Heterocyclic Building Blocks-Tetrahydrofuran

In 2019,Chemistry – An Asian Journal included an article by Ni, Jixiang; Jiang, Yong; Qi, Zhenjie; Yan, Rulong. Category: tetrahydrofurans. The article was titled 《TFAA-Catalyzed Annulation Synthesis of Spiro Pyrrolo[1,2-a]quinoxaline Derivatives from 1-(2-Aminophenyl)pyrroles and Benzoquinones/Ketones》. The information in the text is summarized as follows:

A metal-free trifluorosulfonate anhydride (TFAA)-catalyzed strategy for the synthesis of spiro pyrrolo[1,2-a]quinoxalines from 1-(2-aminophenyl)pyrroles and benzoquinones/ketones was developed. With this general method, spiro pyrrolo[1,2-a]quinoxalines were accessed via nucleophilic addition and cyclization. This reaction exhibited good functional group tolerance and a wide range of products were obtained in moderate to good yields. The results came from multiple reactions, including the reaction of 2,5-Dimethoxytetrahydrofuran(cas: 696-59-3Category: tetrahydrofurans)

2,5-Dimethoxytetrahydrofuran(cas: 696-59-3) is a member of ether. Friedel Crafts reaction, for example, adds an alkyl or acyl group to aromatic ethers when they react with an alkyl or acyl halide in the presence of a Lewis acid as a catalyst.Category: tetrahydrofurans

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

In 2019,Advanced Synthesis & Catalysis included an article by Wei, Zhao; Zhang, Jinlong; Yang, Huameng; Jiang, Gaoxi. Reference of 2,5-Dimethoxytetrahydrofuran. The article was titled 《Bronsted Acid-Catalyzed Asymmetric Ring-Closing Alkylation of Inert N-substituted Pyrroles with α, β-Unsaturated Ketones》. The information in the text is summarized as follows:

A chiral Bronsted acid catalyzed asym. intramol. ring-closing alkylation of inert pyrroles with α, β-unsaturated ketones has been developed. This approach gave a wide range of 4-phenyl-4,5-dihydro-6H-benzo[f]pyrrolo[1,2-a]azepin-6-ones in high yields with good enantioselectivities under mild reaction conditions. The experimental process involved the reaction of 2,5-Dimethoxytetrahydrofuran(cas: 696-59-3Reference of 2,5-Dimethoxytetrahydrofuran)

2,5-Dimethoxytetrahydrofuran(cas: 696-59-3) is a member of ether. Friedel Crafts reaction, for example, adds an alkyl or acyl group to aromatic ethers when they react with an alkyl or acyl halide in the presence of a Lewis acid as a catalyst.Reference of 2,5-Dimethoxytetrahydrofuran

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

The author of 《Nucleophilic Substitution of Hydrogen Atom in Initially Inactivated Pyrrole Ring》 were Pozharskii, Alexander F.; Ozeryanskii, Valery A.; Dyablo, Olga V.; Pogosova, Olga G.; Borodkin, Gennady S.; Filarowski, Aleksander. And the article was published in Organic Letters in 2019. Formula: C6H12O3 The author mentioned the following in the article:

It has been found that 1-dialkylamino-8-(pyrrolyl-1)naphthalenes I[R = Me, Me; (CH2)4], upon treatment with an equimolar amount of HBF4 under ambient conditions, produce 1-dialkylammonium salts which are transformed into 7,7-dialkyl-7H-pyrrolo[1,2-a]perimidine-7-ium tetrafluoroborates II [R = Me, Me; (CH2)4, X =BF4], resp. The reaction proceeds in a highly selective manner and represents the first case of nucleophilic substitution of hydrogen in the initially inactivated pyrrole ring. The scope and limitations of the transformation, apparently operating due to the joint action of the “”proximity effect”” and proton catalysis, are outlined. In the part of experimental materials, we found many familiar compounds, such as 2,5-Dimethoxytetrahydrofuran(cas: 696-59-3Formula: C6H12O3)

2,5-Dimethoxytetrahydrofuran(cas: 696-59-3) is a member of ether. When aromatic ethers are exposed to halogen in the presence or absence of a catalyst, they undergo halogenation, such as bromination.Formula: C6H12O3

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

《Regioselective condensation of hydroxyaromatic compounds with 2,5-dimethoxytetrahydrofuran: facile one-pot synthesis of new substituted diaryl-fused 2,8-dioxabicyclo[3.3.2]nonanes comprising central ketal moieties》 was published in New Journal of Chemistry in 2020. These research results belong to Rahmatpour, Ali. SDS of cas: 696-59-3 The article mentions the following:

A tandem one-pot double Friedel-Crafts alkylation/intramol. double cyclization process to conveniently assemble diaryl-fused 2,8-dioxabicyclo[3.3.2]nonanes with aryl substituents at the C-2 (β) position was developed. A series of new sym. 2,8-dioxabicyclo[3.3.2]nonanes fused with two Ph and two naphthyl groups was synthesized through a straightforward, one-pot protocol based on a two-component regioselective condensation reaction starting from 2,5-dimethoxytetrahydrofuran, p-substituted phenols and 2-naphthol, resp., using p-toluenesulfonic acid (PTSA) as a catalyst in methylene chloride in moderate to good yields and various substitutions on one reaction partner were tolerated. Four chem. bonds (two C-C bonds and two C-O bonds) and two seven-membered cycles were formed in a one-pot operation. In the case of condensation of 2,7-dihydroxynaphthalene with 2,5-dimethoxytetrahydrofuran, 8,16-ethano-16H-dinaphtho[2,1-d:1′,2′-g][1,3]dioxocin-2,14-diol was obtained in good yield.2,5-Dimethoxytetrahydrofuran(cas: 696-59-3SDS of cas: 696-59-3) was used in this study.

2,5-Dimethoxytetrahydrofuran(cas: 696-59-3) is a member of ether. Friedel Crafts reaction, for example, adds an alkyl or acyl group to aromatic ethers when they react with an alkyl or acyl halide in the presence of a Lewis acid as a catalyst.SDS of cas: 696-59-3

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

HPLC of Formula: 696-59-3In 2021 ,《N,N-Dimethylformamide as Carbon Synthons for the Synthesis of N-Heterocycles: Pyrrolo/Indolo[1,2-a]quinoxalines and Quinazolin-4-ones》 appeared in Journal of Organic Chemistry. The author of the article were Li, Shichen; Ren, Jianing; Ding, Chengcheng; Wang, Yishou; Ma, Chen. The article conveys some information:

N,N-dimethylformamide (DMF) as synthetic precursors contributing especially the Me, acyl, and amino groups has played a significant role in heterocycle syntheses and functionalization. In this protocol, a wide range of pyrrolo[1,2-a]quinoxalines I (R = H, Cl, Me; R1 = H, Cl, Me; R2 = H, Cl, F, Br, Me, OMe; R3 = H, Cl, F, Br, Me, CN), II /indolo[1,2-a]quinoxalines III (R4 = H, Cl, Me, CN, etc.; R5 = H, F, Cl, Me) and quinazolin-4-ones IV (R6 = H, 4-Cl, 4-NO2, 5-Fl, 5-Br; R7 = n-Bu, cyclohexyl, Ph, Bn, etc.) were obtained in moderate to good yields by using elemental iodine without any metal or peroxides. N-Me and N-acyl of DMF that participate and complete the reaction sep. through different mechanisms, which displayed potential still to be explored of DMF were considered. In addition to this study using 2,5-Dimethoxytetrahydrofuran, there are many other studies that have used 2,5-Dimethoxytetrahydrofuran(cas: 696-59-3HPLC of Formula: 696-59-3) was used in this study.

2,5-Dimethoxytetrahydrofuran(cas: 696-59-3) is a member of ether. Friedel Crafts reaction, for example, adds an alkyl or acyl group to aromatic ethers when they react with an alkyl or acyl halide in the presence of a Lewis acid as a catalyst.HPLC of Formula: 696-59-3

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Lovey, Raymond G.; Saksena, Anil K.; Girijavallabhan, Vlyyoor M. published their research in Tetrahedron Letters on August 15 ,1994. The article was titled 《PPL-catalyzed enzymic asymmetrization of a 2-substituted prochiral 1,3-diol with remote chiral functionality: improvements toward synthesis of the eutomers of SCH 45012》.Recommanded Product: 160709-02-4 The article contains the following contents:

Porcine pancreatic lipase catalysis has been used to establish both stereocenters of (tetrahydrofuranylmethyl)tosylate I. In addition to the enzymic differentiation of the hydroxyl groups of the pro-chiral 1,3-diol segment of triol (R)-II [R1 = CH(CH2OH)2], successful enzymic resolution of the racemic diol II (R1 = OH) provided an alternate route to the important precursor diol (R)-II (R1 = OH). In the experiment, the researchers used many compounds, for example, ((3R,5R)-5-((1H-1,2,4-Triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methanol(cas: 160709-02-4Recommanded Product: 160709-02-4)

((3R,5R)-5-((1H-1,2,4-Triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methanol(cas: 160709-02-4) is a member of aromaticfluorinated building blocks. Depending on which substituents are present, fluoroaromatic intermediates can be converted into fluorinated or fluorine-free commercial end products.Fluorine-containing aromatics have been incorporated into drugs (hypnotics, tranquilizers, antiinflammatory agents, analgesics, antibacterials).Recommanded Product: 160709-02-4

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

In 2022,Chen, Chen; Ding, Jie; Liu, Liying; Huang, Yujie; Zhu, Bolin published an article in Advanced Synthesis & Catalysis. The title of the article was 《Palladium-Catalyzed Domino Cyclization/Phosphorylation of gem-Dibromoolefins with P(O)H Compounds: Synthesis of Phosphorylated Heteroaromatics》.Computed Properties of C6H12O3 The author mentioned the following in the article:

We presented a palladium-catalyzed domino cyclization/phosphorylation of gem-dibromoolefins, which utilize H-phosphinates and secondary phosphine oxides as the phosphine sources, resp. A variety of phosphorylated heteroaromatics were obtained in moderate to good yields with wide functional group compatibility. This one-pot reaction enables multiple bond-forming events including C-X (X = O, N, S) and C-P bonds using easily available starting materials. Moreover, this protocol can be easily applied to large-scale preparation and late-stage functionalization.2,5-Dimethoxytetrahydrofuran(cas: 696-59-3Computed Properties of C6H12O3) was used in this study.

2,5-Dimethoxytetrahydrofuran(cas: 696-59-3) is a member of ether. Friedel Crafts reaction, for example, adds an alkyl or acyl group to aromatic ethers when they react with an alkyl or acyl halide in the presence of a Lewis acid as a catalyst.Computed Properties of C6H12O3

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Related Products of 696-59-3In 2020 ,《Symmetrical and unsymmetrical fluorine-rich ullazines via controlled cycloaromatizations》 was published in Organic Chemistry Frontiers. The article was written by Zhang, Guoxian; Gautam, Prabhat; Chan, Julian M. W.. The article contains the following contents:

Synthesis of a series of fluorine-rich ullazines I and II via well-controlled cycloaromatizations of highly electron-deficient alkynes was reported. Specifically, three sym.-functionalized and three unsym.-functionalized ullazine cores were constructed from 1-(2,6-dialkynylphenyl)-1H-pyrroles via controlled electrophilic cyclizations of highly electron-poor pentafluorosulfanylated (i.e., SF5-containing)phenylethynyl moieties onto the pyrrole. While the diminished reactivity of the electron-poor alkynes was initially problematic, this feature was subsequently found to be pivotal in facilitating thermal control of mono- vs. double 6-endo-trig ring-closure in the key step. Iodinated ullazine products were shown to undergo further facile transformation into more complex unsym. targets. The synthetic strategies reported herein granted access to a host of sym.- and unsym.-decorated fluorine-rich ullazines with potential value as light-harvesting materials (e.g., dye-sensitized solar cells, organic photovoltaics) or as advanced intermediates for further synthetic elaboration. After reading the article, we found that the author used 2,5-Dimethoxytetrahydrofuran(cas: 696-59-3Related Products of 696-59-3)

2,5-Dimethoxytetrahydrofuran(cas: 696-59-3) is a member of ether. Friedel Crafts reaction, for example, adds an alkyl or acyl group to aromatic ethers when they react with an alkyl or acyl halide in the presence of a Lewis acid as a catalyst.Related Products of 696-59-3

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

SDS of cas: 696-59-3In 2021 ,《BN/BO-Ullazines and Bis-BO-Ullazines: Effect of BO Doping on Aromaticity and Optoelectronic Properties》 was published in Journal of Organic Chemistry. The article was written by Guo, Yongkang; Zhang, Lei; Li, Chenglong; Jin, Mengjia; Zhang, Yanli; Ye, Jincheng; Chen, Yu; Wu, Xiaoming; Liu, Xuguang. The article contains the following contents:

We have achieved substitutional doping of ullazine with either two BO units or with one BO unit and one BN unit. The synthesis of these B-doped ullazines is straightforward, using demethylation and borylative cyclization as the key steps. Ullazine cores of both BN/BO-ullazines (2) and bis-BO-ullazines (3) are very close to being planar. Their electronic and photophys. properties were investigated by UV-visible, fluorescence spectroscopy, cyclic voltammetry, and d. functional theory calculations The experimental part of the paper was very detailed, including the reaction process of 2,5-Dimethoxytetrahydrofuran(cas: 696-59-3SDS of cas: 696-59-3)

2,5-Dimethoxytetrahydrofuran(cas: 696-59-3) is a member of ether. Friedel Crafts reaction, for example, adds an alkyl or acyl group to aromatic ethers when they react with an alkyl or acyl halide in the presence of a Lewis acid as a catalyst.SDS of cas: 696-59-3

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

《Comprehensive insights into xylan structure evolution via multi-perspective analysis during slow pyrolysis process》 was written by Liang, Jiajin; Chen, Jiao; Wu, Shubin; Liu, Chao; Lei, Ming. Recommanded Product: 19444-84-9 And the article was included in Fuel Processing Technology on April 30 ,2019. The article conveys some information:

Comprehension in hemicellulose pyrolysis is critical to generate renewable fuel and valuable chem. Herein, a self-designed tubular reactor was applied to observe the appearance alteration and chem. structure evolution during the whole xylan pyrolysis process. Before 200°C, it was free moisture removal stage without significant chem. structure alteration. Xylan began to depolymerize at 200°C corresponding with the appearance change from its original state to dark brown, cleavage of branched-chain and primary product acids & ketones generation. The main chain of xylan was completely broken at 250-350°C via β-1,4-glycosidic bond cleavage, dehydration, decarboxylation, and decarbonylation reaction. Acids were mainly originated from hemicellulose pyrolysis. The typical signals from FTIR, 13C CP/MAS NMR were disappeared at 350°C. In the carbonation stage, the C/H and C/O ratio reached 2.01 and 4.54, leading to the aromaticity enhancement of char and formation of carbon-centered radicals.3-Hydroxydihydrofuran-2(3H)-one(cas: 19444-84-9Recommanded Product: 19444-84-9) was used in this study.

3-Hydroxydihydrofuran-2(3H)-one(cas: 19444-84-9) may be employed as starting reagent in the synthesis of series of seco-pseudonucleoside synthons via aminolysis. It may be employed as starting reagent in the synthesis of enantiomerically pure orthogonally protected δ-azaproline, via Mitsunobu reaction.Recommanded Product: 19444-84-9

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem