimides (PIs) exhibited good solubility in organic solvents such as N,N-dimethylformamide, N,N-dimethylacetamide, and more. The progress of imidization was observed by proton NMR and IR spectroscopy to confirm that the imidization ratio was up to 98%. Carboxylate group of the side-chains of PIs affected their solubilities despite the high imidization ratio, and the solubility was lost for any organic solvents by decarboxylation at 280°C, confirmed from mass-loss of thermogravimetric anal. Thus, a new series of PIs were obtained with abilities of solvent-molding in PI state and thermal resistivity enhancement by further heating after molding.

Chinese Journal of Polymer Science published new progress about Glass transition temperature. 4415-87-6 belongs to class tetrahydrofurans, and the molecular formula is C8H4O6, Electric Literature of 4415-87-6.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Ishii, Hidenori; Tetsutani, Hisashi; Nagi, Tatsuya published the artcile< Improving liquid crystal alignment ability and UV sensitivity in photodecomposition polyimide film>, Reference of 4415-87-6, the main research area is carboxylic dianhydride liquid crystal UV sensitivity photodecomposition.

A liquid crystal alignment film with fewer processes capable of imparting anisotropy was developed using a polyimide, which utilized the cleavage of a cyclobutane ring by irradiation of polarized UV light at 254 nm. When an aromatic diamine with alkylene in the mol. center was used, an even methylene number of diamines showed superior liquid crystal alignment ability compared with diamines with an odd methylene number Addnl., a diamine containing a mol. structure with a pre-imidized imide group adjoined to a cyclobutane ring was extremely effective in improving liquid crystal alignment ability and sensitivity to polarized UV light.

Journal of Photopolymer Science and Technology published new progress about Anisotropy. 4415-87-6 belongs to class tetrahydrofurans, and the molecular formula is C8H4O6, Reference of 4415-87-6.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Shao, Yuewen; Wang, Junzhe; Sun, Kai; Gao, Guoming; Li, Chao; Zhang, Lijun; Zhang, Shu; Xu, Leilei; Hu, Guangzhi; Hu, Xun published the artcile< Selective hydrogenation of furfural and its derivative over bimetallic NiFe-based catalysts: Understanding the synergy between Ni sites and Ni-Fe alloy>, Category: tetrahydrofurans, the main research area is furfural hydrogenation nickel iron catalyst synergistic effect.

Pentanediols (1,2-pentanediol and 1,5-pentanediol) are important feedstock for synthesis of fine chems., production of which from the biomass-derived furfural or furfuryl alc. (FA) has been considered as a sustainable route and attracted much interest. In this study, the catalysts with Ni-Fe as the metal sites and Mg-Al layered double hydroxides (LDH) as precursor of support were synthesized. The results showed that the presence of Fe in catalyst affected both the development of the pores of the catalyst and the catalytic behaviors of nickel species. A low Fe content facilitated formation of mesoporous structure, but the higher content destroyed the LDH structure, resulting in a decreased surface area. Fe could also react with metallic Ni to form NiFe alloy. This decreased the catalytic activity for the further hydrogenation of the furan ring in FA, and FA would thus have the chance to produce pentanediols via hydrogenolysis. The in-situ diffuse reflectance IR Fourier transform spectroscopy characterization of hydrogenation of FA indicated that the alloying between Fe and Ni resulted in a weak adsorption of C=C group in furan ring and moderate adsorption of C-O-C group, which suppressed the complete hydrogenation of FA while facilitated the ring-opening of FA to form the pentanediols.

Renewable Energy published new progress about Crystallinity. 97-99-4 belongs to class tetrahydrofurans, and the molecular formula is C5H10O2, Category: tetrahydrofurans.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Noda, Takumi; Iwasaki, Takuma; Takada, Kenji; Kaneko, Tatsuo published the artcile< Soluble Biobased Polyimides from Diaminotruxinic Acid with Unique Bending Angles>, Recommanded Product: Cyclobuta[1,2-c:3,4-c’]difuran-1,3,4,6(3aH,3bH,6aH,6bH)-tetraone, the main research area is soluble bio polyimide diaminotruxinic acid bending solubility tensile thermal.

Biobased diamines with unique bending angles, β- and δ-type truxinic acids, were prepared from functionalized 4-nitrocinnamic acid derivatives via solid-state photodimerization and further chem. modification. The obtained diamines were polymerized with tetracarboxylic acid dianhydrides to produce soluble polyimides via chem. imidization at a high efficiency. The obtained δ-type-based polyimides exhibited a high thermostability at 10% weight loss temperature of ~415°C and good solubility in organic solvents. Most of the polyimides were soluble in chloroform and dichloromethane, as well as polar organic solvents. Tensile test results showed that biopolyimide films from cyclobutanetetracarboxylic dianhydride exhibited ~10.2% elongation at break, indicating high flexibility.

Macromolecules (Washington, DC, United States) published new progress about Crystal structure. 4415-87-6 belongs to class tetrahydrofurans, and the molecular formula is C8H4O6, Recommanded Product: Cyclobuta[1,2-c:3,4-c’]difuran-1,3,4,6(3aH,3bH,6aH,6bH)-tetraone.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Chandra, Anshuman; Gurjar, Vaishali; Qamar, Imteyaz; Singh, Nagendra published the artcile< Identification of potential inhibitors of SARS-COV-2 endoribonuclease (EndoU) from FDA approved drugs: a drug repurposing approach to find therapeutics for COVID-19>, Computed Properties of 58-97-9, the main research area is SARS COV2 endoribonuclease EndoU inhibitor drug repurposing; IC50; SARS-CoV-2; binding affinity; drug repurposing; endonuclease; molecular dynamic simulation.

SARS-CoV-2 is causative agent of COVID-19, which is responsible for severe social and economic disruption globally. Lack of vaccine or antiviral drug with clin. efficacy suggested that drug repurposing approach may provide a quick therapeutic solution to COVID-19. Nonstructural protein-15 (NSP15) encodes for an uridylate-specific endoribonuclease (EndoU) enzyme, essential for virus life cycle and an attractive target for drug development. We have performed in silico based virtual screening of FDA approved compounds targeting EndoU in search of COVID-19 drugs from com. available approved mols. Two drugs Glisoxepide and Idarubicin used for treatment for diabetes and leukemia, resp., were selected as stronger binder of EndoU. Both the drugs bound to the active site of the viral endonuclease by forming attractive intermol. interactions with catalytically essential amino acid residues, His235, His250, and Lys290. Mol. dynamics simulation studies showed stable conformation dynamics upon drugs binding to endoU. The binding free energies for Glisoxepide and Idarubicin were calculated to be -141±11 and -136±16kJ/mol, resp. The IC50 were predicted to be 9.2μM and 30μM for Glisoxepide and Idarubicin, resp. Comparative structural anal. showed the stronger binding of EndoU to Glisoxepide and Idarubicin than to uridine monophosphate (UMP). Surface area calculations showed buried are of 361.8 Å2 by Glisoxepide which is almost double of the area occupied by UMP suggesting stronger binding of the drug than the ribonucleotide. However, further studies on these drugs for evaluation of their clin. efficacy and dose formulations may be required, which may provide a quick therapeutic option to treat COVID-19. Communicated by Ramaswamy H. Sarma.

Journal of Biomolecular Structure and Dynamics published new progress about COVID-19. 58-97-9 belongs to class tetrahydrofurans, and the molecular formula is C9H13N2O9P, Computed Properties of 58-97-9.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Li, Xinsheng; Pang, Jifeng; Luo, Wenhao; Zhao, Yu; Pan, Xiaoli; Zheng, Mingyuan published the artcile< Catalytic Conversion of Tetrahydrofurfuryl Alcohol over Stable Pt/MoS2 Catalysts>, Recommanded Product: (Tetrahydrofuran-2-yl)methanol, the main research area is platinum molybdenum disulfide catalyst tetrahydrofurfuryl alc hydrogenation.

MoS2 supported noble metal catalysts were used for the catalytic conversion of terahydrofurfuryl alc. (THFA) to 1,5-pentanediol (1,5-PDO) and its derivate tetrahydropyrane (THP). Over the optimal 4%Pt/MoS2-FR catalyst, 75.8% overall selectivity (35.4% to 1,5-PDO and 40.4% to THP) and 63.7% conversion of 5 wt% THFA solution were obtained after 8 h reaction at 250°C. The catalyst showed stable catalytic performance in five-cycle reactions, demonstrating the robustness of Pt/MoS2 under the harsh hydrothermal and hydrogenation conditions. A variety of characterizations, including CO-DRIFTS, HRTEM, H2-TPR, Raman spectroscopy and XPS revealed that typical behavior of strong metal-support interaction (SMSI) existed between Pt and MoS2, largely caused by the coverage of MoS2 over Pt and rarely reported previously. The Pt/MoS2 had intact structure under the harsh conditions thanks to the SMSI and chem. stability of MoS2. The acidity of Pt/MoS2 was negligible, and the active sites for the reaction were attributed to Pt and the Mo sites interacting closely on the catalysts. The reaction pathway was proposed according to the product distributions and the results of conditional experiments

Catalysis Letters published new progress about Acidity. 97-99-4 belongs to class tetrahydrofurans, and the molecular formula is C5H10O2, Recommanded Product: (Tetrahydrofuran-2-yl)methanol.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Brown, David W.; Mahon, Mary F.; Ninan, Aleyamma; Sainsbury, Malcolm published the artcile< Synthesis and oxidative behavior of reduced indeno[1,2-b]quinoxalines and benzo[b]phenazines>, Formula: C8H14O2, the main research area is quinoxaline tetracyclic preparation oxidation.

New routes to tetracyclic quinoxalines have been explored and their oxidative behavior has been examined Only if such compounds are devoid of benzylic hydrogen atoms are the corresponding cation radicals stable. Attempts to prepare certain polymethylated quinoxalines failed because of steric problems, and evidence is presented to show that in the case of some monohydrochloride salts proton migration between two nitrogen atoms is discernable through 1H NMR spectroscopy.

Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry published new progress about Heterocyclization. 5455-94-7 belongs to class tetrahydrofurans, and the molecular formula is C8H14O2, Formula: C8H14O2.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Tierney, Amber R; Huepfel, William; Shaukat, Aasma P; Lake, John R; Boldt, Mark; Wang, Qi; Hassan, Mohamed A published the artcile< Direct-Acting Antiviral Therapy for Hepatitis C Infection in a Large Immigrant Community.>, Application of C9H13N2O9P, the main research area is Antiviral; Cirrhosis; Ethnicity; Hepatitis C.

Hepatitis C treatment has rapidly evolved with the arrival of direct-acting antiviral therapy. Sustained virologic response (SVR) rates in clinical trials are high but it is unknown how this translates to the immigrant community. Data from December 2013 to September 2015 was collected from a Midwest academic and community practice with a large immigrant population. There were 802 patients with an overall SVR rate of 88%. Ledipasvir/sofosbuvir was associated with favorable response among genotype 1 and 4 patients compared to other regimens (p < 0.001 and p = 0.05). Factors associated with treatment failure included advanced liver disease, male gender, East African/Middle Eastern ethnicity, and non-compliance. Patients with genotype 4 had lower SVR rates than other genotypes (58% vs. 89%, p < 0.001), particularly among East Africans (40% vs. 82% for other ethnicities). Our SVR rate for genotype 4 infection is lower than clinical trials and may be related to cultural, biologic and socioeconomic factors. Journal of immigrant and minority health published new progress about 58-97-9. 58-97-9 belongs to class tetrahydrofurans, and the molecular formula is C9H13N2O9P, Application of C9H13N2O9P.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem