Heterocyclic Building Blocks-Tetrahydrofuran

Application of 696-59-3In 2019 ,《Effects of fused rings linked to the 2,5-position of pyrrole derivatives with near-infrared emission on their aggregation-enhanced emission properties》 appeared in Materials Chemistry Frontiers. The author of the article were Ren, Fei; Shi, Jianbing; Tong, Bin; Cai, Zhengxu; Dong, Yuping. The article conveys some information:

Fluorescent materials with near-IR (NIR) emission are important kinds of functional dyes for bioimaging and medical diagnosis. In this work, a type of pyrrole derivative with NIR emission was designed and synthesized through the introduction of different fused rings at the 2,5-position of pyrrole (MAP) and a furanylidene (FE) group at the 3-position of pyrrole (MAP-FE), which constructed a typical donor-π bridge-acceptor (D-π-A) structure. All MAP-FEs have shown aggregation-enhanced emission (AEE) properties. Different fused rings or different positions of substitution on the same fused ring had significant effects on the NIR photoluminescence (PL) properties. In addition, by comparison with the change in the radiative and nonradiative rates of the precursor MAPs and MAP-FEs in solution and the solid state, it can be concluded that the rings fused to the 2,5-position of pyrrole have a two-sided effect on the PL properties of organic dyes: one effect is an improvement in the quantum yield, and the other effect causes a π-π stacking interaction that is unfavorable for emission. The introduction of FE groups as acceptors in MAP-FEs not only red shifted emission wavelengths but also effectively avoided π-π stacking in the aggregated state, which are beneficial for PL properties. These results could provide general guidance for designing NIR dyes with AEE characteristics when using fused rings to improve their PL properties. In the experimental materials used by the author, we found 2,5-Dimethoxytetrahydrofuran(cas: 696-59-3Application of 696-59-3)

2,5-Dimethoxytetrahydrofuran(cas: 696-59-3) is a member of ether. Friedel Crafts reaction, for example, adds an alkyl or acyl group to aromatic ethers when they react with an alkyl or acyl halide in the presence of a Lewis acid as a catalyst.Application of 696-59-3

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Electric Literature of C6H12O3In 2020 ,《Terminal methyl as a one-carbon synthon: Synthesis of quinoxaline derivatives via radical-type transformation》 appeared in New Journal of Chemistry. The author of the article were Wang, Xinfeng; Liu, Huanhuan; Xie, Caixia; Zhou, Feiyu; Ma, Chen. The article conveys some information:

An iron-promoted method for the construction of pyrrolo[1,2-a]quinoxaline derivatives I [R1 = H, 7-Me, 7-Br, 8-Cl, etc., R2 = H, Me, X, Y = CH, N] and indolo[1,2-a]quinaxaline derivatives II [R3 = H, 3-F, 2-OMe, etc., R4 = H, Me] was developed via sp3 C-H activation and oxidative cyclization of pyrrolyl-anilines/indolyl-anilines and various carbon sources. This method has many advantages including the availability of raw materials, simple operation, reaction efficiency, universal solvent applicability and wide substrate scope. The experimental part of the paper was very detailed, including the reaction process of 2,5-Dimethoxytetrahydrofuran(cas: 696-59-3Electric Literature of C6H12O3)

2,5-Dimethoxytetrahydrofuran(cas: 696-59-3) is a member of ether. Friedel Crafts reaction, for example, adds an alkyl or acyl group to aromatic ethers when they react with an alkyl or acyl halide in the presence of a Lewis acid as a catalyst.Electric Literature of C6H12O3

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

《Processing chocolate milk drink by low-pressure cold plasma technology》 was written by Coutinho, Nathalia M.; Silveira, Marcello R.; Fernandes, Leonardo M.; Moraes, Jeremias; Pimentel, Tatiana C.; Freitas, Monica Q.; Silva, Marcia C.; Raices, Renata S. L.; Ranadheera, C. Senaka; Borges, Fabio O.; Neto, Roberto P. C.; Tavares, Maria Ines B.; Fernandes, Fabiano A. N.; Fonteles, Thatyane V.; Nazzaro, Filomena; Rodrigues, Sueli; Cruz, A. G.. Application In Synthesis of 3-Hydroxydihydrofuran-2(3H)-one And the article was included in Food Chemistry on April 25 ,2019. The article conveys some information:

This study aimed to evaluate the effect of the process time (5, 10, and 15 min) and flow rate (10, 20, and 30 mL/min) of cold plasma technol. on physio-chem. characteristics (pH), bioactive compounds (DPPD, Total Phenolic Compounds, ACE-inhibitory activity values), fatty acid composition, and volatile compounds profile of chocolate milk drink. The mild (lower flow rate and process time) and more severe (higher flow rate and process time) conditions led to a reduction of the bioactive compounds (total phenolic compounds and ACE-inhibitory activity), changes in fatty acid composition (increased saturated fatty acid and decreased monounsaturated fatty acid and polyunsaturated fatty acid), less favorable health indexes (higher atherogenic, thrombogenic and hypercholesterolemic saturated fatty acids and lower desired fatty acids), and lower number of volatile compounds In contrast, in intermediate cold plasma conditions, an adequate concentration of bioactive compounds, fatty acid composition, and health indexes, and increased number of volatile compounds (ketones, esters, and lactones) were observed Overall, cold plasma technol. has proven to be an interesting alternative to chocolate milk drinks, being of paramount importance the study of the cold plasma process parameters. In addition to this study using 3-Hydroxydihydrofuran-2(3H)-one, there are many other studies that have used 3-Hydroxydihydrofuran-2(3H)-one(cas: 19444-84-9Application In Synthesis of 3-Hydroxydihydrofuran-2(3H)-one) was used in this study.

3-Hydroxydihydrofuran-2(3H)-one(cas: 19444-84-9) may be employed as starting reagent in the synthesis of series of seco-pseudonucleoside synthons via aminolysis. It may be employed as starting reagent in the synthesis of enantiomerically pure orthogonally protected δ-azaproline, via Mitsunobu reaction.Application In Synthesis of 3-Hydroxydihydrofuran-2(3H)-one

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

《The composition, physicochemical properties, antimicrobial and antioxidant activity of wood vinegar prepared by pyrolysis of Eucommia ulmoides Oliver branches under different refining methods and storage conditions》 was written by Xue, Rui; Cui, Er-Liang; Hu, Guo-Quan; Zhu, Ming-Qiang. Recommanded Product: 2,5-DimethoxytetrahydrofuranThis research focused onWV EUO pyrolysis refining storage antimicrobial antioxidant physicochem property. The article conveys some information:

To enhance the quality of wood vinegar (WV), the WV prepared by pyrolyzing Eucommia ulmoides Oliver (EUO) branches at the temperature of 650°C were refined by using different physicochem. methods. The crude WV was refined by ultra-low freezing and thawing (WVFT), charcoal adsorption (WVCA), and activated carbon adsorption (WVACA), resp. Meanwhile, the chem. compositions, antimicrobial and antioxidant activity of the crude WV (WVC), the WV (WVS) prepared two years ago, and the photolysis WV (WVP) were investigated. The results showed that the WVFT obtained by ultra-low freezing and thawing method possessed better quality with pH of 3.45, d. of 1.045 g/cm3 , refractive index of 26.85% and total organic acid of 11.00%. It was also found that WVFT had better inhibition rate of 83.33% against Bacterium prodigiosum, indication the excellent antibacterial activity. Moreover, WVFT had significant effect on scavenging rate (98.72%) for hydroxyl radicals. This research could offer some references for the refining methods of WV, and the WV was expected to be a potential candidate for materials of antioxidant and antimicrobial. In the experiment, the researchers used 2,5-Dimethoxytetrahydrofuran(cas: 696-59-3Recommanded Product: 2,5-Dimethoxytetrahydrofuran)

2,5-Dimethoxytetrahydrofuran(cas: 696-59-3) is a member of ether. When aromatic ethers are exposed to halogen in the presence or absence of a catalyst, they undergo halogenation, such as bromination.Recommanded Product: 2,5-Dimethoxytetrahydrofuran

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

HPLC of Formula: 160709-02-4On March 15, 2015, Jin, Feng-min; Zhang, Jing published an article in Zhongguo Xinyao Zazhi. The article was 《Synthesis of posaconazole》. The article mentions the following:

Objective: To improve the synthesis process of posaconazole. Methods: Posaconazole was synthesized from 1-(1-bromomethyl-vinyl)-2,4-difluoro-benzene by several reactions such as esterification, reduction and enzymic acetylation. Results: The overall yield was 27.7%. Conclusion: This synthetic process had the advantages of simpler purifying operation, lower cost and mild condition, so it could be used in industrial manufacturing In the experiment, the researchers used many compounds, for example, ((3R,5R)-5-((1H-1,2,4-Triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methanol(cas: 160709-02-4HPLC of Formula: 160709-02-4)

((3R,5R)-5-((1H-1,2,4-Triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methanol(cas: 160709-02-4) is a member of aromaticfluorinated building blocks. Depending on which substituents are present, fluoroaromatic intermediates can be converted into fluorinated or fluorine-free commercial end products.Fluorine-containing aromatics have been incorporated into drugs (hypnotics, tranquilizers, antiinflammatory agents, analgesics, antibacterials).HPLC of Formula: 160709-02-4

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Recommanded Product: 19444-84-9On March 31, 2021, Kim, Jung-Hun; Jung, Sungyup; Lin, Kun-Yi Andrew; Rinklebe, Jorg; Kwon, Eilhann E. published an article in Bioresource Technology. The article was 《Comparative study on carbon dioxide-cofed catalytic pyrolysis of grass and woody biomass》. The article mentions the following:

This study investigated the mechanistic functions of CO2 on the pyrolysis of two different biomasses to elucidate the effect of CO2 on syngas formations during pyrolysis. To this end, CO2-assisted pyrolysis of cellulosic biomass (barnyard grass, Echinochloa) and lignin-rich woody biomass (retinispora, Chamaecyparis obtusa) were compared. The confirmed mechanistic effectiveness of CO2 on pyrolysis of biomass was gas phase reactions between CO2 and volatile matters from biomass pyrolysis. Lignin-rich biomass had more CO2 susceptibility, resulting in more enhanced CO formation via the gas phase reactions. To expedite the slow reaction rate of the gas phase reactions during biomass pyrolysis, earth-abundant catalysts (Co/SiO2 and Ni/SiO2) were employed for pyrolysis of two biomass substrates. With Co and Ni catalysts, the syngas formations were 2 and 3 times higher comparing to the pyrolysis of without catalyst. The cumulative formations of syngas from lignin-rich biomass was nearly doubled than that from cellulosic biomass. In the experimental materials used by the author, we found 3-Hydroxydihydrofuran-2(3H)-one(cas: 19444-84-9Recommanded Product: 19444-84-9)

3-Hydroxydihydrofuran-2(3H)-one(cas: 19444-84-9) may be employed as starting reagent in the synthesis of series of seco-pseudonucleoside synthons via aminolysis. It may be employed as starting reagent in the synthesis of enantiomerically pure orthogonally protected δ-azaproline, via Mitsunobu reaction.Recommanded Product: 19444-84-9

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Quality Control of 3-Hydroxydihydrofuran-2(3H)-oneOn May 1, 2019 ,《Guava-flavored whey beverage processed by cold plasma technology: Bioactive compounds, fatty acid profile and volatile compounds》 appeared in Food Chemistry. The author of the article were Silveira, Marcello R.; Coutinho, Nathalia M.; Esmerino, Erick A.; Moraes, Jeremias; Fernandes, Leonardo M.; Pimentel, Tatiana C.; Freitas, Monica Q.; Silva, Marcia C.; Raices, Renata S. L.; Senaka Ranadheera, C.; Borges, Fabio O.; Neto, Roberto P. C.; Tavares, Maria Ines B.; Fernandes, Fabiano A. N.; Fonteles, Thatyane V.; Nazzaro, Filomena; Rodrigues, Sueli; Cruz, Adriano G.. The article conveys some information:

The effect of cold plasma processing time and gas flow on bioactive compounds such as vitamin C, carotenoids and phenolic compounds, DPPH, angiotensin-converting-enzyme (ACE) inhibitory activity, fatty acids profile, and volatile compounds of guava-flavored whey beverage was investigated. For comparative purposes, a pasteurized beverage was also manufactured Cold plasma increased the concentration of bioactive and volatile compounds, and proportionated changes in the fatty acids profile. The milder conditions like lower flow rate and processing time, resulted in higher vitamin C and volatile compounds levels, and higher antioxidant activity, but with a lower carotenoids content and a less favorable fatty acids profile. More drastic conditions like higher flow rate and processing time resulted in products with lower vitamin C and volatile compounds levels, but with higher carotenoids content and ACE inhibitory activity. It can be concluded that the cold plasma processing can improve the properties of the guava-flavored whey beverages (increased concentration of bioactive and volatile compounds), while the effect on the fatty acid profile and ACE inhibitory activity is dependent on the process parameters (processing time and flow rate). In the experiment, the researchers used 3-Hydroxydihydrofuran-2(3H)-one(cas: 19444-84-9Quality Control of 3-Hydroxydihydrofuran-2(3H)-one)

3-Hydroxydihydrofuran-2(3H)-one(cas: 19444-84-9) may be employed as starting reagent in the synthesis of series of seco-pseudonucleoside synthons via aminolysis. It may be employed as starting reagent in the synthesis of enantiomerically pure orthogonally protected δ-azaproline, via Mitsunobu reaction.Quality Control of 3-Hydroxydihydrofuran-2(3H)-one

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Chen, Yuce; Cao, Xiaofeng; Chen, Xi; Li, Zhong; Xu, Xiaoyong published their research in Journal of Chemical Research in 2021. The article was titled 《The structure modification of seven-membered aza-brigded neonicotinoids in order to investigate their impact on honey bees》.Name: 2,5-Dimethoxytetrahydrofuran The article contains the following contents:

In order to explore the relationship between the structure and the toxicity to honey bees of seven-membered aza-bridged neonicotinoids, 16 novel seven-membered aza-bridged neonicotinoid analogs are synthesized by replacing the pyridine ring, and changing the substituents on the pyridine ring, the electron-withdrawing group NO2 and the imidazole ring of authors’ previously developed aza-bridged neonicotinoid 1-[(6-chloropyridin-3-yl)methyl]-10-(2,5-dimethylphenyl)-9-nitro-2,3,5,6,7,8-hexahydro-1H-5,8-epiminoimidazo azepine. The insecticidal bioactivities against cowpea aphid (Aphis craccivora) and the bee toxicities of these compounds are tested. Some of the title compounds present good insecticidal activities against cowpea aphid. The results also show that some of the title compounds exhibit lower bee toxicity than that of 1-[(6-chloropyridin-3-yl)methyl]-10-(2,5-dimethylphenyl)-9-nitro-2,3,5,6,7,8-hexahydro-1H-5,8-epiminoimidazo azepine and imidacloprid. This suggests that changing the substituents on the neonicotinoids can influence the toxicity toward honey bees of these analogs. The experimental process involved the reaction of 2,5-Dimethoxytetrahydrofuran(cas: 696-59-3Name: 2,5-Dimethoxytetrahydrofuran)

2,5-Dimethoxytetrahydrofuran(cas: 696-59-3) is a member of ether. Friedel Crafts reaction, for example, adds an alkyl or acyl group to aromatic ethers when they react with an alkyl or acyl halide in the presence of a Lewis acid as a catalyst.Name: 2,5-Dimethoxytetrahydrofuran

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Liu, Meiyan; Cui, Mingkuan; Zhang, Lei; Guo, Yongkang; Xu, Xiaoyang; Li, Wenlong; Li, Yuanhao; Zhen, Bin; Wu, Xiaoming; Liu, Xuguang published an article in 2022. The article was titled 《The rapid construction of bis-BN dipyrrolyl[a,j]anthracenes and a direct comparison with a carbonaceous analogue》, and you may find the article in Organic Chemistry Frontiers.Synthetic Route of C6H12O3 The information in the text is summarized as follows:

A series of bis-BN dipyrrolyl[a,j]anthracenes and one of their representative carbonaceous analogs have been synthesized in a short number of steps. Bis-BN dipyrrolyl[a,j]anthracenes are strongly fluorescent in solution Both the absorption and emission spectra of bis-BN dipyrrolyl[a,j]anthracenes are blue shifted compared to the carbonaceous analog. Moreover, organic light-emitting diodes based on these compounds were fabricated via a solution method. In particular, device II with 4b as an emitter presents a pure-blue emitting color with a high current efficiency (3.84 cd A-1) and CIE coordinates of (0.18, 0.21), whereas device VII based on the carbonaceous analog displays yellowish-green luminescence with lower efficiency. In addition to this study using 2,5-Dimethoxytetrahydrofuran, there are many other studies that have used 2,5-Dimethoxytetrahydrofuran(cas: 696-59-3Synthetic Route of C6H12O3) was used in this study.

2,5-Dimethoxytetrahydrofuran(cas: 696-59-3) is a member of ether. When aromatic ethers are exposed to halogen in the presence or absence of a catalyst, they undergo halogenation, such as bromination.Synthetic Route of C6H12O3

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem